Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CHD-1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
CHD-1 a sequence-selective DNA-binding protein. Contains two chromo (chromatin organization modifier) domains and one SNF2-related helicase and ATPase domains. May play an important role in gene regulation. Note: This description may include information from UniProtKB.
Protein type: Helicase; EC 3.6.4.12; EC 3.6.1.-
Cellular Component: cytoplasm; nucleus
Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; ATP binding; methylated histone residue binding
Biological Process: chromatin remodeling; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; DNA duplex unwinding
Reference #:  O14646 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent helicase CHD1; CHD-1; CHD1; chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1; DKFZp686E2337
Gene Symbols: CHD1
Molecular weight: 196,688 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

CHD-1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 4 S5 ___MNGHSDEESVRN
0 7 S89-p DGAEFWKssPsILAV
0 8 S90-p GAEFWKssPsILAVQ
0 2 S92-p EFWKssPsILAVQRS
0 1 S117 QQQQHQASSNSGSEE
0 1 S118 QQQHQASSNSGSEED
0 1 S120 QHQASSNSGSEEDSS
0 1 S135 SSEDSDDSSSEVKRK
0 1 S136 SEDSDDSSSEVKRKK
0 1 S137 EDSDDSSSEVKRKKH
0 5 T178-p EKSSCDEtESDyEPK
0 5 Y182-p CDEtESDyEPKNKVK
0 18 S215-p QKKRQIDssEEDDDE
0 18 S216-p KKRQIDssEEDDDEE
0 3 Y225-p EDDDEEDyDNDKRSS
0 1 T237-p RSSRRQAtVNVsYKE
0 2 S241-p RQAtVNVsYKEDEEM
0 3 T250-p KEDEEMKtDsDDLLE
0 3 S252-p DEEMKtDsDDLLEVC
0 1 S398-p VERIIAHsNQKSAAG
0 2 T449-p SRNQSKTtPFKDCKV
0 1 S471-p VALKKQPsYIGGHEG
0 2 S719-p QILRMEMsALQKQYY
0 2 S738-p TRNYKALsKGSKGSt
0 2 T745-p sKGSKGStSGFLNIM
0 1 Y823-p MLDILAEyLKYRQFP
0 1 S1025-p QFKVANFsNMDEDDI
0 5 S1040-p ELEPERNsKNWEEII
0 161 Y1068-p QKELEEIyMLPRMRN
0 3 S1081-p RNCAKQIsFNGsEGR
0 1 S1085-p KQIsFNGsEGRRSRS
0 2 Y1095-p RRSRSRRysGsDsDs
0 11 S1096-p RSRSRRysGsDsDsI
0 11 S1098-p RSRRysGsDsDsISE
0 6 S1100-p RRysGsDsDsISEGK
0 5 S1102-p ysGsDsDsISEGKRP
0 2 K1124-u TIPRENIkGFsDAEI
0 3 S1127-p RENIkGFsDAEIRRF
0 1 S1161-p DAELVDKsETDLRRL
0 1 S1283 IKMDPDLSLTHKILP
0 1 T1285 MDPDLSLTHKILPDD
0 4 S1324-p LAKKEALsGAGsSKR
0 2 S1328-p EALsGAGsSKRRKAR
0 2 K1346-a NKAMKSIkVKEEIKs
0 8 S1353-p kVKEEIKsDssPLPs
0 7 S1355-p KEEIKsDssPLPsEK
0 6 S1356-p EEIKsDssPLPsEKs
0 6 S1360-p sDssPLPsEKsDEDD
0 1 S1363-p sPLPsEKsDEDDDKL
0 1 S1371-p DEDDDKLsEsKSDGR
0 1 S1373-p DDDKLsEsKSDGRER
0 2 S1385-p RERSKKSsVsDAPVH
0 2 S1387-p RSKKSsVsDAPVHIT
0 1 S1396-p APVHITAsGEPVPIs
0 1 S1403-p sGEPVPIsEEsEELD
0 1 S1406-p PVPIsEEsEELDQKT
0 1 N1618 RSRDHRSNLEGsLKD
0 3 S1622-p HRSNLEGsLKDRSHS
0 2 S1662-p SRDYRYHsDWQMDHR
0 2 S1672-p QMDHRASssGPRsPL
0 2 S1673-p MDHRASssGPRsPLD
0 32 S1677-p ASssGPRsPLDQRsP
0 16 S1683-p RsPLDQRsPyGsRsP
0 2 Y1685-p PLDQRsPyGsRsPFE
0 8 S1687-p DQRsPyGsRsPFEHs
0 21 S1689-p RsPyGsRsPFEHsVE
0 1 S1694-p sRsPFEHsVEHKstP
0 7 S1699-p EHsVEHKstPEHTWS
0 15 T1700-p HsVEHKstPEHTWSS
  CHD-1 iso2  
S5 ___MNGHSDEESVRN
S89 DGAEFWKSSPSILAV
S90 GAEFWKSSPSILAVQ
S92 EFWKSSPSILAVQRS
S117 QQQQHQASSNSGSEE
S118 QQQHQASSNSGSEED
S120 QHQASSNSGSEEDSS
S135 SSEDSDDSSSEVKRK
S136 SEDSDDSSSEVKRKK
S137 EDSDDSSSEVKRKKH
T178 EKSSCDETESDYEPK
Y182 CDETESDYEPKNKVK
S215 QKKRQIDSSEEDDDE
S216 KKRQIDSSEEDDDEE
Y225 EDDDEEDYDNDKRSS
T237 RSSRRQATVNVSYKE
S241 RQATVNVSYKEDEEM
T250 KEDEEMKTDSDDLLE
S252 DEEMKTDSDDLLEVC
S398 VERIIAHSNQKSAAG
T449 SRNQSKTTPFKDCKV
S471 VALKKQPSYIGGHEG
S719 QILRMEMSALQKQYY
S738 TRNYKALSKGSKGST
T745 SKGSKGSTSGFLNIM
Y823 MLDILAEYLKYRQFP
S1025 QFKVANFSNMDEDDI
S1040 ELEPERNSKNWEEII
Y1068 QKELEEIYMLPRMRN
S1081 RNCAKQISFNGSEGR
S1085 KQISFNGSEGRRSRS
Y1095 RRSRSRRYSGSDSDS
S1096 RSRSRRYSGSDSDSI
S1098 RSRRYSGSDSDSISE
S1100 RRYSGSDSDSISEGK
S1102 YSGSDSDSISEGKRP
K1124 TIPRENIKGFSDAEI
S1127 RENIKGFSDAEIRRF
S1161 DAELVDKSETDLRRL
S1283 IKMDPDLSLTHKILP
T1285 MDPDLSLTHKILPDD
S1324 LAKKEALSGAGSSKR
S1328 EALSGAGSSKRRKAR
K1346 NKAMKSIKVKEEIKS
S1353 KVKEEIKSDSSPLPS
S1355 KEEIKSDSSPLPSEK
S1356 EEIKSDSSPLPSEKS
S1360 SDSSPLPSEKSDEDD
S1363 SPLPSEKSDEDDDKL
S1371 DEDDDKLSESKSDGR
S1373 DDDKLSESKSDGRER
S1385 RERSKKSSVSDAPVH
S1387 RSKKSSVSDAPVHIT
S1396 APVHITASGEPVPIS
S1403 SGEPVPISEESEELD
S1406 PVPISEESEELDQKT
N1618 RSRDHRSNLEGSLKD
S1622 HRSNLEGSLKDRSHS
S1662 SRDYRYHSDWQMDHR
S1672 QMDHRASSSGPRSPL
S1673 MDHRASSSGPRSPLD
S1677 ASSSGPRSPLDQRSY
S1683 RSPLDQRSYGSRsPF
Y1684 SPLDQRSYGSRsPFE
S1686 LDQRSYGSRsPFEHS
S1688-p QRSYGSRsPFEHSVE
S1693 SRsPFEHSVEHKSTP
S1698 EHSVEHKSTPEHTWS
T1699 HSVEHKSTPEHTWSS
  mouse

 
S5-p ___MNGHsDEESVRN
S89-p DGAEFWKssPsILAV
S90-p GAEFWKssPsILAVQ
S92-p EFWKssPsILAVQRS
S116 AQQQRPASSNSGSEE
S117 QQQRPASSNSGSEED
S119 QRPASSNSGSEEDSS
S134 SSEDSDDSSSGAKRK
S135 SEDSDDSSSGAKRKK
S136 EDSDDSSSGAKRKKH
T177 DKSSCDGTESDYEPK
Y181 CDGTESDYEPKNKVR
S214-p QKKRQIDssEDEDDE
S215-p KKRQIDssEDEDDED
Y223 EDEDDEDYDNDKRSS
T235 RSSRRQATVNVSYKE
S239 RQATVNVSYKEDEEM
T248-p KEDEEMKtDsDDLLE
S250-p DEEMKtDsDDLLEVC
S396 VERIIAHSNQKSAAG
T447 SRNQSKTTPFKDCKV
S469 VALKKQPSYIGGHEG
S717 QILRMEMSALQKQYY
S736 TRNYKALSKGSKGST
T743 SKGSKGSTSGFLNIM
Y821 MLDILAEYLKYRQFP
S1023 QFKVANFSNMDEDDI
S1038-p ELEPERNsKNWEEII
Y1066-p QKELEEIyMLPRMRN
S1079 RNCAKQISFNGSEGR
S1083 KQISFNGSEGRRSRS
Y1093 RRSRSRRYsGsDsDs
S1094-p RSRSRRYsGsDsDsI
S1096-p RSRRYsGsDsDsISE
S1098-p RRYsGsDsDsISERK
S1100-p YsGsDsDsISERKRP
K1122 TIPRENIKGFsDAEI
S1125-p RENIKGFsDAEIRRF
S1159 DAELVDKSETDLRRL
S1281-p IKMDPDLsLtHKILP
T1283-p MDPDLsLtHKILPDD
C1324 KREAQRLCGAGGSKR
G1328 QRLCGAGGSKRRKTR
K1346 SKAMKSIKVKEEIKs
S1353-p KVKEEIKsDssPLPs
S1355-p KEEIKsDssPLPsEK
S1356-p EEIKsDssPLPsEKS
S1360-p sDssPLPsEKSDEDD
S1363 sPLPsEKSDEDDDKL
N1371 DEDDDKLNDSKPESK
S1373 DDDKLNDSKPESKDR
V1385 KDRSKKSVVSDAPVH
S1387 RSKKSVVSDAPVHIT
S1396 APVHITASGEPVPIA
A1403 SGEPVPIAEESEELD
S1406 PVPIAEESEELDQKT
S1619-p RSREHRPsLEGGLKD
G1623 HRPsLEGGLKDRCHS
S1663-p SRDYRYLsDWQLDHR
S1673-p QLDHRAAssGPRsPL
S1674-p LDHRAAssGPRsPLD
S1678-p AAssGPRsPLDQRsP
S1684-p RsPLDQRsPyGsRsP
Y1686-p PLDQRsPyGsRsPFE
S1688-p DQRsPyGsRsPFEHS
S1690-p RsPyGsRsPFEHSAE
S1695 sRsPFEHSAEHRStP
S1700 EHSAEHRStPEHTWS
T1701-p HSAEHRStPEHTWSS
  rat

 
S5 ___MNGHSDEESVRN
S89 DGAEFWKSNPSILAV
N90 GAEFWKSNPSILAVQ
S92 EFWKSNPSILAVQRS
S116-p PQQQRPAssNsGSEE
S117-p QQQRPAssNsGSEED
S119-p QRPAssNsGSEEDSS
S134-p SSEDSDAsssDVKRK
S135-p SEDSDAsssDVKRKK
S136-p EDSDAsssDVKRKKH
T177 DKSSCDGTESDYEPK
Y181 CDGTESDYEPKNKVK
S214 QKKRQIDSSEDEDDE
S215 KKRQIDSSEDEDDED
Y223 EDEDDEDYDNDKRSS
T235 RSSRRQATVNVSYKE
S239 RQATVNVSYKEDEEM
T248 KEDEEMKTDSDDLLE
S250 DEEMKTDSDDLLEVC
S396 VERIIAHSNQKSAAG
T447 SRNQSKTTPFKDCKV
S469 VALKKQPSYIGGHEG
S717 QILRMEMSALQKQYY
S736 TRNYKALSKGSKGST
T743 SKGSKGSTSGFLNIM
Y821 MLDILAEYLKYRQFP
S1023 QFKVANFSNMDEDDI
S1038 ELEPERNSKNWEDII
Y1066 QKELEEIYMLPRMRN
S1079 RNCAKQISFNGSEGR
S1083 KQISFNGSEGRRSRS
Y1093 RRSRSRRYSGSDSDS
S1094 RSRSRRYSGSDSDSI
S1096 RSRRYSGSDSDSISE
S1098 RRYSGSDSDSISERK
S1100 YSGSDSDSISERKRP
K1122 TIPRENIKGFSDAEI
S1125 RENIKGFSDAEIRRF
S1159 DAELVDKSETDLRRL
S1281 IKMDPDLSLTHKILP
T1283 MDPDLSLTHKILPDD
S1324 KKEAQRLSGAGGSKR
G1328 QRLSGAGGSKRRKTR
K1346 NKAMKSIKVKEEIKS
S1353 KVKEEIKSDSSPLPS
S1355 KEEIKSDSSPLPSER
S1356 EEIKSDSSPLPSERS
S1360 SDSSPLPSERSEEED
S1363 SPLPSERSEEEDDNV
N1371 EEEDDNVNDSKPESK
S1373 EDDNVNDSKPESKDR
V1385 KDRSKKSVVSDAPVH
S1387 RSKKSVVSDAPVHIT
S1396 APVHITASGEPVPIA
A1403 SGEPVPIAEESEELD
S1406 PVPIAEESEELDQKT
S1619 RSREHRPSVEGSLKD
S1623 HRPSVEGSLKDRCHS
S1663 SRDYRYLSDWQLDHR
S1673 QLDHRAASSGPRSPL
S1674 LDHRAASSGPRSPLD
S1678 AASSGPRSPLDQRSP
S1684 RSPLDQRSPYGSRSP
Y1686 PLDQRSPYGSRSPFE
S1688 DQRSPYGSRSPFEHS
S1690 RSPYGSRSPFEHSAE
S1695 SRSPFEHSAEHRSTP
S1700 EHSAEHRSTPEHTWS
T1701 HSAEHRSTPEHTWSS
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.