Home

CHD-1 (human)

Overview CHD-1 a sequence-selective DNA-binding protein. Contains two chromo (chromatin organization modifier) domains and one SNF2-related helicase and ATPase domains. May play an important role in gene regulation. Note: This description may include information from UniProtKB. Protein type: EC 3.6.1.-; Helicase; EC 3.6.4.12 Cellular Component: cytoplasm; nucleus Molecular Function: ATP-dependent DNA helicase activity; protein binding; DNA binding; ATP binding; methylated histone residue binding Biological Process: regulation of transcription from RNA polymerase II promoter; chromatin remodeling; transcription, DNA-dependent Reference #:  O14646 (UniProtKB) Alt. Names/Synonyms: ATP-dependent helicase CHD1; CHD-1; CHD1; chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1; DKFZp686E2337 Gene Symbols: CHD1 Molecular weight: 196,688 Da Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below CHD-1 2B2T - A/B=268-443, C=268-373 (human) 2B2U - A=268-443, B=268-445, C=268-373 (human) 2B2V - A/B=268-443, C=268-373 (human) 2B2W - A=268-443, B=268-445, C=268-373 (human) 2B2Y - A/B=268-443, C=268-373 (human) 4B4C - A=1119-1327 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2B2T 2B2U 2B2V 2B2W 2B2Y 4B4C  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	4		S5	___MNGHSDEESVRN
0	7		S89-p	DGAEFWKssPsILAV
0	8		S90-p	GAEFWKssPsILAVQ
0	2		S92-p	EFWKssPsILAVQRS
0	1		S117	QQQQHQASSNSGSEE
0	1		S118	QQQHQASSNSGSEED
0	1		S120	QHQASSNSGSEEDSS
0	1		S135	SSEDSDDSSSEVKRK
0	1		S136	SEDSDDSSSEVKRKK
0	1		S137	EDSDDSSSEVKRKKH
0	5		T178-p	EKSSCDEtEsDyEPK
0	1		S180-p	SSCDEtEsDyEPKNK
0	5		Y182-p	CDEtEsDyEPKNKVK
0	16		S215-p	QKKRQIDssEEDDDE
0	16		S216-p	KKRQIDssEEDDDEE
0	3		Y225-p	EDDDEEDyDNDKRSs
0	1		S232-p	yDNDKRSsRRQAtVN
0	1		T237-p	RSsRRQAtVNVsYKE
0	2		S241-p	RQAtVNVsYKEDEEM
0	3		T250-p	KEDEEMKtDsDDLLE
0	3		S252-p	DEEMKtDsDDLLEVC
0	1		K348-a	QNVRGMKkLDNYKKK
0	1		Y388-p	TDDLHKQyQIVERII
0	1		S398-p	VERIIAHsNQKSAAG
0	2		T449-p	SRNQSKTtPFKDCKV
0	1		Y472-p	ALKKQPSyIGGHEGL
0	1		Y681	EHGKGREYGYASLHK
0	1		Y683	GKGREYGYASLHKEL
0	2		S719-p	QILRMEMsALQKQYY
0	2		S738-p	TRNYKALsKGSKGSt
0	2		T745-p	sKGSKGStSGFLNIM
0	1		Y823-p	MLDILAEyLKYRQFP
0	1		S1025-p	QFKVANFsNMDEDDI
0	4		S1040-p	ELEPERNsKNWEEII
0	161		Y1068-p	QKELEEIyMLPRMRN
0	2		S1081-p	RNCAKQIsFNGsEGR
0	1		S1085-p	KQIsFNGsEGRRSRS
0	2		Y1095-p	RRSRSRRysGsDsDs
0	9		S1096-p	RSRSRRysGsDsDsI
0	9		S1098-p	RSRRysGsDsDsISE
0	5		S1100-p	RRysGsDsDsISEGK
0	4		S1102-p	ysGsDsDsISEGKRP
0	2		K1124-u	TIPRENIkGFsDAEI
0	3		S1127-p	RENIkGFsDAEIRRF
0	1		S1183-p	CIKALKDssSGtERT
0	1		S1184-p	IKALKDssSGtERTG
0	1		T1187-p	LKDssSGtERTGGRL
0	1		S1283	IKMDPDLSLTHKILP
0	1		T1285	MDPDLSLTHKILPDD
0	4		S1324-p	LAKKEALsGAGssKR
0	2		S1328-p	EALsGAGssKRRKAR
0	1		S1329-p	ALsGAGssKRRKARA
0	1		K1338-a	RRKARAKkNkAMkSI
0	1		K1340-a	KARAKkNkAMkSIkV
0	1		K1343-a	AKkNkAMkSIkVKEE
0	2		K1346-a	NkAMkSIkVKEEIKs
0	8		S1353-p	kVKEEIKsDssPLPs
0	7		S1355-p	KEEIKsDssPLPsEK
0	6		S1356-p	EEIKsDssPLPsEKs
0	6		S1360-p	sDssPLPsEKsDEDD
0	1		S1363-p	sPLPsEKsDEDDDKL
0	1		S1371-p	DEDDDKLsEsKSDGR
0	1		S1373-p	DDDKLsEsKSDGRER
0	1		S1385-p	RERSKKSsVsDAPVH
0	2		S1387-p	RSKKSsVsDAPVHIT
0	1		S1396-p	APVHITAsGEPVPIs
0	1		S1403-p	sGEPVPIsEEsEELD
0	1		S1406-p	PVPIsEEsEELDQKT
0	1		R1491-m1	KFTEFDArKLHKLYK
0	1		S1539-p	ENTNHDDsSRDSYSs
0	1		S1543	HDDsSRDSYSsDRHL
0	1		S1546-p	sSRDSYSsDRHLTQY
0	1		S1578-p	SRKRPYSsFSNGKDH
0	1		Y1591-p	DHRDWDHyKQDSRYY
0	1		N1618	RSRDHRSNLEGsLKD
0	2		S1622-p	HRSNLEGsLKDRSHS
0	2		S1662-p	SRDYRYHsDWQMDHR
0	1		S1672	QMDHRASSsGPRsPL
0	2		S1673-p	MDHRASSsGPRsPLD
0	30		S1677-p	ASSsGPRsPLDQRsP
0	16		S1683-p	RsPLDQRsPyGsRsP
0	2		Y1685-p	PLDQRsPyGsRsPFE
0	8		S1687-p	DQRsPyGsRsPFEHs
0	20		S1689-p	RsPyGsRsPFEHsVE
0	1		S1694-p	sRsPFEHsVEHKstP
0	7		S1699-p	EHsVEHKstPEHTWS
0	15		T1700-p	HsVEHKstPEHTWSS

	CHD-1 iso2
S5	___MNGHSDEESVRN
S89	DGAEFWKSSPSILAV
S90	GAEFWKSSPSILAVQ
S92	EFWKSSPSILAVQRS
S117	QQQQHQASSNSGSEE
S118	QQQHQASSNSGSEED
S120	QHQASSNSGSEEDSS
S135	SSEDSDDSSSEVKRK
S136	SEDSDDSSSEVKRKK
S137	EDSDDSSSEVKRKKH
T178	EKSSCDETESDYEPK
S180	SSCDETESDYEPKNK
Y182	CDETESDYEPKNKVK
S215	QKKRQIDSSEEDDDE
S216	KKRQIDSSEEDDDEE
Y225	EDDDEEDYDNDKRSS
S232	YDNDKRSSRRQATVN
T237	RSSRRQATVNVSYKE
S241	RQATVNVSYKEDEEM
T250	KEDEEMKTDSDDLLE
S252	DEEMKTDSDDLLEVC
K348	QNVRGMKKLDNYKKK
Y388	TDDLHKQYQIVERII
S398	VERIIAHSNQKSAAG
T449	SRNQSKTTPFKDCKV
Y472	ALKKQPSYIGGHEGL
Y681	EHGKGREYGYASLHK
Y683	GKGREYGYASLHKEL
S719	QILRMEMSALQKQYY
S738	TRNYKALSKGSKGST
T745	SKGSKGSTSGFLNIM
Y823	MLDILAEYLKYRQFP
S1025	QFKVANFSNMDEDDI
S1040	ELEPERNSKNWEEII
Y1068	QKELEEIYMLPRMRN
S1081	RNCAKQISFNGSEGR
S1085	KQISFNGSEGRRSRS
Y1095	RRSRSRRYSGSDSDS
S1096	RSRSRRYSGSDSDSI
S1098	RSRRYSGSDSDSISE
S1100	RRYSGSDSDSISEGK
S1102	YSGSDSDSISEGKRP
K1124	TIPRENIKGFSDAEI
S1127	RENIKGFSDAEIRRF
S1183	CIKALKDSSSGTERT
S1184	IKALKDSSSGTERTG
T1187	LKDSSSGTERTGGRL
S1283	IKMDPDLSLTHKILP
T1285	MDPDLSLTHKILPDD
S1324	LAKKEALSGAGSSKR
S1328	EALSGAGSSKRRKAR
S1329	ALSGAGSSKRRKARA
K1338	RRKARAKKNKAMKSI
K1340	KARAKKNKAMKSIKV
K1343	AKKNKAMKSIKVKEE
K1346	NKAMKSIKVKEEIKS
S1353	KVKEEIKSDSSPLPS
S1355	KEEIKSDSSPLPSEK
S1356	EEIKSDSSPLPSEKS
S1360	SDSSPLPSEKSDEDD
S1363	SPLPSEKSDEDDDKL
S1371	DEDDDKLSESKSDGR
S1373	DDDKLSESKSDGRER
S1385	RERSKKSSVSDAPVH
S1387	RSKKSSVSDAPVHIT
S1396	APVHITASGEPVPIS
S1403	SGEPVPISEESEELD
S1406	PVPISEESEELDQKT
R1491	KFTEFDARKLHKLYK
S1539	ENTNHDDSSRDSYSS
S1543	HDDSSRDSYSSDRHL
S1546	SSRDSYSSDRHLTQY
S1578	SRKRPYSSFSNGKDH
Y1591	DHRDWDHYKQDSRYY
N1618	RSRDHRSNLEGSLKD
S1622	HRSNLEGSLKDRSHS
S1662	SRDYRYHSDWQMDHR
S1672	QMDHRASSSGPRSPL
S1673	MDHRASSSGPRSPLD
S1677	ASSSGPRSPLDQRSY
S1683	RSPLDQRSYGSRSPF
Y1684	SPLDQRSYGSRSPFE
S1686	LDQRSYGSRSPFEHS
S1688	QRSYGSRSPFEHSVE
S1693	SRSPFEHSVEHKSTP
S1698	EHSVEHKSTPEHTWS
T1699	HSVEHKSTPEHTWSS

	mouse
S5-p	___MNGHsDEESVRN
S89-p	DGAEFWKssPsILAV
S90-p	GAEFWKssPsILAVQ
S92-p	EFWKssPsILAVQRS
S116	AQQQRPASSNSGSEE
S117	QQQRPASSNSGSEED
S119	QRPASSNSGSEEDSS
S134	SSEDSDDSSSGAKRK
S135	SEDSDDSSSGAKRKK
S136	EDSDDSSSGAKRKKH
T177	DKSSCDGTESDYEPK
S179	SSCDGTESDYEPKNK
Y181	CDGTESDYEPKNKVR
S214-p	QKKRQIDssEDEDDE
S215-p	KKRQIDssEDEDDED
Y223	EDEDDEDYDNDKRSS
S230	YDNDKRSSRRQATVN
T235	RSSRRQATVNVSYKE
S239	RQATVNVSYKEDEEM
T248-p	KEDEEMKtDsDDLLE
S250-p	DEEMKtDsDDLLEVC
K346	QNVRGMKKLDNYKKK
Y386	TDDLHKQYQIVERII
S396	VERIIAHSNQKSAAG
T447	SRNQSKTTPFKDCKV
Y470	ALKKQPSYIGGHEGL
Y679	EHGKGREYGYASLHK
Y681	GKGREYGYASLHKEL
S717	QILRMEMSALQKQYY
S736	TRNYKALSKGSKGST
T743	SKGSKGSTSGFLNIM
Y821	MLDILAEYLKYRQFP
S1023	QFKVANFSNMDEDDI
S1038-p	ELEPERNsKNWEEII
Y1066-p	QKELEEIyMLPRMRN
S1079	RNCAKQISFNGSEGR
S1083	KQISFNGSEGRRSRS
Y1093	RRSRSRRYsGsDsDs
S1094-p	RSRSRRYsGsDsDsI
S1096-p	RSRRYsGsDsDsISE
S1098-p	RRYsGsDsDsISERK
S1100-p	YsGsDsDsISERKRP
K1122	TIPRENIKGFsDAEI
S1125-p	RENIKGFsDAEIRRF
S1181	CVKALKDSSSGTERA
S1182	VKALKDSSSGTERAG
T1185	LKDSSSGTERAGGRL
S1281-p	IKMDPDLsLtHKILP
T1283-p	MDPDLsLtHKILPDD
C1324	KREAQRLCGAGGSKR
G1328	QRLCGAGGSKRRKTR
S1329	RLCGAGGSKRRKTRA
K1338	RRKTRAKKSKAMKSI
K1340	KTRAKKSKAMKSIKV
K1343	AKKSKAMKSIKVKEE
K1346	SKAMKSIKVKEEIKs
S1353-p	KVKEEIKsDssPLPs
S1355-p	KEEIKsDssPLPsEK
S1356-p	EEIKsDssPLPsEKS
S1360-p	sDssPLPsEKSDEDD
S1363	sPLPsEKSDEDDDKL
N1371	DEDDDKLNDSKPESK
S1373	DDDKLNDSKPESKDR
V1385	KDRSKKSVVSDAPVH
S1387	RSKKSVVSDAPVHIT
S1396	APVHITASGEPVPIA
A1403	SGEPVPIAEESEELD
S1406	PVPIAEESEELDQKT
R1491	KFTEFDARKLHKLYK
S1540	ENTNHDDSSRDsYSS
S1544-p	HDDSSRDsYSSDRHL
S1547	SSRDsYSSDRHLSQY
S1579	SRKRPYSSFSNGKDH
Y1592	DHREWDHYRQDSRYY
S1619-p	RSREHRPsLEGGLKD
G1623	HRPsLEGGLKDRCHS
S1663-p	SRDYRYLsDWQLDHR
S1673-p	QLDHRAAssGPRsPL
S1674-p	LDHRAAssGPRsPLD
S1678-p	AAssGPRsPLDQRsP
S1684-p	RsPLDQRsPyGsRsP
Y1686-p	PLDQRsPyGsRsPFE
S1688-p	DQRsPyGsRsPFEHS
S1690-p	RsPyGsRsPFEHSAE
S1695	sRsPFEHSAEHRStP
S1700	EHSAEHRStPEHTWS
T1701-p	HSAEHRStPEHTWSS

	rat
S5	___MNGHSDEESVRN
S89	DGAEFWKSNPSILAV
N90	GAEFWKSNPSILAVQ
S92	EFWKSNPSILAVQRS
S116-p	PQQQRPAssNsGSEE
S117-p	QQQRPAssNsGSEED
S119-p	QRPAssNsGSEEDSS
S134-p	SSEDSDAsssDVKRK
S135-p	SEDSDAsssDVKRKK
S136-p	EDSDAsssDVKRKKH
T177	DKSSCDGTESDYEPK
S179	SSCDGTESDYEPKNK
Y181	CDGTESDYEPKNKVK
S214	QKKRQIDSSEDEDDE
S215	KKRQIDSSEDEDDED
Y223	EDEDDEDYDNDKRSS
S230	YDNDKRSSRRQATVN
T235	RSSRRQATVNVSYKE
S239	RQATVNVSYKEDEEM
T248	KEDEEMKTDSDDLLE
S250	DEEMKTDSDDLLEVC
K346	QNVRGMKKLDNYKKK
Y386	TDDLHKQYQIVERII
S396	VERIIAHSNQKSAAG
T447	SRNQSKTTPFKDCKV
Y470	ALKKQPSYIGGHEGL
Y679-p	EHGKGREyGyASLHK
Y681-p	GKGREyGyASLHKEL
S717	QILRMEMSALQKQYY
S736	TRNYKALSKGSKGST
T743	SKGSKGSTSGFLNIM
Y821	MLDILAEYLKYRQFP
S1023	QFKVANFSNMDEDDI
S1038	ELEPERNSKNWEDII
Y1066	QKELEEIYMLPRMRN
S1079	RNCAKQISFNGSEGR
S1083	KQISFNGSEGRRSRS
Y1093	RRSRSRRYSGSDSDS
S1094	RSRSRRYSGSDSDSI
S1096	RSRRYSGSDSDSISE
S1098	RRYSGSDSDSISERK
S1100	YSGSDSDSISERKRP
K1122	TIPRENIKGFSDAEI
S1125	RENIKGFSDAEIRRF
S1181	CVKALKDSSSGTERA
S1182	VKALKDSSSGTERAG
T1185	LKDSSSGTERAGGRL
S1281	IKMDPDLSLTHKILP
T1283	MDPDLSLTHKILPDD
S1324	KKEAQRLSGAGGSKR
G1328	QRLSGAGGSKRRKTR
S1329	RLSGAGGSKRRKTRA
K1338	RRKTRAKKNKAMKSI
K1340	KTRAKKNKAMKSIKV
K1343	AKKNKAMKSIKVKEE
K1346	NKAMKSIKVKEEIKS
S1353	KVKEEIKSDSSPLPS
S1355	KEEIKSDSSPLPSER
S1356	EEIKSDSSPLPSERS
S1360	SDSSPLPSERSEEED
S1363	SPLPSERSEEEDDNV
N1371	EEEDDNVNDSKPESK
S1373	EDDNVNDSKPESKDR
V1385	KDRSKKSVVSDAPVH
S1387	RSKKSVVSDAPVHIT
S1396	APVHITASGEPVPIA
A1403	SGEPVPIAEESEELD
S1406	PVPIAEESEELDQKT
R1491	KFTEFDARKLHKLYK
S1540	ENTNHDDSSRDGYSS
G1544	HDDSSRDGYSSDRHL
S1547	SSRDGYSSDRHLSQC
S1579	SRKRPYSSFSNGKDH
Y1592	DHREWDHYRQDSRYY
S1619	RSREHRPSVEGSLKD
S1623	HRPSVEGSLKDRCHS
S1663	SRDYRYLSDWQLDHR
S1673	QLDHRAASSGPRSPL
S1674	LDHRAASSGPRSPLD
S1678	AASSGPRSPLDQRSP
S1684	RSPLDQRSPYGSRSP
Y1686	PLDQRSPYGSRSPFE
S1688	DQRSPYGSRSPFEHS
S1690	RSPYGSRSPFEHSAE
S1695	SRSPFEHSAEHRSTP
S1700	EHSAEHRSTPEHTWS
T1701	HSAEHRSTPEHTWSS

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.