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Protein Page:
Cas-L (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Cas-L a widely expressed docking protein which plays a central coordinating role for tyrosine-kinase-based signaling in cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Phosphorylated following integrin beta-1, antigen receptor, or C1a calcitonin receptor signaling. Transformation of fibroblasts with v-ABL results in an increase in its tyrosine phosphorylation. Phosphorylated by focal adhesion kinase. Highly expressed in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: spindle pole; Golgi apparatus; focal adhesion; lamellipodium; cytoplasm; spindle; cell cortex; nucleus
Molecular Function: protein binding
Biological Process: integrin-mediated signaling pathway; actin filament bundle formation; mitosis; regulation of growth; cytoskeleton organization and biogenesis; signal transduction; cell adhesion
Reference #:  Q14511 (UniProtKB)
Alt. Names/Synonyms: Cas scaffolding protein family member 2; CAS-L; cas-like docking; CAS2; CASL; CASS2; Crk-associated substrate related; CRK-associated substrate-related protein; dJ49G10.2; dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)); dJ761I2.1; dJ761I2.1 (enhancer of filamentation (HEF1)); Enhancer of filamentation 1; Enhancer of filamentation 1 p55; hEF1; NEDD-9; NEDD9; Neural precursor cell expressed developmentally down-regulated protein 9; neural precursor cell expressed, developmentally down-regulated 9; p105; Renal carcinoma antigen NY-REN-12
Gene Symbols: NEDD9
Molecular weight: 92,861 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Cas-L

Protein Structure Not Found.


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Sites Implicated In
protein degradation: S369‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 Y12-p NLMARALyDNVPECA
0 312 Y92-p TFGQQKLyQVPNPQA
0 13 Y106-p AAPRDTIyQVPPSyQ
0 3 Y112-p IyQVPPSyQNQGIyQ
0 8 Y118-p SyQNQGIyQVPTGHG
0 3 T126-p QVPTGHGtQEQEVyQ
0 15 Y132-p GtQEQEVyQVPPSVQ
0 20 Y164-p PVRTGHGyVyEyPSR
0 584 Y166-p RTGHGyVyEyPSRyQ
0 7 Y168-p GHGyVyEyPSRyQKD
0 7 Y172-p VyEyPSRyQKDVyDI
0 79 Y177-p SRyQKDVyDIPPsHt
0 22 S182-p DVyDIPPsHttQGVy
0 8 T184-p yDIPPsHttQGVyDI
0 7 T185-p DIPPsHttQGVyDIP
1 125 Y189-p sHttQGVyDIPPSSA
0 1 S195 VyDIPPSSAKGPVFS
1 235 Y214-p EIKPQGVyDIPPtKG
0 7 T219-p GVyDIPPtKGVyAIP
0 12 Y223-p IPPtKGVyAIPPsAC
0 4 S228-p GVyAIPPsACRDEAG
0 237 Y241-p AGLREKDyDFPPPMR
0 32 Y261-p DLRPEGVyDIPPTCT
1 4 S296-p PVARRHQsLSPNHPP
0 1 S309-p PPPQLGQsVGsQNDA
0 6 S312-p QLGQsVGsQNDAyDV
0 702 Y317-p VGsQNDAyDVPRGVQ
0 369 Y345-p PQERDGVyDVPLHNP
1 0 S369-p VDGINRLsFSSTGST
0 1 K388-u STSSTSSkESSLSAS
0 1 K400-u SASPAQDkRLFLDPD
0 63 Y629-p ERSWMDDyDyVHLQG
0 49 Y631-p SWMDDyDyVHLQGKE
  mouse

 
Y12-p NLMARALyDNVPECA
Y91-p TFGQQKLyQVPNSQA
Y105-p AASRDTIyQVPPSYQ
Y111 IyQVPPSYQNQGIyQ
Y117-p SYQNQGIyQVPTGHG
T125 QVPTGHGTPEQDVyQ
Y131-p GTPEQDVyQVPPSVQ
Y163-p PVRTGHGyVyEYPSR
Y165-p RTGHGyVyEYPSRYQ
Y167 GHGyVyEYPSRYQKD
Y171 VyEYPSRYQKDVyDV
Y176-p SRYQKDVyDVPPsHs
S181-p DVyDVPPsHsTQGVy
S183-p yDVPPsHsTQGVyDI
T184 DVPPsHsTQGVyDIP
Y188-p sHsTQGVyDIPPSsV
S194-p VyDIPPSsVKGPVFS
Y213 EIKPQGVYDIPPTQG
T218 GVYDIPPTQGVYAIP
Y222 IPPTQGVYAIPPSAC
S227 GVYAIPPSACRDEAG
Y240-p AGLREKEyDFPPPMK
Y260-p DTRPEGVyDIPPTST
S295-p PMARRHQsFSLHHAP
S308-p APSQLGQsGDtQSDA
T311-p QLGQsGDtQSDAyDV
Y316-p GDtQSDAyDVPRGVQ
Y344-p PEERDGVyDVPLHNP
S368 VDGINRLSFSSTGST
K387 STSSTSSKESSLSAS
K399 SASPSQDKRLRLDPD
Y628-p ERSWMDDyDyVHLQG
Y630-p SWMDDyDyVHLQGKE
  rat

 
Y12 NLMARALYDNVPECA
Y91 NFGQQKLYQVPNSQA
Y105 AAPRDTIYQVPPSYQ
Y111 IYQVPPSYQNQGIYQ
Y117 SYQNQGIYQVPTGHG
T125 QVPTGHGTPEQDVYQ
Y131 GTPEQDVYQVPPSVQ
Y163 PVRVGHGYVyEHPSR
Y165-p RVGHGYVyEHPSRYQ
H167 GHGYVyEHPSRYQKD
Y171 VyEHPSRYQKDVYDV
Y176 SRYQKDVYDVPPSHT
S181 DVYDVPPSHTTQGVY
T183 YDVPPSHTTQGVYDI
T184 DVPPSHTTQGVYDIP
Y188 SHTTQGVYDIPPSSV
S194 VYDIPPSSVKGPVFS
Y213 ELKPQGVYDIPPTQG
T218 GVYDIPPTQGVYAIP
Y222 IPPTQGVYAIPPSAC
S227 GVYAIPPSACRDEAG
Y240 AGLREKEYDFPPPMK
Y260-p DTRPEGVyDIPPTST
S295 PMARRHQSLSLHHAP
S308 APSQVGPSGDTQSDA
T311 QVGPSGDTQSDAyDV
Y316-p GDTQSDAyDVPRGVQ
Y344-p LEERDGVyDVPLHNP
S368 VDGINRLSFSSTGST
K387 STSSTSSKESSLSAS
K399 SASPSQDKRLLLDPD
Y628 ERSWMDDYDYVHLQG
Y630 SWMDDYDYVHLQGKE
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