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Protein Page:
Cas-L (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Cas-L a widely expressed docking protein which plays a central coordinating role for tyrosine-kinase-based signaling in cell adhesion. May function in transmitting growth control signals between focal adhesions at the cell periphery and the mitotic spindle in response to adhesion or growth factor signals initiating cell proliferation. Integrin beta-1 stimulation leads to recruitment of various proteins including CRK, NCK and SHPTP2 to the tyrosine phosphorylated form. Phosphorylated following integrin beta-1, antigen receptor, or C1a calcitonin receptor signaling. Transformation of fibroblasts with v-ABL results in an increase in its tyrosine phosphorylation. Phosphorylated by focal adhesion kinase. Highly expressed in kidney, lung, and placenta. Also detected in T-cells, B-cells and diverse cell lines. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold
Cellular Component: Golgi apparatus; spindle pole; focal adhesion; lamellipodium; cytoplasm; spindle; cell cortex; nucleus
Molecular Function: protein binding
Biological Process: integrin-mediated signaling pathway; mitosis; actin filament bundle formation; regulation of growth; cytoskeleton organization and biogenesis; cell adhesion; signal transduction
Reference #:  Q14511 (UniProtKB)
Alt. Names/Synonyms: Cas scaffolding protein family member 2; CAS-L; cas-like docking; CAS2; CASL; CASS2; Crk-associated substrate related; CRK-associated substrate-related protein; dJ49G10.2; dJ49G10.2 (Enhancer of Filamentation 1 (HEF1)); dJ761I2.1; dJ761I2.1 (enhancer of filamentation (HEF1)); Enhancer of filamentation 1; Enhancer of filamentation 1 p55; hEF1; NEDD-9; NEDD9; Neural precursor cell expressed developmentally down-regulated protein 9; neural precursor cell expressed, developmentally down-regulated 9; p105; Renal carcinoma antigen NY-REN-12
Gene Symbols: NEDD9
Molecular weight: 92,861 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Cas-L

Protein Structure Not Found.


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Sites Implicated In
protein degradation: S369‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 4 Y12-p NLMARALyDNVPECA
0 319 Y92-p TFGQQKLyQVPNPQA
0 1 P97 KLyQVPNPQAAPRDt
0 1 T104-p PQAAPRDtIyQVPPs
0 14 Y106-p AAPRDtIyQVPPsyQ
0 1 S111-p tIyQVPPsyQNQGIy
0 3 Y112-p IyQVPPsyQNQGIyQ
0 8 Y118-p syQNQGIyQVPtGHG
0 1 T122-p QGIyQVPtGHGtQEQ
0 3 T126-p QVPtGHGtQEQEVyQ
0 15 Y132-p GtQEQEVyQVPPSVQ
0 1 T160-p KVITPVRtGHGyVyE
0 18 Y164-p PVRtGHGyVyEyPSR
0 562 Y166-p RtGHGyVyEyPSRyQ
0 7 Y168-p GHGyVyEyPSRyQKD
0 6 Y172-p VyEyPSRyQKDVyDI
0 74 Y177-p SRyQKDVyDIPPsHt
0 22 S182-p DVyDIPPsHttQGVy
0 8 T184-p yDIPPsHttQGVyDI
0 7 T185-p DIPPsHttQGVyDIP
1 117 Y189-p sHttQGVyDIPPSSA
0 1 S195 VyDIPPSSAKGPVFS
1 224 Y214-p EIKPQGVyDIPPtKG
0 8 T219-p GVyDIPPtKGVyAIP
0 12 Y223-p IPPtKGVyAIPPsAC
0 4 S228-p GVyAIPPsACRDEAG
0 227 Y241-p AGLREKDyDFPPPMR
0 36 Y261-p DLRPEGVyDIPPTCT
1 4 S296-p PVARRHQsLSPNHPP
0 1 S309-p PPPQLGQsVGsQNDA
0 6 S312-p QLGQsVGsQNDAyDV
0 695 Y317-p VGsQNDAyDVPRGVQ
0 1 S333-p LEPPAETsEKANPQE
0 363 Y345-p PQERDGVyDVPLHNP
1 0 S369-p VDGINRLsFSSTGST
0 1 K388-ub STSSTSSkESSLSAs
0 1 S395-p kESSLSAsPAQDkRL
0 1 K400-ub SAsPAQDkRLFLDPD
0 1 S576-p GPESIMNsTEYPHGG
0 1 S616-p KEQAPDCsssDGsER
0 1 S617-p EQAPDCsssDGsERS
0 1 S618-p QAPDCsssDGsERSW
0 1 S621-p DCsssDGsERSWMDD
0 64 Y629-p ERSWMDDyDyVHLQG
0 48 Y631-p SWMDDyDyVHLQGKE
  mouse

 
Y12-p NLMARALyDNVPECA
Y91-p TFGQQKLyQVPNsQA
S96-p KLyQVPNsQAASRDT
T103 sQAASRDTIyQVPPS
Y105-p AASRDTIyQVPPSYQ
S110 TIyQVPPSYQNQGIy
Y111 IyQVPPSYQNQGIyQ
Y117-p SYQNQGIyQVPTGHG
T121 QGIyQVPTGHGTPEQ
T125 QVPTGHGTPEQDVyQ
Y131-p GTPEQDVyQVPPSVQ
T159 KVITPVRTGHGyVyE
Y163-p PVRTGHGyVyEYPSR
Y165-p RTGHGyVyEYPSRYQ
Y167 GHGyVyEYPSRYQKD
Y171 VyEYPSRYQKDVyDV
Y176-p SRYQKDVyDVPPsHs
S181-p DVyDVPPsHsTQGVy
S183-p yDVPPsHsTQGVyDI
T184 DVPPsHsTQGVyDIP
Y188-p sHsTQGVyDIPPSsV
S194-p VyDIPPSsVKGPVFS
Y213 EIKPQGVYDIPPTQG
T218 GVYDIPPTQGVYAIP
Y222 IPPTQGVYAIPPSAC
S227 GVYAIPPSACRDEAG
Y240-p AGLREKEyDFPPPMK
Y260-p DTRPEGVyDIPPTST
S295-p PMARRHQsFSLHHAP
S308-p APSQLGQsGDtQSDA
T311-p QLGQsGDtQSDAyDV
Y316-p GDtQSDAyDVPRGVQ
S332 LEVPTETSEKANPEE
Y344-p PEERDGVyDVPLHNP
S368 VDGINRLSFSSTGST
K387 STSSTSSKESSLSAS
S394 KESSLSASPSQDKRL
K399 SASPSQDKRLRLDPD
S575 GPNSIMNSSEYTHPG
G615 KDQPPDCGSSDGSER
S616 DQPPDCGSSDGSERS
S617 QPPDCGSSDGSERSW
S620 DCGSSDGSERSWMDD
Y628-p ERSWMDDyDyVHLQG
Y630-p SWMDDyDyVHLQGKE
  rat

 
Y12 NLMARALYDNVPECA
Y91 NFGQQKLYQVPNSQA
S96 KLYQVPNSQAAPRDT
T103 SQAAPRDTIYQVPPS
Y105 AAPRDTIYQVPPSYQ
S110 TIYQVPPSYQNQGIY
Y111 IYQVPPSYQNQGIYQ
Y117 SYQNQGIYQVPTGHG
T121 QGIYQVPTGHGTPEQ
T125 QVPTGHGTPEQDVYQ
Y131 GTPEQDVYQVPPSVQ
V159 KVITPVRVGHGYVyE
Y163 PVRVGHGYVyEHPSR
Y165-p RVGHGYVyEHPSRYQ
H167 GHGYVyEHPSRYQKD
Y171 VyEHPSRYQKDVYDV
Y176 SRYQKDVYDVPPSHT
S181 DVYDVPPSHTTQGVY
T183 YDVPPSHTTQGVYDI
T184 DVPPSHTTQGVYDIP
Y188 SHTTQGVYDIPPSSV
S194 VYDIPPSSVKGPVFS
Y213 ELKPQGVYDIPPTQG
T218 GVYDIPPTQGVYAIP
Y222 IPPTQGVYAIPPSAC
S227 GVYAIPPSACRDEAG
Y240 AGLREKEYDFPPPMK
Y260-p DTRPEGVyDIPPTST
S295 PMARRHQSLSLHHAP
S308 APSQVGPSGDTQSDA
T311 QVGPSGDTQSDAyDV
Y316-p GDTQSDAyDVPRGVQ
S332 LEVPTESSEKANLEE
Y344-p LEERDGVyDVPLHNP
S368 VDGINRLSFSSTGST
K387 STSSTSSKESSLSAS
S394 KESSLSASPSQDKRL
K399 SASPSQDKRLLLDPD
S575 GPDSITNSIEYTHTG
S615 KEQPPDCSSSDGSER
S616 EQPPDCSSSDGSERS
S617 QPPDCSSSDGSERSW
S620 DCSSSDGSERSWMDD
Y628 ERSWMDDYDYVHLQG
Y630 SWMDDYDYVHLQGKE
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