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Protein Page:
SHIP-2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SHIP-2 an SH2-containing inositol phosphatase. Recruited to activated receptor complexes including insulin R, PDGFR and Fc-gamma-R. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.n1; Phosphatase, lipid; Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.86; Motility/polarity/chemotaxis
Cellular Component: Golgi apparatus; cytoskeleton; lamellipodium; cytoplasm; plasma membrane; cytosol; filopodium
Molecular Function: protein binding; hydrolase activity; SH2 domain binding; actin binding; SH3 domain binding
Biological Process: inositol phosphate metabolic process; immune system process; glucose metabolic process; actin filament organization; endocytosis; post-embryonic development; response to insulin stimulus; negative regulation of cell proliferation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; cell adhesion; endochondral ossification
Reference #:  O15357 (UniProtKB)
Alt. Names/Synonyms: 51C protein; inositol polyphosphate phosphatase-like 1; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; INPPL1; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Protein 51C; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP-2; SHIP2
Gene Symbols: INPPL1
Molecular weight: 138,599 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SHIP-2

Protein Structure Not Found.


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Sites Implicated In
intracellular localization: S132‑p
phosphorylation: T958‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S49-p GSFLVRDsESVAGAF
0 1 Y62-p AFALCVLyQKHVHTY
2 14 S132-p PPDDRDAsDGEDEKP
0 1 S147 PLPPRSGSTSISAPT
0 1 T148 LPPRSGSTSISAPTG
0 1 S149 PPRSGSTSISAPTGP
0 2 S158-p SAPTGPSsPLPAPEt
0 1 A162 GPSsPLPAPEtPtAP
0 1 T165-p sPLPAPEtPtAPAAE
0 1 T167-p LPAPEtPtAPAAESA
0 1 A168 PAPEtPtAPAAESAP
0 1 S182-p PNGLSTVsHDyLKGs
0 1 Y185-p LSTVsHDyLKGsyGL
0 2 S189-p sHDyLKGsyGLDLEA
0 17 Y190-p HDyLKGsyGLDLEAV
0 1 K224-ub RLHSEVDkVLSGLEI
0 1 K234-ub SGLEILSkVFDQQSs
0 6 S241-p kVFDQQSsPMVTRLL
0 1 T245 QQSsPMVTRLLQQQN
0 1 K272-ac VLKLSVLkDFLSGIQ
0 1 T306 PSTRKAKTIPVQAFE
1 0 K315-ub PVQAFEVkLDVTLGD
0 2 K331-ub TKIGKSQkFTLSVDV
0 1 S352-p LLRRQRDsQEDWTTF
0 1 K412-ub CQLLQLMkNKHSKQD
0 51 Y622-p DIQEILNyISRKEFE
0 8 Y661-p EISFPPTyRyERGSR
0 12 Y663-p SFPPTyRyERGSRDT
0 109 Y671-p ERGSRDTyAWHKQKP
0 1 K741-ub ISKKGLSkTSDQAYI
0 3 S827-p HLLLTVKsMDGyEsY
0 136 Y831-p TVKsMDGyEsYGECV
0 1 S833-p KsMDGyEsYGECVVA
0 1 T854-p STAQQFLtFLsHRGE
0 1 S857-p QQFLtFLsHRGEETG
0 17 T881-p VPTERLGtRERLyEW
0 549 Y886-p LGtRERLyEWIsIDK
0 4 S890-p ERLyEWIsIDKDEAG
0 1 K901 DEAGAKSKAPSVSRG
0 1 S904 GAKSKAPSVSRGSQE
1 3 T958-p APREEPLtPRLKPEG
0 1 P963 PLtPRLKPEGAPEPE
0 82 S980-p AAPPPKNsFNNPAyy
2 936 Y986-p NsFNNPAyyVLEGVP
1 210 Y987-p sFNNPAyyVLEGVPH
0 162 S1003-p LLPPEPPsPARAPVP
0 26 S1011-p PARAPVPsAtKNKVA
0 22 T1013-p RAPVPsAtKNKVAIT
0 1 T1047-p SDEESGGtLPPPDFP
1 5 S1104-p PPLPPGPsPASTFLG
0 1 T1129-p SVLQMAKtLsEVDyA
0 14 S1131-p LQMAKtLsEVDyAPA
1 720 Y1135-p KtLsEVDyAPAGPAr
0 1 R1142-m1 yAPAGPArSALLPGP
0 26 S1160-p QPPRGLPsDyGRPLs
0 351 Y1162-p PRGLPsDyGRPLsFP
0 9 S1167-p sDyGRPLsFPPPRIR
0 1 S1176-p PPPRIREsIQEDLAE
0 1 S1202-p GLGEAGMsAWLRAIG
0 9 Y1213-p RAIGLERyEEGLVHN
1 0 T1253-p HKRLLLDtLQLsK__
1 3 S1257-p LLDtLQLsK______
2008 : Phospho-SHIP2 (Tyr986/987) Antibody
2008 : Phospho-SHIP2 (Tyr986/987) Antibody
2007 : Phospho-SHIP2 (Tyr1135) Antibody
5445 : Phospho-SHIP2 (Tyr1135) (D33C6) XP(R) Rabbit mAb
  mouse

 
S49 GSFLVRDSESVAGAF
Y62 AFALCVLYQKHVHTY
S132-p PPDDRDAsDVEDEKP
S147-p PLPPRSGstsISAPV
T148-p LPPRSGstsISAPVG
S149-p PPRSGstsISAPVGP
S158-p SAPVGPSsPLPtPET
T162-p GPSsPLPtPETPTtP
T165 sPLPtPETPTtPAAE
T167 LPtPETPTtPAAEST
T168-p PtPETPTtPAAESTP
S182 PNGLSTVSHEYLKGS
Y185 LSTVSHEYLKGSYGL
S189 SHEYLKGSYGLDLEA
Y190 HEYLKGSYGLDLEAV
K224 RLHSEVDKVLSGLEI
K234 SGLEILSKVFDQQSs
S241-p KVFDQQSsPMVtRLL
T245-p QQSsPMVtRLLQQQS
K272 VLKLSVLKDFLSGIQ
T307-p PSIRKAKtIPVQAFE
K316 PVQAFEVKLDVTLGD
K332-ub TKIGKSQkFTLSVDV
S353 LLRRQRDSQEDWTTF
K413 CQLLQLMKNRHSKQD
Y623 DIQEILNYISRREFE
Y662-p EISFPPTyRYERGSR
Y664 SFPPTyRYERGSRDT
Y672-p ERGSRDTyAWHKQKP
K742 ISKKGLSKTSDQAYI
S828 HLLLTVKSMDGYESY
Y832 TVKSMDGYESYGECV
S834 KSMDGYESYGECVVA
T855 STAQQFLTFLSHRGE
S858 QQFLTFLSHRGEETG
T882 VPTERLGTRERLyEW
Y887-p LGTRERLyEWISIDK
S891 ERLyEWISIDKDDTG
K902-ac DDTGAKSkVPsVSRG
S905-p GAKSkVPsVSRGSQE
N959 VPREEPLNPRLKsEG
S964-p PLNPRLKsEGTSEQE
S981 AAPPPKNSFNNPAyy
Y987-p NSFNNPAyyVLEGVP
Y988-p SFNNPAyyVLEGVPH
S1004 LLPLEPPSLARAPLP
P1012 LARAPLPPATKNKVA
T1014 RAPLPPATKNKVAIT
T1048 SDEDSGGTLPPPDFP
S1105 PPLPPGTSPASTFLG
T1130 SVLQMAKTLsEVDyA
S1132-p LQMAKTLsEVDyAPG
Y1136-p KTLsEVDyAPGPGRS
R1142 DyAPGPGRSALLPNP
S1159 LQPPRGPSDyGRPLS
Y1161-p PPRGPSDyGRPLSFP
S1166 SDyGRPLSFPPPRIR
S1175 PPPRIRESIQEDLAE
G1201 GLGEAGMGAWLRAIG
Y1212 RAIGLERYEEGLVHN
T1252 HKRLLLDTLQLSK__
S1256 LLDTLQLSK______
2008 : Phospho-SHIP2 (Tyr986/987) Antibody
2008 : Phospho-SHIP2 (Tyr986/987) Antibody
  rat

 
S49 GSFLVRDSESVAGAF
Y62 AFALCVLYQKHVHTY
S132-p PPDDRDAsDVEDEKP
S147 PLPPRSGSTSISVPA
T148 LPPRSGSTSISVPAG
S149 PPRSGSTSISVPAGP
S158 SVPAGPSSPLPAPET
A162 GPSSPLPAPETPTTP
T165 SPLPAPETPTTPAAE
T167 LPAPETPTTPAAEST
T168 PAPETPTTPAAESTP
S182 PNGLSTVSHEYLKGS
Y185 LSTVSHEYLKGSYGL
S189 SHEYLKGSYGLDLEA
Y190 HEYLKGSYGLDLEAV
K224 RLHSEVDKVLSGLEI
K234 SGLEILSKVFDQQSS
S241 KVFDQQSSPMVTRLL
T245 QQSSPMVTRLLQQQS
K272 VLKLSVLKDFLSGIQ
T307 PSIRKAKTIPVQAFE
K316 PVQAFEVKLDVTLGD
K332 TKIGKSQKFTLSVDV
S353 LLRRQRDSQEDWTTF
K413 CQLLQLMKNKHSKQD
Y623 DIQEILNYISRREFE
Y662 EISFPPTYRYERGSR
Y664 SFPPTYRYERGSRDT
Y672 ERGSRDTYAWHKQKP
K742 ISKKGLSKTSDQAYI
S828 HLLLTVKSMDGYESY
Y832 TVKSMDGYESYGECV
S834 KSMDGYESYGECVVA
T855 STAQQFLTFLSHRGE
S858 QQFLTFLSHRGEETG
T882 VPTERLGTRERLYEW
Y887 LGTRERLYEWISIDK
S891 ERLYEWISIDKDDTG
K902 DDTGAKSKAPSVLRG
S905 GAKSKAPSVLRGSQE
N959 VPREESLNPRLKSEG
S964 SLNPRLKSEGTPEQE
S981 AAPPPKNSFNNPAyy
Y987-p NSFNNPAyyVLEGVP
Y988-p SFNNPAyyVLEGVPH
S1004 LLPLEPTSFARAPIP
P1012 FARAPIPPTTKNKVA
T1014 RAPIPPTTKNKVAIT
T1048 SDEDSGGTLPPPDFP
S1105 PPLPPGTSPASTFLE
T1130 SVLQMAKTLSEVDyS
S1132 LQMAKTLSEVDySPG
Y1136-p KTLSEVDySPGPGRS
R1142 DySPGPGRSALLPNP
S1159 LQLPRGPSDYGRPLS
Y1161 LPRGPSDYGRPLSFP
S1166 SDYGRPLSFPPPRIR
S1175 PPPRIRESIQEDLAE
G1201 GLGEAGMGAWLRAIG
Y1212 RAIGLERYEEGLVHN
T1252 HKRLLLDTLQLSK__
S1256 LLDTLQLSK______
2008 : Phospho-SHIP2 (Tyr986/987) Antibody
2008 : Phospho-SHIP2 (Tyr986/987) Antibody
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