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SHIP-2 (human)

Overview SHIP-2 an SH2-containing inositol phosphatase. Recruited to activated receptor complexes including insulin R, PDGFR and Fc-gamma-R. Note: This description may include information from UniProtKB. Protein type: Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; Phosphatase, lipid; EC 3.1.3.86; EC 3.1.3.n1 Cellular Component: Golgi apparatus; lamellipodium; cytoplasm; plasma membrane; cytosol Molecular Function: identical protein binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; hydrolase activity; SH2 domain binding; actin binding; SH3 domain binding Biological Process: response to drug; negative regulation of MAP kinase activity; negative regulation of insulin-like growth factor receptor signaling pathway; glucose metabolic process; actin filament organization; negative regulation of insulin receptor signaling pathway; endocytosis; inositol trisphosphate metabolic process; response to insulin stimulus; post-embryonic development; negative regulation of cell proliferation; negative regulation of DNA replication; phosphoinositide phosphorylation; phospholipid metabolic process; phosphatidylinositol biosynthetic process; brain development; cell adhesion Reference #:  O15357 (UniProtKB) Alt. Names/Synonyms: 51C protein; inositol polyphosphate phosphatase-like 1; Inositol polyphosphate phosphatase-like protein 1; INPPL-1; INPPL1; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Protein 51C; SH2 domain-containing inositol phosphatase 2; SH2 domain-containing inositol-5'-phosphatase 2; SHIP-2; SHIP2 Gene Symbols: INPPL1 Molecular weight: 138,599 Da Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below SHIP-2 2K4P - A=1194-1258 (human) 2KSO - B=1200-1258 (human) 3NR8 - A/B=419-732 (human) 4A9C - A/B=419-732 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2K4P 2KSO 3NR8 4A9C  |  ENZYME  |  Phospho3D  |  DISEASE  |  UCSD-Nature  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
intracellular localization: S132‑p phosphorylation: T958‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S49-p	GSFLVRDsESVAGAF
0	1		Y62-p	AFALCVLyQKHVHTY
2	5		S132-p	PPDDRDAsDGEDEKP
0	1		S158-p	SAPTGPSsPLPAPEt
0	1		T165-p	sPLPAPEtPtAPAAE
0	1		T167-p	LPAPEtPtAPAAESA
0	1		S182-p	PNGLSTVsHDYLKGs
0	2		S189-p	sHDYLKGsyGLDLEA
0	18		Y190-p	HDYLKGsyGLDLEAV
0	1		K224-u	RLHSEVDkVLSGLEI
0	1		K234-u	SGLEILSkVFDQQSs
0	3		S241-p	kVFDQQSsPMVTRLL
0	1		K272-a	VLKLSVLkDFLSGIQ
0	1		T306	PSTRKAKTIPVQAFE
1	0		K315-u	PVQAFEVkLDVTLGD
0	2		K331-u	TKIGKSQkFTLSVDV
0	1		K412-u	CQLLQLMkNKHSKQD
0	46		Y622-p	DIQEILNyISRKEFE
0	9		Y661-p	EISFPPTyRyERGSR
0	13		Y663-p	SFPPTyRyERGSRDT
0	108		Y671-p	ERGSRDTyAWHKQKP
0	1		K741-u	ISKKGLSkTSDQAYI
0	3		S827-p	HLLLTVKsMDGyEsY
0	138		Y831-p	TVKsMDGyEsYGECV
0	1		S833-p	KsMDGyEsYGECVVA
0	12		T881-p	VPTERLGtRERLyEW
0	514		Y886-p	LGtRERLyEWIsIDK
0	3		S890-p	ERLyEWIsIDKDEAG
0	1		K901	DEAGAKSKAPSVSRG
1	1		T958-p	APREEPLtPRLKPEG
0	1		P963	PLtPRLKPEGAPEPE
0	78		S980-p	AAPPPKNsFNNPAyy
1	926		Y986-p	NsFNNPAyyVLEGVP
1	217		Y987-p	sFNNPAyyVLEGVPH
0	149		S1003-p	LLPPEPPsPARAPVP
0	25		S1011-p	PARAPVPsAtKNKVA
0	18		T1013-p	RAPVPsAtKNKVAIT
1	3		S1104-p	PPLPPGPsPASTFLG
0	1		T1129-p	SVLQMAKtLsEVDyA
0	11		S1131-p	LQMAKtLsEVDyAPA
0	699		Y1135-p	KtLsEVDyAPAGPAr
0	1		R1142-m1	yAPAGPArSALLPGP
0	26		S1160-p	QPPRGLPsDyGRPLs
0	341		Y1162-p	PRGLPsDyGRPLsFP
0	9		S1167-p	sDyGRPLsFPPPRIR
0	1		S1202-p	GLGEAGMsAWLRAIG
0	7		Y1213-p	RAIGLERyEEGLVHN
1	0		T1253-p	HKRLLLDtLQLsK__
1	0		S1257-p	LLDtLQLsK______

	mouse
S49	GSFLVRDSESVAGAF
Y62	AFALCVLYQKHVHTY
S132-p	PPDDRDAsDVEDEKP
S158	SAPVGPSSPLPTPET
T165	SPLPTPETPTTPAAE
T167	LPTPETPTTPAAEST
S182	PNGLSTVSHEYLKGS
S189	SHEYLKGSYGLDLEA
Y190	HEYLKGSYGLDLEAV
K224	RLHSEVDKVLSGLEI
K234	SGLEILSKVFDQQSS
S241	KVFDQQSSPMVTRLL
K272	VLKLSVLKDFLSGIQ
T307-p	PSIRKAKtIPVQAFE
K316	PVQAFEVKLDVTLGD
K332-u	TKIGKSQkFTLSVDV
K413	CQLLQLMKNRHSKQD
Y623	DIQEILNYISRREFE
Y662-p	EISFPPTyRYERGSR
Y664	SFPPTyRYERGSRDT
Y672-p	ERGSRDTyAWHKQKP
K742	ISKKGLSKTSDQAYI
S828	HLLLTVKSMDGYESY
Y832	TVKSMDGYESYGECV
S834	KSMDGYESYGECVVA
T882	VPTERLGTRERLyEW
Y887-p	LGTRERLyEWISIDK
S891	ERLyEWISIDKDDTG
K902-a	DDTGAKSkVPSVSRG
N959	VPREEPLNPRLKsEG
S964-p	PLNPRLKsEGTSEQE
S981	AAPPPKNSFNNPAyy
Y987-p	NSFNNPAyyVLEGVP
Y988-p	SFNNPAyyVLEGVPH
S1004	LLPLEPPSLARAPLP
P1012	LARAPLPPATKNKVA
T1014	RAPLPPATKNKVAIT
S1105	PPLPPGTSPASTFLG
T1130	SVLQMAKTLsEVDyA
S1132-p	LQMAKTLsEVDyAPG
Y1136-p	KTLsEVDyAPGPGRS
R1142	DyAPGPGRSALLPNP
S1159	LQPPRGPSDyGRPLS
Y1161-p	PPRGPSDyGRPLSFP
S1166	SDyGRPLSFPPPRIR
G1201	GLGEAGMGAWLRAIG
Y1212	RAIGLERYEEGLVHN
T1252	HKRLLLDTLQLSK__
S1256	LLDTLQLSK______

	rat
S49	GSFLVRDSESVAGAF
Y62	AFALCVLYQKHVHTY
S132	PPDDRDASDVEDEKP
S158	SVPAGPSSPLPAPET
T165	SPLPAPETPTTPAAE
T167	LPAPETPTTPAAEST
S182	PNGLSTVSHEYLKGS
S189	SHEYLKGSYGLDLEA
Y190	HEYLKGSYGLDLEAV
K224	RLHSEVDKVLSGLEI
K234	SGLEILSKVFDQQSS
S241	KVFDQQSSPMVTRLL
K272	VLKLSVLKDFLSGIQ
T307	PSIRKAKTIPVQAFE
K316	PVQAFEVKLDVTLGD
K332	TKIGKSQKFTLSVDV
K413	CQLLQLMKNKHSKQD
Y623	DIQEILNYISRREFE
Y662	EISFPPTYRYERGSR
Y664	SFPPTYRYERGSRDT
Y672	ERGSRDTYAWHKQKP
K742	ISKKGLSKTSDQAYI
S828	HLLLTVKSMDGYESY
Y832	TVKSMDGYESYGECV
S834	KSMDGYESYGECVVA
T882	VPTERLGTRERLYEW
Y887	LGTRERLYEWISIDK
S891	ERLYEWISIDKDDTG
K902	DDTGAKSKAPSVLRG
N959	VPREESLNPRLKSEG
S964	SLNPRLKSEGTPEQE
S981	AAPPPKNSFNNPAyy
Y987-p	NSFNNPAyyVLEGVP
Y988-p	SFNNPAyyVLEGVPH
S1004	LLPLEPTSFARAPIP
P1012	FARAPIPPTTKNKVA
T1014	RAPIPPTTKNKVAIT
S1105	PPLPPGTSPASTFLE
T1130	SVLQMAKTLSEVDyS
S1132	LQMAKTLSEVDySPG
Y1136-p	KTLSEVDySPGPGRS
R1142	DySPGPGRSALLPNP
S1159	LQLPRGPSDYGRPLS
Y1161	LPRGPSDYGRPLSFP
S1166	SDYGRPLSFPPPRIR
G1201	GLGEAGMGAWLRAIG
Y1212	RAIGLERYEEGLVHN
T1252	HKRLLLDTLQLSK__
S1256	LLDTLQLSK______

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