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Protein Page:
SHIP (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
SHIP an SH2-containing inositol phosphatase. A hemopoietic-specific phosphatase that regulates cell survival, growth, cell cycle arrest and apoptosis. Hydrolyzes Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3. A cytosolic protein with a SH2 domain in its N-terminus and two NPXY Shc binding motifs at its C-terminus. Upon receptor cross-linking, SHIP is first recruited to the plasma membrane by its SH2, followed by tyrosine phosphorylation on the NPXY motif. Both membrane relocalization and phosphorylation are essential for its regulatory function. Associates with SHC after cytokine stimulation. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.n1; Motility/polarity/chemotaxis; EC 3.1.3.86; Phosphatase, lipid
Cellular Component: membrane; cytosol
Molecular Function: protein binding; PTB domain binding; inositol-polyphosphate 5-phosphatase activity; SH3 domain binding
Biological Process: negative regulation of osteoclast differentiation; inositol phosphate metabolic process; apoptosis; positive regulation of apoptosis; positive regulation of erythrocyte differentiation; negative regulation of immune response; negative regulation of interleukin-6 biosynthetic process; determination of adult life span; negative regulation of B cell proliferation; signal transduction; negative regulation of monocyte differentiation; phosphate metabolic process; T cell receptor signaling pathway; negative regulation of neutrophil differentiation; negative regulation of signal transduction; phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; positive regulation of B cell differentiation; immunoglobulin mediated immune response; negative regulation of bone resorption; blood coagulation; leukocyte migration
Reference #:  Q92835 (UniProtKB)
Alt. Names/Synonyms: hp51CN; Inositol polyphosphate-5-phosphatase of 145 kDa; inositol polyphosphate-5-phosphatase, 145kDa; INPP5D; MGC104855; MGC142140; MGC142142; p150Ship; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1; SH2 containing inositol phosphatase, isoform b; SH2 domain-containing inositol phosphatase 1; SH2 domain-containing inositol-5'-phosphatase 1; SHIP; SHIP-1; SHIP1; signaling inositol polyphosphate 5 phosphatase SIP-145; SIP-145
Gene Symbols: INPP5D
Molecular weight: 133,292 Da
Basal Isoelectric point: 7.38  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SHIP

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y865‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K14-ub HGNITRSkAEELLSR
0 5 K24-ub ELLSRTGkDGSFLVR
1 0 S27 SRTGkDGSFLVRASE
1 1 S35 FLVRASESISRAyAL
0 12 Y40-p SESISRAyALCVLyR
0 19 Y46-p AyALCVLyRNCVYTY
0 3 K78-ub VSMRFFTkLDQLIEF
0 10 K141-ub TASSCEAkEVPFSNE
1 0 S159 ATETSRPSLSETLFQ
1 2 S170 TLFQRLQSMDTSGLP
0 2 K182-ub GLPEEHLkAIQDYLS
0 1 K200-ub AQDSEFVkTGSSsLP
0 1 S205-p FVkTGSSsLPHLKKL
0 1 T213-p LPHLKKLtTLLCKEL
0 1 Y221-p TLLCKELyGEVIRTL
1 7 S243-p RLFDQQLsPGLRPRP
1 2 N257 PQVPGEANPINMVSK
1 1 S266 INMVSKLSQLTSLLS
0 1 S274-p QLTSLLSsIEDKVKA
0 1 S289-p LLHEGPEsPHRPSLI
0 5 Y339-p DGSEDKFySHKKILQ
0 1 K365-ub VILVETEkEKILRkE
0 1 K371-ac EkEKILRkEyVFADS
0 1 Y373-p EKILRkEyVFADSKK
0 2 T423-p APPPKKItSWFLSKG
1 0 S438 QGKTRDDSADYIPHD
0 4 Y556-p KLRRNQNyMNILRFL
0 1 K607-ub ETIIQKIkQQQyADL
0 1 Y611-p QKIkQQQyADLLSHD
0 9 Y644-p EITFAPTyRFERLTR
0 1 S699-p STSDIMTsDHSPVFA
0 1 Y737 QIEFLRCYATLKTKs
0 1 S744-p YATLKTKsQTKFYLE
0 1 S754-p KFYLEFHssCLESFV
0 1 S755-p FYLEFHssCLESFVK
1 0 S772 EGENEEGSEGELVVk
0 70 K779-ub SEGELVVkFGETLPk
0 4 K786-ub kFGETLPkLKPIISD
0 21 Y796-p PIISDPEyLLDQHIL
0 2 Y834-p TETQLPIytPLTHHG
0 1 T835-p ETQLPIytPLTHHGE
0 1 K852 GHFQGEIKLQTSQGk
0 7 K859-ub KLQTSQGkTREkLyD
0 3 K863-ub SQGkTREkLyDFVkT
0 377 Y865-p GkTREkLyDFVkTER
0 5 K869-ub EkLyDFVkTERDESS
0 4 K879-ub RDESSGPktLkSLTs
0 1 T880-p DESSGPktLkSLTsH
0 4 K882-ub SSGPktLkSLTsHDP
0 2 S886-p ktLkSLTsHDPMkQW
0 6 K891-ub LTsHDPMkQWEVTSR
2 180 Y915-p TEIINPNyMGVGPFG
0 1 Q931 PMPLHVKQTLsPDQQ
1 4 S934-p LHVKQTLsPDQQPTA
0 2 T940 LsPDQQPTAWSyDQP
0 11 Y944-p QQPTAWSyDQPPKDs
0 1 S951-p yDQPPKDsPLGPCRG
0 1 P952 DQPPKDsPLGPCRGE
0 2 S960-p LGPCRGEsPPtPPGQ
1 10 T963-p CRGEsPPtPPGQPPI
0 4 G966 EsPPtPPGQPPIsPK
1 11 S971-p PPGQPPIsPKkFLPs
0 4 K974-ub QPPIsPKkFLPstAN
1 0 L976 PIsPKkFLPstANRG
0 1 S978-p sPKkFLPstANRGLP
0 1 T979-p PKkFLPstANRGLPP
0 2 T1003-p LGKNAGDtLPQEDLP
0 1 K1013-ub QEDLPLTkPEMFENP
6 209 Y1022-p EMFENPLyGsLssFP
1 10 S1024-p FENPLyGsLssFPKP
0 2 S1026-p NPLyGsLssFPKPAP
0 1 S1027-p PLyGsLssFPKPAPR
0 2 S1039-p APRKDQEsPKMPRkE
0 5 K1045-ub EsPKMPRkEPPPCPE
0 1 S1057-p CPEPGILsPSIVLTK
0 2 K1076-ub DRGEGPGkQVPAPRL
0 1 A1080 GPGkQVPAPRLRsFT
0 1 S1085-p VPAPRLRsFTCSSSA
1 0 T1087 APRLRsFTCSSSAEG
0 5 K1107-ub DKSQGKPktPVSSQA
0 1 T1108-p KSQGKPktPVSSQAP
1 0 P1109 SQGKPktPVSSQAPV
0 2 K1119-ub SQAPVPAkRPIkPSR
0 1 K1123-ub VPAkRPIkPSRSEIN
0 1 S1147 RPPLPVKSPAVLHLQ
1 2 S1156 AVLHLQHSkGRDyRD
0 1 K1157-ub VLHLQHSkGRDyRDN
0 15 Y1161-p QHSkGRDyRDNTELP
0 6 K1172-ub TELPHHGkHRPEEGP
3941 : Phospho-SHIP1 (Tyr1020) Antibody
  mouse

 
K17 HGNITRSKAEELLSR
K27 ELLSRAGKDGsFLVR
S30-p SRAGKDGsFLVRASE
S38-p FLVRASEsIPRAYAL
Y43 SEsIPRAYALCVLFR
F49 AYALCVLFRNCVYTY
K81 VPMRFFTKLDQLIDF
K144 SAGPSEAKDLPLATE
S162-p APEVTRLsLSETLFQ
S173-p TLFQRLQsMDTSGLP
K185 GLPEEHLKAIQDYLS
K203 LLDSDFLKTGSSNLP
N208 FLKTGSSNLPHLKKL
M216 LPHLKKLMSLLCKEL
H224 SLLCKELHGEVIRTL
S246-p RLFDQQLsPGLRPRP
S260-p PQVPGEAsPITMVAK
S269-p ITMVAKLsQLTSLLS
S277 QLTSLLSSIEDKVKS
S292 LLHEGSESTNRRSLI
Y342 DGSEDKFYSHKKILQ
K368 VILVETEKEKILRKE
K374 EKEKILRKEYVFADS
Y376 EKILRKEYVFADSKK
T426 APPPKKITSWFLSKG
S441-p QGKTRDDsADYIPHD
Y559 KLRRNQNYMNILRFL
K610 EAIIQKIKQQQYSDL
Y614 QKIKQQQYSDLLAHD
Y647-p EITFAPTyRFERLTR
S702 STSDIMTSDHSPVFA
Y740-p QIEFLACyATLKTKS
S747 yATLKTKSQTKFYLE
S757 KFYLEFHSSCLESFV
S758 FYLEFHSSCLESFVK
S775-p EGENEEGsEGELVVR
R782 sEGELVVRFGETLPK
K789 RFGETLPKLKPIISD
Y799-p PIISDPEyLLDQHIL
Y837-p TEAQHPIyTPLTHHG
T838 EAQHPIyTPLTHHGE
K855-ac GHFRGEIkLQTSQGK
K862 kLQTSQGKMREKLyD
K866 SQGKMREKLyDFVKT
Y868-p GKMREKLyDFVKTER
K872 EKLyDFVKTERDESS
K882 RDESSGMKCLKNLTs
C883 DESSGMKCLKNLTsH
K885 SSGMKCLKNLTsHDP
S889-p KCLKNLTsHDPMRQW
R894 LTsHDPMRQWEPSGR
Y918-p NEMINPNyIGMGPFG
S932-p GQPLHGKsTLsPDQQ
S935-p LHGKsTLsPDQQLtA
T941-p LsPDQQLtAWSyDQL
Y945-p QQLtAWSyDQLPKDS
S952 yDQLPKDSsLGPGRG
S953-p DQLPKDSsLGPGRGE
G961 LGPGRGEGPPtPPsQ
T964-p GRGEGPPtPPsQPPL
S967-p EGPPtPPsQPPLsPK
S972-p PPsQPPLsPKKFsSS
K975 QPPLsPKKFsSSTAN
S977-p PLsPKKFsSSTANRG
S979 sPKKFsSSTANRGPC
T980 PKKFsSSTANRGPCP
A1002 GDLGKVEALLQEDLL
K1012 QEDLLLTKPEMFENP
Y1021-p EMFENPLyGsVSSFP
S1023-p FENPLyGsVSSFPKL
S1025 NPLyGsVSSFPKLVP
S1026 PLyGsVSSFPKLVPR
S1038 VPRKEQESPKMLRKE
K1044 ESPKMLRKEPPPCPD
S1056-p CPDPGISsPSIVLPK
K1075 ESVKGTSKQAPVPVL
T1085-p PVPVLGPtPRIRsFt
S1090-p GPtPRIRsFtCSSSA
T1092-p tPRIRsFtCSSSAEG
K1112 DKSQGKPKAsASSQA
A1113 KSQGKPKAsASSQAP
S1114-p SQGKPKAsASSQAPV
K1124 SQAPVPVKRPVKPSR
K1128 VPVKRPVKPSRSEMS
S1152-p RPPLPVKsPAVLQLQ
S1161-p AVLQLQHsKGRDyRD
K1162 VLQLQHsKGRDyRDN
Y1166-p QHsKGRDyRDNTELP
K1177 TELPHHGKHRQEEGL
3941 : Phospho-SHIP1 (Tyr1020) Antibody
  rat

 
K17 HGNITRSKAEELLSR
K27 ELLSRAGKDGSFLVR
S30 SRAGKDGSFLVRASE
S38 FLVRASESIPRAYAL
Y43 SESIPRAYALCVLFR
F49 AYALCVLFRNCVYTY
K81 VPMRFFTKLDQLIEF
K143 SGGPCEAKDLPLPTE
S161 APEVTRLSLSETLFQ
S172 TLFQRLQSMDTSGLP
K184 GLPEEHLKAIQDYLS
K202 MLDSDFLKTGSSNLP
N207 FLKTGSSNLPHLKKL
T215 LPHLKKLTSLLCKEL
H223 SLLCKELHGEVIRTL
S245-p RLFDQQLsPGLRPRP
N259 PQVPGEANPITMVAK
S268 ITMVAKLSQLTSLLS
S276 QLTSLLSSIEDKVKA
S291 LLHEGSESTNRRSLI
Y341 DGSEDKFYSHKKILQ
K367 VILVETEKEKILRkE
K373-ac EKEKILRkEYVFSDS
Y375 EKILRkEYVFSDSKK
T425 APPPKKITSWFLSKG
S440 QGKTRDDSADYIPHD
Y558 KLRRNQNYMNILRFL
K609 EAIIQKIKQQQYSDL
Y613 QKIKQQQYSDLLAHD
Y646 EITFAPTYRFERLTR
S701 STSDIMTSDHSPVFA
Y739 QIEFLACYATLKTKS
S746 YATLKTKSQTKFYLE
S756 KFYLELHSSCLESFV
S757 FYLELHSSCLESFVK
D774 EGENEEGDEGELVVR
R781 DEGELVVRFGETLPK
K788 RFGETLPKLKPIISD
Y798 PIISDPEYLLDQHIL
Y836 TESQLPIYTPLTHHG
T837 ESQLPIYTPLTHHGE
K854 GHFRGEIKLQTSEGK
K861 KLQTSEGKMREKLYD
K865 SEGKMREKLYDFVKT
Y867 GKMREKLYDFVKTER
K871 EKLYDFVKTERDESS
K881 RDESSGMKCLKNLTS
C882 DESSGMKCLKNLTSH
K884 SSGMKCLKNLTSHDP
S888 KCLKNLTSHDPMRQW
R893 LTSHDPMRQWEPAGR
Y917 NEIINPNYIGMGPFG
S931 GQPLHGKSTLSPDQQ
S934 LHGKSTLSPDQQLTA
T940 LSPDQQLTAWSYDQL
Y944 QQLTAWSYDQLPKDS
S951 YDQLPKDSSLGPGRG
S952 DQLPKDSSLGPGRGE
G960 LGPGRGEGPPtPPSQ
T963-p GRGEGPPtPPSQPPL
S966 EGPPtPPSQPPLsPK
S971-p PPSQPPLsPKKFSSS
K974 QPPLsPKKFSSSTAN
S976 PLsPKKFSSSTANRG
S978 sPKKFSSSTANRGSC
T979 PKKFSSSTANRGSCP
A1001 GDLGKVEALPQEDLP
K1011 QEDLPLTKPEMFENP
Y1020-p EMFENPLyGSVSPFP
S1022 FENPLyGSVSPFPKL
S1024 NPLyGSVSPFPKLVP
P1025 PLyGSVSPFPKLVPR
S1037 VPRKEQESPKMMRKE
K1043 ESPKMMRKEPPPCPD
S1055 CPDPGVSSPSIMLPK
K1074 ENVKGTSKQAPVPVF
T1084 PVPVFGPTPRIRSFT
S1089 GPTPRIRSFTCSSSA
T1091 TPRIRSFTCSSSAEG
K1111 DKSQGKPKAPASSQA
A1112 KSQGKPKAPASSQAP
P1113 SQGKPKAPASSQAPV
K1123 SQAPVPVKRPVKPSR
K1127 VPVKRPVKPSRSEMS
S1151 RPPLPVKSPAVLQLQ
S1160 AVLQLQHSKGRDYRD
K1161 VLQLQHSKGRDYRDN
Y1165 QHSKGRDYRDNTELP
K1176 TELPHHGKHRQEESL
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