an SH2-containing inositol phosphatase. A hemopoietic-specific phosphatase that regulates cell survival, growth, cell cycle arrest and apoptosis. Hydrolyzes Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3. A cytosolic protein with a SH2 domain in its N-terminus and two NPXY Shc binding motifs at its C-terminus. Upon receptor cross-linking, SHIP is first recruited to the plasma membrane by its SH2, followed by tyrosine phosphorylation on the NPXY motif. Both membrane relocalization and phosphorylation are essential for its regulatory function. Associates with SHC after cytokine stimulation. Note: This description may include information from UniProtKB.
Protein type: EC 220.127.116.11; Phosphatase, lipid; Motility/polarity/chemotaxis; EC 3.1.3.n1
Biological Process: negative regulation of osteoclast differentiation; inositol phosphate metabolic process; apoptosis; positive regulation of apoptosis; positive regulation of erythrocyte differentiation; negative regulation of immune response; negative regulation of interleukin-6 biosynthetic process; negative regulation of B cell proliferation; determination of adult life span; signal transduction; negative regulation of monocyte differentiation; phosphate metabolic process; T cell receptor signaling pathway; negative regulation of neutrophil differentiation; negative regulation of signal transduction; phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; positive regulation of B cell differentiation; immunoglobulin mediated immune response; negative regulation of bone resorption; blood coagulation; leukocyte migration
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.