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Protein Page:
TREX1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TREX1 the major 3' DNA exonuclease in mammalian cells. Normally associates with the endoplasmic reticulum (ER). Translocates to the nucleus at S phase after DNA damage by gamma-irradiation or hydroxyurea. Trex1-deficient cells show defective G1/S transition, with single-stranded DNA molecules persisting after S phase and accumulating in the ER. Degrades ssDNA. Prevents chronic checkpoint activation and inappropriate immune activation. Mutations cause Aicardi-Goutieres syndrome, an autoimmune disorder. Trex1a(-/-) mice have autoinflammatory responses. The gene for this protein is either identical to or adjacent to that of ATRIP. Some of the mRNAs that encode TREX1 also encode ATRIP in another reading frame. Three alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Cell cycle regulation; EC 3.1.11.2; DNA repair, damage; Deoxyribonuclease
Cellular Component: endoplasmic reticulum membrane; nucleolus; nuclear envelope; cytosol; nucleus
Molecular Function: protein homodimerization activity; metal ion binding; double-stranded DNA binding; exodeoxyribonuclease III activity; 3'-5'-exodeoxyribonuclease activity; MutLalpha complex binding; adenyl deoxyribonucleotide binding; 3'-5' exonuclease activity; MutSalpha complex binding; single-stranded DNA binding
Biological Process: cell death; regulation of interferon type I production; mismatch repair; positive regulation of interferon type I production; innate immune response; DNA catabolic process, exonucleolytic; DNA replication; DNA repair; DNA metabolic process; DNA recombination
Reference #:  Q9NSU2 (UniProtKB)
Alt. Names/Synonyms: 3'-5' exonuclease TREX1; DNase III; Three prime repair exonuclease 1; TREX1
Gene Symbols: TREX1
Molecular weight: 38,923 Da
Basal Isoelectric point: 8.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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TREX1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
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Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 5 S133-p VAPGKACsPAASEIT
0 2 S222-p KALERASsPSEHGPR
0 1 S233 HGPRKSYSLGSIYTR
0 3 S316-p LATTRNTsPSLGESR
0 1 D327 GESRGTKDLPPVkDP
0 1 K332-m2 TKDLPPVkDPGALSR
  mouse

 
S78-p IAPGKACsPGASEIT
S167-p KALEQASsPSGNGSR
S178-p NGSRKSYsLGSIYTR
S261 PLATANGSPSNGRSR
S272-p GRSRRPKsPPPEKVP
K277 PKsPPPEKVPEAPSQ
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