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NFAT2 (human)

Overview NFAT2 a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Six splice variant isoforms have been identified. Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: cytoplasm; nuclear chromatin; cytosol Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; FK506 binding; mitogen-activated protein kinase p38 binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; heart development; positive regulation of transcription, DNA-dependent; calcium ion transport; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; G1/S transition of mitotic cell cycle Reference #:  O95644 (UniProtKB) Alt. Names/Synonyms: MGC138448; NF-ATc; NF-ATc1; NFAC1; NFAT transcription complex cytosolic component; NFAT2; NFATC; NFATC1; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 Gene Symbols: NFATC1 Molecular weight: 101,243 Da Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NFAT2 1A66 - A=416-591 (human) 1NFA - A=416-591 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1A66 1NFA  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S172‑p, S187‑p activation: S172‑p inhibition: S245‑p, S269‑p, S294‑p intracellular localization: S172‑p, S187‑p, S245‑p, S269‑p, S294‑p phosphorylation: S245‑p, S269‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S169-p	LEAYRDPsCLsPASS
1	0		S172-p	YRDPsCLsPASSLSS
0	1		S184-p	LSSRSCNsEAsSYES
1	1		S187-p	RSCNsEAsSYESNYS
0	1		Y197-p	ESNYSYPyASPQTSP
0	10		S233-p	GACTLLGsPRHSPST
0	1		S237	LLGsPRHSPSTSPRA
0	1		S241	PRHSPSTSPRAsVTE
2	2		S245-p	PSTSPRAsVTEEsWL
0	2		S250-p	RAsVTEEsWLGARSS
0	15		S261-p	ARSSRPAsPCNKRKY
2	2		S269-p	PCNKRKYsLNGRQPP
1	0		S294-p	PHGSPRVsVTDDSWL
2	0		K349-s	QPPSVALkVEPVGED
0	2		P360	VGEDLGSPPPPADFA
1	0		Y371-p	ADFAPEDySSFQHIR
0	5		Y386-p	KGGFCDQyLAVPQHP
0	2		Y394-p	LAVPQHPyQWAKPKP
0	1		Y426-p	LPSHSGPyELRIEVQ
0	1		T504-p	ITGKTVStTSHEAIL
0	1		S512-p	TSHEAILsNTKVLEI
0	1		S526-p	IPLLPENsMRAVIDC
0	4		S542-p	GILKLRNsDIELRKG
1	0		K548	NsDIELRKGETDIGR
0	1		K612-a	SYPVVGGkKMVLSGH
0	1		K626-a	HNFLQDSkVIFVEKA
0	8		S670-p	FRNQRITsPVHVSFY
1	0		K702-s	PANVPIIkTEPTDDy
0	2		Y709-p	kTEPTDDyEPAPTCG
0	1		A760	QRSTLMPAAPGVsPK
0	1		S765-p	MPAAPGVsPKLHDLS
0	1		S903-p	PEVHEDGsPNLAPIP
0	1		T912-p	NLAPIPVtVkREPEE
1	0		K914-s	APIPVtVkREPEELD

	mouse ► Hide Isoforms
S171	LEAYRDPSCLSPASS
S174	YRDPSCLSPASSLSS
S186	LSSRSCNSEASSYES
S189	RSCNSEASSYESNYS
Y199	ESNYSYPYASPQTSP
S235-p	GACHLLGsPRHsPST
S239-p	LLGsPRHsPSTsPRA
S243-p	PRHsPSTsPRAsITE
S247-p	PSTsPRAsITEESWL
S252	RAsITEESWLGARGS
S263-p	ARGSRPTsPCNKRKY
S271-p	PCNKRKYsLNGRQPS
S296	PHGSPRVSVTEDTWL
K351-s	HAPSVALkVEPAGED
T362-p	AGEDLGTtPPTSDFP
-	under review
Y387	KGAFCEQYLSVPQAS
Y395	LSVPQASYQWAKPKS
Y427	LPSHSGPYELRIEVQ
T505	ITGKTVSTTSHEIIL
S513	TSHEIILSNTKVLEI
N527	IPLLPENNMRAIIDC
S543-p	GILKLRNsDIELRkG
K549-a	NsDIELRkGETDIGR
K613	SYPVIGGKKMVLSGH
K627	HNFLQDSKVIFVEKA
S671	FRNQRITSPAQVSFY
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap
-	gap

	NFAT2 iso2
S171	LEAYRDPSCLSPASS
S174	YRDPSCLSPASSLSS
S186	LSSRSCNSEASSYES
S189	RSCNSEASSYESNYS
Y199	ESNYSYPYASPQTSP
S235	GACHLLGSPRHSPST
S239	LLGSPRHSPSTSPRA
S243	PRHSPSTSPRASITE
S247	PSTSPRASITEESWL
S252	RASITEESWLGARGS
S263	ARGSRPTSPCNKRKY
S271	PCNKRKYSLNGRQPS
S296	PHGSPRVSVTEDTWL
K351	HAPSVALKVEPAGED
T362	AGEDLGTTPPTSDFP
-	under review
Y387	KGAFCEQYLSVPQAS
Y395	LSVPQASYQWAKPKS
Y427	LPSHSGPYELRIEVQ
T505	ITGKTVSTTSHEIIL
S513	TSHEIILSNTKVLEI
N527	IPLLPENNMRAIIDC
S543	GILKLRNSDIELRKG
K549	NSDIELRKGETDIGR
K613	SYPVIGGKKMVLSGH
K627	HNFLQDSKVIFVEKA
S671	FRNQRITSPVQVSFY
K703	PANVPIIKTEPTDDF
F710	KTEPTDDFEPALTCG
T761-p	QRNTLMPtPPNAsPK
S766-p	MPtPPNAsPKLHDLS
-	gap
-	gap
-	gap

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