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Protein Page:
NFAT2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
NFAT2 a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Six splice variant isoforms have been identified. Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; DNA binding protein
Cellular Component: nucleoplasm; transcription factor complex; nuclear chromatin; cytoplasm; cytosol
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; FK506 binding; mitogen-activated protein kinase p38 binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; calcium ion transport; positive regulation of transcription, DNA-dependent; heart development; epithelial to mesenchymal transition; innate immune response; positive regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; G1/S transition of mitotic cell cycle
Reference #:  O95644 (UniProtKB)
Alt. Names/Synonyms: MGC138448; NF-ATc; NF-ATc1; NFAC1; NFAT transcription complex cytosolic component; NFAT2; NFATC; NFATC1; Nuclear factor of activated T-cells, cytoplasmic 1; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
Gene Symbols: NFATC1
Molecular weight: 101,243 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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NFAT2

Protein Structure Not Found.


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Sites Implicated In
transcription, inhibited: S172‑p
activity, inhibited: S245‑p, S269‑p, S294‑p
intracellular localization: S172‑p, S187‑p, S245‑p, S269‑p, S294‑p
phosphorylation: S245‑p, S269‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S169-p LEAYRDPsCLsPASS
1 0 S172-p YRDPsCLsPASSLSS
0 1 S184-p LSSRSCNsEAsSYES
1 1 S187-p RSCNsEAsSYESNYS
0 1 Y197-p ESNYSYPyASPQTSP
0 13 S233-p GACTLLGsPRHSPST
0 1 S237 LLGsPRHSPSTSPRA
0 1 S241 PRHSPSTSPRAsVTE
2 3 S245-p PSTSPRAsVTEEsWL
0 2 S250-p RAsVTEEsWLGARSS
0 16 S261-p ARSSRPAsPCNKRKY
2 2 S269-p PCNKRKYsLNGRQPP
1 0 S294-p PHGSPRVsVTDDSWL
2 0 K349-sm QPPSVALkVEPVGED
0 3 P360 VGEDLGSPPPPADFA
0 1 P363 DLGSPPPPADFAPED
0 1 A364 LGSPPPPADFAPEDy
2 0 Y371-p ADFAPEDySSFQHIR
0 5 Y386-p KGGFCDQyLAVPQHP
0 2 Y394-p LAVPQHPyQWAKPKP
0 1 Y426-p LPSHSGPyELRIEVQ
0 1 T504-p ITGKTVStTSHEAIL
0 1 S512-p TSHEAILsNTKVLEI
0 1 S526-p IPLLPENsMRAVIDC
0 5 S542-p GILKLRNsDIELRKG
1 0 K548 NsDIELRKGETDIGR
0 1 K612-ac SYPVVGGkKMVLSGH
0 1 K626-ac HNFLQDSkVIFVEKA
0 8 S670-p FRNQRITsPVHVSFY
1 0 K702-sm PANVPIIkTEPTDDy
0 2 Y709-p kTEPTDDyEPAPTCG
0 1 A760 QRSTLMPAAPGVsPK
0 1 S765-p MPAAPGVsPKLHDLS
0 1 S903-p PEVHEDGsPNLAPIP
0 1 T912-p NLAPIPVtVkREPEE
1 0 K914-sm APIPVtVkREPEELD
  mouse

► Hide Isoforms
 
S171 LEAYRDPSCLSPASS
S174 YRDPSCLSPASSLSS
S186 LSSRSCNSEASSYES
S189 RSCNSEASSYESNYS
Y199 ESNYSYPYASPQTSP
S235-p GACHLLGsPRHsPST
S239-p LLGsPRHsPSTsPRA
S243-p PRHsPSTsPRAsITE
S247-p PSTsPRAsITEESWL
S252 RAsITEESWLGARGS
S263-p ARGSRPTsPCNKRKY
S271-p PCNKRKYsLNGRQPS
S296 PHGSPRVSVTEDTWL
K351-sm HAPSVALkVEPAGED
T362-p AGEDLGTtPPtsDFP
T365-p DLGTtPPtsDFPPEE
S366-p LGTtPPtsDFPPEEY
Y373 sDFPPEEYTFQHLRK
Y387 KGAFCEQYLSVPQAS
Y395 LSVPQASYQWAKPKS
Y427 LPSHSGPYELRIEVQ
T505 ITGKTVSTTSHEIIL
S513 TSHEIILSNTKVLEI
N527 IPLLPENNMRAIIDC
S543-p GILKLRNsDIELRkG
K549-ac NsDIELRkGETDIGR
K613 SYPVIGGKKMVLSGH
K627 HNFLQDSKVIFVEKA
S671 FRNQRITSPAQVSFY
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  NFAT2 iso2  
S171 LEAYRDPSCLSPASS
S174 YRDPSCLSPASSLSS
S186 LSSRSCNSEASSYES
S189 RSCNSEASSYESNYS
Y199 ESNYSYPYASPQTSP
S235 GACHLLGSPRHSPST
S239 LLGSPRHSPSTSPRA
S243 PRHSPSTSPRASITE
S247 PSTSPRASITEESWL
S252 RASITEESWLGARGS
S263 ARGSRPTSPCNKRKY
S271 PCNKRKYSLNGRQPS
S296 PHGSPRVSVTEDTWL
K351 HAPSVALKVEPAGED
T362 AGEDLGTTPPTSDFP
T365 DLGTTPPTSDFPPEE
S366 LGTTPPTSDFPPEEY
Y373 SDFPPEEYTFQHLRK
Y387 KGAFCEQYLSVPQAS
Y395 LSVPQASYQWAKPKS
Y427 LPSHSGPYELRIEVQ
T505 ITGKTVSTTSHEIIL
S513 TSHEIILSNTKVLEI
N527 IPLLPENNMRAIIDC
S543 GILKLRNSDIELRKG
K549 NSDIELRKGETDIGR
K613 SYPVIGGKKMVLSGH
K627 HNFLQDSKVIFVEKA
S671 FRNQRITSPVQVSFY
K703 PANVPIIKTEPTDDF
F710 KTEPTDDFEPALTCG
T761-p QRNTLMPtPPNAsPK
S766-p MPtPPNAsPKLHDLS
- gap
- gap
- gap
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