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Protein Page:
NFAT3 (human)

Overview
NFAT3 a transcription factor that plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Also control gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of lymphoid and nonlymphoid cells. Highly expressed in placenta, lung, kidney, testis and ovary. Weakly expressed in spleen and thymus. Not expressed in peripheral blood lymphocytes. Note: This description may include information from UniProtKB.
Protein type: DNA binding protein; Transcription factor
Cellular Component: transcription factor complex; intermediate filament cytoskeleton; cytoplasm; nucleus; cytosol
Molecular Function: peroxisome proliferator activated receptor binding; protein binding; DNA binding; transcription coactivator activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; patterning of blood vessels; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of apoptosis; heart development; cellular respiration; muscle cell development; regulation of synaptic plasticity; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; inflammatory response
Reference #:  Q14934 (UniProtKB)
Alt. Names/Synonyms: NF-AT3; NF-ATc4; NFAC4; NFAT3; NFATC4; Nuclear factor of activated T-cells, cytoplasmic 4; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4; T cell transcription factor NFAT3; T-cell transcription factor NFAT3
Gene Symbols: NFATC4
Molecular weight: 95,449 Da
Basal Isoelectric point: 5.29  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NFAT3

Protein Structure Not Found.


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Sites Implicated In
cell differentiation, altered: S168‑p, S170‑p
cell growth, altered: S168‑p, S170‑p
transcription, altered: S168‑p, S170‑p, S281‑p, S285‑p
transcription, induced: S213‑p, S217‑p, S676‑p
activity, induced: S676‑p
activity, inhibited: S168‑p, S170‑p
intracellular localization: S168‑p, S170‑p

Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 - gap
0 1 S120 CPSIRITSISPTPEP
6 1 S168-p QGGGAFFsPsPGsSS
6 1 S170-p GGAFFsPsPGsSSLS
0 1 S173-p FFsPsPGsSSLSSWS
1 4 S213-p ASRFGLGsPLPsPRA
1 5 S217-p GLGsPLPsPRAsPRP
0 1 S221-p PLPsPRAsPRPWtPE
0 7 T226-p RAsPRPWtPEDPWSL
0 1 Y234-p PEDPWSLyGPsPGGR
0 2 S237-p PWSLyGPsPGGRGPE
0 1 S246-p GGRGPEDsWLLLSAP
0 2 T256-p LLSAPGPtPAsPRPA
0 1 S259-p APGPtPAsPRPAsPC
0 7 S264-p PAsPRPAsPCGKRRY
0 6 S272-p PCGKRRYsSSGTPSS
0 1 S274 GKRRYsSSGTPSSAs
1 0 S281-p SGTPSSAsPALsRRG
1 0 S285-p SSAsPALsRRGsLGE
1 10 S289-p PALsRRGsLGEEGsE
0 2 S295-p GsLGEEGsEPPPPPP
0 4 S311-p PLARDPGsPGPFDyV
0 1 Y317-p GsPGPFDyVGAPPAE
0 1 T333-p IPQKTRRtssEQAVA
0 7 S334-p PQKTRRtssEQAVAL
0 3 S335-p QKTRRtssEQAVALP
1 1 S344-p QAVALPRsEEPASCN
0 5 S532-p GILKLRNsDIELRKG
0 1 Y653-p LTLTVPEysNKRVSR
0 1 S654-p TLTVPEysNKRVSRP
2 0 S676-p SNGRRKRsPTQSFRF
0 1 T772-p FPETRGTtGCAQPPA
  NFAT3 iso11  
S12-p LPSLLPAsLAsISHR
S15-p LLPAsLAsISHRVTN
S183 CPSIRITSISPTPEP
S231 QGGGAFFSPSPGSSS
S233 GGAFFSPSPGSSSLS
S236 FFSPSPGSSSLSSWS
S276 ASRFGLGSPLPSPRA
S280 GLGSPLPSPRASPRP
S284 PLPSPRASPRPWTPE
T289 RASPRPWTPEDPWSL
Y297 PEDPWSLYGPSPGGR
S300 PWSLYGPSPGGRGPE
S309 GGRGPEDSWLLLSAP
T319 LLSAPGPTPASPRPA
S322 APGPTPASPRPASPC
S327 PASPRPASPCGKRRY
S335 PCGKRRYSSSGTPSS
S337 GKRRYSSSGTPSSAS
S344 SGTPSSASPALSRRG
S348 SSASPALSRRGSLGE
S352 PALSRRGSLGEEGSE
S358 GSLGEEGSEPPPPPP
S374 PLARDPGSPGPFDYV
Y380 GSPGPFDYVGAPPAE
T396 IPQKTRRTSSEQAVA
S397 PQKTRRTSSEQAVAL
S398 QKTRRTSSEQAVALP
S407 QAVALPRSEEPASCN
S595 GILKLRNSDIELRKG
Y716 LTLTVPEYSNKRVSR
S717 TLTVPEYSNKRVSRP
S739 SNGRRKRSPTQSFRF
- under review  
  mouse

 
- gap
- gap
S120-p CPSIRITsISPTPDP
S168-p QGGGAFFsPsPGSSS
S170-p GGAFFsPsPGSSSLS
S173 FFsPsPGSSSLSSWS
S213-p ASRFGLSsPLPsPRA
S217-p GLSsPLPsPRASPRP
S221 PLPsPRASPRPWtPE
T226-p RASPRPWtPEDPWSL
Y234 PEDPWSLYGPSSGGR
S237 PWSLYGPSSGGRAPE
S246 GGRAPEDSWLLLSAP
V256 LLSAPGPVPASPRPA
S259 APGPVPASPRPAsPC
S264-p PASPRPAsPCGKRRY
S272-p PCGKRRYsSsGTPSS
S274-p GKRRYsSsGTPSSAS
S281 sGTPSSASPALSRRG
S285 SSASPALSRRGsLGE
S289-p PALSRRGsLGEEGPE
P295 GsLGEEGPEPPPPPP
S311 PLVRDPSSPGPFDYV
Y317 SSPGPFDYVGAPPTE
T333 IPQKTRRTsSEQAVA
S334-p PQKTRRTsSEQAVAL
S335 QKTRRTsSEQAVALP
S344 QAVALPRSEEPPSCN
S532-p GILKLRNsDIELRKG
Y653 LTLTIPEYSNKRVSR
S654 TLTIPEYSNKRVSRP
S676-p SNGRRKRsPTQSFKF
T772 FPETGGTTGCARLPS
  rat

 
- gap
- gap
S120 CPSIRITSISPTPDP
S168 QGGGAFFSPSPGSSS
S170 GGAFFSPSPGSSSLS
S173 FFSPSPGSSSLSSWS
S213 ASRFGLSSPLPSPRA
S217 GLSSPLPSPRASPRP
S221 PLPSPRASPRPWTPE
T226 RASPRPWTPEDPWSL
Y234 PEDPWSLYGPSSGGR
S237 PWSLYGPSSGGRAPE
S246 GGRAPEDSWLLLSAP
I256 LLSAPGPIPASPRPA
S259 APGPIPASPRPAsPC
S264-p PASPRPAsPCGKRRY
S272 PCGKRRYSSSGTPSS
S274 GKRRYSSSGTPSSAS
S281 SGTPSSASPALSRRG
S285 SSASPALSRRGSLGE
S289 PALSRRGSLGEEGPE
P295 GSLGEEGPEPPPPPP
S311 PLVRDPSSSGPFDYV
Y317 SSSGPFDYVGAPPTE
T333 VPQKTRRTsSEQAVA
S334-p PQKTRRTsSEQAVAL
S335 QKTRRTsSEQAVALP
S344 QAVALPRSEEPASCN
S532 GILKLRNSDIELRKG
Y653 LTLTIPEYSNKRVSR
S654 TLTIPEYSNKRVSRP
S676 SNGRRKRSPTQSFKF
T772 FPETGGTTGCARLPS
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