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NFAT4 (human)

Overview NFAT4 a transcription factor that plays a role in the inducible expression of cytokine genes in T cells. Plays a role in the regulation of gene expression in T cells and immature thymocytes. Six spliced isoforms have been identified. Isoform 1 is predominantly expressed in thymus, peripheral blood leukocytes and kidney. Isoform 2 is predominantly expressed in skeletal muscle and is also found in thymus, kidney, testis, spleen, prostate, ovary, small intestine, heart, placenta and pancreas. Isoform 3 is expressed in thymus and kidney. Isoform 4 is expressed in thymus and skeletal muscle. Note: This description may include information from UniProtKB. Protein type: Transcription factor; DNA binding protein Cellular Component: cytoplasm; plasma membrane; nucleolus; cytosol; nucleus Molecular Function: DNA binding; chromatin binding; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; patterning of blood vessels; regulation of transcription from RNA polymerase II promoter; heart development; cellular respiration; muscle cell development; positive regulation of transcription from RNA polymerase II promoter; smooth muscle cell differentiation; inflammatory response Reference #:  Q12968 (UniProtKB) Alt. Names/Synonyms: NF-AT4; NF-ATc3; NFAC3; NFAT4; NFATC3; NFATx; nuclear factor of activated T-cells c3 isoform IE-Xa; Nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4 Gene Symbols: NFATC3 Molecular weight: 115,594 Da Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states CST Pathways:  B Cell Receptor Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below NFAT4 2XRW - B=141-154 (human) 2XS0 - B=141-154 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 2XRW 2XS0  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
transcription, altered: S163‑p, S165‑p intracellular localization: S163‑p, S165‑p, T204‑p, S207‑p, T210‑p, S211‑p, S215‑p

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S82-p	SPSFQLQsHKNyEGt
0	4		Y86-p	QLQsHKNyEGtCEIP
0	1		T89-p	sHKNyEGtCEIPESK
0	5		Y150-p	RPSRDHLyLPLEPSY
0	1		S160	LEPSYRESSLsPsPA
1	2		S163-p	SYRESSLsPsPASSI
2	1		S165-p	RESSLsPsPASSISs
0	1		S172-p	sPASSISsRSWFsDA
1	0		S177-p	ISsRSWFsDAssCEs
1	0		S180-p	RSWFsDAssCEsLsH
1	0		S181-p	SWFsDAssCEsLsHI
1	0		S184-p	sDAssCEsLsHIYDD
1	0		S186-p	AssCEsLsHIYDDVD
1	0		T204-p	NEAAARFtLGsPLts
1	1		S207-p	AARFtLGsPLtsPGG
1	0		T210-p	FtLGsPLtsPGGsPG
1	1		S211-p	tLGsPLtsPGGsPGG
1	0		S215-p	PLtsPGGsPGGCPGE
0	1		S261	WLSPRPASGPSsRPt
0	1		S264	PRPASGPSsRPtsPC
0	4		S265-p	RPASGPSsRPtsPCG
0	2		T268-p	SGPSsRPtsPCGKRR
0	11		S269-p	GPSsRPtsPCGKRRH
0	4		S277-p	PCGKRRHsSAEVCYA
0	1		S278	CGKRRHsSAEVCYAG
0	1		T306	HSPRGSVTEDTWLNA
0	5		S344-p	PLKTRKTsEDQAAIL
0	6		S364-p	LCSDDQGsLsPARET
0	10		S366-p	SDDQGsLsPARETSI
0	1		S415-p	HTPIFRTssLPPLDW
0	3		S416-p	TPIFRTssLPPLDWP
0	4		S546-p	GILKLRNsDIELRKG
0	1		S730-p	PAQTQRPssDSGCSH
0	1		S731-p	AQTQRPssDSGCSHD
0	1		S742-p	CSHDSVLsGQRSLIC
0	3		Y884-p	PHLQSMGyHCSNTGQ
0	4		S1045-p	EIIGRDMsQIsVSQG
0	1		S1048-p	GRDMsQIsVSQGAGV
0	3		S1063-p	SRQAPLPsPEsLDLG
0	2		S1066-p	APLPsPEsLDLGRSD

	mouse
S82	SPSFQLQSHKNYEGT
Y86	QLQSHKNYEGTCEIP
T89	SHKNYEGTCEIPESK
Y150	RPSRDHLYLPLEPSY
S160-p	LEPSYREsSLsPSPA
S163-p	SYREsSLsPSPASSI
S165	REsSLsPSPASSISS
S172	SPASSISSRSWFSDA
S177	ISSRSWFSDASSCES
S180	RSWFSDASSCESLSH
S181	SWFSDASSCESLSHI
S184	SDASSCESLSHIYDD
S186	ASSCESLSHIYDDVD
T204	NEAAARFTLGSPLTS
S207	AARFTLGSPLTSPGG
T210	FTLGSPLTSPGGSPG
S211	TLGSPLTSPGGSPGG
S215	PLTSPGGSPGGCPGE
S261-p	WLSPRPAsGPssRPt
S264-p	PRPAsGPssRPtSPC
S265-p	RPAsGPssRPtSPCG
T268-p	sGPssRPtSPCGKRR
S269	GPssRPtSPCGKRRH
S277-p	PCGKRRHssAEVCYA
S278-p	CGKRRHssAEVCYAG
T306-p	HSPRGSVtEDTWLTA
S344-p	PLKTRKTsEDQAAIL
N364	ICSDDQGNLsPSRET
S366-p	SDDQGNLsPSRETSV
S415	HTPIFRTSsLPPLDW
S416-p	TPIFRTSsLPPLDWP
S546-p	GILKLRNsDIELRKG
S730	SAQAQRPSSETGHPH
S731	AQAQRPSSETGHPHD
S742	HPHDRAMSAPGGLLC
Y883	PHLQSMGYHCSNAGQ
S1044	EIIGRDMSQISVSQA
S1047	GRDMSQISVSQATEV
G1062	MRDTPLPGPAsPDLM
S1065-p	TPLPGPAsPDLMTSH

	rat
G83	SPSFQLQGFKNYEGT
Y87	QLQGFKNYEGTDDIS
T90	GFKNYEGTDDISESK
Y151	RPSRDHLYLPLEPSY
S161	LEPSYRESSLSPSPA
S164	SYRESSLSPSPASSV
S166	RESSLSPSPASSVSS
S173	SPASSVSSRSWFSDA
S178	VSSRSWFSDASSCES
S181	RSWFSDASSCESLSH
S182	SWFSDASSCESLSHI
S185	SDASSCESLSHIYDD
S187	ASSCESLSHIYDDVD
T205	NEAAARFTLGSPLTS
S208	AARFTLGSPLTSPGG
T211	FTLGSPLTSPGGSPG
S212	TLGSPLTSPGGSPGG
S216	PLTSPGGSPGGCPGE
S262-p	WLSPRPAsGPssRPt
S265-p	PRPAsGPssRPtsPC
S266-p	RPAsGPssRPtsPCG
T269-p	sGPssRPtsPCGKRR
S270-p	GPssRPtsPCGKRRH
S278	PCGKRRHSSAEVCYA
S279	CGKRRHSSAEVCYAG
T307	HSPRGSVTEDTWLTA
S345	PLKTRKTSDDQAAIL
S365	VCSDDQGSLSPSRET
S367	SDDQGSLSPSRETSV
S416	HTPIFRTSSLPPLDW
S417	TPIFRTSSLPPLDWP
S547	GILKLRNSDIELRKG
S731	SAQTQRPSSDTGHPH
S732	AQTQRPSSDTGHPHD
S743	HPHDSALSAPRSLIC
Y884	PHLQSMGYHCSSAGQ
-	gap
S1047	SDLEHQPSGSTEKWP
-	gap
-	gap

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