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Protein Page:
RYR2 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
RYR2 ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transporter; Transporter, ion channel; Channel, ligand-gated; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: sarcoplasmic reticulum membrane; protein complex; sarcoplasmic reticulum; membrane; plasma membrane; Z disc
Molecular Function: calcium-induced calcium release activity; calmodulin binding; identical protein binding; protein binding; enzyme binding; protein self-association; calcium-release channel activity; calcium channel activity; calcium ion binding; intracellular ligand-gated calcium channel activity; ryanodine-sensitive calcium-release channel activity
Biological Process: positive regulation of sequestering of calcium ion; cytosolic calcium ion homeostasis; regulation of heart rate; calcium-mediated signaling; response to redox state; positive regulation of heart rate; Wnt receptor signaling pathway through beta-catenin; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine; cellular calcium ion homeostasis; BMP signaling pathway; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; detection of calcium ion; transmembrane transport; cardiac muscle contraction
Reference #:  Q92736 (UniProtKB)
Alt. Names/Synonyms: ARVC2; ARVD2; cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Cardiac muscle-type ryanodine receptor; hRYR-2; Ryanodine receptor 2; ryanodine receptor 2 (cardiac); RYR-2; RYR2; VTSIP
Gene Symbols: RYR2
Molecular weight: 564,567 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
Select Structure to View Below

RYR2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K304 LRHVTTGKYLSLMED
0 3 Y823-p PPGYAPCyEAVLPKE
0 5 K1141-a AFAFDGFkAQRWHQG
0 1 T1223 NFGKDVSTLKYFTIC
0 1 K1253 DITMWLSKRLPQFLQ
0 1 K1284 IDSSPCLKVTQKSFG
0 1 K1288 PCLKVTQKSFGSQNS
0 2 T1317-p CAEVFSKtVAGGLPG
0 2 S1341 LEDYDADSDFEVLMK
0 1 Y1427-p LMQTSTYyySVRIFP
0 1 Y1428-p MQTSTYyySVRIFPG
0 1 K1473 TVTLGDEKGKVHESI
0 2 S1495 VCAGESMSPGQGRNN
0 1 K1561 QFELGRIKNVMPLSA
0 1 K1790 PLDILKSKTIQMLTE
0 1 K1800 QMLTEAVKEGSLHAR
0 3 T1863 TPEEESDTLEKELSV
0 1 K1866 EESDTLEKELSVDDA
0 1 K1874 ELSVDDAKLQGAGEE
1 0 G1886 GEEEAKGGKRPKEGL
8 3 S2031-p TIRGRLLsLVEKVTy
0 1 K2035 RLLsLVEKVTyLKKK
0 1 Y2038-p sLVEKVTyLKKKQAE
0 1 K2136-m3 LLSVRMGkEEEkLMI
0 1 K2140-m3 RMGkEEEkLMIRGLG
0 2 Y2202-p NCCRFLCyFCRISRQ
0 1 Y2220 AMFDHLSYLLENSSV
0 1 S2231 NSSVGLASPAMRGST
0 2 S2363-p DPSRDGPsPNSGSSK
0 1 S2368 GPsPNSGSSKTLDTE
0 1 S2369 PsPNSGSSKTLDTEE
0 1 N2450 PTIAKDGNVVEPDMS
0 1 K2656 FDALSQKKYEQELFK
0 1 T2781-p PIKESLKtMLAWGWR
0 1 S2797 ERTREGDSMALYNRT
26 4 S2808-p YNRTRRIsQTSQVsV
0 3 T2810 RTRRIsQTSQVsVDA
0 4 S2811 TRRIsQTSQVsVDAA
26 9 S2814-p IsQTSQVsVDAAHGY
0 1 S2822 VDAAHGYSPRAIDMS
0 1 K2863 KKMELESKGGGNHPL
0 1 K2880 PYDTLTAKEKAKDRE
0 2 N2899 ILKFLQINGYAVSRG
0 1 K2908 YAVSRGFKDLELDTP
0 2 Y2923-p SIEKRFAySFLQQLI
0 1 S2947 ILEFDGGSRGKGEHF
0 1 K3076 EKTMENLKQGQFTHT
0 4 Y3285-p GNILKIIyNNLGIDE
0 1 K3297 IDEGAWMKRLAVFSQ
0 2 K3325 HFLPLMEKLKKKAAT
0 1 K3329 LMEKLKKKAATVVSE
0 2 Y3367-p TTLARDLyAFYPLLI
0 3 K3438-m1 LITDTKSkMSkAAVS
0 4 K3441-m1 DTKSkMSkAAVSDQE
0 2 Y3459-p MKRKGDRySMQTSLI
0 1 K3532 RWQMALYKDLPNRTD
0 1 C3574 RVGRRHYCLVEHPQR
0 1 S4054 DFHKAMESHKHYTQS
0 2 S4311-p GFFRIICsLLLGGsL
0 2 S4317-p CsLLLGGsLVEGAKK
0 1 Y4391-p LKREGGQyKLIPHNP
0 1 K4392 KREGGQyKLIPHNPN
  mouse

 
K304-u LRHVTTGkYLSLMED
Y823-p PPGYAACyEAVLPKE
K1141-a AFAFDGFkAQRWHQG
T1223-p NFGKDVStLKYFTIC
K1253-u DITMWLSkRLPQFLQ
K1284-u IDSSPCLkVTQkSFG
K1288-u PCLkVTQkSFGSQNN
S1317-p CAEVFSKsVAGGLPG
S1341-p LEDFDVDsDFEVLMK
Y1427 LMQTSTYYYSVRIFP
Y1428 MQTSTYYYSVRIFPG
K1473-u TVTLGDEkGKVHESI
S1495-p VCAGESMsPGQGRNN
K1562-u QFELGRIkNVMPLSA
K1791-u PLDILKAkTIQMLTE
K1801-u QMLTEAVkEGSLHAR
T1864-p VPEEEGGtPEkEISI
K1867-u EEGGtPEkEISIEDA
K1875-u EISIEDAkLEGEEEA
G1885-p GEEEAKGgKRPKEGL
S2030-p TIRGRLLsLVEkVTY
K2034-u RLLsLVEkVTYLKKK
Y2037 sLVEkVTYLKKKQAE
K2135 LLSVRMGKEEEKLMI
K2139 RMGKEEEKLMIRGLG
Y2201 NCCRFLCYFCRISRQ
Y2219 AMFDHLSYLLENSSV
S2230 NSSVGLASPAMRGST
S2362-p DPSRDGPsPTSGssK
S2367-p GPsPTSGssKTLDIE
S2368-p PsPTSGssKTLDIEE
K2449-u PTIAKDGkVVEPDMS
K2655-u FDALSQKkYEQELFK
T2780 PIKESLKTMLAWGWR
S2796-p ERTREGDsMALYNRT
S2807-p YNRTRRIsQtsQVsI
T2809-p RTRRIsQtsQVsIDA
S2810-p TRRIsQtsQVsIDAA
S2813-p IsQtsQVsIDAAHGY
S2821-p IDAAHGYsPRAIDMS
K2862-u KKLELESkGGGNHPL
K2879-u PYDTLTAkEKAKDRE
S2898-p IFKFLQIsGYVVSRG
K2907-u YVVSRGFkDLDLDTP
Y2922 SIEKRFAYSFLQQLI
S2946-p ILEFDGGsRSKGEHF
K3075-u EKTMENLkQGQFTHT
Y3284 GNILKIIYNNLGIDE
K3296-u IDEGAWMkRLAVFSQ
K3324-u HFLPLMEkLKKkAAM
K3328-u LMEkLKKkAAMVVSE
Y3366 TTLARDLYAFYPLLI
K3437-m1 LITDTKSkMSkAAIS
K3440-m1 DTKSkMSkAAISDQE
Y3458 MKRKGDRYSMQTSLI
K3531-u RWQMALYkDLPNRTE
S3573-p YTGRGYFsLVEHPQR
S4053-p DFHKAMEsHKHYTQS
S4310 GFFRIVSSLLLGGSL
S4316 SSLLLGGSLVEGAKK
Y4390-p LKREGGQykLIPHNP
K4391-u KREGGQykLIPHNPN
  rat

 
K297 LRHVTTGKYLSLMED
Y816 PPGYAACYEAVLPKE
K1134 AFAFDGFKAQRWHQG
T1216 NFGKDVSTLKYFTIC
K1246 DITMWLSKRLPQFLQ
K1277 IDSSPCLKVTQKSFG
K1281 PCLKVTQKSFGSQNS
S1310 CAEVFSKSVAGGIPG
S1334 LEDFDVDSDFEVLMK
Y1420 LMQTSTYYYSVRIFP
Y1421 MQTSTYYYSVRIFPG
K1466 TVTLGDEKGKVHESI
S1488 VCAGESMSPGQGRNN
K1555 QFELGRIKNVMPLSA
K1784 PLDILKAKTIQMLTE
K1794 QMLTEAVKEGSLHAR
A1857 TPEEEGGAPEKEISI
K1860 EEGGAPEKEISIDDS
K1868 EISIDDSKLEVKEEA
G1878 VKEEAKAGKRPKEGL
S2021-p TIRGRLLsLVEKVTY
K2025 RLLsLVEKVTYLKKK
Y2028 sLVEKVTYLKKKQAE
- under review  
- under review  
Y2192 NCCRFLCYFCRISRQ
Y2210-p AMFDHLSyLLENSSV
S2221-p NSSVGLAsPAMRGST
S2353 DPSRDGPSPTSGSSK
S2358 GPSPTSGSSKTLDAE
S2359 PSPTSGSSKTLDAEE
K2440 PTIAKDGKVVEPDMS
K2646 FDALSQKKYEQELFK
T2771 PIKESLKTMLAWGWR
S2787 ERTREGDSMALYNRT
S2798-p YNRTRRIsQTSQVsI
T2800 RTRRIsQTSQVsIDA
S2801 TRRIsQTSQVsIDAA
S2804-p IsQTSQVsIDAAHGY
S2812 IDAAHGYSPRAIDMS
K2853 KKMELESKGGGNHPL
K2870 PYDTLTAKEKAKDRE
S2889 IFKFLQISGYAVSRG
K2898 YAVSRGFKDLDLDTP
Y2913-p SIEKRFAySFLQQLI
S2937 ILEFDGGSRSKGEHF
K3066 EKTMENLKQGQFTHT
Y3275-p GNILKIIyNNLGIDE
K3287 IDEGAWMKRLAVFSQ
K3315 HFLPLMEKLKKKAAM
K3319 LMEKLKKKAAMVVSE
Y3357 TTLARNLYAFYPLLI
K3428 LITDTKSKMSKAAIS
K3431 DTKSKMSKAAISDQE
Y3449 MKRKGDRYSMQTSLI
K3522 RWQMALYKDLPNRAE
- gap
S4040 DFHKAMESHKHYTQS
S4297 GFFRIVSSLLLGGSL
S4303 SSLLLGGSLVEGAKK
Y4377 LKREGGQYKLIPHNP
K4378 KREGGQYKLIPHNPN
  rabbit

 
K304 LRHVTTGKYLSLMED
Y823 PPGYAPCYEAVLPKE
K1141 AFAFDGFKAQRWHQG
T1223 NFGKDVSTLKYFTIC
K1253 DITMWLSKRLPQFLQ
K1284 IDSSPCLKVTQKSFG
K1288 PCLKVTQKSFGSQNS
T1317 CAEVFSKTVPGGLPG
S1341 LEDYDADSDFEVLMK
Y1427 LMQTSTYYYSVRIFP
Y1428 MQTSTYYYSVRIFPG
K1473 TVTLGDEKGKVHESI
S1495 VCAGESMSPGQGRNN
K1561 QFELGRIKNVMPLSA
K1790 PLDILKAKTIQMLTE
K1800 QMLTEAVKEGSLHGR
T1863 TPEEEGDTLEEEPSV
E1866 EEGDTLEEEPSVEDT
K1874 EPSVEDTKLEGAGEE
G1886 GEEEAKVGKRPKEGL
S2031 TIRGRLLSLVEKVTY
K2035 RLLSLVEKVTYLKKK
Y2038 SLVEKVTYLKKKQTE
- under review  
- under review  
Y2202 NCCRFLCYFCRISRQ
Y2220 AMFDHLSYLLENSSV
S2231 NSSVGLASPAMRGST
S2364 DPSRDGPSPTSGSSK
S2369 GPSPTSGSSKTLDTE
S2370 PSPTSGSSKTLDTEE
N2451 PTIAKDGNVVEPDMS
K2657 FDALSQKKYEQELFK
T2782 PIKESLKTMLAWGWR
S2798 ERTREGDSMALYNRT
S2809-p YNRTRRIsQTSQVsV
T2811 RTRRIsQTSQVsVDA
S2812 TRRIsQTSQVsVDAA
S2815-p IsQTSQVsVDAAHGY
S2823 VDAAHGYSPRAIDMS
K2864 KKLELESKGGGNHPL
K2881 PYDTLTAKEKAKDRE
N2900 ILKFLQINGYAVSRG
K2909 YAVSRGFKDLELDTP
Y2924 SIEKRFAYSFLQQLI
S2948 ILEFDGGSRSKGEHF
K3077 EKTMENLKQGQFTHT
Y3286 GNILKIIYNNLGIDE
K3298 IDEGAWMKRLAVFSQ
K3326 HFLPLMEKLKKKAAM
K3330 LMEKLKKKAAMVVSE
Y3368 TTLARDLYAFYPLLI
K3439 LITDTKSKMSKAAVS
K3442 DTKSKMSKAAVSDQE
Y3460 MKRKGDRYSMQTSLI
K3533 RWQMALYKDLPNRTE
N3575 FIGRRYYNLVEHPQR
S4055 DFHKAMESHKHYTQS
S4312 GFFRIVCSLLLGGSL
S4318 CSLLLGGSLVEGAKK
Y4392 LKREGGQYKLIPHNP
K4393 KREGGQYKLIPHNPN
  dog

 
K289 LRHVTTGKYLSLMED
Y808 PPGYAPCYEAVLPKE
K1126 AFAFDGFKAQRWHQG
T1208 NFGKDVSTLKYFTIC
K1238 DITMWLSKRLPQFLQ
K1269 IDSSPCLKVTQKSFG
K1273 PCLKVTQKSFGSQNS
T1302 CAEVFSKTVAGGLPG
S1326 LEDYDADSDFEVLMK
Y1412 LMQTSTYYYSVRIFP
Y1413 MQTSTYYYSVRIFPG
K1458 TVTLGDEKGKVHESI
S1480 VCAGESMSPGQGRNN
K1546 QFELGRIKNVMPLSA
K1775 PLDILKAKTIQMLTE
K1785 QMLTEAVKEGSLHAR
A1848 TPDEETEALEKEPCP
K1851 EETEALEKEPCPEDS
K1859 EPCPEDSKSEGAGEE
V1871 GEEEAKGVKRPKEGL
S2016-p TIRGRLLsLVEKVTY
K2020 RLLsLVEKVTYLKKK
Y2023 sLVEKVTYLKKKQAE
- under review  
- under review  
Y2187 NCCRFLCYFCRISRQ
Y2205 AMFDHLSYLLENSSV
S2216 NSSVGLASPAMRGST
S2348 DPSRDGPSPTSGSSK
S2353 GPSPTSGSSKTLDTE
S2354 PSPTSGSSKTLDTEE
N2435 PTIAKDGNVVEPDMS
K2641 FDALSQKKYEQELFK
T2766 PIKESLKTMLAWGWR
S2782 ERTREGDSMALYNRT
S2793-p YNRTRRIsQTSQVsV
T2795 RTRRIsQTSQVsVDA
S2796 TRRIsQTSQVsVDAA
S2799-p IsQTSQVsVDAAHGY
S2807 VDAAHGYSPRAIDMS
K2848 KKMELESKGGGNHPL
K2865 PYDTLTAKEKAKDRE
N2884 ILKFLQINGYAVSRG
K2893 YAVSRGFKDLELDTP
Y2908 SIEKRFAYSFLQQLI
G2932 ILEFDGGGRSKGEHF
K3061 EKTMENLKQGQFTHT
Y3270 GNILKIIYNNLGIDE
K3282 IDEGAWMKRLAVFSQ
K3310 HFLPLMEKLKKKAAM
K3314 LMEKLKKKAAMVVSE
Y3352 TTLARDLYAFYPLLI
K3423 LITDTKSKMSKAAVS
K3426 DTKSKMSKAAVSDQE
Y3444 MKRKGDRYSMQTSLI
K3517 RWQMALYKDLPNRTE
P3559 CIPFIILPQVEHPQR
S4047 DFHKAMESHKHYTQS
S4304 GFFRIICSLLLGGSL
S4310 CSLLLGGSLVEGAKK
Y4384 LKREGGQYKLIPHNP
K4385 KREGGQYKLIPHNPN
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