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Protein Page:
RYR2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
RYR2 ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 1q43
Cellular Component: sarcoplasmic reticulum membrane; protein complex; membrane; sarcoplasmic reticulum; plasma membrane; Z disc
Molecular Function: calcium-induced calcium release activity; calmodulin binding; identical protein binding; protein binding; enzyme binding; protein self-association; calcium channel activity; calcium-release channel activity; calcium ion binding; intracellular ligand-gated calcium channel activity; ryanodine-sensitive calcium-release channel activity
Biological Process: positive regulation of sequestering of calcium ion; cytosolic calcium ion homeostasis; regulation of heart rate; calcium-mediated signaling; positive regulation of heart rate; response to redox state; Wnt receptor signaling pathway through beta-catenin; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine; cellular calcium ion homeostasis; BMP signaling pathway; release of sequestered calcium ion into cytosol; calcium ion transport; response to hypoxia; detection of calcium ion; transmembrane transport; cardiac muscle contraction
Reference #:  Q92736 (UniProtKB)
Alt. Names/Synonyms: ARVC2; ARVD2; cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Cardiac muscle-type ryanodine receptor; hRYR-2; Ryanodine receptor 2; ryanodine receptor 2 (cardiac); RYR-2; RYR2; VTSIP
Gene Symbols: RYR2
Molecular weight: 564,567 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
Select Structure to View Below

RYR2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y196-p ERYLHLSyGNGSLHV
0 1 K304 LRHVTTGKYLSLMED
0 1 K335 AFTFRSSKEKLDVGV
0 1 K337 TFRSSKEKLDVGVRK
0 1 K390-ub RMGSIQRkAIMHHEG
0 1 S406-p MDDGISLsRSQHEES
0 1 Y706 STEGYSPYPGGGEEW
0 1 Y819 KFLPPPGYAPCyEAV
0 3 Y823-p PPGYAPCyEAVLPKE
0 1 Y931 LPEQERNYNLQMSLE
0 1 K998 SQEAMVDKLAENAHN
0 5 K1141-ac AFAFDGFkAQRWHQG
0 1 T1172-p MVDMNEHtMMFtLNG
0 1 T1176-p NEHtMMFtLNGEILL
0 1 T1223 NFGKDVSTLKYFTIC
0 1 K1253 DITMWLSKRLPQFLQ
0 1 K1284 IDSSPCLKVTQKSFG
0 1 K1288 PCLKVTQKSFGSQNS
0 2 T1317-p CAEVFSKtVAGGLPG
0 2 S1341 LEDYDADSDFEVLMK
0 1 S1402 PDYSTSHSARLTEDV
0 1 Y1427-p LMQTSTYyySVRIFP
0 1 Y1428-p MQTSTYyySVRIFPG
0 1 K1473 TVTLGDEKGKVHESI
0 1 S1483-p VHESIKRsNCyMVCA
0 1 Y1486-p SIKRsNCyMVCAGES
0 2 S1495 VCAGESMSPGQGRNN
0 1 K1561 QFELGRIKNVMPLSA
0 1 K1788-ac EFPLDILkSkTIQML
0 1 K1790-ac PLDILkSkTIQMLTE
0 1 K1790 PLDILkSKTIQMLTE
0 1 K1800 QMLTEAVKEGSLHAR
0 3 T1863 TPEEESDTLEKELSV
0 1 K1866 EESDTLEKELSVDDA
0 1 K1874 ELSVDDAKLQGAGEE
1 0 G1886 GEEEAKGGkRPkEGL
0 1 K1887-ac EEEAKGGkRPkEGLL
0 1 K1890-ac AKGGkRPkEGLLQMk
0 1 K1897-ac kEGLLQMkLPEPVkL
0 1 K1903-ac MkLPEPVkLQMCLLL
0 1 Y1944-p QDNQRFRyNEVMQAL
0 1 T1962-p AALTARKtKEFRSPP
8 3 S2031-p TIRGRLLsLVEKVTy
0 1 K2035 RLLsLVEKVTyLKKK
0 1 Y2038-p sLVEKVTyLKKKQAE
0 1 S2073-p MVRWAQEsVIEDPEL
0 1 K2136-m3 LLSVRMGkEEEkLMI
0 1 K2140-m3 RMGkEEEkLMIRGLG
0 1 K2191-ac SKEITFPkMVANCCR
0 2 Y2202-p NCCRFLCyFCRISRQ
0 1 Y2220 AMFDHLSYLLENSSV
0 1 S2231 NSSVGLASPAMRGST
0 2 S2363-p DPSRDGPsPNSGSSK
0 1 S2368 GPsPNSGSSKTLDTE
0 1 S2369 PsPNSGSSKTLDTEE
0 1 N2450 PTIAKDGNVVEPDMS
0 1 Y2519-p MALALNRyLCtAVLP
0 1 T2522-p ALNRyLCtAVLPLLt
0 1 T2529-p tAVLPLLtRCAPLFA
0 1 K2656 FDALSQKKYEQELFK
0 1 S2751-p GEIYSDSsKVQPLMK
0 1 T2781-p PIKESLKtMLAWGWR
0 1 S2797 ERTREGDSMALYNRT
0 1 Y2801 EGDSMALYNRTRRIs
32 4 S2808-p YNRTRRIsQTSQVsV
0 3 T2810 RTRRIsQTSQVsVDA
0 4 S2811 TRRIsQTSQVsVDAA
34 9 S2814-p IsQTSQVsVDAAHGY
0 1 S2822 VDAAHGYSPRAIDMS
0 1 K2863 KKMELESKGGGNHPL
0 1 K2880 PYDTLTAKEKAKDRE
0 2 N2899 ILKFLQINGYAVSRG
0 1 Y2901 KFLQINGYAVSRGFK
0 1 K2908 YAVSRGFKDLELDTP
0 2 Y2923-p SIEKRFAySFLQQLI
0 1 S2947 ILEFDGGSRGKGEHF
0 1 K3076 EKTMENLKQGQFTHT
0 1 Y3228 LAESGIRYTQMPHVM
0 1 H3233 IRYTQMPHVMEVILP
0 1 Y3245 ILPMLCSYMSRWWEH
0 4 Y3285-p GNILKIIyNNLGIDE
0 1 K3297 IDEGAWMKRLAVFsQ
0 1 S3303-p MKRLAVFsQPIINKV
0 2 K3325 HFLPLMEKLKKKAAT
0 1 K3329 LMEKLKKKAATVVSE
0 2 Y3367-p TTLARDLyAFyPLLI
0 1 Y3370-p ARDLyAFyPLLIRFV
0 1 S3437-p FLITDTKskMSkAAV
0 3 K3438-m1 LITDTKskMSkAAVS
0 4 K3441-m1 DTKskMSkAAVSDQE
0 2 Y3459-p MKRKGDRySMQTSLI
0 1 S3497-p ALAKNRFsLKDtEDE
0 1 T3501-p NRFsLKDtEDEVRDI
0 1 K3532 RWQMALYKDLPNRTD
0 1 C3574 RVGRRHYCLVEHPQR
0 1 T3751-p ISASKGEtGPMVAAT
0 1 K4040-ac KEYDPDGkGVISKRD
0 1 K4050-ac ISKRDFHkAMESHKH
0 1 S4054 DFHkAMESHKHYTQS
0 2 S4311-p GFFRIICsLLLGGsL
0 2 S4317-p CsLLLGGsLVEGAKK
0 1 Y4391-p LKREGGQyKLIPHNP
0 1 K4392 KREGGQyKLIPHNPN
0 1 K4452-ac EDGEKEEkAkEDkGk
0 1 K4454-ac GEKEEkAkEDkGkQK
0 1 K4457-ac EEkAkEDkGkQKLRQ
0 1 K4459-ac kAkEDkGkQKLRQLH
0 1 S4550-p KVTSLDSsSHRIIAV
0 1 S4695-p PKKDSSLsAVLNSID
0 1 Y4705-p LNSIDVKyQMWKLGV
0 1 Y4944-p ESYVWKMyQERCWEF
  mouse

 
Y196 ERYLHLSYGNSSWHV
K304-ub LRHVTTGkYLSLMED
K335-ac AFAFRSSkEkLDVGV
K337-ac AFRSSkEkLDVGVRK
K390 RMGSIQRKAIMHHEG
S406 MDDGLNLSRSQHEES
Y706-p STEGYSPyPGGGEEW
Y819-p KFLPPPGyAACyEAV
Y823-p PPGyAACyEAVLPKE
Y931 LPEQERNYNLQMSLE
K998-ac SQEAMVDkLAENAHN
K1141-ac AFAFDGFkAQRWHQG
T1172 MVDMNEHTMMFTLNG
T1176 NEHTMMFTLNGEILL
T1223-p NFGKDVStLKYFTIC
K1253-ub DITMWLSkRLPQFLQ
K1284-ub IDSSPCLkVTQkSFG
K1288-ub PCLkVTQkSFGSQNN
S1317-p CAEVFSKsVAGGLPG
S1341-p LEDFDVDsDFEVLMK
S1402-p PDYSTGHsARLTEDV
Y1427 LMQTSTYYYSVRIFP
Y1428 MQTSTYYYSVRIFPG
K1473-ub TVTLGDEkGKVHESI
S1483 VHESIKRSNCYMVCA
Y1486 SIKRSNCYMVCAGES
S1495-p VCAGESMsPGQGRNN
K1562-ub QFELGRIkNVMPLSA
K1789 EFPLDILKAkTIQML
K1791 PLDILKAKTIQMLTE
K1791-ub PLDILKAkTIQMLTE
K1801-ub QMLTEAVkEGSLHAR
T1864-p VPEEEGGtPEkEISI
K1867-ub EEGGtPEkEISIEDA
K1875-ub EISIEDAkLEGEEEA
G1885-p GEEEAKGgKRPKEGL
K1886 EEEAKGgKRPKEGLL
K1889 AKGgKRPKEGLLQMK
K1896 KEGLLQMKLPEPVKL
K1902 MKLPEPVKLQMCLLL
Y1943 QDNQRFRYNEVMQAL
T1961 AALTARKTREFRSPP
S2030-p TIRGRLLsLVEkVTY
K2034-ub RLLsLVEkVTYLKKK
Y2037 sLVEkVTYLKKKQAE
S2072 MVRWAQESVIEDPEL
K2135 LLSVRMGKEEEKLMI
K2139 RMGKEEEKLMIRGLG
K2190 SKEITFPKMVANCCR
Y2201 NCCRFLCYFCRISRQ
Y2219 AMFDHLSYLLENSSV
S2230 NSSVGLASPAMRGST
S2362-p DPSRDGPsPTSGssK
S2367-p GPsPTSGssKTLDIE
S2368-p PsPTSGssKTLDIEE
K2449-ub PTIAKDGkVVEPDMS
Y2518 MALALNRYLCTAVLP
T2521 ALNRYLCTAVLPLLT
T2528 TAVLPLLTRCAPLFA
K2655-ub FDALSQKkYEQELFK
S2750 GEIYSDSSKIQPLMK
T2780 PIKESLKTMLAWGWR
S2796-p ERTREGDsMALYNRT
Y2800 EGDsMALYNRTRRIs
S2807-p YNRTRRIsQtsQVsI
T2809-p RTRRIsQtsQVsIDA
S2810-p TRRIsQtsQVsIDAA
S2813-p IsQtsQVsIDAAHGY
S2821-p IDAAHGYsPRAIDMS
K2862-ub KKLELESkGGGNHPL
K2879-ub PYDTLTAkEKAKDRE
S2898-p IFKFLQIsGyVVSRG
Y2900-p KFLQIsGyVVSRGFk
K2907-ub yVVSRGFkDLDLDTP
Y2922 SIEKRFAYSFLQQLI
S2946-p ILEFDGGsRSKGEHF
K3075-ub EKTMENLkQGQFTHT
Y3227-p LAESGIRyTQMPyMM
Y3232-p IRyTQMPyMMEVVLP
Y3244-p VLPMLCSyMSRWWEH
Y3284 GNILKIIYNNLGIDE
K3296-ub IDEGAWMkRLAVFSQ
S3302 MkRLAVFSQPIINKV
K3324-ub HFLPLMEkLKKkAAM
K3328-ub LMEkLKKkAAMVVSE
Y3366 TTLARDLYAFYPLLI
Y3369 ARDLYAFYPLLIRFV
S3436 FLITDTKSkMSkAAI
K3437-m1 LITDTKSkMSkAAIS
K3440-m1 DTKSkMSkAAISDQE
Y3458 MKRKGDRYSMQTSLI
S3496 ALAKNRFSLKDTEEE
T3500 NRFSLKDTEEEVRDI
K3531-ub RWQMALYkDLPNRTE
S3573-p YTGRGYFsLVEHPQR
T3750 ISASKGETGPMVAAT
K4039 KEYDPDGKGVISKRD
K4049 ISKRDFHKAMEsHKH
S4053-p DFHKAMEsHKHYTQS
S4310 GFFRIVSSLLLGGSL
S4316 SSLLLGGSLVEGAKK
Y4390-p LKREGGQykLIPHNP
K4391-ub KREGGQykLIPHNPN
K4450 EDGEKEEKAKDEKSK
K4452 GEKEEKAKDEKSKQK
K4455 EEKAKDEKSKQKLRQ
K4457 KAKDEKSKQKLRQLH
S4549 VTNSLDSSPHRIIAV
S4694 PKKDSSLSAVLNSID
Y4704 LNSIDVKYQMWKLGV
Y4943 ESYVWKMYQERCWEF
  rat

 
Y189 ERYLHLSYGNSSWRV
K297 LRHVTTGKYLSLMED
K328 AFAFRSSKEKLDAGV
K330 AFRSSKEKLDAGVRK
K383 RMGSIQRKAIMHHEG
S399 MDDGLNLSRSQHEES
Y699 STEGYSPYPGGGEEW
Y812 KFLPPPGYAACYEAV
Y816 PPGYAACYEAVLPKE
Y924-p LPEQERNyNLQMSLE
K991 SQEAMVDKLAENAHN
K1134-ac AFAFDGFkAQRWHQG
T1165 MVDMNEHTMMFTLNG
T1169 NEHTMMFTLNGEILL
T1216 NFGKDVSTLKYFTIC
K1246 DITMWLSKRLPQFLQ
K1277 IDSSPCLKVTQKSFG
K1281 PCLKVTQKSFGSQNS
S1310 CAEVFSKSVAGGIPG
S1334-p LEDFDVDsDFEVLMK
S1395 PDYSTSHSARLTEDV
Y1420 LMQTSTYYYSVRIFP
Y1421 MQTSTYYYSVRIFPG
K1466 TVTLGDEKGKVHESI
S1476 VHESIKRSNCYMVCA
Y1479 SIKRSNCYMVCAGES
S1488 VCAGESMSPGQGRNN
K1555 QFELGRIKNVMPLSA
K1782 EFPLDILKAKTIQML
K1784 PLDILKAKTIQMLTE
K1784 PLDILKAKTIQMLTE
K1794 QMLTEAVKEGSLHAR
A1857 TPEEEGGAPEKEISI
K1860 EEGGAPEKEISIDDS
K1868 EISIDDSKLEVKEEA
G1878 VKEEAKAGKRPKEGL
K1879 KEEAKAGKRPKEGLL
K1882 AKAGKRPKEGLLQMK
K1889 KEGLLQMKLPEPVKL
K1895 MKLPEPVKLQMCLLL
Y1936 QDNQRFRYNEVMQAL
- gap
S2021-p TIRGRLLsLVEKVTY
K2025 RLLsLVEKVTYLKKK
Y2028 sLVEKVTYLKKKQAE
S2063 MVRWAQESVIEDPEL
K2126 LLSVRMGKEEEKLMI
K2130 RMGKEEEKLMIRGLG
K2181 SKEITFPKMVANCCR
Y2192 NCCRFLCYFCRISRQ
Y2210-p AMFDHLSyLLENSSV
S2221-p NSSVGLAsPAMRGST
S2353 DPSRDGPSPTSGSSK
S2358 GPSPTSGSSKTLDAE
S2359 PSPTSGSSKTLDAEE
K2440 PTIAKDGKVVEPDMS
Y2509 MALALNRYLCTAVLP
T2512 ALNRYLCTAVLPLLT
T2519 TAVLPLLTRCAPLFA
K2646 FDALSQKKYEQELFK
S2741 GEIYSDSSKIQPLMK
T2771 PIKESLKTMLAWGWR
S2787 ERTREGDSMALyNRT
Y2791-p EGDSMALyNRTRRIs
S2798-p yNRTRRIsQTsQVsI
T2800 RTRRIsQTsQVsIDA
S2801-p TRRIsQTsQVsIDAA
S2804-p IsQTsQVsIDAAHGY
S2812 IDAAHGYSPRAIDMS
K2853 KKMELESKGGGNHPL
K2870 PYDTLTAKEKAKDRE
S2889 IFKFLQISGYAVSRG
Y2891 KFLQISGYAVSRGFK
K2898 YAVSRGFKDLDLDTP
Y2913-p SIEKRFAySFLQQLI
S2937 ILEFDGGSRSKGEHF
K3066 EKTMENLKQGQFTHT
Y3218 LAESGIRYTQMPHMM
H3223 IRYTQMPHMMEVVLP
Y3235 VLPMLCSYMSRWWEH
Y3275-p GNILKIIyNNLGIDE
K3287 IDEGAWMKRLAVFSQ
S3293 MKRLAVFSQPIINKV
K3315 HFLPLMEKLKKKAAM
K3319 LMEKLKKKAAMVVSE
Y3357 TTLARDLYAFYPLLI
Y3360 ARDLYAFYPLLIRFV
S3427 FLITDTKSKMSKAAI
K3428 LITDTKSKMSKAAIS
K3431 DTKSKMSKAAISDQE
Y3449 MKRKGDRYSMQTSLI
S3487 ALAKNRFSLKDTEEE
T3491 NRFSLKDTEEEVRDV
K3522 RWQMALYKDLPNRAE
- gap
T3737 FSASKGETGPMVAAT
K4026 KEYDPDGKGVISKRD
K4036 ISKRDFHKAMESHKH
S4040 DFHKAMESHKHYTQS
S4297 GFFRIVSSLLLGGSL
S4303 SSLLLGGSLVEGAKK
Y4377 LKREGGQYKLIPHNP
K4378 KREGGQYKLIPHNPN
K4437 EDGEKEEKAKDDKGK
K4439 GEKEEKAKDDKGKQK
K4442 EEKAKDDKGKQKLRQ
K4444 KAKDDKGKQKLRQLH
S4536 VTTSLDSSPHRIIAV
S4681 PKKDSSLSAVLNSID
Y4691 LNSIDVKYQMWKLGV
Y4930 ESYVWKMYQERCWEF
  rabbit

 
Y196 ERYLHLSYGNGSLHV
K304 LRHVTTGKYLSLMED
K335 AFTFRSSKEKLDGGV
K337 TFRSSKEKLDGGVRK
K390 RMGSIQRKAIMHHEG
S406 MDDGLNLSRSQHEES
Y706 STEGYSPYPGGGEEW
Y819 KFLPPPGYAPCYEAV
Y823 PPGYAPCYEAVLPKE
Y931 LPEQERNYNLQMSLE
K998 SQEAMVDKLAENAHN
K1141 AFAFDGFKAQRWHQG
T1172 MVDMNEHTMMFTLNG
T1176 NEHTMMFTLNGEILL
T1223 NFGKDVSTLKYFTIC
K1253 DITMWLSKRLPQFLQ
K1284 IDSSPCLKVTQKSFG
K1288 PCLKVTQKSFGSQNS
T1317 CAEVFSKTVPGGLPG
S1341 LEDYDADSDFEVLMK
S1402 PDYSTSHSARLTEDV
Y1427 LMQTSTYYYSVRIFP
Y1428 MQTSTYYYSVRIFPG
K1473 TVTLGDEKGKVHESI
S1483 VHESIKRSNCYMVCA
Y1486 SIKRSNCYMVCAGES
S1495 VCAGESMSPGQGRNN
K1561 QFELGRIKNVMPLSA
K1788 EFPLDILKAKTIQML
K1790 PLDILKAKTIQMLTE
K1790 PLDILKAKTIQMLTE
K1800 QMLTEAVKEGSLHGR
T1863 TPEEEGDTLEEEPSV
E1866 EEGDTLEEEPSVEDT
K1874 EPSVEDTKLEGAGEE
G1886 GEEEAKVGKRPKEGL
K1887 EEEAKVGKRPKEGLL
K1890 AKVGKRPKEGLLQMK
K1897 KEGLLQMKLPEPVKL
K1903 MKLPEPVKLQMCLLL
Y1944 QDNQRFRYNEVMQAL
T1962 AALTARKTKEFRSPP
S2031 TIRGRLLSLVEKVTY
K2035 RLLSLVEKVTYLKKK
Y2038 SLVEKVTYLKKKQTE
S2073 MVRWAQESVIEDPEL
K2136 LLSVRMGKEEEKLMI
K2140 RMGKEEEKLMIRGLG
K2191 SKEITFPKMVANCCR
Y2202 NCCRFLCYFCRISRQ
Y2220 AMFDHLSYLLENSSV
S2231 NSSVGLASPAMRGST
S2364 DPSRDGPSPTSGSSK
S2369 GPSPTSGSSKTLDTE
S2370 PSPTSGSSKTLDTEE
N2451 PTIAKDGNVVEPDMS
Y2520 MALALNRYLCTAVLP
T2523 ALNRYLCTAVLPLLT
T2530 TAVLPLLTRCAPLFA
K2657 FDALSQKKYEQELFK
S2752 GEIYSDSSKIQPLMK
T2782 PIKESLKTMLAWGWR
S2798 ERTREGDSMALYNRT
Y2802 EGDSMALYNRTRRIs
S2809-p YNRTRRIsQTSQVsV
T2811 RTRRIsQTSQVsVDA
S2812 TRRIsQTSQVsVDAA
S2815-p IsQTSQVsVDAAHGY
S2823 VDAAHGYSPRAIDMS
K2864 KKLELESKGGGNHPL
K2881 PYDTLTAKEKAKDRE
N2900 ILKFLQINGYAVSRG
Y2902 KFLQINGYAVSRGFK
K2909 YAVSRGFKDLELDTP
Y2924 SIEKRFAYSFLQQLI
S2948 ILEFDGGSRSKGEHF
K3077 EKTMENLKQGQFTHT
Y3229 LAESGIRYTQMPHVM
H3234 IRYTQMPHVMEVILP
Y3246 ILPMLCSYMSRWWEH
Y3286 GNILKIIYNNLGIDE
K3298 IDEGAWMKRLAVFSQ
S3304 MKRLAVFSQPIINKV
K3326 HFLPLMEKLKKKAAM
K3330 LMEKLKKKAAMVVSE
Y3368 TTLARDLYAFYPLLI
Y3371 ARDLYAFYPLLIRFV
S3438 FLITDTKSKMSKAAV
K3439 LITDTKSKMSKAAVS
K3442 DTKSKMSKAAVSDQE
Y3460 MKRKGDRYSMQTSLI
S3498 ALAKNRFSLKATEDE
T3502 NRFSLKATEDEVRDI
K3533 RWQMALYKDLPNRTE
N3575 FIGRRYYNLVEHPQR
T3752 ISASKGETGPMVAAT
K4041 KEYDPDGKGIISKRD
K4051 ISKRDFHKAMESHKH
S4055 DFHKAMESHKHYTQS
S4312 GFFRIVCSLLLGGSL
S4318 CSLLLGGSLVEGAKK
Y4392 LKREGGQYKLIPHNP
K4393 KREGGQYKLIPHNPN
K4453 EDGEKEEKVKEDKGK
K4455 GEKEEKVKEDKGKQK
K4458 EEKVKEDKGKQKLRQ
K4460 KVKEDKGKQKLRQLH
S4552 VTTSLDSSSHRIIAV
S4697 PKKDSSLSAVLNSID
Y4707 LNSIDVKYQMWKLGV
Y4946 ESYVWKMYQERCWEF
  dog

 
Y181 ERYLHLSYGNGSLHV
K289 LRHVTTGKYLSLMED
K320 AFTFRSSKEKLDVGV
K322 TFRSSKEKLDVGVRK
K375 RMGSIQRKAIMHHEG
S391 MDDGLNLSRSQHEES
Y691 STEGYSPYPGGGEEW
Y804 KFLPPPGYAPCYEAV
Y808 PPGYAPCYEAVLPKE
Y916 LPEQERNYNLQMSLE
K983 SQEAMVDKLAENAHN
K1126 AFAFDGFKAQRWHQG
T1157 MVDMTERTMMFTLNG
T1161 TERTMMFTLNGEVLL
T1208 NFGKDVSTLKYFTIC
K1238 DITMWLSKRLPQFLQ
K1269 IDSSPCLKVTQKSFG
K1273 PCLKVTQKSFGSQNS
T1302 CAEVFSKTVAGGLPG
S1326 LEDYDADSDFEVLMK
S1387 PDYSTSHSARLTEDV
Y1412 LMQTSTYYYSVRIFP
Y1413 MQTSTYYYSVRIFPG
K1458 TVTLGDEKGKVHESI
S1468 VHESIKRSNCYMVCA
Y1471 SIKRSNCYMVCAGES
S1480 VCAGESMSPGQGRNN
K1546 QFELGRIKNVMPLSA
K1773 EFPLDILKAKTIQML
K1775 PLDILKAKTIQMLTE
K1775 PLDILKAKTIQMLTE
K1785 QMLTEAVKEGSLHAR
A1848 TPDEETEALEKEPCP
K1851 EETEALEKEPCPEDS
K1859 EPCPEDSKSEGAGEE
V1871 GEEEAKGVKRPKEGL
K1872 EEEAKGVKRPKEGLL
K1875 AKGVKRPKEGLLQMK
K1882 KEGLLQMKLPEPVKL
K1888 MKLPEPVKLQMCLLL
Y1929 QDNQRFRYNEVMQAL
T1947 AALTARKTKEFRSPP
S2016-p TIRGRLLsLVEKVTY
K2020 RLLsLVEKVTYLKKK
Y2023 sLVEKVTYLKKKQAE
S2058 MVRWAQESVIEDPDL
K2121 LLSVRMGKEEEKLMI
K2125 RMGKEEEKLMIRGLG
K2176 SKEITFPKMVANCCR
Y2187 NCCRFLCYFCRISRQ
Y2205 AMFDHLSYLLENSSV
S2216 NSSVGLASPAMRGST
S2348 DPSRDGPSPTSGSSK
S2353 GPSPTSGSSKTLDTE
S2354 PSPTSGSSKTLDTEE
N2435 PTIAKDGNVVEPDMS
Y2504 MALALNRYLCTAVLP
T2507 ALNRYLCTAVLPLLT
T2514 TAVLPLLTRCAPLFA
K2641 FDALSQKKYEQELFK
S2736 GEIYSDSSKVQPLMK
T2766 PIKESLKTMLAWGWR
S2782 ERTREGDSMALYNRT
Y2786 EGDSMALYNRTRRIs
S2793-p YNRTRRIsQTSQVsV
T2795 RTRRIsQTSQVsVDA
S2796 TRRIsQTSQVsVDAA
S2799-p IsQTSQVsVDAAHGY
S2807 VDAAHGYSPRAIDMS
K2848 KKMELESKGGGNHPL
K2865 PYDTLTAKEKAKDRE
N2884 ILKFLQINGYAVSRG
Y2886 KFLQINGYAVSRGFK
K2893 YAVSRGFKDLELDTP
Y2908 SIEKRFAYSFLQQLI
G2932 ILEFDGGGRSKGEHF
K3061 EKTMENLKQGQFTHT
Y3213 LAESGIRYTQMPHVM
H3218 IRYTQMPHVMEVILP
Y3230 ILPMLCSYMSRWWEH
Y3270 GNILKIIYNNLGIDE
K3282 IDEGAWMKRLAVFSQ
S3288 MKRLAVFSQPIINKV
K3310 HFLPLMEKLKKKAAM
K3314 LMEKLKKKAAMVVSE
Y3352 TTLARDLYAFYPLLI
Y3355 ARDLYAFYPLLIRFV
S3422 FLITDTKSKMSKAAV
K3423 LITDTKSKMSKAAVS
K3426 DTKSKMSKAAVSDQE
Y3444 MKRKGDRYSMQTSLI
S3482 ALAKNRFSMKDTEDE
T3486 NRFSMKDTEDEVRDI
K3517 RWQMALYKDLPNRTE
P3559 CIPFIILPQVEHPQR
T3744 ISASKGDTGPMVAAT
K4033 KEYDPDGKGVISKRD
K4043 ISKRDFHKAMESHKH
S4047 DFHKAMESHKHYTQS
S4304 GFFRIICSLLLGGSL
S4310 CSLLLGGSLVEGAKK
Y4384 LKREGGQYKLIPHNP
K4385 KREGGQYKLIPHNPN
K4445 EDGEKEEKAKEDKGK
K4447 GEKEEKAKEDKGKQK
K4450 EEKAKEDKGKQKLRQ
K4452 KAKEDKGKQKLRQLH
G4543 KVSSLDSGSPRIITV
S4688 PKKDSSLSAVLNSID
Y4698 LNSIDVKYQMWKLGV
Y4937 ESYVWKMYQERCWEF
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