Home

PLA2G2F (human)

Overview PLA2G2F PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference. Belongs to the phospholipase A2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Lipid Metabolism - glycerophospholipid; Secreted; Lipid Metabolism - linoleic acid; Lipid Metabolism - arachidonic acid; Secreted, signal peptide; Lipid Metabolism - alpha-linolenic acid; Phospholipase; Lipid Metabolism - ether lipid; EC 3.1.1.4 Cellular Component: extracellular region; cytosol Molecular Function: phospholipase A2 activity; calcium ion binding Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process Reference #:  Q9BZM2 (UniProtKB) Alt. Names/Synonyms: GIIF sPLA2; Group IIF secretory phospholipase A2; PA2GF; Phosphatidylcholine 2-acylhydrolase 2F; RP3-340N1.1; sPLA2-IIF Gene Symbols: PLA2G2F Molecular weight: 18,658 Da Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states

Select Structure to View Below PLA2G2F

Scansite  |  Pfam  |  ENZYME 3.1.1.4 GC01P020465  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		-	gap
0	1		T6-p	__MKKFFtVAILAGs
0	1		S13-p	tVAILAGsVLstAHG
0	1		S16-p	ILAGsVLstAHGsLL
0	1		T17-p	LAGsVLstAHGsLLN
0	1		S21-p	VLstAHGsLLNLKAM

	PLA2G2F iso2
S22-p	KVLDRCFsGWRGPRF
T49	LGMKKFFTVAILAGS
S56	TVAILAGSVLSTAHG
S59	ILAGSVLSTAHGSLL
T60	LAGSVLSTAHGSLLN
S64	VLSTAHGSLLNLKAM

	mouse
-	gap
A6	__MKKFFAIAVLAGS
S13	AIAVLAGSVVTTAHS
T16	VLAGSVVTTAHSSLL
T17	LAGSVVTTAHSSLLN
S21	VVTTAHSSLLNLKSM

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.