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Protein Page:
PLA2G2F (human)

Overview
PLA2G2F PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference. Belongs to the phospholipase A2 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; EC 3.1.1.4; Lipid Metabolism - arachidonic acid; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - linoleic acid; Phospholipase; Secreted; Secreted, signal peptide
Cellular Component: extracellular region; cytosol
Molecular Function: phospholipase A2 activity; calcium ion binding
Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; lipid catabolic process
Reference #:  Q9BZM2 (UniProtKB)
Alt. Names/Synonyms: GIIF sPLA2; Group IIF secretory phospholipase A2; PA2GF; Phosphatidylcholine 2-acylhydrolase 2F; RP3-340N1.1; sPLA2-IIF
Gene Symbols: PLA2G2F
Molecular weight: 18,658 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Select Structure to View Below

PLA2G2F

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 - gap
0 1 T6-p __MKKFFtVAILAGs
0 1 S13-p tVAILAGsVLstAHG
0 1 S16-p ILAGsVLstAHGsLL
0 1 T17-p LAGsVLstAHGsLLN
0 1 S21-p VLstAHGsLLNLKAM
  PLA2G2F iso2  
S22-p KVLDRCFsGWRGPRF
T49 LGMKKFFTVAILAGS
S56 TVAILAGSVLSTAHG
S59 ILAGSVLSTAHGSLL
T60 LAGSVLSTAHGSLLN
S64 VLSTAHGSLLNLKAM
  mouse

 
- gap
A6 __MKKFFAIAVLAGS
S13 AIAVLAGSVVTTAHS
T16 VLAGSVVTTAHSSLL
T17 LAGSVVTTAHSSLLN
S21 VVTTAHSSLLNLKSM
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