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VEGF
Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Defects in VEGFA are a cause of susceptibility to microvascular complications of diabetes type 1 (MVCD1). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the PDGF/VEGF growth factor family. 13 isoforms of the human protein are produced by alternative promoter. Note: This description may include information from UniProtKB.
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| Protein type: Secreted, signal peptide; Secreted; Cytokine; Motility/polarity/chemotaxis |
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Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; membrane; cytoplasm; extracellular region; basement membrane; secretory granule
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Molecular Function: heparin binding; identical protein binding; protein homodimerization activity; growth factor activity; extracellular matrix binding; platelet-derived growth factor receptor binding; cytokine activity; vascular endothelial growth factor receptor 1 binding; cell surface binding; vascular endothelial growth factor receptor binding; receptor agonist activity; protein binding; vascular endothelial growth factor receptor 2 binding; protein heterodimerization activity; fibronectin binding; chemoattractant activity
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Biological Process: heart morphogenesis; macrophage differentiation; positive regulation of positive chemotaxis; positive regulation of cell adhesion; positive regulation of leukocyte migration; cellular response to stress; positive regulation of receptor internalization; cell maturation; basophil chemotaxis; positive regulation of MAP kinase activity; regulation of cell shape; positive chemotaxis; positive regulation of mesenchymal cell proliferation; mesoderm development; kidney development; positive regulation of neuroblast proliferation; nervous system development; platelet activation; T-helper 1 type immune response; monocyte differentiation; mRNA stabilization; positive regulation of blood vessel endothelial cell migration; activation of CREB transcription factor; positive regulation of protein amino acid autophosphorylation; positive regulation of vascular permeability; regulation of transcription from RNA polymerase II promoter; patterning of blood vessels; positive regulation of angiogenesis; eye photoreceptor cell development; positive regulation of peptidyl-tyrosine phosphorylation; camera-type eye morphogenesis; cell migration during sprouting angiogenesis; branching morphogenesis of a tube; cardiac muscle fiber development; positive regulation of cell division; activation of protein kinase activity; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; alveolus development; surfactant homeostasis; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; lactation; post-embryonic camera-type eye development; behavior; positive regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of caspase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; induction of positive chemotaxis; platelet degranulation; ovarian follicle development; epithelial cell differentiation; positive regulation of focal adhesion formation; positive regulation of cell proliferation; angiogenesis; vasculogenesis; negative regulation of bone resorption; in utero embryonic development; positive regulation of cell motility; positive regulation of peptidyl-serine phosphorylation; cell proliferation; positive regulation of protein complex assembly; response to hypoxia; artery morphogenesis; blood vessel remodeling; positive regulation of protein amino acid phosphorylation; response to cold; vascular endothelial growth factor receptor signaling pathway; blood coagulation; lung development; growth; positive regulation of cell migration
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Reference #:
P15692 (UniProtKB)
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| Alt. Names/Synonyms: Vascular endothelial growth factor A; Vascular permeability factor; VEGF-A; VEGFA |
| Gene Symbols: VEGFA |
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Molecular weight: 27,042 Da
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Basal Isoelectric point: 9.21
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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