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Protein Page:
VAV2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
VAV2 a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; GEFs, Rac/Rho; GEFs
Chromosomal Location of Human Ortholog: 9q34.1
Cellular Component: plasma membrane; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; guanyl-nucleotide exchange factor activity; metal ion binding; epidermal growth factor receptor binding
Biological Process: lamellipodium biogenesis; platelet activation; axon guidance; cell migration; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of phosphoinositide 3-kinase activity; signal transduction; regulation of small GTPase mediated signal transduction; regulation of gene expression; small GTPase mediated signal transduction; regulation of blood coagulation; innate immune response; angiogenesis; blood coagulation; positive regulation of Rho GTPase activity; positive regulation of GTPase activity
Reference #:  P52735 (UniProtKB)
Alt. Names/Synonyms: Guanine nucleotide exchange factor VAV2; oncogene VAV2; Protein vav-2; vav 2 guanine nucleotide exchange factor; vav 2 oncogene; VAV-2; VAV2
Gene Symbols: VAV2
Molecular weight: 101,289 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VAV2

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 68 Y142-p TENDDDVyRSLEELA
1 4 Y159-p HDLGEDIyDCVPCED
2 1 Y172-p EDGGDDIyEDIIKVE
0 1 T194 YMQKMGMTEDDKRNC
0 1 Y426-p NHTKQDRyLFLFDKV
0 1 K465 TDDPMNNKDVKKSHG
0 1 K469 MNNKDVKKSHGKMWS
0 1 K515-ac EMAMSNIkPDKANAN
0 2 T575-p VIPPCKFtsPADLDA
0 8 S576-p IPPCKFtsPADLDAs
0 2 S583-p sPADLDAsGAGPGPK
0 3 S626-p LLRGDPEsPWWEGRL
0 1 S639-p RLVQTRKsGYFPSSS
0 1 S663-p PPISRPPsREIDYTA
0 1 Y746 SLLELVEYYQCHSLK
0 1 T761 ESFKQLDTTLKYPYK
0 1 T762 SFKQLDTTLKYPYKS
0 3 S778-p ERSASRAssRSPASC
0 8 S779-p RSASRAssRSPASCA
0 11 S781 ASRAssRSPASCASY
0 2 T814 APFWSVFTPRVIGTA
  VAV2 iso3  
Y142-p TENDDDVyRSLEELA
Y159 HDLGEDIYDCVPCED
Y172 EDGGDDIYEDIIKVE
T189-p QPMKMGMtEDDKRNC
Y421 NHTKQDRYLFLFDKV
K460 TDDPMNNKDVKKWSY
K464 MNNKDVKKWSYGFYL
K505-ac EMAMSNIkPDKANAN
T565 VIPPCKFTSPADLDA
S566 IPPCKFTSPADLDAS
S573 SPADLDASGAGPGPK
S616 LLRGDPESPWWEGRL
S629 RLVQTRKSGYFPSSS
S653 PPISRPPSREIDYTA
Y736 SLLELVEYYQCHSLK
T751 ESFKQLDTTLKYPYK
T752 SFKQLDTTLKYPYKS
S768-p ERSASRAssRsPVFt
S769-p RSASRAssRsPVFtP
S771-p ASRAssRsPVFtPRV
T775-p ssRsPVFtPRVIGTA
  mouse

 
Y142-p AENDDDVyRSLEELA
Y159 HDLGEDIYDCVPCED
Y172 EDEGDDIYEDIIKVE
T189 QPMKMGMTEDDKRSC
Y421 NHTKQDRYLFLFDKV
K460-ub TDDPMHNkDIKkWSY
K464-ub MHNkDIKkWSYGFYL
K505 EMAMSNIKPDKANAN
S565 VIPPCKMSSPADVDA
S566 IPPCKMSSPADVDAP
P573 SPADVDAPGAGPGPK
S616 LLRGDPDSPWWEGRL
S629 RLVQTRKSGYFPSSS
S653 PPTGRPPSREIDYTA
Y736 SLLELVEYYQCHSLK
T751 ESFKQLDTTLKFPYK
T752 SFKQLDTTLKFPYKS
S768 ERTTSRASSRSPASC
S769 RTTSRASSRSPASCA
S771 TSRASSRSPASCASY
T804 APFWSVFTPRVIGTA
  rat

 
Y142 AENDDDVYRSLEELA
Y159 HDLGEDIYDCVPCED
Y172 EDEGDDIYEDIIKVE
T189 QPMKMGLTEDDKRSC
Y421 NHTKQDRYLFLFDKV
K460 TDDPMHNKDIKKWSY
K464 MHNKDIKKWSYGFYL
K505 EMAMSNIKPDKANAN
S565 VIPPCKMSSPADADA
S566 IPPCKMSSPADADAP
P573 SPADADAPGAGLGPK
S616 LLRGDPDSPWWEGRL
S629 RLVQTRKSGYFPSSS
S653 PPVGRPPSREIDYTA
Y736-p SLLELVEyYQCHSLK
T751-p ESFKQLDttLKFPYK
T752-p SFKQLDttLKFPYKS
S768 ERAATRASSRSPASC
S769 RAATRASSRSPASCA
S771 ATRASSRSPASCASY
T804 APFWSVFTPRVIGTA
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