Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
VAV2 (human)

Overview
VAV2 a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues. Note: This description may include information from UniProtKB.
Protein type: GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis
Cellular Component: plasma membrane; cytosol
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; metal ion binding; guanyl-nucleotide exchange factor activity; epidermal growth factor receptor binding
Biological Process: lamellipodium biogenesis; axon guidance; platelet activation; cell migration; regulation of GTPase activity; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of phosphoinositide 3-kinase activity; signal transduction; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; innate immune response; angiogenesis; blood coagulation
Reference #:  P52735 (UniProtKB)
Alt. Names/Synonyms: Guanine nucleotide exchange factor VAV2; oncogene VAV2; Protein vav-2; vav 2 guanine nucleotide exchange factor; vav 2 oncogene; VAV-2; VAV2
Gene Symbols: VAV2
Molecular weight: 101,289 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

VAV2

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
1 74 Y142-p TENDDDVyRSLEELA
1 4 Y159-p HDLGEDIyDCVPCED
1 1 Y172-p EDGGDDIyEDIIKVE
0 2 T575-p VIPPCKFtsPADLDA
0 5 S576-p IPPCKFtsPADLDAS
0 1 S626-p LLRGDPEsPWWEGRL
0 1 Y746 SLLELVEYYQCHSLK
0 1 T761 ESFKQLDTTLKYPYK
0 1 T762 SFKQLDTTLKYPYKS
0 2 S778-p ERSASRAssRSPASC
0 5 S779-p RSASRAssRSPASCA
0 8 S781 ASRAssRSPASCASY
0 2 T814 APFWSVFTPRVIGTA
  VAV2 iso3  
Y142-p TENDDDVyRSLEELA
Y159 HDLGEDIYDCVPCED
Y172 EDGGDDIYEDIIKVE
T565 VIPPCKFTSPADLDA
S566 IPPCKFTSPADLDAS
S616 LLRGDPESPWWEGRL
Y736 SLLELVEYYQCHSLK
T751 ESFKQLDTTLKYPYK
T752 SFKQLDTTLKYPYKS
S768-p ERSASRAssRsPVFt
S769-p RSASRAssRsPVFtP
S771-p ASRAssRsPVFtPRV
T775-p ssRsPVFtPRVIGTA
  mouse

 
Y142-p AENDDDVyRSLEELA
Y159 HDLGEDIYDCVPCED
Y172 EDEGDDIYEDIIKVE
S565 VIPPCKMSSPADVDA
S566 IPPCKMSSPADVDAP
S616 LLRGDPDSPWWEGRL
Y736 SLLELVEYYQCHSLK
T751 ESFKQLDTTLKFPYK
T752 SFKQLDTTLKFPYKS
S768 ERTTSRASSRSPASC
S769 RTTSRASSRSPASCA
S771 TSRASSRSPASCASY
T804 APFWSVFTPRVIGTA
  rat

 
Y142 AENDDDVYRSLEELA
Y159 HDLGEDIYDCVPCED
Y172 EDEGDDIYEDIIKVE
S565 VIPPCKMSSPADADA
S566 IPPCKMSSPADADAP
S616 LLRGDPDSPWWEGRL
Y736-p SLLELVEyYQCHSLK
T751-p ESFKQLDttLKFPYK
T752-p SFKQLDttLKFPYKS
S768 ERAATRASSRSPASC
S769 RAATRASSRSPASCA
S771 ATRASSRSPASCASY
T804 APFWSVFTPRVIGTA
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.