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Protein Page:
YAP1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
YAP1 an adaptor protein that binds to HER4 and the SH3 domain of the Yes tyrosine kinase. Associates with multiple transcription factors in the nucleus, and appears to be a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. Contains a WW domain that is found in various structural, regulatory and signaling molecules. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; transcription coactivator activity; chromatin binding; transcription corepressor activity
Biological Process: paraxial mesoderm development; transcription initiation from RNA polymerase II promoter; somatic stem cell maintenance; lateral mesoderm development; negative regulation of epithelial cell differentiation; notochord development; positive regulation of organ growth; keratinocyte differentiation; cell proliferation; positive regulation of cell proliferation; gene expression; positive regulation of transcription from RNA polymerase II promoter; vasculogenesis; response to DNA damage stimulus; negative regulation of apoptosis
Reference #:  P46937 (UniProtKB)
Alt. Names/Synonyms: 65 kDa Yes-associated protein; YAP; YAP1; YAP2; YAP65; Yes-associated protein 1; Yes-associated protein 1, 65kDa; yes-associated protein 2; YKI; Yorkie homolog
Gene Symbols: YAP1
Molecular weight: 54,462 Da
Basal Isoelectric point: 5  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

YAP1
Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S127‑p
apoptosis, induced: Y407‑p
apoptosis, inhibited: S127‑p
cell adhesion, altered: S127‑p
cell growth, altered: S127‑p, S432‑p
cell growth, inhibited: S127‑p
transcription, altered: S94‑p, S127‑p, Y407‑p
inhibition: Y407‑p
intracellular localization: S127‑p
molecular association, regulation: S127‑p
protein stabilization: Y407‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
2 20 S61-p IVHVRGDsEtDLEAL
0 11 T63-p HVRGDsEtDLEALFN
2 3 S94-p RLRKLPDsFFkPPEP
1 0 K97-s KLPDsFFkPPEPKsH
0 58 S103-p FkPPEPKsHsRQAst
0 315 S105-p PPEPKsHsRQAstDA
3 338 S109-p KsHsRQAstDAGtAG
1 278 T110-p sHsRQAstDAGtAGA
0 44 T114-p QAstDAGtAGALtPQ
0 114 T119-p AGtAGALtPQHVRAH
16 174 S127-p PQHVRAHssPAsLQL
1 80 S128-p QHVRAHssPAsLQLG
0 50 S131-p RAHssPAsLQLGAVs
1 86 S138-p sLQLGAVsPGtLtPt
0 24 T141-p LGAVsPGtLtPtGVV
0 48 T143-p AVsPGtLtPtGVVsG
0 18 T145-p sPGtLtPtGVVsGPA
0 11 S149-p LtPtGVVsGPAAtPt
0 9 T154-p VVsGPAAtPtAQHLR
0 2 T156-p sGPAAtPtAQHLRQs
0 20 S163-p tAQHLRQssFEIPDD
2 48 S164-p AQHLRQssFEIPDDV
0 2 S274-p FAMNQRIsQsAPVkQ
0 1 S276-p MNQRIsQsAPVkQPP
1 0 K280-s IsQsAPVkQPPPLAP
0 6 S289-p PPPLAPQsPQGGVMG
0 1 S340-p INPSTANsPKCQELA
0 1 T354 ALRSQLPTLEQDGGt
0 1 T361-p TLEQDGGtQNPVssP
0 2 S366-p GGtQNPVssPGMsQE
1 21 S367-p GtQNPVssPGMsQEL
0 20 S371-p PVssPGMsQELRTMT
0 2 S382-p RTMTTNSsDPFLNSG
0 1 T390-p DPFLNSGtyHSRDEs
0 4 Y391-p PFLNSGtyHSRDEst
1 7 S397-p tyHSRDEstDSGLSM
0 2 T398-p yHSRDEstDSGLSMS
1 2 S400 SRDEstDSGLSMSSy
1 1 S403 EstDSGLSMSSySVP
2 5 Y407-p SGLSMSSySVPRTPD
1 2 T412 SSySVPRTPDDFLNS
1 0 S432-p TGDTINQsTLPSQQN
0 6 K497-u LAATKLDkESFLTWL
0 1 - gap
4911 : Phospho-YAP (Ser127) Antibody
  YAP1 iso2  
S61-p IVHVRGDsEtDLEAL
T63-p HVRGDsEtDLEALFN
S94 RLRKLPDSFFKPPEP
K97 KLPDSFFKPPEPKsH
S103-p FKPPEPKsHsRQAst
S105-p PPEPKsHsRQAstDA
S109-p KsHsRQAstDAGtAG
T110-p sHsRQAstDAGtAGA
T114-p QAstDAGtAGALtPQ
T119-p AGtAGALtPQHVRAH
S127-p PQHVRAHssPASLQL
S128-p QHVRAHssPASLQLG
S131 RAHssPASLQLGAVs
S138-p SLQLGAVsPGtLtPT
T141-p LGAVsPGtLtPTGVV
T143-p AVsPGtLtPTGVVsG
T145 sPGtLtPTGVVsGPA
S149-p LtPTGVVsGPAAtPT
T154-p VVsGPAAtPTAQHLR
T156 sGPAAtPTAQHLRQs
S163-p TAQHLRQssFEIPDD
S164-p AQHLRQssFEIPDDV
S274 FAMNQRISQSAPVKQ
S276 MNQRISQSAPVKQPP
K280 ISQSAPVKQPPPLAP
S289-p PPPLAPQsPQGGVMG
- gap
T338 ALRSQLPTLEQDGGT
T345 TLEQDGGTQNPVSsP
S350 GGTQNPVSsPGMsQE
S351-p GTQNPVSsPGMsQEL
S355-p PVSsPGMsQELRTMT
S366 RTMTTNSSDPFLNSG
T374 DPFLNSGTYHSRDEs
Y375 PFLNSGTYHSRDEsT
S381-p TYHSRDEsTDsGLsM
T382 YHSRDEsTDsGLsMS
S384-p SRDEsTDsGLsMSSY
S387-p EsTDsGLsMSSYSVP
Y391 sGLsMSSYSVPRtPD
T396-p SSYSVPRtPDDFLNS
S416 TGDTINQSTLPSQQN
K481 LAATKLDKESFLTWL
- gap
  mouse

 
S46-p VVHVRGDsEtDLEAL
T48-p HVRGDsEtDLEALFN
S79-p RLRKLPDsFFKPPEP
K82 KLPDsFFKPPEPKsH
S88-p FKPPEPKsHsRQAst
S90-p PPEPKsHsRQAstDA
S94-p KsHsRQAstDAGtAG
T95-p sHsRQAstDAGtAGA
T99-p QAstDAGtAGALtPQ
T104-p AGtAGALtPQHVRAH
S112-p PQHVRAHssPAsLQL
S113-p QHVRAHssPAsLQLG
S116-p RAHssPAsLQLGAVs
S123-p sLQLGAVsPGtLTAs
T126-p LGAVsPGtLTAsGVV
T128 AVsPGtLTAsGVVsG
S130-p sPGtLTAsGVVsGPA
S134-p LTAsGVVsGPAAAPA
A139 VVsGPAAAPAAQHLR
A141 sGPAAAPAAQHLRQs
S148-p AAQHLRQssFEIPDD
S149-p AQHLRQssFEIPDDV
T259 FAMNQRITQSAPVKQ
S261 MNQRITQSAPVKQPP
K265 ITQSAPVKQPPPLAP
S274-p PPPLAPQsPQGGVLG
A325 INPSTANAPKCQELA
T339 ALRSQLPTLEQDGGT
T346 TLEQDGGTPNAVSSP
S351 GGTPNAVSSPGMSQE
S352 GTPNAVSSPGMSQEL
S356 AVSSPGMSQELRTMT
S367-p RTMTTNSsDPFLNSG
T375 DPFLNSGTYHSRDEs
Y376 PFLNSGTYHSRDEsT
S382-p TYHSRDEsTDsGLSM
T383 YHSRDEsTDsGLSMS
S385-p SRDEsTDsGLSMSSY
S388 EsTDsGLSMSSYSIP
Y392 sGLSMSSYSIPRtPD
T397-p SSYSIPRtPDDFLNS
S417 TGDTISQSTLPSQQS
K481-u LAATKLDkESFLTWL
- gap
4911 : Phospho-YAP (Ser127) Antibody
  rat

► Hide Isoforms 		 
S46-p VVHVRGDsETDLEAL
T48 HVRGDsETDLEALFN
S79 RLRKLPDSFFKPPEP
K82 KLPDSFFKPPEPKsH
S88-p FKPPEPKsHsRQAst
S90-p PPEPKsHsRQAstDA
S94-p KsHsRQAstDAGTAG
T95-p sHsRQAstDAGTAGA
T99 QAstDAGTAGALtPQ
T104-p AGTAGALtPQHVRAH
S112 PQHVRAHSSPASLQL
S113 QHVRAHSSPASLQLG
S116 RAHSSPASLQLGAGT
- gap
T123 SLQLGAGTLTASGVV
T125 QLGAGTLTASGVVSG
S127 GAGTLTASGVVSGPA
S131 LTASGVVSGPAATPA
T136 VVSGPAATPAAQHLR
A138 SGPAATPAAQHLRQS
S145 AAQHLRQSsFEIPDD
S146-p AQHLRQSsFEIPDDV
T256 FAMNQRITQSAPVKQ
S258 MNQRITQSAPVKQPP
K262 ITQSAPVKQPPPLAP
S271 PPPLAPQSPQGGVLG
- gap
S320-p ALRSQLPsLEQDGGt
T327-p sLEQDGGtQNAVssP
S332-p GGtQNAVssPGMTQE
S333-p GtQNAVssPGMTQEL
T337 AVssPGMTQELRTMT
S348 RTMTTNSSDPFLNSG
T356 DPFLNSGTYHSRDES
Y357 PFLNSGTYHSRDEST
S363 TYHSRDESTDSGLSM
T364 YHSRDESTDSGLSMS
S366 SRDESTDSGLSMSSY
S369 ESTDSGLSMSSYSIP
Y373 SGLSMSSYSIPRTPD
T378 SSYSIPRTPDDFLNS
S398 TGDTISQSTLPSQQS
K462 LAATKLDKESFLTWL
- gap
  YAP1 iso3  
S46 VVHVRGDSETDLEAL
T48 HVRGDSETDLEALFN
S79 RLRKLPDSFFKPPEP
K82 KLPDSFFKPPEPKSH
S88 FKPPEPKSHSRQAST
S90 PPEPKSHSRQASTDA
S94 KSHSRQASTDAGTAG
T95 SHSRQASTDAGTAGA
T99 QASTDAGTAGALTPQ
T104 AGTAGALTPQHVRAH
S112 PQHVRAHSSPASLQL
S113 QHVRAHSSPASLQLG
S116 RAHSSPASLQLGAGT
- gap
T123 SLQLGAGTLTASGVV
T125 QLGAGTLTASGVVSG
S127 GAGTLTASGVVSGPA
S131 LTASGVVSGPAATPA
T136 VVSGPAATPAAQHLR
A138 SGPAATPAAQHLRQS
S145 AAQHLRQSSFEIPDD
S146 AQHLRQSSFEIPDDV
T256 FAMNQRITQSAPVKQ
S258 MNQRITQSAPVKQPP
K262 ITQSAPVKQPPPLAP
S271 PPPLAPQSPQGGVLG
A322 INPSTANAPKCQTVR
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
R313-m1 ELFRQAIrNINPSTA
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