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Protein Page:
YAP1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
YAP1 an adaptor protein that binds to HER4 and the SH3 domain of the Yes tyrosine kinase. Associates with multiple transcription factors in the nucleus, and appears to be a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. Contains a WW domain that is found in various structural, regulatory and signaling molecules. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; cytosol; nucleus
Molecular Function: protein binding; transcription coactivator activity; chromatin binding; transcription corepressor activity
Biological Process: paraxial mesoderm development; transcription initiation from RNA polymerase II promoter; somatic stem cell maintenance; lateral mesoderm development; negative regulation of epithelial cell differentiation; notochord development; positive regulation of organ growth; keratinocyte differentiation; cell proliferation; positive regulation of cell proliferation; gene expression; positive regulation of transcription from RNA polymerase II promoter; vasculogenesis; response to DNA damage stimulus
Reference #:  P46937 (UniProtKB)
Alt. Names/Synonyms: 65 kDa Yes-associated protein; YAP; YAP1; YAP2; YAP65; Yes-associated protein 1; Yes-associated protein 1, 65kDa; yes-associated protein 2; YKI; Yorkie homolog
Gene Symbols: YAP1
Molecular weight: 54,462 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

YAP1

Protein Structure Not Found.


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Sites Implicated In
apoptosis, altered: S127‑p
apoptosis, induced: Y407‑p
apoptosis, inhibited: S127‑p
cell adhesion, altered: S127‑p
cell growth, altered: S127‑p
cell growth, inhibited: S127‑p
transcription, altered: S127‑p
transcription, inhibited: Y407‑p
activity, inhibited: Y407‑p
intracellular localization: S127‑p
molecular association, regulation: S127‑p
protein stabilization: Y407‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
6 25 S61-p IVHVRGDsEtDLEAL
0 15 T63-p HVRGDsEtDLEALFN
2 3 S94-p RLRKLPDsFFkPPEP
0 1 K97-ac KLPDsFFkPPEPKsH
1 0 K97-sm KLPDsFFkPPEPKsH
0 58 S103-p FkPPEPKsHsRQAst
0 317 S105-p PPEPKsHsRQAstDA
7 360 S109-p KsHsRQAstDAGtAG
1 285 T110-p sHsRQAstDAGtAGA
0 48 T114-p QAstDAGtAGALtPQ
1 120 T119-p AGtAGALtPQHVRAH
28 195 S127-p PQHVRAHssPAsLQL
2 83 S128-p QHVRAHssPAsLQLG
0 65 S131-p RAHssPAsLQLGAVs
2 92 S138-p sLQLGAVsPGtLtPt
0 26 T141-p LGAVsPGtLtPtGVV
0 52 T143-p AVsPGtLtPtGVVsG
1 19 T145-p sPGtLtPtGVVsGPA
0 12 S149-p LtPtGVVsGPAAtPt
0 11 T154-p VVsGPAAtPtAQHLR
0 2 T156-p sGPAAtPtAQHLRQs
0 22 S163-p tAQHLRQssFEIPDD
5 50 S164-p AQHLRQssFEIPDDV
1 0 S217-p MNVTAPTsPPVQQNM
0 5 S274-p FAMNQRIsQsAPVkQ
0 4 S276-p MNQRIsQsAPVkQPP
1 0 K280-sm IsQsAPVkQPPPLAP
2 12 S289-p PPPLAPQsPQGGVMG
0 2 S300-p GVMGGSNsNQQQQMR
0 3 S340-p INPSTANsPKCQELA
0 1 - gap
0 1 T354 ALRSQLPTLEQDGGt
0 2 T361-p TLEQDGGtQNPVssP
0 2 S366-p GGtQNPVssPGMsQE
4 24 S367-p GtQNPVssPGMsQEL
0 23 S371-p PVssPGMsQELRTMT
0 2 S381-p LRTMTTNssDPFLNs
0 4 S382-p RTMTTNssDPFLNsG
0 1 S388-p ssDPFLNsGtyHSRD
0 1 T390-p DPFLNsGtyHSRDEs
1 4 Y391-p PFLNsGtyHSRDEst
6 10 S397-p tyHSRDEstDSGLSM
0 3 T398-p yHSRDEstDSGLSMS
1 3 S400 SRDEstDSGLSMSSy
1 1 S403 EstDSGLSMSSySVP
3 5 Y407-p SGLSMSSySVPRtPD
2 4 T412-p SSySVPRtPDDFLNs
0 2 S419-p tPDDFLNsVDEMDTG
0 6 K497-ub LAATKLDkEsFLTWL
0 1 S499-p ATKLDkEsFLTWL__
4911 : Phospho-YAP (Ser127) Antibody
13008 : Phospho-YAP (Ser127) (D9W2I) Rabbit mAb
13619 : Phospho-YAP (Ser397) (D1E7Y) Rabbit mAb
  YAP1 iso2  
S61-p IVHVRGDsEtDLEAL
T63-p HVRGDsEtDLEALFN
S94-p RLRKLPDsFFKPPEP
K97 KLPDsFFKPPEPKsH
K97 KLPDsFFKPPEPKsH
S103-p FKPPEPKsHsRQAst
S105-p PPEPKsHsRQAstDA
S109-p KsHsRQAstDAGtAG
T110-p sHsRQAstDAGtAGA
T114-p QAstDAGtAGALtPQ
T119-p AGtAGALtPQHVRAH
S127-p PQHVRAHssPASLQL
S128-p QHVRAHssPASLQLG
S131 RAHssPASLQLGAVs
S138-p SLQLGAVsPGtLtPT
T141-p LGAVsPGtLtPTGVV
T143-p AVsPGtLtPTGVVsG
T145 sPGtLtPTGVVsGPA
S149-p LtPTGVVsGPAAtPT
T154-p VVsGPAAtPTAQHLR
T156 sGPAAtPTAQHLRQs
S163-p TAQHLRQssFEIPDD
S164-p AQHLRQssFEIPDDV
S217 MNVTAPTSPPVQQNM
S274 FAMNQRISQSAPVKQ
S276 MNQRISQSAPVKQPP
K280 ISQSAPVKQPPPLAP
S289-p PPPLAPQsPQGGVMG
S300 GVMGGSNSNQQQQMR
- gap
- gap
T338 ALRSQLPTLEQDGGT
T345 TLEQDGGTQNPVSsP
S350 GGTQNPVSsPGMsQE
S351-p GTQNPVSsPGMsQEL
S355-p PVSsPGMsQELRTMT
S365 LRTMTTNSSDPFLNS
S366 RTMTTNSSDPFLNSG
S372 SSDPFLNSGTYHSRD
T374 DPFLNSGTYHSRDEs
Y375 PFLNSGTYHSRDEsT
S381-p TYHSRDEsTDsGLsM
T382 YHSRDEsTDsGLsMS
S384-p SRDEsTDsGLsMSSY
S387-p EsTDsGLsMSSYSVP
Y391 sGLsMSSYSVPRtPD
T396-p SSYSVPRtPDDFLNS
S403 tPDDFLNSVDEMDTG
K481 LAATKLDKESFLTWL
S483 ATKLDKESFLTWL__
13619 : Phospho-YAP (Ser397) (D1E7Y) Rabbit mAb
  YAP1 iso3  
S61 IVHVRGDSETDLEAL
T63 HVRGDSETDLEALFN
S94 RLRKLPDSFFKPPEP
K97 KLPDSFFKPPEPKSH
K97 KLPDSFFKPPEPKSH
S103 FKPPEPKSHSRQAST
S105 PPEPKSHSRQASTDA
S109 KSHSRQASTDAGTAG
T110 SHSRQASTDAGTAGA
T114 QASTDAGTAGALtPQ
T119-p AGTAGALtPQHVRAH
S127 PQHVRAHSSPASLQL
S128 QHVRAHSSPASLQLG
S131 RAHSSPASLQLGAVs
S138-p SLQLGAVsPGTLTPT
T141 LGAVsPGTLTPTGVV
T143 AVsPGTLTPTGVVSG
T145 sPGTLTPTGVVSGPA
S149 LTPTGVVSGPAAtPT
T154-p VVSGPAAtPTAQHLR
T156 SGPAAtPTAQHLRQS
S163 TAQHLRQSSFEIPDD
S164 AQHLRQSSFEIPDDV
S217 MNVTAPTSPPVQQNM
S236-p SAMNQRIsQsAPVKQ
S238-p MNQRIsQsAPVKQPP
K242 IsQsAPVKQPPPLAP
S251 PPPLAPQSPQGGVMG
S262 GVMGGSNSNQQQQMR
- gap
- gap
T304 ALRSQLPTLEQDGGT
T311 TLEQDGGTQNPVSsP
S316 GGTQNPVSsPGMSQE
S317-p GTQNPVSsPGMSQEL
S321 PVSsPGMSQELRTMT
S331 LRTMTTNSSDPFLNS
S332 RTMTTNSSDPFLNSG
S338 SSDPFLNSGTYHSRD
T340 DPFLNSGTYHSRDES
Y341 PFLNSGTYHSRDEST
S347 TYHSRDESTDSGLSM
T348 YHSRDESTDSGLSMS
S350 SRDESTDSGLSMSSY
S353 ESTDSGLSMSSYSVP
Y357 SGLSMSSYSVPRtPD
T362-p SSYSVPRtPDDFLNS
S369 tPDDFLNSVDEMDTG
K447 LAATKLDKESFLTWL
S449 ATKLDKESFLTWL__
13619 : Phospho-YAP (Ser397) (D1E7Y) Rabbit mAb
  mouse

 
S46-p VVHVRGDsEtDLEAL
T48-p HVRGDsEtDLEALFN
S79-p RLRKLPDsFFKPPEP
K82 KLPDsFFKPPEPKsH
K82 KLPDsFFKPPEPKsH
S88-p FKPPEPKsHsRQAst
S90-p PPEPKsHsRQAstDA
S94-p KsHsRQAstDAGtAG
T95-p sHsRQAstDAGtAGA
T99-p QAstDAGtAGALtPQ
T104-p AGtAGALtPQHVRAH
S112-p PQHVRAHssPAsLQL
S113-p QHVRAHssPAsLQLG
S116-p RAHssPAsLQLGAVs
S123-p sLQLGAVsPGtLTAs
T126-p LGAVsPGtLTAsGVV
T128 AVsPGtLTAsGVVsG
S130-p sPGtLTAsGVVsGPA
S134-p LTAsGVVsGPAAAPA
A139 VVsGPAAAPAAQHLR
A141 sGPAAAPAAQHLRQs
S148-p AAQHLRQssFEIPDD
S149-p AQHLRQssFEIPDDV
- under review  
T259-p FAMNQRItQSAPVKQ
S261 MNQRItQSAPVKQPP
K265 ItQSAPVKQPPPLAP
S274-p PPPLAPQsPQGGVLG
S285-p GVLGGGSsNQQQQIQ
- gap
- gap
T339 ALRSQLPTLEQDGGt
T346-p TLEQDGGtPNAVSSP
S351 GGtPNAVSSPGMSQE
S352 GtPNAVSSPGMSQEL
S356 AVSSPGMSQELRTMT
S366-p LRTMTTNssDPFLNS
S367-p RTMTTNssDPFLNSG
S373 ssDPFLNSGTyHSRD
T375 DPFLNSGTyHSRDEs
Y376-p PFLNSGTyHSRDEst
S382-p TyHSRDEstDsGLSM
T383-p yHSRDEstDsGLSMS
S385-p SRDEstDsGLSMSSY
S388 EstDsGLSMSSYSIP
Y392 sGLSMSSYSIPRtPD
T397-p SSYSIPRtPDDFLNS
S404 tPDDFLNSVDEMDTG
K481-ub LAATKLDkESFLTWL
S483 ATKLDkESFLTWL__
4911 : Phospho-YAP (Ser127) Antibody
13008 : Phospho-YAP (Ser127) (D9W2I) Rabbit mAb
13619 : Phospho-YAP (Ser397) (D1E7Y) Rabbit mAb
  rat

► Hide Isoforms
 
S46-p VVHVRGDsEtDLEAL
T48-p HVRGDsEtDLEALFN
S79 RLRKLPDSFFkPPEP
K82-ac KLPDSFFkPPEPKsH
K82 KLPDSFFKPPEPKsH
S88-p FkPPEPKsHsRQAst
S90-p PPEPKsHsRQAstDA
S94-p KsHsRQAstDAGTAG
T95-p sHsRQAstDAGTAGA
T99 QAstDAGTAGALtPQ
T104-p AGTAGALtPQHVRAH
S112 PQHVRAHSSPASLQL
S113 QHVRAHSSPASLQLG
S116 RAHSSPASLQLGAGT
- gap
T123 SLQLGAGTLTASGVV
T125 QLGAGTLTASGVVSG
S127 GAGTLTASGVVSGPA
S131 LTASGVVSGPAATPA
T136 VVSGPAATPAAQHLR
A138 SGPAATPAAQHLRQS
S145 AAQHLRQSsFEIPDD
S146-p AQHLRQSsFEIPDDV
- under review  
T256 FAMNQRITQSAPVKQ
S258 MNQRITQSAPVKQPP
K262 ITQSAPVKQPPPLAP
S271 PPPLAPQSPQGGVLG
S282 GVLGGGSSNQQQQIQ
- gap
- gap
S320-p ALRSQLPsLEQDGGt
T327-p sLEQDGGtQNAVssP
S332-p GGtQNAVssPGMTQE
S333-p GtQNAVssPGMTQEL
T337 AVssPGMTQELRTMT
S347 LRTMTTNSsDPFLNS
S348-p RTMTTNSsDPFLNSG
S354 SsDPFLNSGTYHSRD
T356 DPFLNSGTYHSRDES
Y357 PFLNSGTYHSRDEST
S363 TYHSRDESTDSGLSM
T364 YHSRDESTDSGLSMS
S366 SRDESTDSGLSMSSY
S369 ESTDSGLSMSSYSIP
Y373 SGLSMSSYSIPRTPD
T378 SSYSIPRTPDDFLNS
S385 TPDDFLNSVDEMDTG
K462 LAATKLDKESFLTWL
S464 ATKLDKESFLTWL__
4911 : Phospho-YAP (Ser127) Antibody
13008 : Phospho-YAP (Ser127) (D9W2I) Rabbit mAb
13619 : Phospho-YAP (Ser397) (D1E7Y) Rabbit mAb
  YAP1 iso3  
S46 VVHVRGDSETDLEAL
T48 HVRGDSETDLEALFN
S79 RLRKLPDSFFKPPEP
K82 KLPDSFFKPPEPKSH
K82 KLPDSFFKPPEPKSH
S88 FKPPEPKSHSRQAST
S90 PPEPKSHSRQASTDA
S94 KSHSRQASTDAGTAG
T95 SHSRQASTDAGTAGA
T99 QASTDAGTAGALTPQ
T104 AGTAGALTPQHVRAH
S112 PQHVRAHSSPASLQL
S113 QHVRAHSSPASLQLG
S116 RAHSSPASLQLGAGT
- gap
T123 SLQLGAGTLTASGVV
T125 QLGAGTLTASGVVSG
S127 GAGTLTASGVVSGPA
S131 LTASGVVSGPAATPA
T136 VVSGPAATPAAQHLR
A138 SGPAATPAAQHLRQS
S145 AAQHLRQSSFEIPDD
S146 AQHLRQSSFEIPDDV
- under review  
T256 FAMNQRITQSAPVKQ
S258 MNQRITQSAPVKQPP
K262 ITQSAPVKQPPPLAP
S271 PPPLAPQSPQGGVLG
S282 GVLGGGSSNQQQQIQ
- gap
R313-m1 ELFRQAIrNINPSTA
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
  sheep

 
- gap
- gap
S9 RLRKLPDSFFKPPEP
K12 KLPDSFFKPPEPKSH
K12 KLPDSFFKPPEPKSH
S18 FKPPEPKSHSRQAST
S20 PPEPKSHSRQASTDA
S24 KSHSRQASTDAGTAG
T25 SHSRQASTDAGTAGA
T29 QASTDAGTAGALTPQ
T34 AGTAGALTPQHVRAH
S42-p PQHVRAHsSPAPLQL
S43 QHVRAHsSPAPLQLG
P46 RAHsSPAPLQLGAVS
S53 PLQLGAVSPGTLTPT
T56 LGAVSPGTLTPTGVV
T58 AVSPGTLTPTGVVSG
T60 SPGTLTPTGVVSGPA
S64 LTPTGVVSGPAAAPA
A69 VVSGPAAAPAAQHLR
A71 SGPAAAPAAQHLRQS
S78 AAQHLRQSSFEIPDD
S79 AQHLRQSSFEIPDDV
S132 MNVTAPTSPPVQQNM
S189 FAMNQRISQSAPVKQ
S191 MNQRISQSAPVKQPP
K195 ISQSAPVKQPPPLAP
S204 PPPLAPQSPQGGVLG
S215 GVLGGGSSNQQQQMR
- gap
- gap
T253 ALRSQLPTLEQDGGT
T260 TLEQDGGTQNPVSSP
S265 GGTQNPVSSPGMSQE
S266 GTQNPVSSPGMSQEL
S270 PVSSPGMSQELRTMT
S280 LRTMTTNSSDPFLNS
S281 RTMTTNSSDPFLNSG
S287 SSDPFLNSGTYHSRD
T289 DPFLNSGTYHSRDES
Y290 PFLNSGTYHSRDEST
S296 TYHSRDESTDSGLSM
T297 YHSRDESTDSGLSMS
S299 SRDESTDSGLSMSSY
S302 ESTDSGLSMSSYSVP
Y306 SGLSMSSYSVPRTPD
T311 SSYSVPRTPDDFLNS
S318 TPDDFLNSVDEMDTG
K396 LAATKLDKESFLTWL
S398 ATKLDKESFLTWL__
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