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BAFF (human)

Overview BAFF Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral; Cytokine; Cell cycle regulation; Apoptosis Cellular Component: extracellular space; integral to membrane; plasma membrane Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: cell proliferation; B cell costimulation; B cell homeostasis; immunoglobulin secretion; positive regulation of cell proliferation; T cell costimulation; positive regulation of B cell proliferation; positive regulation of germinal center formation; positive regulation of T cell proliferation; immune response; signal transduction Reference #:  Q9Y275 (UniProtKB) Alt. Names/Synonyms: ApoL related ligand TALL-1; B lymphocyte stimulator; B-cell activating factor; B-cell-activating factor; B-lymphocyte stimulator; BAFF; BLYS; CD257; delta BAFF; Dendritic cell-derived TNF-like molecule; DTL; TALL-1; TALL1; THANK; TN13B; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNF- and APOL-related leukocyte expressed ligand 1; TNFSF13B; TNFSF20; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; Tumor necrosis factor ligand superfamily member 13B; Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form; tumor necrosis factor superfamily, member 13b; tumor necrosis factor-like protein ZTNF4; ZTNF4 Gene Symbols: TNFSF13B Molecular weight: 31,223 Da Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below BAFF 1JH5 - F/A/J/E/B/H/C/D/I/G=142-285 (human) 1KD7 - A/M/C/K/L/B=122-285 (human) 1KXG - F/A/D/C/E/B=134-285 (human) 1OQE - F/A/J/E/B/H/C/D/I/G=142-285 (human) 1OSG - F/A/D/C/E/B=82-285 (human) 1OTZ - S/a/T/N/7/K/d/2/Y/E/j/Z/u/1/k/g/t/e/J/W/v/s/B/H/c/q/b/D/I/G/U/w/F/r/x/V/Q/h/M/C/0/f/L/i/6/A/n/O/X/3/P/m/9/l/8/p/4/R/o/5=138-285 (human) 3V56 - F/A/D/C/E/B=82-285 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1JH5 1KD7 1KXG 1OQD 1OQE 1OSG 1OTZ 3V56  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S41-p	KESPSVRsSKDGKLL
0	1		C60	LLALLSCCLTVVSFY
0	1		T62	ALLSCCLTVVSFYQV
0	1		K184-a	ALEEKENkILVKETG
0	1		K204-a	GQVLYTDkTYAMGHL

	mouse
-	under review
S61-p	LLALLSSsFtAMSLY
T63-p	ALLSSsFtAMSLYQL
K208	ALEEKENKIVVRQTG
P228	SQVLYTDPIFAMGHV

	rat
-	under review
S76	LLALLSSSFTAMSLY
T78	ALLSSSFTAMSLYQL
-	gap
-	gap

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