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Protein Page:
Lasp-1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Lasp-1 a member of the LIM protein subfamily, characterized by a LIM motif and SH3 domain. Functions as an actin-binding protein, possibly in cytoskeletal organization. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Actin binding protein
Cellular Component: cortical actin cytoskeleton; focal adhesion
Molecular Function: actin filament binding; protein binding; SH3/SH2 adaptor activity; zinc ion binding; ion transmembrane transporter activity
Biological Process: ion transport
Reference #:  Q14847 (UniProtKB)
Alt. Names/Synonyms: LASP-1; LASP1; LIM and SH3 domain protein 1; LIM and SH3 protein 1; Metastatic lymph node gene 50 protein; MLN 50; MLN50
Gene Symbols: LASP1
Molecular weight: 29,717 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Lasp-1
Protein Structure Not Found.


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Sites Implicated In
apoptosis, induced: Y171‑p
cell motility, altered: Y171‑p
intracellular localization: S146‑p, Y171‑p
molecular association, regulation: S146‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

 
0 3 K10-u PNCARCGkIVyPTEK
0 1 Y13-p ARCGkIVyPTEKVNC
0 1 K17 kIVyPTEKVNCLDkF
0 3 K23-a EKVNCLDkFWHKACF
0 1 K23-u EKVNCLDkFWHKACF
0 2 K36-a CFHCETCkMtLNMkN
0 2 T38-p HCETCkMtLNMkNYK
0 1 K42-a CkMtLNMkNYKGyEK
0 1 K42-u CkMtLNMkNYKGyEK
0 1 Y44 MtLNMkNYKGyEKkP
0 2 Y47-p NMkNYKGyEKkPyCN
0 1 K50-u NYKGyEKkPyCNAHy
0 18 Y52-p KGyEKkPyCNAHyPK
0 87 Y57-p kPyCNAHyPKQsFTM
0 3 S61-p NAHyPKQsFTMVADt
0 29 T68-p sFTMVADtPENLRLk
0 3 K75-m1 tPENLRLkQQSELQs
0 4 K75-u tPENLRLkQQSELQs
0 5 S82-p kQQSELQsQVRyKEE
0 6 Y86-p ELQsQVRyKEEFEkN
0 3 K92-a RyKEEFEkNKGkGFS
0 3 K96-a EFEkNKGkGFSVVAD
0 3 K96-u EFEkNKGkGFSVVAD
1 0 S99 kNKGkGFSVVADtPE
0 36 T104-p GFSVVADtPELQRIK
0 9 T113-p ELQRIKKtQDQIsNI
0 8 S118-p KKtQDQIsNIkyHEE
0 2 K121-u QDQIsNIkyHEEFEk
0 1 K121 QDQIsNIKyHEEFEk
0 114 Y122-p DQIsNIkyHEEFEkS
0 1 K128-a kyHEEFEkSRMGPSG
0 1 K128 kyHEEFEKSRMGPSG
3 116 S146-p MEPERRDsQDGssyR
0 9 S150-p RRDsQDGssyRRPLE
0 2 S151-p RDsQDGssyRRPLEQ
0 1 Y152-p DsQDGssyRRPLEQQ
1 3 L156 GssyRRPLEQQQPHH
0 32 T166-p QQPHHIPtsAPVyQQ
0 17 S167-p QPHHIPtsAPVyQQP
2 424 Y171-p IPtsAPVyQQPQQQP
0 6 S182-p QQQPVAQsyGGyKEP
0 18 Y183-p QQPVAQsyGGyKEPA
0 66 Y186-p VAQsyGGyKEPAAPV
0 2 S194-p KEPAAPVsIQRSAPG
0 7 K205-a SAPGGGGkRYRAVYD
0 4 Y241-p QIDDGWMyGTVERTG
0 1 T243 DDGWMyGTVERTGDT
0 3 Y257-p TGMLPANyVEAI___
  mouse

 
K10 PNCARCGKIVYPTEk
Y13 ARCGKIVYPTEkVNC
K17-u KIVYPTEkVNCLDkY
K23-a EkVNCLDkYWHKACF
K23 EkVNCLDKYWHKACF
K36 CFHCETCKMTLNMKN
T38 HCETCKMTLNMKNYK
K42 CKMTLNMKNYKGYEK
K42 CKMTLNMKNYKGYEK
Y44 MTLNMKNYKGYEKKP
Y47 NMKNYKGYEKKPyCN
K50 NYKGYEKKPyCNAHy
Y52-p KGYEKKPyCNAHyPK
Y57-p KPyCNAHyPKQsFTM
S61-p NAHyPKQsFTMVADT
T68 sFTMVADTPENLRLk
K75 TPENLRLKQQSELQS
K75-u TPENLRLkQQSELQS
S82 kQQSELQSQVRYKEE
Y86 ELQSQVRYKEEFEKN
K92 RYKEEFEKNKGkGFS
K96 EFEKNKGKGFSVVAD
K96-u EFEKNKGkGFSVVAD
S99 KNKGkGFSVVADtPE
T104-p GFSVVADtPELQRIK
T113 ELQRIKKTQDQISNI
S118 KKTQDQISNIkYHEE
K121 QDQISNIKYHEEFEk
K121-a QDQISNIkYHEEFEk
Y122 DQISNIkYHEEFEkS
K128 kYHEEFEKSRMGPSG
K128-u kYHEEFEkSRMGPSG
A146 VEPERREAQDSSSYR
S150 RREAQDSSSYRRPtE
S151 REAQDSSSYRRPtEQ
Y152 EAQDSSSYRRPtEQQ
T156-p SSSYRRPtEQQQPQP
T168 PQPHHIPTSAPVyQQ
S169 QPHHIPTSAPVyQQP
Y173-p IPTSAPVyQQPQQQQ
S184 QQQQMTSSYGGyKEP
Y185 QQQMTSSYGGyKEPA
Y188-p MTSSYGGyKEPAAPV
S196 KEPAAPVSIQRSAPG
K207-a SAPGGGGkRYRAVYD
Y243-p QIDDGWMyGtVERTG
T245-p DDGWMyGtVERTGDT
Y259 TGMLPANYVEAI___
  rat

 
K10 PNCARCGKIVYPTEK
Y13 ARCGKIVYPTEKVNC
K17 KIVYPTEKVNCLDKF
K23 EKVNCLDKFWHKACF
K23 EKVNCLDKFWHKACF
K36 CFHCETCKMTLNMKN
T38 HCETCKMTLNMKNyK
K42 CKMTLNMKNyKGyEK
K42 CKMTLNMKNyKGyEK
Y44-p MTLNMKNyKGyEKKP
Y47-p NMKNyKGyEKKPYCN
K50 NyKGyEKKPYCNAHY
Y52 KGyEKKPYCNAHYPK
Y57 KPYCNAHYPKQSFTM
S61 NAHYPKQSFTMVADT
T68 SFTMVADTPENLRLK
K75 TPENLRLKQQSELQS
K75 TPENLRLKQQSELQS
S82 KQQSELQSQVRYKEE
Y86 ELQSQVRYKEEFEKN
K92 RYKEEFEKNKGKGFS
K96 EFEKNKGKGFSVVAD
K96 EFEKNKGKGFSVVAD
S99 KNKGKGFSVVADTPE
T104 GFSVVADTPELQRIK
T113 ELQRIKKTQDQISNI
S118 KKTQDQISNIKYHEE
K121 QDQISNIKYHEEFEK
K121 QDQISNIKYHEEFEK
Y122 DQISNIKYHEEFEKS
K128 KYHEEFEKSRMGPSG
K128 KYHEEFEKSRMGPSG
A146 IEPERREAQDSSSYR
S150 RREAQDSSSYRRPTE
S151 REAQDSSSYRRPTEQ
Y152 EAQDSSSYRRPTEQQ
T156 SSSYRRPTEQQQPQP
T168 PQPHHIPTSAPVYQQ
S169 QPHHIPTSAPVYQQP
Y173 IPTSAPVYQQPQQQQ
S184 QQQQVTPSYGGYKEP
Y185 QQQVTPSYGGYKEPA
Y188 VTPSYGGYKEPAAPV
S196 KEPAAPVSIQRSAPG
K207 SAPGGGGKRYRAVYD
Y243 QIDDGWMYGTVERTG
T245 DDGWMYGTVERTGDT
Y259 TGMLPANYVEAI___
  rabbit

 
K10 PNCARCGKIVYPTEK
Y13 ARCGKIVYPTEKVNC
K17 KIVYPTEKVNCLDKF
K23 EKVNCLDKFWHKACF
K23 EKVNCLDKFWHKACF
K36 CFHCETCKMTLNMKN
T38 HCETCKMTLNMKNYK
K42 CKMTLNMKNYKGYEK
K42 CKMTLNMKNYKGYEK
Y44 MTLNMKNYKGYEKKP
Y47 NMKNYKGYEKKPYCN
K50 NYKGYEKKPYCNAHY
Y52 KGYEKKPYCNAHYPK
Y57 KPYCNAHYPKQSFTM
S61 NAHYPKQSFTMVADT
T68 SFTMVADTPENLRLK
K75 TPENLRLKQQSELQS
K75 TPENLRLKQQSELQS
S82 KQQSELQSQVRYKEE
Y86 ELQSQVRYKEEFEKN
K92 RYKEEFEKNKGRGFs
R96 EFEKNKGRGFsVVAD
R96 EFEKNKGRGFsVVAD
S99-p KNKGRGFsVVADTPE
T104 GFsVVADTPELQRIK
T113 ELQRIKKTQDQISNI
S118 KKTQDQISNIKYHEE
K121 QDQISNIKYHEEFEK
K121 QDQISNIKYHEEFEK
Y122 DQISNIKYHEEFEKS
K128 KYHEEFEKSRMGPSG
K128 KYHEEFEKSRMGPSG
S146-p AEPERRDsQDSSNYR
S150 RRDsQDSSNYRRPPE
N151 RDsQDSSNYRRPPEQ
Y152 DsQDSSNYRRPPEQQ
P156 SSNYRRPPEQQQPPQ
T169 PQPHHIPTSTPAYQQ
S170 QPHHIPTSTPAYQQP
Y174 IPTSTPAYQQPQPQQ
S185 QPQQVAQSYGYKEPA
Y186 PQQVAQSYGYKEPAA
Y188 QVAQSYGYKEPAAPV
S196 KEPAAPVSTQRGAPG
K207 GAPGGGGKRYRAVFD
Y243 QIDDGWMYGTVERTG
T245 DDGWMYGTVERTGDT
Y259 TGMLPANYVEAI___
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