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Protein Page:
hnRNP C1/C2 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
hnRNP C1/C2 a heterogeneous nuclear ribonucleoprotein. May play a role in ribonucleosome assembly by neutralizing basic proteins such as A and B core hnRNP. Contains 1 RNA recognition motif (RRM) domain. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: RNA binding protein; Spliceosome; RNA splicing
Cellular Component: nucleoplasm; spliceosome; protein complex; membrane; nuclear chromatin; nucleolus; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; nucleosomal DNA binding; mRNA 3'-UTR binding; RNA binding; nucleotide binding; poly(U) binding
Biological Process: nuclear mRNA splicing, via spliceosome; osteoblast differentiation; RNA splicing; ATP-dependent chromatin remodeling; gene expression
Reference #:  P07910 (UniProtKB)
Alt. Names/Synonyms: C2; heterogeneous nuclear ribonucleoprotein C (C1/C2); Heterogeneous nuclear ribonucleoproteins C1/C2; hnRNP C1/C2; HNRNPC; HNRPC; MGC104306; MGC105117; MGC117353; MGC131677; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein; SNRPC
Gene Symbols: HNRNPC
Molecular weight: 33,670 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

hnRNP C1/C2

Protein Structure Not Found.


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Sites Implicated In
molecular association, regulation: Y57‑p, S253‑p, S260‑p, S299‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 K8-sc MASNVTNktDPRSMN
0 1 T9-p ASNVTNktDPRSMNS
0 26 K29-ub NLNTLVVkkSDVEAI
0 19 K30-ub LNTLVVkkSDVEAIF
0 7 K39-ac DVEAIFSkYGkIVGC
0 36 K39-ub DVEAIFSkYGkIVGC
0 35 K42-ub AIFSkYGkIVGCSVH
0 9 K50-ac IVGCSVHkGFAFVQy
0 25 K50-ub IVGCSVHkGFAFVQy
1 2 Y57-p kGFAFVQyVNERNAR
0 17 K89-ub INLAAEPkVNRGKAG
0 11 Y105-p KRSAAEMyGsVtEHP
0 1 S107-p SAAEMyGsVtEHPsP
0 3 T109-p AEMyGsVtEHPsPsP
0 6 S113-p GsVtEHPsPsPLLss
0 11 S115-p VtEHPsPsPLLsssF
0 2 S119-p PsPsPLLsssFDLDy
0 32 S120-p sPsPLLsssFDLDyD
0 31 S121-p PsPLLsssFDLDyDF
1 163 Y126-p sssFDLDyDFQRDyy
0 31 Y132-p DyDFQRDyyDRMysy
0 34 Y133-p yDFQRDyyDRMysyP
0 347 Y137-p RDyyDRMysyPARVP
0 96 S138-p DyyDRMysyPARVPP
0 29 Y139-p yyDRMysyPARVPPP
0 1 R151-m1 PPPPPIArAVVPSkR
0 1 K157-ac ArAVVPSkRQrVsGN
0 1 R160-m1 VVPSkRQrVsGNtsR
0 8 S162-p PSkRQrVsGNtsRRG
0 7 T165-p RQrVsGNtsRRGkSG
0 2 S166-p QrVsGNtsRRGkSGF
0 2 K170-ac GNtsRRGkSGFNSkS
0 1 K170-ub GNtsRRGkSGFNSkS
0 4 K176-ub GkSGFNSkSGQRGSS
0 1 K176-sc GkSGFNSkSGQRGSS
0 2 K189-ub SSKSGKLkGDDLQAI
0 1 K197-sc GDDLQAIkKELTQIK
0 3 K206-ub ELTQIKQkVDsLLEN
0 5 S209-p QIKQkVDsLLENLEk
0 2 K216-ub sLLENLEkIEKEQSk
0 2 K223-ub kIEKEQSkQAVEMkN
0 1 K223-sc kIEKEQSkQAVEMkN
0 11 - gap
0 5 - gap
0 15 - gap
0 11 K229-ub SkQAVEMkNDksEEE
0 6 K232-ac AVEMkNDksEEEQss
0 17 K232-ub AVEMkNDksEEEQss
0 1 K232-sm AVEMkNDksEEEQss
0 39 S233-p VEMkNDksEEEQsss
0 8 S238-p DksEEEQssssVkkD
0 4 S239-p ksEEEQssssVkkDE
0 3 S240-p sEEEQssssVkkDEt
0 14 S241-p EEEQssssVkkDEtN
0 6 K243-ub EQssssVkkDEtNVk
0 1 K243-sc EQssssVkkDEtNVk
0 3 K244-ub QssssVkkDEtNVkM
0 1 T247-p ssVkkDEtNVkMEsE
0 1 K250-ub kkDEtNVkMEsEGGA
1 0 K250 kkDEtNVKMEsEGGA
2 41 S253-p EtNVkMEsEGGADDs
2 128 S260-p sEGGADDsAEEGDLL
3 120 S299-p EGEDDRDsANGEDDs
0 10 S306-p sANGEDDs_______
  hnRNP C1/C2 iso2  
K8 MASNVTNKTDPRSMN
T9 ASNVTNKTDPRSMNS
K29 NLNTLVVKKSDVEAI
K30 LNTLVVKKSDVEAIF
K39 DVEAIFSKYGKIVGC
K39 DVEAIFSKYGKIVGC
K42 AIFSKYGKIVGCSVH
K50 IVGCSVHKGFAFVQY
K50 IVGCSVHKGFAFVQY
Y57 KGFAFVQYVNERNAR
K89 INLAAEPKVNRGKAG
Y105-p KRSAAEMyGssFDLD
- gap
- gap
- gap
- gap
- gap
S107-p SAAEMyGssFDLDyD
S108-p AAEMyGssFDLDyDF
Y113-p GssFDLDyDFQRDyy
Y119-p DyDFQRDyyDRMysY
Y120-p yDFQRDyyDRMysYP
Y124-p RDyyDRMysYPARVP
S125-p DyyDRMysYPARVPP
Y126 yyDRMysYPARVPPP
R138 PPPPPIARAVVPSKR
K144 ARAVVPSKRQRVSGN
R147 VVPSKRQRVSGNTSR
S149 PSKRQRVSGNTSRRG
T152 RQRVSGNTSRRGKSG
S153 QRVSGNTSRRGKSGF
K157 GNTSRRGKSGFNSKS
K157 GNTSRRGKSGFNSKS
K163 GKSGFNSKSGQRGSS
K163 GKSGFNSKSGQRGSS
K176 SSKSGKLKGDDLQAI
K184 GDDLQAIKKELTQIK
K193 ELTQIKQKVDSLLEN
S196 QIKQKVDSLLENLEK
K203 SLLENLEKIEKEQSK
K210 KIEKEQSKQAVEMKN
K210 KIEKEQSKQAVEMKN
- gap
- gap
- gap
K216 SKQAVEMKNDKSEEE
K219 AVEMKNDKSEEEQSS
K219 AVEMKNDKSEEEQSS
K219 AVEMKNDKSEEEQSS
S220 VEMKNDKSEEEQSSS
S225 DKSEEEQSSSSVKKD
S226 KSEEEQSSSSVKKDE
S227 SEEEQSSSSVKKDET
S228 EEEQSSSSVKKDETN
K230 EQSSSSVKKDETNVk
K230 EQSSSSVKKDETNVk
K231 QSSSSVKKDETNVkM
T234 SSVKKDETNVkMESE
K237 KKDETNVKMESEGGA
K237-sm KKDETNVkMESEGGA
S240 ETNVkMESEGGADDS
S247 SEGGADDSAEEGDLL
S286 EGEDDRDSANGEDDS
S293 SANGEDDS_______
  hnRNP C1/C2 iso4  
K8 MASNVTNKTDPRSMN
T9 ASNVTNKTDPRSMNS
K29 NLNTLVVKKSDVEAI
K30 LNTLVVKKSDVEAIF
K39 DVEAIFSKYGKIVGC
K39 DVEAIFSKYGKIVGC
K42 AIFSKYGKIVGCSVH
K50 IVGCSVHKGFAFVQY
K50 IVGCSVHKGFAFVQY
Y57 KGFAFVQYVNERNAR
K89 INLAAEPKVNRGKAG
Y105-p KRSAAEMyGssFDLD
- gap
- gap
- gap
- gap
- gap
S107-p SAAEMyGssFDLDyD
S108-p AAEMyGssFDLDyDF
Y113-p GssFDLDyDFQRDyy
Y119-p DyDFQRDyyDRMysY
Y120-p yDFQRDyyDRMysYP
Y124-p RDyyDRMysYPARVP
S125-p DyyDRMysYPARVPP
Y126 yyDRMysYPARVPPP
R138 PPPPPIARAIKKELT
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
K141 PPIARAIKKELTQIK
K150 ELTQIKQKVDSLLEN
S153 QIKQKVDSLLENLEK
K160 SLLENLEKIEKEQSK
K167 KIEKEQSKQAVEMKN
K167 KIEKEQSKQAVEMKN
- gap
- gap
- gap
K173 SKQAVEMKNDKSEEE
K176 AVEMKNDKSEEEQSS
K176 AVEMKNDKSEEEQSS
K176 AVEMKNDKSEEEQSS
S177 VEMKNDKSEEEQSSS
S182 DKSEEEQSSSSVKKD
S183 KSEEEQSSSSVKKDE
S184 SEEEQSSSSVKKDET
S185 EEEQSSSSVKKDETN
K187 EQSSSSVKKDETNVK
K187 EQSSSSVKKDETNVK
K188 QSSSSVKKDETNVKM
T191 SSVKKDETNVKMESE
K194 KKDETNVKMESEGGA
K194 KKDETNVKMESEGGA
S197 ETNVKMESEGGADDS
S204 SEGGADDSAEEGDLL
S243 EGEDDRDSANGEDDS
S250 SANGEDDS_______
  mouse

► Hide Isoforms
 
K8 MASNVTNKTDPRSMN
T9 ASNVTNKTDPRSMNS
K29-ub NLNTLVVkKSDVEAI
K30 LNTLVVkKSDVEAIF
K39 DVEAIFSKYGKIVGC
K39-ub DVEAIFSkYGKIVGC
K42 AIFSkYGKIVGCSVH
K50 IVGCSVHKGFAFVQY
K50 IVGCSVHKGFAFVQY
Y57 KGFAFVQYVNERNAR
K89-ub INLAAEPkVNRGKAG
Y105 KRSAAEMYGSVPEHP
S107 SAAEMYGSVPEHPSP
P109 AEMYGSVPEHPSPSP
S113 GSVPEHPSPSPLLsS
S115 VPEHPSPSPLLsSsF
S119-p PSPSPLLsSsFDLDY
S120 SPSPLLsSsFDLDYD
S121-p PSPLLsSsFDLDYDF
Y126 sSsFDLDYDFQRDYY
Y132 DYDFQRDYYDRMysY
Y133 YDFQRDYYDRMysYP
Y137-p RDYYDRMysYPARVP
S138-p DYYDRMysYPARVPP
Y139 YYDRMysYPARVPPP
R151 PPPPPIARAVVPSKR
K157 ARAVVPSKRQRVsGN
R160 VVPSKRQRVsGNTSR
S162-p PSKRQRVsGNTSRRG
T165 RQRVsGNTSRRGKSG
S166 QRVsGNTSRRGKSGF
K170 GNTSRRGKSGFNSkS
K170 GNTSRRGKSGFNSkS
K176-ub GKSGFNSkSGQRGSS
K176 GKSGFNSKSGQRGSS
K190-ub SSKSGKLkGDDLQAI
K198 GDDLQAIKKELTQIK
K207-ub ELTQIKQkVDSLLES
S210 QIKQkVDSLLESLEk
K217-ub SLLESLEkIEKEQSk
K224-ub kIEKEQSkQADLsFs
K224 kIEKEQSKQADLsFs
S229-p QSkQADLsFssPVEM
S231-p kQADLsFssPVEMkN
S232-p QADLsFssPVEMkNE
K237-ub FssPVEMkNEksEEE
K240 PVEMkNEKsEEEQss
K240-ub PVEMkNEksEEEQss
K240 PVEMkNEKsEEEQss
S241-p VEMkNEksEEEQssA
S246-p EksEEEQssAsVKKD
S247-p ksEEEQssAsVKKDE
A248 sEEEQssAsVKKDET
S249-p EEEQssAsVKKDETN
K251 EQssAsVKKDETNVK
K251 EQssAsVKKDETNVK
K252 QssAsVKKDETNVKM
T255 AsVKKDETNVKMEsE
K258 KKDETNVKMEsEAGA
K258 KKDETNVKMEsEAGA
S261-p ETNVKMEsEAGADDs
S268-p sEAGADDsAEEGDLL
S306-p EGEDDRDsANGEDDs
S313-p sANGEDDs_______
  hnRNP C1/C2 iso2  
K8 MASNVTNKTDPRSMN
T9 ASNVTNKTDPRSMNS
K29 NLNTLVVKKSDVEAI
K30 LNTLVVKKSDVEAIF
K39 DVEAIFSKYGKIVGC
K39 DVEAIFSKYGKIVGC
K42 AIFSKYGKIVGCSVH
K50 IVGCSVHKGFAFVQY
K50 IVGCSVHKGFAFVQY
Y57 KGFAFVQYVNERNAR
K89 INLAAEPKVNRGKAG
Y105 KRSAAEMYGsSFDLD
- gap
- gap
- gap
- gap
- gap
S107-p SAAEMYGsSFDLDYD
S108 AAEMYGsSFDLDYDF
Y113 GsSFDLDYDFQRDYY
Y119 DYDFQRDYYDRMYSY
Y120 YDFQRDYYDRMYSYP
Y124 RDYYDRMYSYPARVP
S125 DYYDRMYSYPARVPP
Y126 YYDRMYSYPARVPPP
R138 PPPPPIARAVVPSKR
K144 ARAVVPSKRQRVSGN
R147 VVPSKRQRVSGNTSR
S149 PSKRQRVSGNTSRRG
T152 RQRVSGNTSRRGKSG
S153 QRVSGNTSRRGKSGF
K157 GNTSRRGKSGFNSKS
K157 GNTSRRGKSGFNSKS
K163 GKSGFNSKSGQRGSS
K163 GKSGFNSKSGQRGSS
K177 SSKSGKLKGDDLQAI
K185 GDDLQAIKKELTQIK
K194 ELTQIKQKVDSLLES
S197 QIKQKVDSLLESLEK
K204 SLLESLEKIEKEQSK
K211 KIEKEQSKQADLSFS
K211 KIEKEQSKQADLSFS
S216 QSKQADLSFSSPVEM
S218 KQADLSFSSPVEMKN
S219 QADLSFSSPVEMKNE
K224 FSSPVEMKNEKSEEE
K227 PVEMKNEKSEEEQSS
K227 PVEMKNEKSEEEQSS
K227 PVEMKNEKSEEEQSS
S228 VEMKNEKSEEEQSSA
S233 EKSEEEQSSASVKKD
S234 KSEEEQSSASVKKDE
A235 SEEEQSSASVKKDET
S236 EEEQSSASVKKDETN
K238 EQSSASVKKDETNVK
K238 EQSSASVKKDETNVK
K239 QSSASVKKDETNVKM
T242 ASVKKDETNVKMESE
K245 KKDETNVKMESEAGA
K245 KKDETNVKMESEAGA
S248 ETNVKMESEAGADDS
S255 SEAGADDSAEEGDLL
S293 EGEDDRDSANGEDDS
S300 SANGEDDS_______
  hnRNP C1/C2 iso3  
K8 MASNVTNKTDPRSMN
T9 ASNVTNKTDPRSMNS
K29 NLNTLVVKKSDVEAI
K30 LNTLVVKKSDVEAIF
K39 DVEAIFSKYGKIVGC
K39 DVEAIFSKYGKIVGC
K42 AIFSKYGKIVGCSVH
K50 IVGCSVHKGFAFVQY
K50 IVGCSVHKGFAFVQY
Y57 KGFAFVQYVNERNAR
K89 INLAAEPKVNRGKAG
Y105 KRSAAEMYGSSFDLD
- gap
- gap
- gap
- gap
- gap
S107 SAAEMYGSSFDLDYD
S108 AAEMYGSSFDLDYDF
Y113 GSSFDLDYDFQRDYY
Y119 DYDFQRDYYDRMYSY
Y120 YDFQRDYYDRMYSYP
Y124 RDYYDRMYSYPARVP
S125 DYYDRMYSYPARVPP
Y126 YYDRMYSYPARVPPP
R138 PPPPPIARAVVPSKR
K144 ARAVVPSKRQRVSGN
R147 VVPSKRQRVSGNTSR
S149 PSKRQRVSGNTSRRG
T152 RQRVSGNTSRRGKSG
S153 QRVSGNTSRRGKSGF
K157 GNTSRRGKSGFNSKS
K157 GNTSRRGKSGFNSKS
K163 GKSGFNSKSGQRGSS
K163 GKSGFNSKSGQRGSS
K175 GSSSKSGKLKGDDLQ
K185 GDDLQAIKKELTQIK
K194 ELTQIKQKVDSLLES
S197 QIKQKVDSLLESLEK
K204 SLLESLEKIEKEQSK
K211 KIEKEQSKQAVEMKN
K211 KIEKEQSKQAVEMKN
- gap
- gap
- gap
K217 SKQAVEMKNEKsEEE
K220 AVEMKNEKsEEEQSS
K220 AVEMKNEKsEEEQSS
K220 AVEMKNEKsEEEQSS
S221-p VEMKNEKsEEEQSSA
S226 EKsEEEQSSASVKKD
S227 KsEEEQSSASVKKDE
A228 sEEEQSSASVKKDET
S229 EEEQSSASVKKDETN
K231 EQSSASVKKDETNVK
K231 EQSSASVKKDETNVK
K232 QSSASVKKDETNVKM
T235 ASVKKDETNVKMESE
K238 KKDETNVKMESEAGA
K238 KKDETNVKMESEAGA
S241 ETNVKMESEAGADDS
S248 SEAGADDSAEEGDLL
S286 EGEDDRDSANGEDDS
S293 SANGEDDS_______
  rat

 
K8 MASNVTNKTDPRSMN
T9 ASNVTNKTDPRSMNS
K29 NLNTLVVKKSDVEAI
K30 LNTLVVKKSDVEAIF
K39 DVEAIFSKYGKIVGC
K39 DVEAIFSKYGKIVGC
K42 AIFSKYGKIVGCSVH
K50 IVGCSVHKGFAFVQY
K50 IVGCSVHKGFAFVQY
Y57 KGFAFVQYVNERNAR
K89 INLAAEPKVNRGKAG
Y105 KRSAAEMYGSSFDLD
- gap
- gap
- gap
- gap
- gap
S107 SAAEMYGSSFDLDYD
S108 AAEMYGSSFDLDYDF
Y113 GSSFDLDYDFQRDYY
Y119 DYDFQRDYYDRMYSY
Y120 YDFQRDYYDRMYSYP
Y124 RDYYDRMYSYPARVP
S125 DYYDRMYSYPARVPP
Y126 YYDRMYSYPARVPPP
R138 PPPPPIARAVVPSKR
K144 ARAVVPSKRQRVsGN
R147 VVPSKRQRVsGNTSR
S149-p PSKRQRVsGNTSRRG
T152 RQRVsGNTSRRGKSG
S153 QRVsGNTSRRGKSGF
K157 GNTSRRGKSGFNSKS
K157 GNTSRRGKSGFNSKS
K163 GKSGFNSKSGQRGSS
K163 GKSGFNSKSGQRGSS
K175 GSSSKSVKGDDLQAI
K183 GDDLQAIKKELTQIK
K192 ELTQIKQKVDSLLES
S195 QIKQKVDSLLESLEK
K202 SLLESLEKIEKEQSK
K209 KIEKEQSKQADLsFS
K209 KIEKEQSKQADLsFS
S214-p QSKQADLsFSsPVEM
S216 KQADLsFSsPVEMKN
S217-p QADLsFSsPVEMKNE
K222 FSsPVEMKNEKsEEE
K225 PVEMKNEKsEEEQss
K225 PVEMKNEKsEEEQss
K225 PVEMKNEKsEEEQss
S226-p VEMKNEKsEEEQssA
S231-p EKsEEEQssAsVKKD
S232-p KsEEEQssAsVKKDE
A233 sEEEQssAsVKKDET
S234-p EEEQssAsVKKDETN
K236 EQssAsVKKDETNVK
K236 EQssAsVKKDETNVK
K237 QssAsVKKDETNVKM
T240 AsVKKDETNVKMEsE
K243 KKDETNVKMEsEAGA
K243 KKDETNVKMEsEAGA
S246-p ETNVKMEsEAGADDs
S253-p sEAGADDsAEEGDLL
S291-p EGEDDRDsANGEDDS
S298 sANGEDDS_______
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