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MST4 (human)

Overview MST4 a S/T protein kinase of the STE20 family. Mst kinases regulate processes such as apoptosis, morphogenesis, and cytoskeletal rearrangements, and are upstream activators of MAPK pathways that. The amino-terminal kinase domain of Mst is considerably homologous to the kinase domain of yeast STE20 kinase and other p21-activated kinases. otential mediator of cell growth. Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.1; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; STE group; STE20 family; YSK subfamily Cellular Component: Golgi membrane; cytosol Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; magnesium ion binding; ATP binding; protein kinase activity Biological Process: regulation of apoptosis; apoptosis; protein amino acid phosphorylation; cell structure disassembly during apoptosis Reference #:  Q9P289 (UniProtKB) Alt. Names/Synonyms: Mammalian STE20-like protein kinase 4; mammalian sterile 20-like 4; MASK; MST-4; Mst3 and SOK1-related kinase; MST4; serine/threonine protein kinase MASK; serine/threonine protein kinase MST4; Serine/threonine-protein kinase MASK; Serine/threonine-protein kinase MST4; STE20-like kinase MST4 Gene Symbols: MST4 Molecular weight: 46,529 Da Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below MST4 3GGF - A/B=1-300 (human) 4FZA - A=11-334 (human) 4FZD - A=11-334 (human) 4FZF - A=11-334 (human) 4GEH - A/C=9-212 (human)

STRING  |  Scansite  |  KinBase  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 3GGF 4FZA 4FZD 4FZF 4GEH  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene

	Sites Implicated In
cytoskeletal reorganization: T178‑p intracellular localization: T178‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	7		S4-p	____MAHsPVAVQVP
0	2		K32-u	TKLERIGkGSFGEVF
0	1		Y86-p	SSYVTKYyGSyLKGS
0	1		Y89-p	VTKYyGSyLKGSKLW
0	1		Y101-p	KLWIIMEyLGGGSAL
0	2		K146-u	KKIHRDIkAANVLLS
0	2		T170-p	FGVAGQLtDtQIkRN
0	30		T172-p	VAGQLtDtQIkRNtF
0	5		K175-u	QLtDtQIkRNtFVGt
1	50		T178-p	DtQIkRNtFVGtPFW
0	3		T182-p	kRNtFVGtPFWMAPE
0	6		K214-u	ITAIELAkGEPPNSD
0	2		K233-u	RVLFLIPkNNPPTLV
0	1		S260-p	ACLNKDPsFRPtAKE
0	1		T264-p	KDPsFRPtAKELLKH
0	5		K280-u	FIVKNSKkTsYLTEL
0	1		S282-p	VKNSKkTsYLTELID
0	12		S300-p	RWKAEGHsDDEsDsE
0	10		S304-p	EGHsDDEsDsEGsDS
0	9		S306-p	HsDDEsDsEGsDSES
0	10		S309-p	DEsDsEGsDSESTSR
0	1		T320-p	STSRENNtHPEWsFt
0	7		S325-p	NNtHPEWsFttVRKK
0	8		T327-p	tHPEWsFttVRKKPD
0	8		T328-p	HPEWsFttVRKKPDP
0	1		K401-u	GITDKMVkKLIEKFQ

	mouse
S4-p	____MAHsPVAVQVP
K32	TKLERIGKGSFGEVF
Y86	SSYVTKYYGSYLKGS
Y89	VTKYYGSYLKGSKLW
Y101	KLWIIMEYLGGGSAL
K146	KKIHRDIKAANVLLS
T170-p	FGVAGQLtDtQIKRN
T172-p	VAGQLtDtQIKRNtF
K175	QLtDtQIKRNtFVGt
T178-p	DtQIKRNtFVGtPFW
T182-p	KRNtFVGtPFWMAPE
K214	ITAIELAKGEPPNSD
K233	RVLFLIPKNNPPTLI
S260	ACLNKDPSFRPTAKE
T264	KDPSFRPTAKELLKH
K280-u	FIVKNSKkTsYLTEL
S282-p	VKNSKkTsYLTELID
S300-p	RWKAEGHsDEEsDsE
S304-p	EGHsDEEsDsEGsDS
S306-p	HsDEEsDsEGsDSES
S309-p	EEsDsEGsDSESSSR
P320	SSSRESNPHPEWSFT
S325	SNPHPEWSFTTVRKK
T327	PHPEWSFTTVRKKPD
T328	HPEWSFTTVRKKPDP
K401	GITDKMVKKLIEKFQ

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