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Protein Page:
MST4 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
MST4 a S/T protein kinase of the STE20 family. Mst kinases regulate processes such as apoptosis, morphogenesis, and cytoskeletal rearrangements, and are upstream activators of MAPK pathways that. The amino-terminal kinase domain of Mst is considerably homologous to the kinase domain of yeast STE20 kinase and other p21-activated kinases. otential mediator of cell growth. Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; STE group; STE20 family; YSK subfamily
Chromosomal Location of Human Ortholog: Xq26.2
Cellular Component: Golgi membrane; Golgi apparatus; centrosome; cytoplasm; cytosol; nucleus
Molecular Function: protein serine/threonine kinase activity; identical protein binding; protein binding; magnesium ion binding; ATP binding; protein kinase activity
Biological Process: regulation of apoptosis; apoptosis; protein amino acid phosphorylation; cell structure disassembly during apoptosis
Reference #:  Q9P289 (UniProtKB)
Alt. Names/Synonyms: Mammalian STE20-like protein kinase 4; mammalian sterile 20-like 4; MASK; MST-4; Mst3 and SOK1-related kinase; MST4; serine/threonine protein kinase MASK; serine/threonine protein kinase MST4; Serine/threonine-protein kinase MASK; Serine/threonine-protein kinase MST4; STE20-like kinase MST4
Gene Symbols: MST4
Molecular weight: 46,529 Da
Basal Isoelectric point: 5.16  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

MST4

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: T178‑p
intracellular localization: T178‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 11 S4-p ____MAHsPVAVQVP
0 2 K32-ub TKLERIGkGSFGEVF
0 1 Y86-p SSYVTKYyGSyLKGS
0 1 Y89-p VTKYyGSyLKGSKLW
0 1 Y101-p KLWIIMEyLGGGSAL
0 1 K130 TMLKEILKGLDYLHS
0 2 K146-ub KKIHRDIkAANVLLS
0 4 T170-p FGVAGQLtDtQIkRN
0 38 T172-p VAGQLtDtQIkRNtF
0 5 K175-ub QLtDtQIkRNtFVGt
1 66 T178-p DtQIkRNtFVGtPFW
0 5 T182-p kRNtFVGtPFWMAPE
0 6 K214-ub ITAIELAkGEPPNSD
0 2 K233-ub RVLFLIPkNNPPTLV
0 1 S260-p ACLNKDPsFRPtAKE
0 1 T264-p KDPsFRPtAKELLKH
0 5 K280-ub FIVKNSKkTsYLTEL
0 1 S282-p VKNSKkTsYLTELID
0 16 S300-p RWKAEGHsDDEsDsE
0 14 S304-p EGHsDDEsDsEGsDS
0 12 S306-p HsDDEsDsEGsDSES
0 14 S309-p DEsDsEGsDSESTSR
0 1 T320-p STSRENNtHPEWsFt
0 10 S325-p NNtHPEWsFttVRKK
0 11 T327-p tHPEWsFttVRKKPD
0 11 T328-p HPEWsFttVRKKPDP
0 1 K401-ub GITDKMVkKLIEKFQ
  mouse

 
S4-p ____MAHsPVAVQVP
K32 TKLERIGKGSFGEVF
Y86 SSYVTKYYGSYLKGS
Y89 VTKYYGSYLKGSKLW
Y101 KLWIIMEYLGGGSAL
K130-ac TMLKEILkGLDYLHS
K146 KKIHRDIKAANVLLS
T170-p FGVAGQLtDtQIKRN
T172-p VAGQLtDtQIKRNtF
K175 QLtDtQIKRNtFVGt
T178-p DtQIKRNtFVGtPFW
T182-p KRNtFVGtPFWMAPE
K214 ITAIELAKGEPPNSD
K233 RVLFLIPKNNPPTLI
S260 ACLNKDPSFRPTAKE
T264 KDPSFRPTAKELLKH
K280-ub FIVKNSKkTsYLTEL
S282-p VKNSKkTsYLTELID
S300-p RWKAEGHsDEEsDsE
S304-p EGHsDEEsDsEGsDS
S306-p HsDEEsDsEGsDSES
S309-p EEsDsEGsDSESSSR
P320 SSSRESNPHPEWSFT
S325 SNPHPEWSFTTVRKK
T327 PHPEWSFTTVRKKPD
T328 HPEWSFTTVRKKPDP
K401 GITDKMVKKLIEKFQ
  rat

 
S4-p ____MAHsPVAVQVP
K32 TKLERIGKGSFGEVF
Y86 SSYVTKYYGSYLKGS
Y89 VTKYYGSYLKGSKLW
Y101 KLWIIMEYLGGGSAL
K130-ac TMLKEILkGLDYLHS
K146 KKIHRDIKAANVLLS
T170 FGVAGQLTDtQIKRN
T172-p VAGQLTDtQIKRNTF
K175 QLTDtQIKRNTFVGT
T178 DtQIKRNTFVGTPFW
T182 KRNTFVGTPFWMAPE
K214 ITAIELAKGEPPNSD
K233 RVLFLIPKNNPPTLV
S260 ACLNKDPSFRPtAKE
T264-p KDPSFRPtAKELLKH
K280 FIVKNSKKTSYLTEL
S282 VKNSKKTSYLTELID
S300 RWKAEGHSDEESDSE
S304 EGHSDEESDSEGSDS
S306 HSDEESDSEGSDSES
S309 EESDSEGSDSESSSR
T320 SSSRESNTHPEWSFT
S325 SNTHPEWSFTTVRKK
T327 THPEWSFTTVRKKPD
T328 HPEWSFTTVRKKPDP
K401 GITDKMVKKLIEKFQ
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