a S/T protein kinase of the STE20 family. Mst kinases regulate processes such as apoptosis, morphogenesis, and cytoskeletal rearrangements, and are upstream activators of MAPK pathways that. The amino-terminal kinase domain of Mst is considerably homologous to the kinase domain of yeast STE20 kinase and other p21-activated kinases. otential mediator of cell growth. Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-178, possibly as a consequence of stabilization of dimer formation. May also be activated by C-terminal cleavage. Note: This description may include information from UniProtKB.
Protein type: Kinase, protein; EC 22.214.171.124; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; STE group; STE20 family; YSK subfamily
Chromosomal Location of Human Ortholog: Xq26.2
Cellular Component: nucleoplasm; Golgi membrane; Golgi apparatus; centrosome; perinuclear region of cytoplasm; cytoplasm; apical plasma membrane; Golgi-associated vesicle; nucleus; cytosol
Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; magnesium ion binding; ATP binding; protein kinase activity
Biological Process: regulation of apoptosis; microvillus biogenesis; response to hydrogen peroxide; apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; cell structure disassembly during apoptosis
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.