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Protein Page:
Obscn (rat)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
Obscn a Ca(2+)/calmodulin-dependent protein kinase of the Trio family. A giant protein with one Rho GEF domain, one PH domain and two kinase domains. Expressed in skeletal and cardiac muscle, concentrating around Z-disks and M-lines of striated muscle. Binds ankyrin 1 interacts with sarcomeric myosin. May play a critical role in its ability to assemble into A bands in striated muscle. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Protein kinase, CAMK; Kinase, protein; CAMK group; Trio family
Cellular Component: sarcomere; M band; Z disc
Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; titin binding; ankyrin binding
Reference #:  XP_340808 (RefSeq)
Alt. Names/Synonyms: Obscn; Obscurin; obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Gene Symbols: Obscn
Molecular weight: 874,902 Da
Basal Isoelectric point: 5.75  Predict pI for various phosphorylation states
Select Structure to View Below

Obscn

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
0 2 S236 RAEGVPPSPPGAGTR
0 2 G239 GVPPSPPGAGTRTCT
0 5 K270 PKPETVWKKDGQLVN
0 5 Y285 EGRRHVVYEDEQENF
0 1 S393 RLTVRNVSADDDAVY
0 1 K705 ALGLPSNKLPAVAAR
0 2 W838 LQYDMGLWHCLGAAL
0 2 K930 LVVQQAGKADAGEYS
0 2 K1022 LVVQQAGKADAGEYS
0 2 K1114 LVVQQAGKADAGEYS
0 2 - gap
0 2 K1298 LVVQQAGKADAGEYS
0 2 K1390 LVVQQAGKADAGEYS
0 2 K1482 LVVQQAGKADAGEYS
0 2 K1574 LVVQQAGKADAGEYS
0 2 K1666 LVVQQAGKADAGEYS
0 2 K1758 LVVQQAGKADAGEYS
0 2 K1850 LVVQQVGKADAGEYS
0 3 S2602 LTLHKTCSTMTGPVH
0 1 K2856 DKYDFLHKAGVRSLT
0 1 S2881 LYTCQVGSKETQSRV
0 2 T2903 GITKRLKTVEVLEGE
0 4 S3048 VLVVRKASLKDSGEY
0 1 S3206-p LDKTPLHsNELNEIT
0 1 Y3219-p ITVQSGGyHVLTLRQ
0 6 T3223 SGGyHVLTLRQLTLK
0 6 S3232 RQLTLKDSGTVYFEA
0 1 T3448 NKEATEGTMATLRCE
0 1 M3449 KEATEGTMATLRCEL
0 1 N3529 HFIRRLRNKEATEGD
0 1 T3762 RGLAVVDTGTYSSLP
0 1 S3766 VVDTGTYSSLPAKFT
0 1 A3770 GTYSSLPAKFTEGLR
0 2 S3805 PVEWRKGSETLRDGG
0 1 - gap
0 3 S4157 PVEWRKGSETLRDGG
0 1 - gap
0 1 S4335 SVEWRKGSLQLFPCA
0 5 S4396 KFKTGLQSKEQEAGG
0 2 T4918 LVIKGFRTEDQGEYR
0 32 S4982 LARKRRMSREPTLDS
0 33 T4986 RRMSREPTLDSISEL
0 19 S4989 SREPTLDSISELPEE
0 10 S4991 EPTLDSISELPEEDS
0 3 S5015 EEAAPDLSEGYSTAD
0 1 S5019 PDLSEGYSTADELAR
0 10 T5020 DLSEGYSTADELART
0 1 S5033 RTGEADLSHTSSDDE
0 1 T5035 GEADLSHTSSDDESR
0 2 S5036 EADLSHTSSDDESRA
0 4 S5037 ADLSHTSSDDESRAG
0 1 T5045 DDESRAGTPSLITYL
0 2 S5266 SEEELFLSADEGPME
0 1 K5445 SMGVSSTKAELRVEL
0 1 T5484 SSREQEGTESDEGQL
0 1 S5486 REQEGTESDEGQLPQ
0 6 S5795 LQVPGGDSDEESKTP
0 1 S5799 GGDSDEESKTPSASP
0 3 T5801 DSDEESKTPSASPRH
0 1 S5803 DEESKTPSASPRHGR
0 3 S5805 ESKTPSASPRHGRSR
0 1 Y6096 CALLEQAYAVVSALP
0 1 S6170 ICKPRRDSRTDTFSY
0 1 N6186 FRNMMKLNSIDLNDQ
0 1 S6187 RNMMKLNSIDLNDQV
0 1 S6394 RMVNEPRSGMLVLVI
0 1 S6433 GGELYMQSPALRAWD
0 1 - gap
0 1 S6905 APFARAKSLPPSPVT
0 1 S6909 RAKSLPPSPVTHSPL
0 1 S6914 PPSPVTHSPLLHPRG
0 1 S6926 PRGFLRPSASLPEET
0 2 S6928 GFLRPSASLPEETEA
0 1 - under review  
0 1 K7491 LGLRQRVKASMAHIS
0 1 K7502 AHISRILKGKPEGPE
0 1 K7517 KEGPPRKKAGLASFR
0 2 S7522 RKKAGLASFRLSGLK
0 1 S7526 GLASFRLSGLKGRDQ
  human

► Hide Isoforms
 
S238-p RAEGAPAsPPsTGTR
S241-p GAPAsPPsTGTRTCT
K272-a PKPETVWkKDGQLVT
Y287-p EGRRHVVyEDAQENF
S395 RLTVRNVSADDDAVY
K707 APGLTANKPPAAAAR
- gap
- gap
R862 LVAATVTRQDEGTYS
Q954 LVVQQAGQADAGEYS
- gap
K1138 LVLPQAGKADAGEYS
K1230 LVVQQVGKADAGEYS
Q1322 LVVQQAGQADAGEYT
Q1414 LVVQQACQADTGEYS
Q1506 LVVQQAGQAVAGEYS
Q1598 LVVQEAGQADAGEYS
Q1690 LVVQQAGQAEAGEYS
S2443-p LMLRRTCsTMTGPVH
T2697 DKYDFLHTAGTRGLV
S2722 LYTCHVGSEETRARV
T2744 GITKRLKTMEVLEGE
S2889 MLVIRGASLKDAGEY
A3047 LDKTPLHANELNEID
Y3060 IDAQPGGYHVLtLRQ
T3064-p PGGYHVLtLRQLALK
S3073-p RQLALKDsGTIYFEA
A3289 NKEATEGATATLRCE
T3290 KEATEGATATLRCEL
H3370 HFIGRLRHQESIEGA
T3603 RGLAMADTGEYSCVC
- gap
- gap
- gap
- gap
S3837-p PVEWRKGsETLRGGD
- gap
S4015 SVEWRKGSLQLFPCA
S4076-p KFKTRLQsLEQETGD
A4687 LVIKGFTAEDQGEYH
S4750-p LARKRRMsREPtLDs
T4754-p RRMsREPtLDsIsEL
S4757-p sREPtLDsIsELPEE
S4759-p EPtLDsIsELPEEDG
S4783 EEVAPDLSEGYstAD
S4787-p PDLSEGYstADELAR
T4788-p DLSEGYstADELART
S4801 RTGDADLSHTSsDDE
T4803 GDADLSHTSsDDESR
S4804 DADLSHTSsDDESRA
S4805-p ADLSHTSsDDESRAG
T4813 DDESRAGTPSLVTYL
S5034 SDEELFLSADEGPAE
K5211 SMGVSSTKAELRVDL
T5250 SSREQEGTESTTDEG
S5252 REQEGTESTTDEGQL
S5563-p LQVPGGDsDEDSKtP
S5567 GGDsDEDSKtPSASP
T5569-p DsDEDSKtPSASPRH
S5571 DEDSKtPSASPRHGR
S5573 DSKtPSASPRHGRSR
Y5864-p CALLEQAyAVVSALP
S5938 ICKPRRDSRTDTVSY
S5954-p FRNMMKLssIDLNDQ
S5955-p RNMMKLssIDLNDQV
S6162-p QTLSEPRsGLLVLVI
S6201 SAELRIQSPMLQAQE
T6222 LVAAVEDTTLERADQ
S6808-p APFARAKsLPPsPVT
S6812-p RAKsLPPsPVTHsPL
S6817-p PPsPVTHsPLLHPRG
S6829-p PRGFLRPsAsLPEEA
S6831-p GFLRPsAsLPEEAEA
S7244-p QQEARAEsPLPQVSA
K7419 LGLRERVKASVEHIS
K7430 EHISRILKGRPEGLE
K7445 KEGPPRKKPGLASFR
S7450 RKKPGLASFRLSGLK
S7454 GLASFRLSGLKSWDR
  Obscn iso3  
S238 RAEGAPASPPSTGTR
S241 GAPASPPSTGTRTCT
K272 PKPETVWKKDGQLVT
Y287 EGRRHVVYEDAQENF
S395 RLTVRNVSADDDAVY
K707 APGLTANKPPAAAAR
- gap
- gap
R862 LVAATVTRQDEGTYS
Q954 LVVQQAGQADAGEYS
- gap
K1138 LVLPQAGKADAGEYS
K1230 LVVQQVGKADAGEYS
Q1322 LVVQQAGQADAGEYT
Q1414 LVVQQACQADTGEYS
Q1506 LVVQQAGQAVAGEYS
Q1598 LVVQEAGQADAGEYS
Q1690 LVVQQAGQAEAGEYS
S2443 LMLRRTCSTMTGPVH
T2697 DKYDFLHTAGTRGLV
S2722 LYTCHVGSEETRARV
T2744 GITKRLKTMEVLEGE
S2889 MLVIRGASLKDAGEY
A3047 LDKTPLHANELNEID
Y3060 IDAQPGGYHVLTLRQ
T3064 PGGYHVLTLRQLALK
S3073 RQLALKDSGTIYFEA
A3289 NKEATEGATATLRCE
T3290 KEATEGATATLRCEL
H3370 HFIGRLRHQESIEGA
T3603 RGLAMADTGEYSCVC
- gap
- gap
- gap
- gap
S3837 PVEWRKGSETLRGGD
- gap
S4015 SVEWRKGSLQLFPCA
S4076 KFKTRLQSLEQETGD
A4687 LVIKGFTAEDQGEYH
S4750 LARKRRMSREPTLDS
T4754 RRMSREPTLDSISEL
S4757 SREPTLDSISELPEE
S4759 EPTLDSISELPEEDG
S4783 EEVAPDLSEGYSTAD
S4787 PDLSEGYSTADELAR
T4788 DLSEGYSTADELART
S4801 RTGDADLSHTSSDDE
T4803 GDADLSHTSSDDESR
S4804 DADLSHTSSDDESRA
S4805 ADLSHTSSDDESRAG
T4813 DDESRAGTPSLVTYL
S5034 SDEELFLSADEGPAE
K5211 SMGVSSTKAELRVDL
T5250 SSREQEGTESTTDEG
S5252 REQEGTESTTDEGQL
S5563 LQVPGGDSDEDSKTP
S5567 GGDSDEDSKTPSASP
T5569 DSDEDSKTPSASPRH
S5571 DEDSKTPSASPRHGR
S5573 DSKTPSASPRHGRSR
Y5864 CALLEQAYAVVSALP
S5938 ICKPRRDSRTDTVSY
S5954 FRNMMKLSSIDLNDQ
S5955 RNMMKLSSIDLNDQV
S6162 QTLSEPRSGLLVLVI
S6201 SAELRIQSPMLQAQE
T6222-p LVAAVEVtEQETKVP
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
  mouse

► Hide Isoforms
 
S236 RAEGIPPSPPGAGTR
G239 GIPPSPPGAGTRTCT
K270 PKPETVWKKDGQLVT
Y285 EGRRHVVYEDEQENF
S393-p RLTVRNVsADDDAVY
K705-u ALGLPSSkLPAAAAR
K927-u LVVQQAGkADAGEYS
K1019-u LVVQQAGkADAGEYS
K1111-u LVVQQAGkADAGEYS
K1203-u LVVQQAGkADAGEYS
K1295-u LVVQQAGkADAGEYS
K1479-u LVVQQAGkADAGEYS
K1571-u LVVQQAGkADAGEYS
K1663-u LVVQQAGkADAGEYS
K1755-u LVVQQAGkADAGEYS
K1847-u LVVQQAGkADAGEYS
K1939-u LVVQQAGkADAGEYS
K2123-u LVVQQAGkADAGEYS
S2875 LTLHKTCSTMTGPVH
K3129-u DKYDFLHkAGARGLT
S3154-p LYTCQVGsKETQSKV
T3176-p GITKRLKtVEVLEGE
S3321-p VLVVRKAsLKDSGEY
S3479 LDKTPLHSNELNEIT
Y3492 ITVQPGGYHVLTLRQ
T3496 PGGYHVLTLRQLALK
S3505 RQLALKDSGTVYFEA
T3721-p NKEATEGttVTLRCE
T3722-p KEATEGttVTLRCEL
S3802-p HFVRRLRsKEATEGD
T4035-p RGLAVVDtGTYsLPt
S4039-p VVDtGTYsLPtKFTE
T4042-p tGTYsLPtKFTEGLR
S4077-p PVEWRKGsETLRDGD
T4156-p LRCQMSKtAPVEWKK
S4517-p PVEWRKGsETLRDGD
S4774-p CKLSKKAsVVWKKGS
S4959-p SVEWRKGsLQLFPCA
S5020 KFKTDLQSTEQEAGG
T5626-p LVIKGFRtEDQGEYR
S5690-p LARKRRMsREPtLDs
T5694-p RRMsREPtLDsIsEL
S5697-p sREPtLDsIsELPEE
S5699-p EPtLDsIsELPEEDS
S5723-p EETAPDLsEGYstAD
S5727-p PDLsEGYstADELAR
T5728-p DLsEGYstADELART
S5741-p RTGEADLsHtssDDE
T5743-p GEADLsHtssDDESR
S5744-p EADLsHtssDDESRA
S5745-p ADLsHtssDDESRAG
T5753-p DDESRAGtPSLVTYL
S5974-p SEEELFLsADEGPGE
K6153-u SMGVSSTkAELRVEL
T6192-p SSREQEGtEsDEGQL
S6194-p REQEGtEsDEGQLPQ
S6503-p LQVPGGDsDEEtKtP
T6507-p GGDsDEEtKtPsAsP
T6509-p DsDEEtKtPsAsPRH
S6511-p DEEtKtPsAsPRHGR
S6513-p EtKtPsAsPRHGRSR
Y6804 CALLEQAYAVVSALP
S6878-p ICKPRRDsRTDTFSY
S6894 FRNMMKLSSIDLNDQ
S6895 RNMMKLSSIDLNDQV
S7102 RMLNEPRSGVLVLVI
S7141-p GGELYMQsPALRARD
C7162 IVAAVEVCSHDTSVE
S7755 APFARAKSLPPSPVT
S7759 RAKSLPPSPVTHSPL
S7764 PPSPVTHSPLLHPRG
S7776 PRGFLRPSASLPEET
S7778 GFLRPSASLPEETEA
- under review  
K8341-u LGLRQRVkASMAHIS
K8352-u AHISRILkGRPEGPE
K8367-u REGPPRKkAGLAsFR
S8372-p RKkAGLAsFRLsGLK
S8376-p GLAsFRLsGLKGRDQ
  Obscn iso2  
S236 RAEGIPPSPPGAGTR
G239 GIPPSPPGAGTRTCT
K270 PKPETVWKKDGQLVT
Y285 EGRRHVVYEDEQENF
S393 RLTVRNVSADDDAVY
K705 ALGLPSSKLPAAAAR
K860 LVVQQAGKADAGEYS
K952 LVVQQAGKADAGEYS
K1044 LVVQQAGKADAGEYS
K1136 LVVQQAGKADAGEYS
K1228 LVVQQAGKADAGEYS
K1412 LVVQQAGKADAGEYS
K1504 LVVQQAGKADAGEYS
K1596 LVVQQAGKADAGEYS
K1688 LVVQQAGKADAGEYS
K1780 LVVQQAGKADAGEYS
K1872 LVVQQAGKADAGEYS
K2056 LVVQQAGKADAGEYS
S2808 LTLHKTCSTMTGPVH
K3062 DKYDFLHKAGARGLT
S3087 LYTCQVGSKETQSKV
T3109 GITKRLKTVEVLEGE
S3254 VLVVRKASLKDSGEY
S3412 LDKTPLHSNELNEIT
Y3425 ITVQPGGYHVLTLRQ
T3429 PGGYHVLTLRQLALK
S3438 RQLALKDSGTVYFEA
T3654 NKEATEGTTVTLRCE
T3655 KEATEGTTVTLRCEL
S3735 HFVRRLRSKEATEGD
T3968 RGLAVVDTGTYSSLP
S3972 VVDTGTYSSLPTKFT
T3976 GTYSSLPTKFTEGLR
S4011 PVEWRKGSETLRDGD
T4090 LRCQMSKTAPVEWKK
S4451 PVEWRKGSETLRDGD
S4708 CKLSKKASVVWKKGS
S4893 SVEWRKGSLQLFPCA
S4954 KFKTDLQSTEQEAGG
T5568 LVIKGFRTEDQGEYR
S5632 LARKRRMSREPTLDS
T5636 RRMSREPTLDSISEL
S5639 SREPTLDSISELPEE
S5641 EPTLDSISELPEEDS
S5665 EETAPDLSEGYSTAD
S5669 PDLSEGYSTADELAR
T5670 DLSEGYSTADELART
S5683 RTGEADLSHTSSDDE
T5685 GEADLSHTSSDDESR
S5686 EADLSHTSSDDESRA
S5687 ADLSHTSSDDESRAG
T5695 DDESRAGTPSLVTYL
S5916 SEEELFLSADEGPGE
K6095 SMGVSSTKAELRVEL
T6134 SSREQEGTESDEGQL
S6136 REQEGTESDEGQLPQ
S6445 LQVPGGDSDEETKTP
T6449 GGDSDEETKTPSASP
T6451 DSDEETKTPSASPRH
S6453 DEETKTPSASPRHGR
S6455 ETKTPSASPRHGRSR
Y6746 CALLEQAYAVVSALP
S6820 ICKPRRDSRTDTFSY
S6836 FRNMMKLSSIDLNDQ
S6837 RNMMKLSSIDLNDQV
S7044 RMLNEPRSGVLVLVI
S7083 GGELYMQSPALRARD
- gap
- gap
- gap
- gap
- gap
- gap
- under review  
- gap
- gap
- gap
- gap
- gap
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