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Protein Page:
SPTAN1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
SPTAN1 a cytoskeletal protein which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Capable to forming dimers which can further associate to tetramers. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cytoskeletal protein; Motility/polarity/chemotaxis
Cellular Component: spectrin; membrane; fascia adherens; Z disc; cytosol; lateral plasma membrane
Molecular Function: calmodulin binding; protein binding; spectrin binding; structural constituent of cytoskeleton; protein heterodimerization activity; calcium ion binding; actin binding
Biological Process: axon guidance; actin filament capping; apoptosis; cell structure disassembly during apoptosis
Reference #:  Q13813 (UniProtKB)
Alt. Names/Synonyms: (ALPHA)II-SPECTRIN; Alpha-II spectrin; FLJ44613; Fodrin alpha chain; NEAS; non-erythrocytic spectrin alpha; Spectrin alpha chain, brain; spectrin, alpha, non-erythrocytic 1 (alpha-fodrin); Spectrin, non-erythroid alpha chain; SPTA2; SPTAN1
Gene Symbols: SPTAN1
Molecular weight: 284,539 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

SPTAN1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T34-p HRFKELStLRRQKLE
0 1 K63 LEKWIQEKLQIASDE
0 1 K73 IASDENYKDPTNLQG
0 1 S289-p DFGRDLAsVQALLRK
0 1 S324 EADRLQQSHPLSATQ
0 1 S324 EADRLQQSHPLSATQ
0 1 S328 LQQSHPLSATQIQVK
0 1 T330 QSHPLSATQIQVKRE
0 1 S391-p INADELAsDVAGAEA
0 1 S423-p SFKSADEsGQALLAA
0 1 S435-p LAAGHYAsDEVREKL
0 1 K441 AsDEVREKLTVLSEE
0 1 K514 KKHEDFEKSLsAQEE
0 1 S517-p EDFEKSLsAQEEKIT
0 1 S553-p TRRDALLsRRNALHE
0 1 S572 RRAQLADSFHLQQFF
0 2 S587 RDSDELKSWVNEkMK
0 2 K592-a LKSWVNEkMKTATDE
0 8 Y601-p KTATDEAyKDPSNLQ
0 1 K613-a NLQGKVQkHQAFEAE
0 1 K633 SRIDALEKAGQkLID
0 1 K637-a ALEKAGQkLIDVNHy
0 1 Y644-p kLIDVNHyAKDEVAA
0 1 S658 ARMNEVISLWKKLLE
0 2 T667-p WKKLLEAtELKGIKL
0 1 K718 TNVQNLQKKHALLEA
0 4 Y766-p QEALVARyEALKEPM
0 1 K779-a PMVARKQkLADsLRL
0 2 S783-p RKQkLADsLRLQQLF
0 2 K803 EETWIREKEPIAAST
0 1 K814 AASTNRGKDLIGVQN
0 1 K824 IGVQNLLKKHQALQA
0 1 K909 AESWMREKEPIVGST
0 1 K920 VGSTDYGKDEDSAEA
0 1 S937 KKHEALMSDLSAyGs
0 1 S940 EALMSDLSAyGsSIQ
0 3 Y942-p LMSDLSAyGsSIQAL
0 1 S944-p SDLSAyGsSIQALRE
0 1 K969 PTDDETGKELVLALy
0 3 Y976-p KELVLALyDYQEKsP
0 1 K981 ALyDYQEKsPREVTM
0 3 S982-p LyDYQEKsPREVTMK
0 1 K990 PREVTMKKGDILTLL
0 2 S999-p DILTLLNsTNKDWWK
0 11 Y1020-p QGFVPAAyVkKLDPA
0 1 K1022-a FVPAAyVkKLDPAQs
0 1 K1022 FVPAAyVKKLDPAQs
0 5 S1029-p kKLDPAQsAsRENLL
0 1 S1029 kKLDPAQSAsRENLL
0 17 S1031-p LDPAQsAsRENLLEE
0 44 S1041-p NLLEEQGsIALRQEQ
0 1 T1053-p QEQIDNQtRITkEAG
0 6 K1057-u DNQtRITkEAGSVsL
0 1 S1063-p TkEAGSVsLRMKQVE
0 1 K1067 GSVsLRMKQVEELyH
1 24 Y1073-p MKQVEELyHsLLELG
0 1 S1075-p QVEELyHsLLELGEK
0 1 K1082 sLLELGEKRKGMLEK
0 1 K1138 KKFDDFQKDLKANES
0 1 K1152 SRLKDINKVAEDLEs
0 1 S1159-p KVAEDLEsEGLMAEE
2 155 Y1176-p AVQQQEVyGMMPRDE
0 4 S1186-p MPRDETDsktAsPWK
0 2 K1187-u PRDETDsktAsPWKS
0 2 T1188-p RDETDsktAsPWKSA
0 38 S1190-p ETDsktAsPWKSARL
0 1 T1204 LMVHTVATFNsIkEL
0 5 S1207-p HTVATFNsIkELNER
0 5 K1209-u VATFNsIkELNERWR
0 85 S1217-p ELNERWRsLQQLAEE
0 1 S1226-p QQLAEERsQLLGSAH
0 4 Y1261-p QALNTDNyGHDLASV
0 1 K1288 DLAALGDKVNsLGET
0 2 S1291-p ALGDKVNsLGETAER
1 1 S1302-p TAERLIQsHPEsAED
0 2 S1306-p LIQsHPEsAEDLQEK
0 2 S1322-p TELNQAWssLGKRAD
0 19 S1323-p ELNQAWssLGKRADQ
0 1 S1338-p RKAKLGDsHDLQRFL
0 1 K1369 VSSDELAKDVTGAEA
0 1 T1386-p ERHQEHRtEIDARAG
0 25 Y1411-p QLLAHGHyAsPEIKQ
0 10 S1413-p LAHGHyAsPEIKQKL
0 1 K1419 AsPEIKQKLDILDQE
0 1 K1473 AFLNTEDKGdSLdSV
0 1 D1475-ca LNTEDKGdSLdSVEA
0 1 S1476 NTEDKGdSLdSVEAL
0 1 D1478-ca EDKGdSLdSVEALIK
0 1 S1479 DKGdSLdSVEALIKK
0 1 K1519-a IAAGHYAkGDISSRR
0 3 K1519-u IAAGHYAkGDISSRR
0 1 K1546 QMIEKRSKLGEsQTL
0 6 S1550-p KRSKLGEsQTLQQFS
0 2 S1557 sQTLQQFSRDVDEIE
0 3 S1578-p LQTASDEsyKDPTNI
0 2 Y1579-p QTASDEsyKDPTNIQ
0 1 K1580 TASDEsyKDPTNIQS
0 2 S1615-p GVIDMGNsLIERGAC
0 1 K1630 AGSEDAVKARLAALA
0 1 K1646 QWQFLVQKsAEKSQK
0 1 S1647-p WQFLVQKsAEKSQKL
0 1 T1665 NKQQNFNTGIKDFDF
0 1 S1692-p DYGKDLAsVNNLLKK
0 1 K1715 SAHEDRLKDLNSQAD
0 1 S1751-p GRFQKIKsMAAsRRA
0 1 S1755-p KIKsMAAsRRAKLNE
0 2 T1797-p EDYGRDLtGVQNLRK
0 1 K1829 GVLDTGKKLSDDNTI
0 2 K1938 TNGQDLIKKNNHHEE
0 1 S1959-p KGLNGKVsDLEKAAA
0 1 K1995 VESWIGEKENSLKTD
0 1 S2009 DDYGRDLSsVQTLLt
0 1 S2010-p DYGRDLSsVQTLLtK
0 1 T2016-p SsVQTLLtKQETFDA
0 2 T2020 TLLtKQETFDAGLQA
0 1 K2047 KDQLLAAKHVQSkAI
0 1 K2052-a AAKHVQSkAIEARHA
0 2 K2052-u AAKHVQSkAIEARHA
0 3 K2063 ARHASLMKRWsQLLA
0 3 S2066-p ASLMKRWsQLLANSA
0 1 S2072 WsQLLANSAARKKKL
0 1 A2074 QLLANSAARKKKLLE
0 2 S2084-p KKLLEAQsHFRKVED
0 1 K2088 EAQsHFRKVEDLFLT
0 2 K2098-a DLFLTFAkKASAFNS
0 1 K2127 CNSLEEIKALREAHD
0 1 S2159-p ELDRQIKsFRVASNP
0 1 S2340-p KHFDKDKsGRLNHQE
0 1 K2404 SRETENVKSSEEIES
0 1 K2421-a RALSSEGkPyVtkEE
0 349 Y2423-p LSSEGkPyVtkEELy
0 2 T2425-p SEGkPyVtkEELyQN
0 1 T2425 SEGkPyVTkEELyQN
0 1 K2426-a EGkPyVtkEELyQNL
0 2 K2426-u EGkPyVtkEELyQNL
0 145 Y2430-p yVtkEELyQNLTREQ
0 4 Y2440-p LTREQADyCVSHMKP
0 1 K2446 DyCVSHMKPYVDGKG
0 1 K2452 MKPYVDGKGRELPTA
0 4 Y2462-p ELPTAFDyVEFTRSL
  SPTAN1 iso2  
T34 HRFKELSTLRRQKLE
K63 LEKWIQEKLQIASDE
K73 IASDENYKDPTNLQG
S289 DFGRDLASVQALLRK
S324 EADRLQQSHPLSATQ
S324 EADRLQQSHPLSATQ
S328 LQQSHPLSATQIQVK
T330 QSHPLSATQIQVKRE
S391 INADELASDVAGAEA
S423 SFKSADESGQALLAA
S435 LAAGHYASDEVREKL
K441 ASDEVREKLTVLSEE
K514 KKHEDFEKSLSAQEE
S517 EDFEKSLSAQEEKIT
S553 TRRDALLSRRNALHE
S572 RRAQLADSFHLQQFF
S587 RDSDELKSWVNEKMK
K592 LKSWVNEKMKTATDE
Y601 KTATDEAYKDPSNLQ
K613 NLQGKVQKHQAFEAE
K633 SRIDALEKAGQKLID
K637 ALEKAGQKLIDVNHY
Y644 KLIDVNHYAKDEVAA
S658 ARMNEVISLWKKLLE
T667 WKKLLEATELKGIKL
K718 TNVQNLQKKHALLEA
Y766 QEALVARYEALKEPM
K779 PMVARKQKLADSLRL
S783 RKQKLADSLRLQQLF
K803 EETWIREKEPIAAST
K814 AASTNRGKDLIGVQN
K824 IGVQNLLKKHQALQA
K909 AESWMREKEPIVGST
K920 VGSTDYGKDEDSAEA
S937 KKHEALMSDLSAYGS
S940 EALMSDLSAYGSSIQ
Y942 LMSDLSAYGSSIQAL
S944 SDLSAYGSSIQALRE
K969 PTDDETGKELVLALY
Y976 KELVLALYDYQEKSP
K981 ALYDYQEKSPREVTM
S982 LYDYQEKSPREVTMK
K990 PREVTMKKGDILTLL
S999 DILTLLNSTNKDWWK
Y1020 QGFVPAAYVKKLDPA
K1022 FVPAAYVKKLDPAQS
K1022 FVPAAYVKKLDPAQS
S1029 KKLDPAQSASRENLL
S1029 KKLDPAQSASRENLL
S1031 LDPAQSASRENLLEE
S1041 NLLEEQGSIALRQEQ
T1053 QEQIDNQTRITKEAG
K1057 DNQTRITKEAGSVSL
S1063 TKEAGSVSLRMKQVE
K1067 GSVSLRMKQVEELYH
Y1073 MKQVEELYHSLLELG
S1075 QVEELYHSLLELGEK
K1082 SLLELGEKRKGMLEK
K1138 KKFDDFQKDLKANES
K1152 SRLKDINKVAEDLES
S1159 KVAEDLESEGLMAEE
Y1176 AVQQQEVYGMMPRDE
S1186 MPRDETDSKTASPWK
K1187 PRDETDSKTASPWKS
T1188 RDETDSKTASPWKSA
S1190 ETDSKTASPWKSARL
T1204 LMVHTVATFNSIKEL
S1207 HTVATFNSIKELNER
K1209 VATFNSIKELNERWR
S1217 ELNERWRSLQQLAEE
S1226 QQLAEERSQLLGSAH
Y1261 QALNTDNYGHDLASV
K1288 DLAALGDKVNSLGET
S1291 ALGDKVNSLGETAER
S1302 TAERLIQSHPESAED
S1306 LIQSHPESAEDLQEK
S1322 TELNQAWSSLGKRAD
S1323 ELNQAWSSLGKRADQ
S1338 RKAKLGDSHDLQRFL
K1369 VSSDELAKDVTGAEA
T1386 ERHQEHRTEIDARAG
Y1411 QLLAHGHYASPEIKQ
S1413 LAHGHYASPEIKQKL
K1419 ASPEIKQKLDILDQE
K1473 AFLNTEDKGDSLDSV
D1475 LNTEDKGDSLDSVEA
S1476 NTEDKGDSLDSVEAL
D1478 EDKGDSLDSVEALIK
S1479 DKGDSLDSVEALIKK
K1519 IAAGHYAKGDISSRR
K1519 IAAGHYAKGDISSRR
K1546 QMIEKRSKLGESQTL
S1550 KRSKLGESQTLQQFS
S1557 SQTLQQFSRDVDEIE
S1578-p LQTASDEsYKDPTNI
Y1579 QTASDEsYKDPTNIQ
K1580 TASDEsYKDPTNIQL
S1620 GVIDMGNSLIERGAC
K1635 AGSEDAVKARLAALA
K1651 QWQFLVQKSAEKSQK
S1652 WQFLVQKSAEKSQKL
T1670 NKQQNFNTGIKDFDF
S1697 DYGKDLASVNNLLKK
K1720 SAHEDRLKDLNSQAD
S1756 GRFQKIKSMAASRRA
S1760 KIKSMAASRRAKLNE
T1802 EDYGRDLTGVQNLRK
K1834 GVLDTGKKLSDDNTI
K1943 TNGQDLIKKNNHHEE
S1964 KGLNGKVSDLEKAAA
K2000 VESWIGEKENSLKTD
S2014 DDYGRDLSSVQTLLT
S2015 DYGRDLSSVQTLLTK
T2021 SSVQTLLTKQETFDA
T2025 TLLTKQETFDAGLQA
K2052 KDQLLAAKHVQSKAI
K2057 AAKHVQSKAIEARHA
K2057 AAKHVQSKAIEARHA
K2068 ARHASLMKRWSQLLA
S2071 ASLMKRWSQLLANSA
S2077 WSQLLANSAARKKKL
A2079 QLLANSAARKKKLLE
S2089 KKLLEAQSHFRKVED
K2093 EAQSHFRKVEDLFLT
K2103 DLFLTFAKKASAFNS
K2132 CNSLEEIKALREAHD
S2164 ELDRQIKSFRVASNP
S2345 KHFDKDKSGRLNHQE
K2409 SRETENVKSSEEIES
K2426 RALSSEGKPYVTKEE
Y2428 LSSEGKPYVTKEELY
T2430 SEGKPYVTKEELYQN
T2430 SEGKPYVTKEELYQN
K2431 EGKPYVTKEELYQNL
K2431 EGKPYVTKEELYQNL
Y2435 YVTKEELYQNLTREQ
Y2445 LTREQADYCVSHMKP
K2451 DYCVSHMKPYVDGKG
K2457 MKPYVDGKGRELPTA
Y2467 ELPTAFDYVEFTRSL
  SPTAN1 iso3  
T34 HRFKELSTLRRQKLE
K63 LEKWIQEKLQIASDE
K73 IASDENYKDPTNLQG
S289 DFGRDLASVQALLRK
S324 EADRLQQSHPLSATQ
S324 EADRLQQSHPLSATQ
S328 LQQSHPLSATQIQVK
T330 QSHPLSATQIQVKRE
S391 INADELASDVAGAEA
S423 SFKSADESGQALLAA
S435 LAAGHYASDEVREKL
K441 ASDEVREKLTVLSEE
K514 KKHEDFEKSLSAQEE
S517 EDFEKSLSAQEEKIT
S553 TRRDALLSRRNALHE
S572 RRAQLADSFHLQQFF
S587 RDSDELKSWVNEKMK
K592 LKSWVNEKMKTATDE
Y601 KTATDEAYKDPSNLQ
K613 NLQGKVQKHQAFEAE
K633 SRIDALEKAGQKLID
K637 ALEKAGQKLIDVNHY
Y644 KLIDVNHYAKDEVAA
S658 ARMNEVISLWKKLLE
T667 WKKLLEATELKGIKL
K718 TNVQNLQKKHALLEA
Y766 QEALVARYEALKEPM
K779 PMVARKQKLADSLRL
S783 RKQKLADSLRLQQLF
K803 EETWIREKEPIAAST
K814 AASTNRGKDLIGVQN
K824 IGVQNLLKKHQALQA
K909 AESWMREKEPIVGST
K920 VGSTDYGKDEDSAEA
S937 KKHEALMSDLSAYGS
S940 EALMSDLSAYGSSIQ
Y942 LMSDLSAYGSSIQAL
S944 SDLSAYGSSIQALRE
K969 PTDDETGKELVLALY
Y976 KELVLALYDYQEKSP
K981 ALYDYQEKSPREVTM
S982 LYDYQEKSPREVTMK
K990 PREVTMKKGDILTLL
S999 DILTLLNSTNKDWWK
Y1020 QGFVPAAYVKKLDPA
K1022 FVPAAYVKKLDPAQS
K1022 FVPAAYVKKLDPAQS
S1029 KKLDPAQSASRENLL
S1029 KKLDPAQSASRENLL
S1031 LDPAQSASRENLLEE
S1041 NLLEEQGSIALRQEQ
- gap
- gap
- gap
- gap
Y1053-p QEQIDNQyHSLLELG
S1055 QIDNQyHSLLELGEK
K1062 SLLELGEKRKGMLEK
K1118 KKFDDFQKDLKANES
K1132 SRLKDINKVAEDLES
S1139 KVAEDLESEGLMAEE
Y1156 AVQQQEVYGMMPRDE
S1166 MPRDETDSKTASPWK
K1167 PRDETDSKTASPWKS
T1168 RDETDSKTASPWKSA
S1170 ETDSKTASPWKSARL
T1184 LMVHTVATFNSIKEL
S1187 HTVATFNSIKELNER
K1189 VATFNSIKELNERWR
S1197 ELNERWRSLQQLAEE
S1206 QQLAEERSQLLGSAH
Y1241 QALNTDNYGHDLASV
K1268 DLAALGDKVNSLGET
S1271 ALGDKVNSLGETAER
S1282 TAERLIQSHPESAED
S1286 LIQSHPESAEDLQEK
S1302 TELNQAWSSLGKRAD
S1303 ELNQAWSSLGKRADQ
S1318 RKAKLGDSHDLQRFL
K1349 VSSDELAKDVTGAEA
T1366 ERHQEHRTEIDARAG
Y1391 QLLAHGHYASPEIKQ
S1393 LAHGHYASPEIKQKL
K1399 ASPEIKQKLDILDQE
K1453 AFLNTEDKGDSLDSV
D1455 LNTEDKGDSLDSVEA
S1456 NTEDKGDSLDSVEAL
D1458 EDKGDSLDSVEALIK
S1459 DKGDSLDSVEALIKK
K1499 IAAGHYAKGDISSRR
K1499 IAAGHYAKGDISSRR
K1526 QMIEKRSKLGESQTL
S1530 KRSKLGESQTLQQFS
S1537 SQTLQQFSRDVDEIE
S1558 LQTASDESYKDPTNI
Y1559 QTASDESYKDPTNIQ
K1560 TASDESYKDPTNIQS
S1595 GVIDMGNSLIERGAC
K1610 AGSEDAVKARLAALA
K1626 QWQFLVQKSAEKSQK
S1627 WQFLVQKSAEKSQKL
T1645 NKQQNFNTGIKDFDF
S1672 DYGKDLASVNNLLKK
K1695 SAHEDRLKDLNSQAD
S1731 GRFQKIKSMAASRRA
S1735 KIKSMAASRRAKLNE
T1777 EDYGRDLTGVQNLRK
K1809 GVLDTGKKLSDDNTI
K1918 TNGQDLIKKNNHHEE
S1939 KGLNGKVSDLEKAAA
K1975 VESWIGEKENSLKTD
S1989 DDYGRDLSSVQTLLT
S1990 DYGRDLSSVQTLLTK
T1996 SSVQTLLTKQETFDA
T2000 TLLTKQETFDAGLQA
K2027 KDQLLAAKHVQSKAI
K2032 AAKHVQSKAIEARHA
K2032 AAKHVQSKAIEARHA
K2043 ARHASLMKRWSQLLA
S2046 ASLMKRWSQLLANSA
S2052 WSQLLANSAARKKKL
A2054 QLLANSAARKKKLLE
S2064 KKLLEAQSHFRKVED
K2068 EAQSHFRKVEDLFLT
K2078 DLFLTFAKKASAFNS
K2107 CNSLEEIKALREAHD
S2139 ELDRQIKSFRVASNP
S2320 KHFDKDKSGRLNHQE
K2384 SRETENVKSSEEIES
K2401 RALSSEGKPYVTKEE
Y2403 LSSEGKPYVTKEELY
T2405 SEGKPYVTKEELYQN
T2405 SEGKPYVTKEELYQN
K2406 EGKPYVTKEELYQNL
K2406 EGKPYVTKEELYQNL
Y2410 YVTKEELYQNLTREQ
Y2420 LTREQADYCVSHMKP
K2426 DYCVSHMKPYVDGKG
K2432 MKPYVDGKGRELPTA
Y2442 ELPTAFDYVEFTRSL
  mouse

► Hide Isoforms
 
T34-p HRFKELStLRRQKLE
K63-u LEKWIQEkLQVASDE
K73-u VASDENYkDPTNLQG
S289-p DFGRDLAsVQALLRK
S324-p EADRLQQsHPLsAsQ
S324-gl EADRLQQsHPLsAsQ
S328-p LQQsHPLsAsQIQVK
S330-p QsHPLsAsQIQVKRE
N391 INADELANDVAGAEA
S423 SFKSADESGQALLAA
S435 LAASHYASDEVREkL
K441-u ASDEVREkLSILSEE
K514-u KKHEDFEkSLSAQEE
S517 EDFEkSLSAQEEKIT
S553 TRRDALLSRRNALHE
S572-p RRAQLADsFHLQQFF
S587-p RDSDELKsWVNEKMK
K592 LKsWVNEKMKTATDE
Y601 KTATDEAYKDPSNLQ
K613 NLQGKVQKHQAFEAE
K633-u SRIDALEkAGQKLID
K637 ALEkAGQKLIDVNHY
Y644 KLIDVNHYAKEEVAA
S658-p ARMNEVIsLWKKLLE
T667-p WKKLLEAtELKGIKL
K718-u TNVQNLQkKHALLEA
Y766 QEALVARYEALKEPM
K779 PMVARKQKLADsLRL
S783-p RKQKLADsLRLQQLF
K803-u EETWIREkEPIAAST
K814-u AASTNRGkDLIGVQN
K824-u IGVQNLLkKHQALQA
K909-u AESWMREkEPIVGST
K920-u VGSTDYGkDEDSAEA
S937-p KKHEALMsDLsAYGS
S940-p EALMsDLsAYGSSIQ
Y942 LMsDLsAYGSSIQAL
S944 sDLsAYGSSIQALRE
K969-u PMDDETGkELVLALY
Y976 kELVLALYDYQEksP
K981-u ALYDYQEksPREVTM
S982-p LYDYQEksPREVTMK
K990-u PREVTMKkGDILTLL
S999-p DILTLLNsTNKDWWK
Y1020 QGFVPAAYVkKLDPA
K1022 FVPAAYVKKLDPAQs
K1022-u FVPAAYVkKLDPAQs
S1029-p kKLDPAQsAsRENLL
S1029-gl kKLDPAQsAsRENLL
S1031-p LDPAQsAsRENLLEE
S1041-p NLLEEQGsIALRQGQ
T1053 QGQIDNQTRITkEAG
K1057-u DNQTRITkEAGSVSL
S1063 TkEAGSVSLRMkQVE
K1067-u GSVSLRMkQVEELyQ
Y1073-p MkQVEELyQSLLELG
S1075 QVEELyQSLLELGEk
K1082-u SLLELGEkRKGMLEK
K1138-u KKFDDFQkDLKANES
K1152-u SRLKDINkVAEDLES
S1159 kVAEDLESEGLMAEE
Y1176-p AVQQQEVyGAMPRDE
S1186-p MPRDEADsktAsPWK
K1187-u PRDEADsktAsPWKS
T1188-p RDEADsktAsPWKSA
S1190-p EADsktAsPWKSARL
T1204-p LMVHTVAtFNsIKEL
S1207-p HTVAtFNsIKELNER
K1209 VAtFNsIKELNERWR
S1217-p ELNERWRsLQQLAEE
S1226 QQLAEERSQLLGSAH
Y1261 QALNTDNYGHDLASV
K1288-u DLAALGDkVNsLGET
S1291-p ALGDkVNsLGETAQR
S1302-p TAQRLIQsHPEsAED
S1306-p LIQsHPEsAEDLKEK
T1322-p TELNQAWtsLGKRAD
S1323-p ELNQAWtsLGKRADQ
S1338-p RKAKLGDsHDLQRFL
K1369-u VSSDELAkDVTGAEA
T1386 ERHQEHRTEIDARAG
Y1411-p QLLAHGHyAsPEIKE
S1413-p LAHGHyAsPEIKEkL
K1419-u AsPEIKEkLDILDQE
K1473-u AFLNTEDkGDsLDsV
D1475 LNTEDkGDsLDsVEA
S1476-p NTEDkGDsLDsVEAL
D1478 EDkGDsLDsVEALIK
S1479-p DkGDsLDsVEALIKK
K1519 IAVDHYAKGDIANRR
K1519 IAVDHYAKGDIANRR
K1546-u QMIEKRSkLGEsQTL
S1550-p KRSkLGEsQTLQQFs
S1557-p sQTLQQFsRDVDEIE
S1578 LQTASDESYKDPTNI
Y1579 QTASDESYKDPTNIQ
K1580 TASDESYKDPTNIQS
S1615-p GVIDMGNsLIERGAC
K1630-u AGSEDAVkARLAALA
K1646-u QWQFLVQkSAEKSQK
S1647 WQFLVQkSAEKSQKL
T1665-p NKQQNFNtGIKDFDF
S1692 DYGKDLASVNNLLKK
K1715-u SAHEDRLkDLNSQAD
S1751-p GRFQKIKsMATsRRA
S1755-p KIKsMATsRRAKLSE
T1797-p EDYGRDLtGVQNLRK
K1829-u GVLDTGKkLSDDNTI
K1938 TNGQDLIKKNNHHEE
S1959 KGLNGKVSDLEKAAA
K1995-u VESWIGEkENSLKTD
S2009-p DDYGRDLssVQTLLT
S2010-p DYGRDLssVQTLLTK
T2016 ssVQTLLTKQEtFDA
T2020-p TLLTKQEtFDAGLQA
K2047-u KDQLLAAkHIQSkAI
K2052 AAkHIQSKAIEARHA
K2052-u AAkHIQSkAIEARHA
K2063-a ARHASLMkRWtQLLA
T2066-p ASLMkRWtQLLANsA
S2072-p WtQLLANsAtRKKKL
T2074-p QLLANsAtRKKKLLE
S2084-p KKLLEAQsHFRkVED
K2088-u EAQsHFRkVEDLFLT
K2098 DLFLTFAKKASAFNS
K2127-u CNSLEEIkALREAHD
S2159 ELDRQIKSFRVASNP
S2340 KHFDKDKSGRLNHQE
K2404-u SRETENVkSSEEIES
K2421 RALSSEGKPyVtkEE
Y2423-p LSSEGKPyVtkEELy
T2425 SEGKPyVTkEELyQN
T2425-gl SEGKPyVtkEELyQN
K2426 EGKPyVtKEELyQNL
K2426-u EGKPyVtkEELyQNL
Y2430-p yVtkEELyQNLTREQ
Y2440 LTREQADYCVSHMkP
K2446-u DYCVSHMkPYVDGkG
K2452-u MkPYVDGkGRELPTA
Y2462 ELPTAFDYVEFTRSL
  SPTAN1 iso2  
T34 HRFKELSTLRRQKLE
K63 LEKWIQEKLQVASDE
K73 VASDENYKDPTNLQG
S289 DFGRDLASVQALLRK
S324 EADRLQQSHPLSASQ
S324 EADRLQQSHPLSASQ
S328 LQQSHPLSASQIQVK
S330 QSHPLSASQIQVKRE
N391 INADELANDVAGAEA
S423 SFKSADESGQALLAA
S435 LAASHYASDEVREKL
K441 ASDEVREKLSILSEE
K514 KKHEDFEKSLSAQEE
S517 EDFEKSLSAQEEKIT
S553 TRRDALLSRRNALHE
S572 RRAQLADSFHLQQFF
S587 RDSDELKSWVNEKMK
K592 LKSWVNEKMKTATDE
Y601 KTATDEAYKDPSNLQ
K613 NLQGKVQKHQAFEAE
K633 SRIDALEKAGQKLID
K637 ALEKAGQKLIDVNHY
Y644 KLIDVNHYAKEEVAA
S658 ARMNEVISLWKKLLE
T667 WKKLLEATELKGIKL
K718 TNVQNLQKKHALLEA
Y766 QEALVARYEALKEPM
K779 PMVARKQKLADSLRL
S783 RKQKLADSLRLQQLF
K803 EETWIREKEPIAAST
K814 AASTNRGKDLIGVQN
K824 IGVQNLLKKHQALQA
K909 AESWMREKEPIVGST
K920 VGSTDYGKDEDSAEA
S937 KKHEALMSDLSAYGS
S940 EALMSDLSAYGSSIQ
Y942 LMSDLSAYGSSIQAL
S944 SDLSAYGSSIQALRE
K969 PMDDETGKELVLALY
Y976 KELVLALYDYQEKSP
K981 ALYDYQEKSPREVTM
S982 LYDYQEKSPREVTMK
K990 PREVTMKKGDILTLL
S999 DILTLLNSTNKDWWK
Y1020 QGFVPAAYVKKLDPA
K1022 FVPAAYVKKLDPAQS
K1022 FVPAAYVKKLDPAQS
S1029 KKLDPAQSASRENLL
S1029 KKLDPAQSASRENLL
S1031 LDPAQSASRENLLEE
S1041 NLLEEQGSIALRQGQ
- gap
- gap
- gap
- gap
Y1053 QGQIDNQYQsLLELG
S1055-p QIDNQYQsLLELGEK
K1062 sLLELGEKRKGMLEK
K1118 KKFDDFQKDLKANES
K1132 SRLKDINKVAEDLES
S1139 KVAEDLESEGLMAEE
Y1156 AVQQQEVYGAMPRDE
S1166 MPRDEADSKTASPWK
K1167 PRDEADSKTASPWKS
T1168 RDEADSKTASPWKSA
S1170 EADSKTASPWKSARL
T1184 LMVHTVATFNSIKEL
S1187 HTVATFNSIKELNER
K1189 VATFNSIKELNERWR
S1197 ELNERWRSLQQLAEE
S1206 QQLAEERSQLLGSAH
Y1241 QALNTDNYGHDLASV
K1268 DLAALGDKVNSLGET
S1271 ALGDKVNSLGETAQR
S1282 TAQRLIQSHPESAED
S1286 LIQSHPESAEDLKEK
T1302 TELNQAWTSLGKRAD
S1303 ELNQAWTSLGKRADQ
S1318 RKAKLGDSHDLQRFL
K1349 VSSDELAKDVTGAEA
T1366 ERHQEHRTEIDARAG
Y1391 QLLAHGHYASPEIKE
S1393 LAHGHYASPEIKEKL
K1399 ASPEIKEKLDILDQE
K1453 AFLNTEDKGDSLDSV
D1455 LNTEDKGDSLDSVEA
S1456 NTEDKGDSLDSVEAL
D1458 EDKGDSLDSVEALIK
S1459 DKGDSLDSVEALIKK
K1499 IAVDHYAKGDIANRR
K1499 IAVDHYAKGDIANRR
K1526 QMIEKRSKLGESQTL
S1530 KRSKLGESQTLQQFS
S1537 SQTLQQFSRDVDEIE
S1558 LQTASDESYKDPTNI
Y1559 QTASDESYKDPTNIQ
K1560 TASDESYKDPTNIQS
S1595 GVIDMGNSLIERGAC
K1610 AGSEDAVKARLAALA
K1626 QWQFLVQKSAEKSQK
S1627 WQFLVQKSAEKSQKL
T1645 NKQQNFNTGIKDFDF
S1672 DYGKDLASVNNLLKK
K1695 SAHEDRLKDLNSQAD
S1731 GRFQKIKSMATSRRA
S1735 KIKSMATSRRAKLSE
T1777 EDYGRDLTGVQNLRK
K1809 GVLDTGKKLSDDNTI
K1918 TNGQDLIKKNNHHEE
S1939 KGLNGKVSDLEKAAA
K1975 VESWIGEKENSLKTD
S1989 DDYGRDLSSVQTLLT
S1990 DYGRDLSSVQTLLTK
T1996 SSVQTLLTKQETFDA
T2000 TLLTKQETFDAGLQA
K2027 KDQLLAAKHIQSKAI
K2032 AAKHIQSKAIEARHA
K2032 AAKHIQSKAIEARHA
K2043 ARHASLMKRWTQLLA
T2046 ASLMKRWTQLLANSA
S2052 WTQLLANSATRKKKL
T2054 QLLANSATRKKKLLE
S2064 KKLLEAQSHFRKVED
K2068 EAQSHFRKVEDLFLT
K2078 DLFLTFAKKASAFNS
K2107 CNSLEEIKALREAHD
S2139 ELDRQIKSFRVASNP
S2320 KHFDKDKSGRLNHQE
K2384 SRETENVKSSEEIES
K2401 RALSSEGKPYVTKEE
Y2403 LSSEGKPYVTKEELY
T2405 SEGKPYVTKEELYQN
T2405 SEGKPYVTKEELYQN
K2406 EGKPYVTKEELYQNL
K2406 EGKPYVTKEELYQNL
Y2410 YVTKEELYQNLTREQ
Y2420 LTREQADYCVSHMKP
K2426 DYCVSHMKPYVDGKG
K2432 MKPYVDGKGRELPTA
Y2442 ELPTAFDYVEFTRSL
  SPTAN1 iso3  
T34 HRFKELSTLRRQKLE
K63 LEKWIQEKLQVASDE
K73 VASDENYKDPTNLQG
S289 DFGRDLASVQALLRK
S324 EADRLQQSHPLSASQ
S324 EADRLQQSHPLSASQ
S328 LQQSHPLSASQIQVK
S330 QSHPLSASQIQVKRE
N391 INADELANDVAGAEA
S423 SFKSADESGQALLAA
S435 LAASHYASDEVREKL
K441 ASDEVREKLSILSEE
K514 KKHEDFEKSLSAQEE
S517 EDFEKSLSAQEEKIT
S553 TRRDALLSRRNALHE
S572 RRAQLADSFHLQQFF
S587 RDSDELKSWVNEKMK
K592 LKSWVNEKMKTATDE
Y601 KTATDEAYKDPSNLQ
K613 NLQGKVQKHQAFEAE
K633 SRIDALEKAGQKLID
K637 ALEKAGQKLIDVNHY
Y644 KLIDVNHYAKEEVAA
S658 ARMNEVISLWKKLLE
T667 WKKLLEATELKGIKL
K718 TNVQNLQKKHALLEA
Y766 QEALVARYEALKEPM
K779 PMVARKQKLADSLRL
S783 RKQKLADSLRLQQLF
K803 EETWIREKEPIAAST
K814 AASTNRGKDLIGVQN
K824 IGVQNLLKKHQALQA
K909 AESWMREKEPIVGST
K920 VGSTDYGKDEDSAEA
S937 KKHEALMSDLSAYGS
S940 EALMSDLSAYGSSIQ
Y942 LMSDLSAYGSSIQAL
S944 SDLSAYGSSIQALRE
K969 PMDDETGKELVLALY
Y976 KELVLALYDYQEKSP
K981 ALYDYQEKSPREVTM
S982 LYDYQEKSPREVTMK
K990 PREVTMKKGDILTLL
S999 DILTLLNSTNKDWWK
Y1020 QGFVPAAYVKKLDPA
K1022 FVPAAYVKKLDPAQS
K1022 FVPAAYVKKLDPAQS
S1029 KKLDPAQSASRENLL
S1029 KKLDPAQSASRENLL
S1031 LDPAQSASRENLLEE
S1041 NLLEEQGSIALRQGQ
- gap
- gap
- gap
- gap
Y1053 QGQIDNQYQSLLELG
S1055 QIDNQYQSLLELGEK
K1062 SLLELGEKRKGMLEK
K1118 KKFDDFQKDLKANES
K1132 SRLKDINKVAEDLES
S1139 KVAEDLESEGLMAEE
Y1156 AVQQQEVYGAMPRDE
S1166 MPRDEADSKTASPWK
K1167 PRDEADSKTASPWKS
T1168 RDEADSKTASPWKSA
S1170 EADSKTASPWKSARL
T1184 LMVHTVATFNSIKEL
S1187 HTVATFNSIKELNER
K1189 VATFNSIKELNERWR
S1197 ELNERWRSLQQLAEE
S1206 QQLAEERSQLLGSAH
Y1241 QALNTDNYGHDLASV
K1268 DLAALGDKVNSLGET
S1271 ALGDKVNSLGETAQR
S1282 TAQRLIQSHPESAED
S1286 LIQSHPESAEDLKEK
T1302 TELNQAWTSLGKRAD
S1303 ELNQAWTSLGKRADQ
S1318 RKAKLGDSHDLQRFL
K1349 VSSDELAKDVTGAEA
T1366 ERHQEHRTEIDARAG
Y1391 QLLAHGHYASPEIKE
S1393 LAHGHYASPEIKEKL
K1399 ASPEIKEKLDILDQE
K1453 AFLNTEDKGDSLDSV
D1455 LNTEDKGDSLDSVEA
S1456 NTEDKGDSLDSVEAL
D1458 EDKGDSLDSVEALIK
S1459 DKGDSLDSVEALIKK
K1499 IAVDHYAKGDIANRR
K1499 IAVDHYAKGDIANRR
K1526 QMIEKRSKLGESQTL
S1530 KRSKLGESQTLQQFS
S1537 SQTLQQFSRDVDEIE
S1558 LQTASDESYkDPTNI
Y1559 QTASDESYkDPTNIQ
K1560-u TASDESYkDPTNIQL
S1600 GVIDMGNSLIERGAC
K1615 AGSEDAVKARLAALA
K1631 QWQFLVQKSAEKSQK
S1632 WQFLVQKSAEKSQKL
T1650 NKQQNFNTGIKDFDF
S1677 DYGKDLASVNNLLKK
K1700 SAHEDRLKDLNSQAD
S1736 GRFQKIKSMATSRRA
S1740 KIKSMATSRRAKLSE
T1782 EDYGRDLTGVQNLRK
K1814 GVLDTGKKLSDDNTI
K1923 TNGQDLIKKNNHHEE
S1944 KGLNGKVSDLEKAAA
K1980 VESWIGEKENSLKTD
S1994 DDYGRDLSSVQTLLT
S1995 DYGRDLSSVQTLLTK
T2001 SSVQTLLTKQETFDA
T2005 TLLTKQETFDAGLQA
K2032 KDQLLAAKHIQSKAI
K2037 AAKHIQSKAIEARHA
K2037 AAKHIQSKAIEARHA
K2048 ARHASLMKRWTQLLA
T2051 ASLMKRWTQLLANSA
S2057 WTQLLANSATRKKKL
T2059 QLLANSATRKKKLLE
S2069 KKLLEAQSHFRKVED
K2073 EAQSHFRKVEDLFLT
K2083 DLFLTFAKKASAFNS
K2112 CNSLEEIKALREAHD
S2144 ELDRQIKSFRVASNP
S2346 KHFDKDKSGRLNHQE
K2410 SRETENVKSSEEIES
K2427 RALSSEGKPYVTKEE
Y2429 LSSEGKPYVTKEELY
T2431 SEGKPYVTKEELYQN
T2431 SEGKPYVTKEELYQN
K2432 EGKPYVTKEELYQNL
K2432 EGKPYVTKEELYQNL
Y2436 YVTKEELYQNLTREQ
Y2446 LTREQADYCVSHMKP
K2452 DYCVSHMKPYVDGKG
K2458 MKPYVDGKGRELPTA
Y2468 ELPTAFDYVEFTRSL
  rat

 
T34 HRFKELSTLRRQKLE
K63 LEKWIQEKLQVASDE
K73 VASDENYKDPTNLQG
S289 DFGRDLASVQALLRK
S324 EADRLQQSHPLSANQ
S324 EADRLQQSHPLSANQ
S328 LQQSHPLSANQIQVK
N330 QSHPLSANQIQVKRE
N391 INADELANDVAGAEA
S423 SFKSADESGQALLAA
S435 LAAGHYASDEVREKL
K441 ASDEVREKLSILSEE
K514 KKHEDFEKSLSAQEE
S517 EDFEKSLSAQEEKIT
S553 TRRDALLSRRNALHE
S572 RRAQLADSFHLQQFF
S587 RDSDELKSWVNEkMK
K592-a LKSWVNEkMKTATDE
Y601 KTATDEAYKDPSNLQ
K613 NLQGKVQKHQAFEAE
K633 SRIDALEKAGQKLID
K637 ALEKAGQKLIDVNHY
Y644 KLIDVNHYAKEEVAA
S658 ARMNEVISLWKKLLE
T667 WKKLLEATELKGVKL
K718 TNVQNLQKKHALLEA
Y766 QEALVARYEALKEPM
K779 PMVARKQKLADSLRL
S783 RKQKLADSLRLQQLF
K803 EETWIREKEPIAAST
K814 AASTNRGKDLIGVQN
K824 IGVQNLLKKHQALQA
K909 AESWMREKEPIVGST
K920 VGSTDYGKDEDSAEA
S937 KKHEALMSDLSAYGS
S940 EALMSDLSAYGSSIQ
Y942 LMSDLSAYGSSIQAL
S944 SDLSAYGSSIQALRE
K969 PMDDETGKELVLALY
Y976 KELVLALYDYQEKSP
K981 ALYDYQEKSPREVTM
S982 LYDYQEKSPREVTMK
K990 PREVTMKKGDILTLL
S999 DILTLLNSTNKDWWK
Y1020 QGFVPAAYVKKLDPA
K1022 FVPAAYVKKLDPAQs
K1022 FVPAAYVKKLDPAQs
S1029-p KKLDPAQsAsRENLL
S1029 KKLDPAQSAsRENLL
S1031-p LDPAQsAsRENLLEE
S1041 NLLEEQGSIALRQGQ
T1053 QGQIDNQTRITKEAG
K1057 DNQTRITKEAGSVSL
S1063 TKEAGSVSLRMKQVE
K1067 GSVSLRMKQVEELYQ
Y1073 MKQVEELYQSLLELG
S1075 QVEELYQSLLELGEK
K1082 SLLELGEKRKGMLEK
K1138 KKFDDFQKDLKANES
K1152 SRLKDINKVAEDLES
S1159 KVAEDLESEGLMAEE
Y1176-p AVQQQEVyGMMPRDE
S1186 MPRDEADSKTASPWK
K1187 PRDEADSKTASPWKS
T1188 RDEADSKTASPWKSA
S1190 EADSKTASPWKSARL
T1204 LMVHTVATFNSIKEL
S1207 HTVATFNSIKELNER
K1209 VATFNSIKELNERWR
S1217-p ELNERWRsLQQLAEE
S1226 QQLAEERSQLLGSAH
Y1261 QALNTDNYGHDLASV
K1288 DLAALGDKVNSLGET
S1291 ALGDKVNSLGETAQR
S1302 TAQRLIQSHPESAED
S1306 LIQSHPESAEDLKEK
T1322 TELNQAWTSLGKRAD
S1323 ELNQAWTSLGKRADQ
S1338 RKAKLGDSHDLQRFL
K1369 VSSDELAKDVTGAEA
T1386 ERHQEHRTEIDARAG
Y1411 QLLAHGHYASPEIKE
S1413 LAHGHYASPEIKEKL
K1419 ASPEIKEKLDILDQE
K1473 AFLNTEDKGDSLDSV
D1475 LNTEDKGDSLDSVEA
S1476 NTEDKGDSLDSVEAL
D1478 EDKGDSLDSVEALIK
S1479 DKGDSLDSVEALIKK
K1519 IAVDHYAKGDIANRR
K1519 IAVDHYAKGDIANRR
K1546 QMIEKRSKLGEsQTL
S1550-p KRSKLGEsQTLQQFS
S1557 sQTLQQFSRDVDEIE
S1578 LQTASDESYKDPTNI
Y1579 QTASDESYKDPTNIQ
K1580 TASDESYKDPTNIQS
S1615 GVIDMGNSLIERGAC
K1630 AGSEDAVKARLAALA
K1646 QWQFLVQKSAEKSQK
S1647 WQFLVQKSAEKSQKL
T1665 NKQQNFNTGIKDFDF
S1692 DYGKDLASVNNLLKK
K1715 SAHEDRLKDLNSQAD
S1751 GRFQKIKSMATSRRA
S1755 KIKSMATSRRAKLSE
T1797 EDYGRDLTGVQNLRK
K1829 GVLDTGKKLSDDNTI
K1938-a TNGQDLIkKNNHHEE
S1959 KGLNGKVSDLEKAAA
K1995 VESWIGEKENSLKTD
S2009 DDYGRDLSSVQTLLT
S2010 DYGRDLSSVQTLLTK
T2016 SSVQTLLTKQETFDA
T2020 TLLTKQETFDAGLQA
K2047 KDQLLAAKHIQSKAI
K2052 AAKHIQSKAIEARHA
K2052 AAKHIQSKAIEARHA
K2063 ARHASLMKRWTQLLA
T2066 ASLMKRWTQLLANSA
S2072 WTQLLANSATRKKKL
T2074 QLLANSATRKKKLLE
S2084 KKLLEAQSHFRKVED
K2088 EAQSHFRKVEDLFLT
K2098 DLFLTFAKKASAFNS
K2127 CNSLEEIKALREAHD
S2159 ELDRQIKSFRVASNP
S2340 KHFDKDKSGRLNHQE
K2404 SRETENVKSSEEIES
K2421 RALSSEGKPyVTKEE
Y2423-p LSSEGKPyVTKEELy
T2425 SEGKPyVTKEELyQN
T2425 SEGKPyVTKEELyQN
K2426 EGKPyVTKEELyQNL
K2426 EGKPyVTKEELyQNL
Y2430-p yVTKEELyQNLTREQ
Y2440 LTREQADYCVSHMKP
K2446 DYCVSHMKPYVDGKG
K2452 MKPYVDGKGRELPTA
Y2462 ELPTAFDYVEFTRSL
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