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TK (human)

Overview TK cytosolic thymidine kinase. Phosphorylated during mitosis. Its enzymatic activity is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells. Note: This description may include information from UniProtKB. Protein type: Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; Kinase, other; EC 2.7.1.21 Cellular Component: cytosol Molecular Function: nucleoside kinase activity; zinc ion binding; thymidine kinase activity; ATP binding Biological Process: pyrimidine base metabolic process; nucleotide biosynthetic process; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; pyrimidine nucleoside salvage; DNA replication; protein homotetramerization Reference #:  P04183 (UniProtKB) Alt. Names/Synonyms: KITH; thymidine kinase 1 soluble isoform; thymidine kinase 1, soluble; Thymidine kinase, cytosolic; thymidine kinase-1; TK1; TK2 Gene Symbols: TK1 Molecular weight: 25,469 Da Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below TK 1W4R - A/B/C/D/E/F/G/H=15-194 (human) 1XBT - A/B/C/D/E/F/G/H=1-193 (human) 2ORV - A/B=1-234 (human) 2WVJ - F/A/E/B/H/C/D/G=1-193 (human)

STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  RCSB PDB 1W4R 1XBT 2ORV 2WVJ  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Sites Implicated In
enzymatic activity, inhibited: S13‑p molecular association, regulation: S13‑p protein degradation: S13‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		G12	NLPTVLPGsPSKTRG
3	5		S13-p	LPTVLPGsPSKTRGQ
0	1		K16	VLPGsPSKTRGQIQV
0	1		K32-a	LGPMFSGkSTELMRR
0	1		Y48-p	RRFQIAQyKCLVIKy
0	1		Y55-p	yKCLVIKyAKDTRYS
0	1		T127	IVAALDGTFQRkPFG
0	5		K131-u	LDGTFQRkPFGAILN
0	1		K164-a	FREAAYTkRLGTEkE
0	1		K170-u	TkRLGTEkEVEVIGG
0	1		K180-u	EVIGGADkyHsVCRL
0	14		Y181-p	VIGGADkyHsVCRLC
0	2		S183-p	GGADkyHsVCRLCYF
0	3		K203-u	QPAGPDNkENCPVPG
0	9		K220-a	GEAVAARkLFAPQQI
0	1		K220-u	GEAVAARkLFAPQQI
0	13		S231-p	PQQILQCsPAN____

	mouse
S12-p	NLPTVLPssPSkTRG
S13-p	LPTVLPssPSkTRGQ
K16-u	VLPssPSkTRGQIQV
K32	LGPMFSGKSTELMRR
Y48	RRFQIAQYKCLVIKY
Y55	YKCLVIKYAKDTRYS
T127-p	IVAALDGtFQRkAFG
K131-u	LDGtFQRkAFGSILN
K164	FREAAYTKRLGLEKE
K170	TKRLGLEKEVEVIGG
K180	EVIGGADKYHSVCRL
Y181	VIGGADKYHSVCRLC
S183	GGADKYHSVCRLCYF
K203-u	QTAGSDNkNCLVLGQ
K219	GEALVVRKLFASQQV
K219	GEALVVRKLFASQQV
N230	SQQVLQYNSAN____

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