cytosolic thymidine kinase. Phosphorylated during mitosis. Its enzymatic activity is high in proliferating cells and peaks during the S-phase of the cell cycle; it is very low in resting cells. Note: This description may include information from UniProtKB.
Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; EC 188.8.131.52; Kinase, other; Nucleotide Metabolism - pyrimidine
Cellular Component: cytosol
Molecular Function: identical protein binding; nucleoside kinase activity; zinc ion binding; thymidine kinase activity; ATP binding
Biological Process: response to nutrient levels; skeletal muscle cell proliferation; nucleobase, nucleoside and nucleotide metabolic process; response to toxin; liver development; fetal process involved in parturition; deoxyribonucleoside monophosphate biosynthetic process; protein homotetramerization; response to cortisol stimulus; response to copper ion; pyrimidine base metabolic process; gut development; nucleotide biosynthetic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; pyrimidine nucleoside salvage; thymidine metabolic process; DNA replication; phosphorylation
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.