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NUP98 (rat)

Overview NUP98 Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport. Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M. Belongs to the nucleoporin GLFG family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: Nucleoporin; Motility/polarity/chemotaxis Cellular Component: nucleoplasm; kinetochore; nuclear envelope; nuclear pore; nucleus Molecular Function: protein binding; peptide binding Biological Process: mRNA transport; transport; protein import into nucleus, docking; DNA replication Reference #:  P49793 (UniProtKB) Alt. Names/Synonyms: 98 kDa nucleoporin; nuclear pore complex protein Nup98; nuclear pore complex protein Nup98-Nup96; nuclear pore complex protein Nup98-Nup96 proprotein; nucleoporin 98; nucleoporin 98kDa; nucleoporin Nup98; Nup98; P49793; P49793-2 Gene Symbols: Nup98 Molecular weight: 197,283 Da Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states

Select Structure to View Below NUP98 1KO6 - A/C=695-880, B/D=881-931 (human) 2Q5X - A=733-887 (human) 2Q5Y - A/C=729-880 D/B=881-887 (human) 3MMY - H/F/D/B=158-213 (human) 3TKN - F/C/I=732-880 (mouse)

Scansite  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			rat
0	1		T168	TIKFNPPTGTDTMVK
0	2		T170	KFNPPTGTDTMVKAG
0	2		T172	NPPTGTDTMVKAGVS
0	1		S179	TMVKAGVSTNISTKH
0	1		T184	GVSTNISTKHQCITA
1	2		S511	HLNSLTYSPFGDSPL
1	2		S516	TYSPFGDSPLFRNPM
0	3		S524	PLFRNPMSDPKKKEE
0	2		T536	KEERLKPTNPAAQKA
0	1		T545	PAAQKALTTPTHYKL
1	11		T546	AAQKALTTPTHYKLT
0	2		T548	QKALTTPTHYKLTPR
0	1		Y550	ALTTPTHYKLTPRPA
1	16		T553	TPTHYKLTPRPATRV
0	1		T558	KLTPRPATRVRPKAL
0	1		T567	VRPKALQTTGTAKSH
0	1		T568	RPKALQTTGTAKSHL
0	2		K572	LQTTGTAKSHLFDGL
0	1		K572	LQTTGTAKSHLFDGL
1	1		S585	GLDDDEPSLANGAFM
0	2		K594	ANGAFMPKKSIKKLV
0	7		S596	GAFMPKKSIKKLVLK
0	1		K603	SIKKLVLKNLNNSNL
0	3		K603	SIKKLVLKNLNNSNL
1	13		S608	VLKNLNNSNLFSPVN
2	25		S612	LNNSNLFSPVNHDSE
0	4		S618	FSPVNHDSEDLASPS
1	34		S623	HDSEDLASPSEYPEN
0	3		S625	SEDLASPSEYPENGE
0	3		Y627	DLASPSEYPENGERF
0	5		S635	PENGERFSFLSKPVD
0	1		S638	GERFSFLSKPVDENH
0	10		K639	ERFSFLSKPVDENHQ
1	9		S653	QQDGDDDSLVSRFYT
0	1		Y659	DSLVSRFYTNPIAKP
0	8		K665	FYTNPIAKPIPQTPE
1	22		T670	IAKPIPQTPESAGNK
0	8		S673	PIPQTPESAGNKNNS
0	2		N679	ESAGNKNNSSSNVED
0	2		S680	SAGNKNNSSSNVEDT
1	5		S681	AGNKNNSSSNVEDTF
0	3		N683	NKNNSSSNVEDTFIA
0	2		T687	SSSNVEDTFIALNMR
0	1		A726	RDEIENSAFQIHPAG
0	2		Y741	IVLTKVGYYTIPSMD
0	1		K752	PSMDDLAKITNEKGE
0	8		K757	LAKITNEKGECIVSD
0	2		K818	VGEGLNRKAEVTLDG
0	2		K831	DGVWPTDKTSRCLIK
1	28		S839	TSRCLIKSPDRLADI
0	1		Y848	DRLADINYEGRLEAV
1	1		S878	GSWVFKVSHFSKYGL
0	39		S888-p	SKYGLQDsDEEEEEH
0	1		T900	EEHPPKTTSKKLKTA
0	1		T916	LPPAGQATTFQMTLN
0	1		K925	FQMTLNGKPAPPPQS
0	1		S932	KPAPPPQSQSPEVEQ
0	12		S934	APPPQSQSPEVEQLG
0	1		S948	GRVVELDSDMVDITQ
0	1		S966	PDSVLEESVPEDQEP
0	6		S997	VLQIMKASLLVDEED
0	22		V1000	IMKASLLVDEEDVDA
0	1		H1014	AMEQRFGHFPSRGDT
0	22		S1017	QRFGHFPSRGDTAQE
0	1		R1018	RFGHFPSRGDTAQEI
0	20		T1021	HFPSRGDTAQEICSP
0	12		A1022	FPSRGDTAQEICSPR
0	20		S1027	DTAQEICSPRLPISA
0	1		S1033	CSPRLPISASHSSKS
0	2		S1033	CSPRLPISASHSSKS
0	2		S1035	PRLPISASHSSKSRS
0	2		S1040	SASHSSKSRSIVGGL
0	18		S1042	SHSSKSRSIVGGLLQ
0	1		A1053	GLLQSKFASGTFLSP
0	2		S1054	LLQSKFASGTFLSPS
0	39		S1059	FASGTFLSPSASVQE
0	2		S1061	SGTFLSPSASVQECR
0	16		S1063	TFLSPSASVQECRTP
0	36		T1069	ASVQECRTPRTSSLM
0	2		S1098	ATVFTVPSPAPEVPL
0	1		S1173	ENHQVAESMEYGFLP
0	1		K1199	PFKVHLEKLGLRQRK
0	1		K1206	KLGLRQRKLDEDLQL
0	1		Q1212	RKLDEDLQLYQTPLE
0	6		Y1214	LDEDLQLYQTPLELK
0	1		K1221	YQTPLELKLKHSTVH
0	1		S1340	VFSYLTGSRISEACC
0	24		S1340	VFSYLTGSRISEACC
0	1		S1362	HRLALLLSQLVGSQS
0	1		P1464	EGDKYACPPLPSYLE
0	1		Y1498	CFHLLKLYSDRHYGL
0	1		Y1503	KLYSDRHYGLNQLLE
0	1		K1607	KETFLTQKLCVPAEW
0	1		S1688	LIQDWETSGLVYLDY
0	1		T1767	LQHTPDATSNSTPDP
0	1		S1768	QHTPDATSNSTPDPQ
0	2		S1770	TPDATSNSTPDPQRV
0	14		T1771	PDATSNSTPDPQRVP
0	1		G1802	YALEELRGLTQSYLR
0	1		T1804	LEELRGLTQSYLREL

	human ► Hide Isoforms
T168-p	TIKFNPPtGtDtMVK
T170-p	KFNPPtGtDtMVKAG
T172-p	NPPtGtDtMVKAGVs
S179-p	tMVKAGVsTNIStKH
T184-g	GVsTNIStKHQCITA
S511-p	HINSLTYsPFGDsPL
S516-p	TYsPFGDsPLFRNPM
S524-p	PLFRNPMsDPKKKEE
T536-p	KEERLKPtNPAAQKA
T545-p	PAAQKALttPtHyKL
T546-p	AAQKALttPtHyKLt
T548-p	QKALttPtHyKLtPR
Y550-p	ALttPtHyKLtPRPA
T553-p	tPtHyKLtPRPATRV
T558	KLtPRPATRVRPKAL
T567-g	VRPKALQttGTAkSH
T568-g	RPKALQttGTAkSHL
K572-a	LQttGTAkSHLFDGL
K572-u	LQttGTAkSHLFDGL
S585	GLDDDEPSLANGAFM
K594-a	ANGAFMPkKsIKKLV
S596-p	GAFMPkKsIKKLVLk
K603-a	sIKKLVLkNLNNsNL
K603-u	sIKKLVLkNLNNsNL
S608-p	VLkNLNNsNLFsPVN
S612-p	LNNsNLFsPVNRDsE
S618-p	FsPVNRDsENLAsPs
S623-p	RDsENLAsPsEyPEN
S625-p	sENLAsPsEyPENGE
Y627-p	NLAsPsEyPENGERF
S635-p	PENGERFsFLskPVD
S638-p	GERFsFLskPVDENH
K639-u	ERFsFLskPVDENHQ
S653-p	QQDGDEDsLVSHFyT
Y659-p	DsLVSHFyTNPIAkP
K665-u	FyTNPIAkPIPQtPE
T670-p	IAkPIPQtPEsAGNK
S673-p	PIPQtPEsAGNKHsN
S679-p	EsAGNKHsNsNsVDD
N680	sAGNKHsNsNsVDDt
S681-p	AGNKHsNsNsVDDtI
S683-p	NKHsNsNsVDDtIVA
T687-p	NsNsVDDtIVALNMR
S726-p	REEIENNsYHMHPAG
Y741-p	IILTKVGyYTIPSMD
K752-u	PSMDDLAkITNEkGE
K757-u	LAkITNEkGECIVSD
K818-u	VGEGLNRkAEVTLDG
K831-u	DGVWPTDkTSRCLIK
S839-p	TSRCLIKsPDRLADI
Y848-p	DRLADINyEGRLEAV
S878	GSWVFKVSHFSKYGL
S888-p	SKYGLQDsDEEEEEH
S900-p	EEHPSKTsTKKLKTA
T916-p	LPPASQTtPLQMALN
K925-u	LQMALNGkPAPPPQs
S932-p	kPAPPPQsQsPEVEQ
S934-p	APPPQsQsPEVEQLG
S948-p	GRVVELDsDMVDITQ
S966-p	LDTMLEEsMPEDQEP
S997-p	VLQIMKAsLLtDEED
T1000-p	IMKAsLLtDEEDVDM
S1014-p	MALDQRFsRLPsKAD
S1018-p	QRFsRLPsKADtsQE
K1019	RFsRLPsKADtsQEI
T1022-p	RLPsKADtsQEICsP
S1023-p	LPsKADtsQEICsPR
S1028-p	DtsQEICsPRLPIsA
S1034-p	CsPRLPIsAsHSSKt
S1034	CsPRLPISAsHSSKt
S1036-p	PRLPIsAsHSSKtRs
T1041-p	sAsHSSKtRsLVGGL
S1043-p	sHSSKtRsLVGGLLQ
T1054-p	GLLQSKFtsGAFLsP
S1055-p	LLQSKFtsGAFLsPs
S1060-p	FtsGAFLsPsVsVQE
S1062-p	sGAFLsPsVsVQECR
S1064-p	AFLsPsVsVQECRtP
T1070-p	VsVQECRtPRAASLM
S1099-p	TSVFTMPsPAPEVPL
S1174-p	ENHQIADsMEFGFLP
K1200	PFKVHLEKLSLRQRK
K1207	KLSLRQRKPDEDMkL
K1213-u	RKPDEDMkLyQTPLE
Y1215-p	PDEDMkLyQTPLELk
K1222-u	yQTPLELkLKHSTVH
K1341-a	VFSYLTGkRISEACS
K1341-u	VFSYLTGkRISEACS
S1363-p	HRLALLLsQFVGSQS
S1465-p	DSDRYACsPLPSYLE
Y1499-p	CFHLLKLySDRHyDL
Y1504-p	KLySDRHyDLNQLLE
K1608-u	KETFLTQkLRVPAKW
S1689-p	LIQDWETsGLVYLDY
T1768-p	LHHPPDRtsDstPDP
S1769-p	HHPPDRtsDstPDPQ
S1771-p	PPDRtsDstPDPQRV
T1772-p	PDRtsDstPDPQRVP
S1803	YAMDELRSLTQSYLR
T1805	MDELRSLTQSYLREL

	NUP98 iso2
T168	TIKFNPPTGTDTMVK
T170	KFNPPTGTDTMVKAG
T172	NPPTGTDTMVKAGVS
S179	TMVKAGVSTNISTKH
T184	GVSTNISTKHQCITA
S494-p	HINSLTYsPFGDsPL
S499-p	TYsPFGDsPLFRNPM
S507	PLFRNPMSDPKKKEE
T519	KEERLKPTNPAAQKA
T528-p	PAAQKALttPTHYKL
T529-p	AAQKALttPTHYKLt
T531	QKALttPTHYKLtPR
Y533	ALttPTHYKLtPRPA
T536-p	tPTHYKLtPRPATRV
T541	KLtPRPATRVRPKAL
T550	VRPKALQTTGTAkSH
T551	RPKALQTTGTAkSHL
K555-a	LQTTGTAkSHLFDGL
K555	LQTTGTAKSHLFDGL
S568-p	GLDDDEPsLANGAFM
K577-a	ANGAFMPkKsIKKLV
S579-p	GAFMPkKsIKKLVLK
K586	sIKKLVLKNLNNsNL
K586	sIKKLVLKNLNNsNL
S591-p	VLKNLNNsNLFsPVN
S595-p	LNNsNLFsPVNRDSE
S601	FsPVNRDSENLAsPS
S606-p	RDSENLAsPSEYPEN
S608	SENLAsPSEYPENGE
Y610	NLAsPSEYPENGERF
S618	PENGERFSFLSKPVD
S621	GERFSFLSKPVDENH
K622	ERFSFLSKPVDENHQ
S636-p	QQDGDEDsLVSHFYT
Y642	DsLVSHFYTNPIAKP
K648	FYTNPIAKPIPQtPE
T653-p	IAKPIPQtPESAGNK
S656	PIPQtPESAGNKHSN
S662	ESAGNKHSNsNSVDD
N663	SAGNKHSNsNSVDDT
S664-p	AGNKHSNsNSVDDTI
S666	NKHSNsNSVDDTIVA
T670	NsNSVDDTIVALNMR
S709	REEIENNSYHMHPAG
Y724	IILTKVGYYTIPSMD
K735	PSMDDLAKITNEKGE
K740	LAKITNEKGECIVSD
K801	VGEGLNRKAEVTLDG
K814	DGVWPTDKTSRCLIK
S822-p	TSRCLIKsPDRLADI
Y831	DRLADINYEGRLEAV
S861-p	GSWVFKVsHFSKYGL
S871	SKYGLQDSDEEEEEH
S883	EEHPSKTSTKKLKTA
T899	LPPASQTTPLQMALN
K908	LQMALNGKPAPPPQS
S915	KPAPPPQSQSPEVEQ
S917	APPPQSQSPEVEQLG
S931	GRVVELDSDMVDITQ
S949	LDTMLEESMPEDQEP
S980	VLQIMKASLLtDEED
T983-p	IMKASLLtDEEDVDM
S997	MALDQRFSRLPSKAD
S1001	QRFSRLPSKADTSQE
K1002	RFSRLPSKADTSQEI
T1005	RLPSKADTSQEICSP
S1006	LPSKADTSQEICSPR
S1011	DTSQEICSPRLPISA
S1017	CSPRLPISASHSSKT
S1017	CSPRLPISASHSSKT
S1019	PRLPISASHSSKTRS
T1024	SASHSSKTRSLVGGL
S1026	SHSSKTRSLVGGLLQ
T1037	GLLQSKFTSGAFLSP
S1038	LLQSKFTSGAFLSPS
S1043	FTSGAFLSPSVSVQE
S1045	SGAFLSPSVSVQECR
S1047	AFLSPSVSVQECRtP
T1053-p	VSVQECRtPRAASLM
S1082	TSVFTMPSPAPEVPL
S1157	ENHQIADSMEFGFLP
K1183	PFKVHLEKLSLRQRK
K1190	KLSLRQRKPDEDMKL
K1196	RKPDEDMKLYQTPLE
Y1198	PDEDMKLYQTPLELK
K1205	YQTPLELKLKHSTVH
K1324	VFSYLTGKRISEACS
K1324	VFSYLTGKRISEACS
S1346	HRLALLLSQFVGSQS
S1448	DSDRYACSPLPSYLE
Y1482	CFHLLKLYSDSIREK
-	gap
K1517	KETFLTQKLRVPAKW
S1598	LIQDWETSGLVYLDY
T1677	LHHPPDRTSDstPDP
S1678	HHPPDRTSDstPDPQ
S1680-p	PPDRTSDstPDPQRV
T1681-p	PDRTSDstPDPQRVP
S1712-p	YAMDELRsLtQSYLR
T1714-p	MDELRsLtQSYLREL

	mouse
T168	TIKFNPPTGTDTMVK
T170	KFNPPTGTDTMVKAG
T172	NPPTGTDTMVKAGVS
S179	TMVKAGVSTNISTKH
T184	GVSTNISTKHQCITA
S511	HLNSLTYSPFGDSPL
S516	TYSPFGDSPLFRNPM
S524-p	PLFRNPMsDPKKKEE
T536-p	KEERLKPtNPAAQKA
T545	PAAQKALTTPTHYKL
T546	AAQKALTTPTHYKLT
T548	QKALTTPTHYKLTPR
Y550	ALTTPTHYKLTPRPA
T553	TPTHYKLTPRPAtRV
T558-p	KLTPRPAtRVRPKAL
T567	VRPKALQTTGTAKSH
T568	RPKALQTTGTAKSHL
K572	LQTTGTAKSHLFDGL
K572	LQTTGTAKSHLFDGL
S585	GLDDDEPSLANGAFM
K594	ANGAFMPKKSIKKLV
S596	GAFMPKKSIKKLVLK
K603	SIKKLVLKNLNNsNL
K603	SIKKLVLKNLNNsNL
S608-p	VLKNLNNsNLFsPVN
S612-p	LNNsNLFsPVNHDsE
S618-p	FsPVNHDsEDLAsPs
S623-p	HDsEDLAsPsEyPEN
S625-p	sEDLAsPsEyPENGE
Y627-p	DLAsPsEyPENGERF
S635-p	PENGERFsFLSkPVD
S638	GERFsFLSkPVDENN
K639-u	ERFsFLSkPVDENNQ
S653-p	QQDGEDDsLVSRFYT
Y659	DsLVSRFYTNPIAkP
K665-u	FYTNPIAkPIPQtPE
T670-p	IAkPIPQtPEsVGNK
S673-p	PIPQtPEsVGNKNNs
N679	EsVGNKNNssSNVED
S680-p	sVGNKNNssSNVEDt
S681-p	VGNKNNssSNVEDtI
N683	NKNNssSNVEDtIVA
T687-p	ssSNVEDtIVALNMR
A726	REEIENNAYHIHPAG
Y741	IVLTKVGYYTIPSMD
K752	PSMDDLAKITNEkGE
K757-u	LAKITNEkGECIVSD
K818-u	VGEGLNRkAEVTLDG
K831	DGVWPTDKTSRCLIK
S839-p	TSRCLIKsPDRLADI
Y848	DRLADINYEGRLEAV
S878	GSWVFKVSHFSKYGL
S888-p	SKYGLQDsDEEEEEH
T900	EEHPPKTTSKKLKTA
T916	LPPAGQATTFQMTLN
K925	FQMTLNGKPAPPPQS
S932	KPAPPPQSQsPEVEQ
S934-p	APPPQSQsPEVEQLG
S948	GRVVELDSDMVDITQ
S966	PDSVLEESVPEDQEP
S997	VLQIMKASLLVDEED
V1000	IMKASLLVDEEDVDA
G1013	DAMDQRFGHIPSkGE
S1017	QRFGHIPSkGETVQE
K1018-u	RFGHIPSkGETVQEI
T1021	HIPSkGETVQEICsP
V1022	IPSkGETVQEICsPR
S1027-p	ETVQEICsPRLPIsA
S1033	CsPRLPISAsHSSKs
S1033-g	CsPRLPIsAsHSSKs
S1035-p	PRLPIsAsHSSKsRs
S1040-p	sAsHSSKsRsIVGGL
S1042-p	sHSSKsRsIVGGLLQ
A1053	GLLQSKFASGTFLsP
S1054	LLQSKFASGTFLsPs
S1059-p	FASGTFLsPsAsVQE
S1061-p	SGTFLsPsAsVQECR
S1063-p	TFLsPsAsVQECRtP
T1069-p	AsVQECRtPRTSSRM
S1098-p	ATVFTVPsPAPEVQL
S1173	ENHQVADSMEYGFLP
K1199-u	PFKVHLEkLGLRQRk
K1206-u	kLGLRQRkLDEDLQL
Q1212	RkLDEDLQLYQTPLE
Y1214	LDEDLQLYQTPLELK
K1221	YQTPLELKLKHSTVH
S1340	VFSYLTGSRISEACC
S1340	VFSYLTGSRISEACC
S1362	HRLALLLSQLVGSQS
S1464	EGDKYACSPLPSYLE
Y1498	CFHLLKLYSDRHYEL
Y1503	KLYSDRHYELNQLLE
K1607	KEAFLTQKLCVPAEW
S1688	LIQDWETSGLVYLDY
T1767	LQHAPDATSNStPDP
S1768	QHAPDATSNStPDPQ
S1770	APDATSNStPDPQRV
T1771-p	PDATSNStPDPQRVP
G1802	YALEELRGLTQSYLR
T1804	LEELRGLTQSYLREL

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