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Protein Page:
NUP98 (rat)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NUP98 Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport. Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M. Belongs to the nucleoporin GLFG family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nucleoporin
Cellular Component: nucleoplasm; kinetochore; nuclear membrane; nuclear pore; nuclear envelope; nucleus; nuclear inclusion body
Molecular Function: protein binding; structural constituent of nuclear pore; peptide binding
Biological Process: nuclear pore complex assembly; mRNA transport; transport; protein import into nucleus, docking; DNA replication
Reference #:  P49793 (UniProtKB)
Alt. Names/Synonyms: 98 kDa nucleoporin; nuclear pore complex protein Nup98; nuclear pore complex protein Nup98-Nup96; nuclear pore complex protein Nup98-Nup96 proprotein; nucleoporin 98; nucleoporin 98kDa; nucleoporin Nup98; Nup98; P49793; P49793-2
Gene Symbols: Nup98
Molecular weight: 197,283 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NUP98

Protein Structure Not Found.


Scansite  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       rat

 
0 2 T170 KFNPPTGTDTMVKAG
0 2 T172 NPPTGTDTMVKAGVS
0 1 T184 GVSTNISTKHQCITA
1 2 S511 HLNSLTYSPFGDSPL
1 2 S516 TYSPFGDSPLFRNPM
0 3 S524 PLFRNPMSDPKKKEE
0 2 T536 KEERLKPTNPAAQKA
1 13 T546 AAQKALTTPTHYKLT
0 2 T548 QKALTTPTHYKLTPR
0 1 Y550 ALTTPTHYKLTPRPA
1 18 T553 TPTHYKLTPRPATRV
0 1 T567 VRPKALQTTGTAKSH
0 1 T568 RPKALQTTGTAKSHL
0 2 K572 LQTTGTAKSHLFDGL
0 1 K572 LQTTGTAKSHLFDGL
1 1 S585 GLDDDEPSLANGAFM
0 2 K594 ANGAFMPKKSIKKLV
0 7 S596 GAFMPKKSIKKLVLK
0 1 K603 SIKKLVLKNLNNSNL
0 3 K603 SIKKLVLKNLNNSNL
1 15 S608 VLKNLNNSNLFSPVN
2 28 S612 LNNSNLFSPVNHDSE
0 5 S618 FSPVNHDSEDLAsPS
1 41 S623-p HDSEDLAsPSEYPEN
0 4 S625 SEDLAsPSEYPENGE
0 4 Y627 DLAsPSEYPENGERF
0 5 S635 PENGERFSFLSKPVD
0 1 S638 GERFSFLSKPVDENH
0 10 K639 ERFSFLSKPVDENHQ
1 11 S653-p QQDGDDDsLVSRFYT
0 8 K665 FYTNPIAKPIPQtPE
1 24 T670-p IAKPIPQtPESAGNK
0 8 S673 PIPQtPESAGNKNNS
0 2 N679 ESAGNKNNSSSNVED
0 2 S680 SAGNKNNSSSNVEDT
1 6 S681 AGNKNNSSSNVEDTF
0 4 N683 NKNNSSSNVEDTFIA
0 2 T687 SSSNVEDTFIALNMR
0 1 A726 RDEIENSAFQIHPAG
0 2 Y741 IVLTKVGYYTIPSMD
0 1 T743 LTKVGYYTIPSMDDL
0 1 K752 PSMDDLAKITNEKGE
0 8 K757 LAKITNEKGECIVSD
0 2 K818 VGEGLNRKAEVTLDG
0 2 K831 DGVWPTDKTSRCLIK
1 30 S839 TSRCLIKSPDRLADI
1 1 S878 GSWVFKVSHFSKYGL
0 46 S888-p SKYGLQDsDEEEEEH
0 1 P897 EEEEEHPPKTTSKKL
0 1 T899 EEEHPPKTTSKKLKT
0 1 T900 EEHPPKTTSKKLKTA
0 1 T916 LPPAGQATTFQMTLN
0 1 K925 FQMTLNGKPAPPPQS
0 2 S932 KPAPPPQSQsPEVEQ
0 14 S934-p APPPQSQsPEVEQLG
0 1 S948 GRVVELDSDMVDITQ
0 1 S966 PDSVLEESVPEDQEP
0 7 S997 VLQIMKASLLVDEED
0 23 V1000 IMKASLLVDEEDVDA
0 22 S1017 QRFGHFPSRGDTAQE
0 1 R1018 RFGHFPSRGDTAQEI
0 20 T1021 HFPSRGDTAQEICsP
0 13 A1022 FPSRGDTAQEICsPR
0 23 S1027-p DTAQEICsPRLPISA
0 1 S1033 CsPRLPISASHSSKS
0 2 S1033 CsPRLPISASHSSKS
0 2 S1035 PRLPISASHSSKSRS
0 2 S1040 SASHSSKSRSIVGGL
0 19 S1042 SHSSKSRSIVGGLLQ
0 1 A1053 GLLQSKFASGTFLsP
0 2 S1054 LLQSKFASGTFLsPS
0 41 S1059-p FASGTFLsPSASVQE
0 2 S1061 SGTFLsPSASVQECR
0 16 S1063 TFLsPSASVQECRTP
0 37 T1069 ASVQECRTPRTSSLM
0 2 S1098 ATVFTVPSPAPEVPL
0 1 S1173 ENHQVAESMEYGFLP
0 1 K1199 PFKVHLEKLGLRQRK
0 1 K1206 KLGLRQRKLDEDLQL
0 6 Y1214 LDEDLQLYQTPLELK
0 1 K1221 YQTPLELKLKHSTVH
0 1 S1328 VSLTRRDSPIEAVFS
0 24 S1340 VFSYLTGSRISEACC
0 1 S1362 HRLALLLSQLVGSQS
0 1 P1464 EGDKYACPPLPSYLE
0 1 K1607 KETFLTQKLCVPAEW
0 1 S1688 LIQDWETSGLVYLDY
0 2 S1770 TPDATSNSTPDPQRV
0 14 T1771 PDATSNSTPDPQRVP
0 1 G1802 YALEELRGLTQSYLR
0 1 T1804 LEELRGLTQSYLREL
  human

► Hide Isoforms
 
T170-p KFNPPTGtDtMVKAG
T172-p NPPTGtDtMVKAGVS
T184-gl GVSTNIStKHQCITA
S511-p HINSLTYsPFGDsPL
S516-p TYsPFGDsPLFRNPM
S524-p PLFRNPMsDPKKKEE
T536-p KEERLKPtNPAAQKA
T546-p AAQKALTtPtHyKLt
T548-p QKALTtPtHyKLtPR
Y550-p ALTtPtHyKLtPRPA
T553-p tPtHyKLtPRPATRV
T567-gl VRPKALQttGTAkSH
T568-gl RPKALQttGTAkSHL
K572-a LQttGTAkSHLFDGL
K572-u LQttGTAkSHLFDGL
S585 GLDDDEPSLANGAFM
K594-a ANGAFMPkKsIKKLV
S596-p GAFMPkKsIKKLVLk
K603-a sIKKLVLkNLNNsNL
K603-u sIKKLVLkNLNNsNL
S608-p VLkNLNNsNLFsPVN
S612-p LNNsNLFsPVNRDsE
S618-p FsPVNRDsENLAsPs
S623-p RDsENLAsPsEyPEN
S625-p sENLAsPsEyPENGE
Y627-p NLAsPsEyPENGERF
S635-p PENGERFsFLskPVD
S638-p GERFsFLskPVDENH
K639-u ERFsFLskPVDENHQ
S653-p QQDGDEDsLVSHFYT
K665-u FYTNPIAkPIPQtPE
T670-p IAkPIPQtPEsAGNK
S673-p PIPQtPEsAGNKHsN
S679-p EsAGNKHsNsNsVDD
N680 sAGNKHsNsNsVDDt
S681-p AGNKHsNsNsVDDtI
S683-p NKHsNsNsVDDtIVA
T687-p NsNsVDDtIVALNMR
S726-p REEIENNsYHMHPAG
Y741-p IILTKVGyYtIPSMD
T743-p LTKVGyYtIPSMDDL
K752-u PSMDDLAkITNEkGE
K757-u LAkITNEkGECIVSD
K818-u VGEGLNRkAEVTLDG
K831-u DGVWPTDkTSRCLIK
S839-p TSRCLIKsPDRLADI
S878 GSWVFKVSHFSKYGL
S888-p SKYGLQDsDEEEEEH
S897-p EEEEEHPsKtsTKKL
T899-p EEEHPsKtsTKKLKT
S900-p EEHPsKtsTKKLKTA
T916-p LPPASQTtPLQMALN
K925-u LQMALNGkPAPPPQs
S932-p kPAPPPQsQsPEVEQ
S934-p APPPQsQsPEVEQLG
S948-p GRVVELDsDMVDITQ
S966-p LDTMLEEsMPEDQEP
S997-p VLQIMKAsLLtDEED
T1000-p IMKAsLLtDEEDVDM
S1018-p QRFSRLPsKADtsQE
K1019 RFSRLPsKADtsQEI
T1022-p RLPsKADtsQEICsP
S1023-p LPsKADtsQEICsPR
S1028-p DtsQEICsPRLPIsA
S1034-p CsPRLPIsAsHSSKt
S1034 CsPRLPISAsHSSKt
S1036-p PRLPIsAsHSSKtRs
T1041-p sAsHSSKtRsLVGGL
S1043-p sHSSKtRsLVGGLLQ
T1054-p GLLQSKFtsGAFLsP
S1055-p LLQSKFtsGAFLsPs
S1060-p FtsGAFLsPsVsVQE
S1062-p sGAFLsPsVsVQECR
S1064-p AFLsPsVsVQECRtP
T1070-p VsVQECRtPRAASLM
S1099-p TSVFTMPsPAPEVPL
S1174-p ENHQIADsMEFGFLP
K1200 PFKVHLEKLSLRQRK
K1207 KLSLRQRKPDEDMKL
Y1215-p PDEDMKLyQTPLELk
K1222-u yQTPLELkLKHSTVH
S1329 VSLTQKNSPVEAVFS
K1341-u VFSYLTGkRISEACS
S1363-p HRLALLLsQFVGSQS
S1465-p DSDRYACsPLPSYLE
K1608-u KETFLTQkLRVPAKW
S1689-p LIQDWETsGLVYLDY
S1771-p PPDRTSDstPDPQRV
T1772-p PDRTSDstPDPQRVP
S1803 YAMDELRSLTQSYLR
T1805 MDELRSLTQSYLREL
  NUP98 iso2  
T170 KFNPPTGTDTMVKAG
T172 NPPTGTDTMVKAGVS
T184 GVSTNISTKHQCITA
S494-p HINSLTYsPFGDsPL
S499-p TYsPFGDsPLFRNPM
S507 PLFRNPMSDPKKKEE
T519 KEERLKPTNPAAQKA
T529-p AAQKALTtPTHYKLt
T531 QKALTtPTHYKLtPR
Y533 ALTtPTHYKLtPRPA
T536-p tPTHYKLtPRPATRV
T550 VRPKALQTTGTAkSH
T551 RPKALQTTGTAkSHL
K555-a LQTTGTAkSHLFDGL
K555 LQTTGTAKSHLFDGL
S568-p GLDDDEPsLANGAFM
K577-a ANGAFMPkKsIKKLV
S579-p GAFMPkKsIKKLVLK
K586 sIKKLVLKNLNNsNL
K586 sIKKLVLKNLNNsNL
S591-p VLKNLNNsNLFsPVN
S595-p LNNsNLFsPVNRDSE
S601 FsPVNRDSENLAsPS
S606-p RDSENLAsPSEYPEN
S608 SENLAsPSEYPENGE
Y610 NLAsPSEYPENGERF
S618 PENGERFSFLSKPVD
S621 GERFSFLSKPVDENH
K622 ERFSFLSKPVDENHQ
S636-p QQDGDEDsLVSHFYT
K648 FYTNPIAKPIPQtPE
T653-p IAKPIPQtPESAGNK
S656 PIPQtPESAGNKHSN
S662 ESAGNKHSNsNSVDD
N663 SAGNKHSNsNSVDDT
S664-p AGNKHSNsNSVDDTI
S666 NKHSNsNSVDDTIVA
T670 NsNSVDDTIVALNMR
S709 REEIENNSYHMHPAG
Y724 IILTKVGYYTIPSMD
T726 LTKVGYYTIPSMDDL
K735 PSMDDLAKITNEKGE
K740 LAKITNEKGECIVSD
K801 VGEGLNRKAEVTLDG
K814 DGVWPTDKTSRCLIK
S822-p TSRCLIKsPDRLADI
S861-p GSWVFKVsHFSKYGL
S871 SKYGLQDSDEEEEEH
S880 EEEEEHPSKTSTKKL
T882 EEEHPSKTSTKKLKT
S883 EEHPSKTSTKKLKTA
T899 LPPASQTTPLQMALN
K908 LQMALNGKPAPPPQS
S915 KPAPPPQSQSPEVEQ
S917 APPPQSQSPEVEQLG
S931 GRVVELDSDMVDITQ
S949 LDTMLEESMPEDQEP
S980 VLQIMKASLLtDEED
T983-p IMKASLLtDEEDVDM
S1001 QRFSRLPSKADTSQE
K1002 RFSRLPSKADTSQEI
T1005 RLPSKADTSQEICSP
S1006 LPSKADTSQEICSPR
S1011 DTSQEICSPRLPISA
S1017 CSPRLPISASHSSKT
S1017 CSPRLPISASHSSKT
S1019 PRLPISASHSSKTRS
T1024 SASHSSKTRSLVGGL
S1026 SHSSKTRSLVGGLLQ
T1037 GLLQSKFTSGAFLSP
S1038 LLQSKFTSGAFLSPS
S1043 FTSGAFLSPSVSVQE
S1045 SGAFLSPSVSVQECR
S1047 AFLSPSVSVQECRtP
T1053-p VSVQECRtPRAASLM
S1082 TSVFTMPSPAPEVPL
S1157 ENHQIADSMEFGFLP
K1183 PFKVHLEKLSLRQRK
K1190 KLSLRQRKPDEDMKL
Y1198 PDEDMKLYQTPLELK
K1205 YQTPLELKLKHSTVH
S1312 VSLTQKNSPVEAVFS
K1324 VFSYLTGKRISEACS
S1346 HRLALLLSQFVGSQS
S1448 DSDRYACSPLPSYLE
K1517 KETFLTQKLRVPAKW
S1598 LIQDWETSGLVYLDY
S1680-p PPDRTSDstPDPQRV
T1681-p PDRTSDstPDPQRVP
S1712-p YAMDELRsLtQSYLR
T1714-p MDELRsLtQSYLREL
  mouse

 
T170 KFNPPTGTDTMVKAG
T172 NPPTGTDTMVKAGVS
T184 GVSTNISTKHQCITA
S511 HLNSLTYSPFGDSPL
S516 TYSPFGDSPLFRNPM
S524-p PLFRNPMsDPKKKEE
T536-p KEERLKPtNPAAQKA
T546-p AAQKALTtPTHYKLT
T548 QKALTtPTHYKLTPR
Y550 ALTtPTHYKLTPRPA
T553 tPTHYKLTPRPATRV
T567 VRPKALQTTGTAKSH
T568 RPKALQTTGTAKSHL
K572 LQTTGTAKSHLFDGL
K572 LQTTGTAKSHLFDGL
S585 GLDDDEPSLANGAFM
K594 ANGAFMPKKSIKKLV
S596 GAFMPKKSIKKLVLK
K603 SIKKLVLKNLNNsNL
K603 SIKKLVLKNLNNsNL
S608-p VLKNLNNsNLFsPVN
S612-p LNNsNLFsPVNHDsE
S618-p FsPVNHDsEDLAsPs
S623-p HDsEDLAsPsEyPEN
S625-p sEDLAsPsEyPENGE
Y627-p DLAsPsEyPENGERF
S635-p PENGERFsFLSkPVD
S638 GERFsFLSkPVDENN
K639-u ERFsFLSkPVDENNQ
S653-p QQDGEDDsLVSRFYT
K665-u FYTNPIAkPIPQtPE
T670-p IAkPIPQtPEsVGNK
S673-p PIPQtPEsVGNKNNs
N679 EsVGNKNNssSNVED
S680-p sVGNKNNssSNVEDt
S681-p VGNKNNssSNVEDtI
N683 NKNNssSNVEDtIVA
T687-p ssSNVEDtIVALNMR
A726 REEIENNAYHIHPAG
Y741 IVLTKVGYYTIPSMD
T743 LTKVGYYTIPSMDDL
K752 PSMDDLAKITNEkGE
K757-u LAKITNEkGECIVSD
K818-u VGEGLNRkAEVTLDG
K831 DGVWPTDKTSRCLIK
S839-p TSRCLIKsPDRLADI
S878 GSWVFKVSHFSKYGL
S888-p SKYGLQDsDEEEEEH
P897 EEEEEHPPKTTSKKL
T899 EEEHPPKTTSKKLKT
T900 EEHPPKTTSKKLKTA
T916 LPPAGQATTFQMTLN
K925 FQMTLNGKPAPPPQS
S932 KPAPPPQSQsPEVEQ
S934-p APPPQSQsPEVEQLG
S948 GRVVELDSDMVDITQ
S966 PDSVLEESVPEDQEP
S997 VLQIMKASLLVDEED
V1000 IMKASLLVDEEDVDA
S1017 QRFGHIPSkGETVQE
K1018-u RFGHIPSkGETVQEI
T1021 HIPSkGETVQEICsP
V1022 IPSkGETVQEICsPR
S1027-p ETVQEICsPRLPIsA
S1033 CsPRLPISAsHSSKs
S1033-gl CsPRLPIsAsHSSKs
S1035-p PRLPIsAsHSSKsRs
S1040-p sAsHSSKsRsIVGGL
S1042-p sHSSKsRsIVGGLLQ
A1053 GLLQSKFAsGTFLsP
S1054-p LLQSKFAsGTFLsPs
S1059-p FAsGTFLsPsAsVQE
S1061-p sGTFLsPsAsVQECR
S1063-p TFLsPsAsVQECRtP
T1069-p AsVQECRtPRTSSRM
S1098-p ATVFTVPsPAPEVQL
S1173 ENHQVADSMEYGFLP
K1199-u PFKVHLEkLGLRQRk
K1206-u kLGLRQRkLDEDLQL
Y1214 LDEDLQLYQTPLELK
K1221 YQTPLELKLKHSTVH
S1328-p VSLTRRDsPVEAVFS
S1340 VFSYLTGSRISGACC
S1362 HRLALLLSQLVGSQS
S1464 EGDKYACSPLPSYLE
K1607 KEAFLTQKLCVPAEW
S1688 LIQDWETSGLVYLDY
S1770-p APDATSNstPDPQRV
T1771-p PDATSNstPDPQRVP
G1802 YALEELRGLTQSYLR
T1804 LEELRGLTQSYLREL
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