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HGK (human)

Overview HGK a Ser/Thr kinase of the STE20 subfamily. May play a role in the response to environmental stress and cytokines such as TNF-alpha. May interact with the SH3 domain of the adapter proteins Nck. Binds, via its CNH regulatory domain, to the N- terminal region of SPG3A. Upregulated in primary tumors and tumor cell lines. Required for anchorage-independent growth and ras-dependent focus formation in multiple cell lines. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MSN subfamily Cellular Component: cytoplasm Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; small GTPase regulator activity Biological Process: protein kinase cascade; response to stress; regulation of JNK cascade; protein amino acid phosphorylation Reference #:  O95819 (UniProtKB) Alt. Names/Synonyms: FLH21957; FLJ10410; FLJ20373; FLJ90111; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; HGK; HPK/GCK-like kinase HGK; KIAA0687; M4K4; MAP4K4; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Mitogen-activated protein kinase kinase kinase kinase 4; Nck-interacting kinase; NIK; ZC1 Gene Symbols: MAP4K4 Molecular weight: 142,101 Da Basal Isoelectric point: 7.09  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HGK

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	2		S5-p	___MANDsPAKSLVD
0	1		T35-p	VEVVGNGtyGQVYKG
0	4		Y36-p	EVVGNGtyGQVYKGR
0	8		Y86-p	HRNIATYyGAFIKKS
0	1		T124-p	VKNTKGNtLKEDWIA
0	2		S175-p	KLVDFGVsAQLDRtV
0	18		T181-p	VsAQLDRtVGRRNtF
0	95		T187-p	RtVGRRNtFIGTPyW
0	1		Y193-p	NtFIGTPyWMAPEVI
0	16		S264-p	KWSKKFFsFIEGCLV
0	1		K285-u	PSTEQLLkHPFIRDQ
0	1		Y323-p	KDETEYEysGsEEEE
0	4		S324-p	DETEYEysGsEEEEE
0	4		S326-p	TEYEysGsEEEEEEV
0	7		Y467-p	RVEREQEyIRRQLEE
0	7		Y520-p	QLQQEQAyLLsLQHD
0	4		S523-p	QEQAyLLsLQHDHRR
0	11		S536-p	RRPHPQHsQQPPPPQ
0	72		Y560-p	APEPKAHyEPADRAR
0	5		S598-p	VLEPPVPsRsEsFsN
0	1		S600-p	EPPVPsRsEsFsNGN
0	3		S602-p	PVPsRsEsFsNGNSE
0	1		S604-p	PsRsEsFsNGNSESV
0	2		-	gap
0	2		-	gap
0	11		-	gap
0	1		-	gap
0	3		-	gap
0	1		T627-p	EPQVPVRttsRsPVL
0	3		T628-p	PQVPVRttsRsPVLS
0	14		S629-p	QVPVRttsRsPVLSR
0	25		S631-p	PVRttsRsPVLSRRD
0	24		S639-p	PVLSRRDsPLQGsGQ
0	2		S644-p	RDsPLQGsGQQNsQA
0	10		S649-p	QGsGQQNsQAGQRNS
0	7		S656	sQAGQRNSTSIEPRL
0	2		T657	QAGQRNSTSIEPRLL
0	2		-	gap
0	7		S677-p	KLVPRPGsGsssGss
0	4		S679-p	VPRPGsGsssGssNs
0	2		S680-p	PRPGsGsssGssNsG
0	2		S681-p	RPGsGsssGssNsGS
0	3		S683-p	GsGsssGssNsGSQP
0	1		S684-p	sGsssGssNsGSQPG
0	1		S686-p	sssGssNsGSQPGsH
0	9		S692-p	NsGSQPGsHPGsQsG
0	14		S696-p	QPGsHPGsQsGsGER
0	7		S698-p	GsHPGsQsGsGERFR
0	14		S700-p	HPGsQsGsGERFRVR
0	51		S708-p	GERFRVRsssKsEGs
0	8		S709-p	ERFRVRsssKsEGsP
0	110		S710-p	RFRVRsssKsEGsPs
0	1		S712-p	RVRsssKsEGsPsQR
0	10		S715-p	sssKsEGsPsQRLEN
0	16		S717-p	sKsEGsPsQRLENAV
0	20		S800-p	PEDTRAAssLNLsNG
0	8		S801-p	EDTRAAssLNLsNGE
0	14		S805-p	AAssLNLsNGEtEsV
0	1		T809-p	LNLsNGEtEsVKTMI
0	1		S811-p	LsNGEtEsVKTMIVH
0	9		S823-p	IVHDDVEsEPAMtPs
0	5		T828-p	VEsEPAMtPsKEGtL
0	7		S830-p	sEPAMtPsKEGtLIV
0	1		K831	EPAMtPsKEGtLIVR
0	11		T834-p	MtPsKEGtLIVRQtQ
0	5		-	gap
0	32		-	gap
0	1		-	gap
0	1		T840-p	GtLIVRQtQsASStL
0	3		S842-p	LIVRQtQsASStLQK
0	1		S845	RQtQsASStLQKHKS
0	5		T846-p	QtQsASStLQKHKSs
0	2		S853-p	tLQKHKSsssFtPFI
0	1		S854-p	LQKHKSsssFtPFID
0	5		S855-p	QKHKSsssFtPFIDP
0	3		T857-p	HKSsssFtPFIDPRL
0	1		S868-p	DPRLLQIsPssGttV
0	1		S870-p	RLLQIsPssGttVts
0	1		S871-p	LLQIsPssGttVtsV
0	2		T873-p	QIsPssGttVtsVVG
0	3		T874-p	IsPssGttVtsVVGF
0	3		T876-p	PssGttVtsVVGFSC
0	5		S877-p	ssGttVtsVVGFSCD
0	22		S900-p	QDPTRKGsVVNVNPt
0	1		T907-p	sVVNVNPtNTRPQsD
0	2		S913-p	PtNTRPQsDtPEIRK
0	8		T915-p	NTRPQsDtPEIRKYK
0	1		Y992-p	KKDKLRVyYLsWLRN
0	8		S995-p	KLRVyYLsWLRNKIL
0	1		Y1026	DLEGCVHYKVVKYER
0	1		S1224-p	SVRSGGSsQVyFMtL
0	11		Y1227-p	SGGSsQVyFMtLGRT
0	1		T1230-p	SsQVyFMtLGRTSLL

	HGK iso3
S5	___MANDSPAKSLVD
T35	VEVVGNGTYGQVYKG
Y36	EVVGNGTYGQVYKGR
Y86	HRNIATYYGAFIKKS
T124	VKNTKGNTLKEDWIA
S175	KLVDFGVSAQLDRTV
T181	VSAQLDRTVGRRNTF
T187	RTVGRRNTFIGTPYW
Y193	NTFIGTPYWMAPEVI
S264	KWSKKFFSFIEGCLV
K285	PSTEQLLKHPFIRDQ
Y323	KDETEYEYSGSEEEE
S324	DETEYEYSGSEEEEE
S326	TEYEYSGSEEEEEEV
Y467	RVEREQEYIRRQLEE
-	gap
-	gap
S505	RRPHPQHSQQPPPPQ
Y529	APEPKAHYEPADRAR
S567	VLEPPVPSRSESFSN
S569	EPPVPSRSESFSNGN
S571	PVPSRSESFSNGNSE
S573	PSRSESFSNGNSESV
-	gap
-	gap
-	gap
-	gap
-	gap
T596	EPQVPVRTTSRSPVL
T597	PQVPVRTTSRSPVLS
S598	QVPVRTTSRSPVLSR
S600	PVRTTSRSPVLSRRD
S608	PVLSRRDSPLQGSGQ
S613	RDSPLQGSGQQNsQA
S618-p	QGSGQQNsQAGQRNs
S625-p	sQAGQRNsTSSIEPR
T626	QAGQRNsTSSIEPRL
S628	GQRNsTSSIEPRLLW
S647	KLVPRPGSGSSSGSS
S649	VPRPGSGSSSGSSNS
S650	PRPGSGSSSGSSNSG
S651	RPGSGSSSGSSNSGS
S653	GSGSSSGSSNSGSQP
S654	SGSSSGSSNSGSQPG
S656	SSSGSSNSGSQPGSH
S662	NSGSQPGSHPGSQSG
S666	QPGSHPGSQSGSGER
S668	GSHPGSQSGSGERFR
S670	HPGSQSGSGERFRVR
S678	GERFRVRSSSKSEGS
S679	ERFRVRSSSKSEGSP
S680	RFRVRSSSKSEGSPS
S682	RVRSSSKSEGSPSQR
S685	SSSKSEGSPSQRLEN
S687	SKSEGSPSQRLENAV
S770	PEDTRAASSLNLSNG
S771	EDTRAASSLNLSNGE
S775	AASSLNLSNGETESV
T779	LNLSNGETESVKTMI
S781	LSNGETESVKTMIVH
S793	IVHDDVESEPAMtPs
T798-p	VESEPAMtPsKEGtL
S800-p	SEPAMtPsKEGtLIV
K801	EPAMtPsKEGtLIVR
T804-p	MtPsKEGtLIVRQst
S810-p	GtLIVRQstVDQKRA
T811-p	tLIVRQstVDQKRAS
S818	tVDQKRASHHESNGF
T874	DKLTANETQSASstL
S876	LTANETQSASstLQK
S879-p	NETQSASstLQKHKS
T880-p	ETQSASstLQKHKSS
S887	tLQKHKSSSSFTPFI
S888	LQKHKSSSSFTPFID
S889	QKHKSSSSFTPFIDP
T891	HKSSSSFTPFIDPRL
S902	DPRLLQISPSSGTTV
S904	RLLQISPSSGTTVTS
S905	LLQISPSSGTTVTSV
T907	QISPSSGTTVTSVVG
T908	ISPSSGTTVTSVVGF
T910	PSSGTTVTSVVGFSC
S911	SSGTTVTSVVGFSCD
S934	QDPTRKGSVVNVNPT
T941	SVVNVNPTNTRPQSD
S947	PTNTRPQSDTPEIRK
T949	NTRPQSDTPEIRKYK
Y1026	KKDKLRVYYLSWLRN
S1029	KLRVYYLSWLRNKIL
Y1060	DLEGCVHYKVVKYER
S1258	SVRSGGSSQVYFMTL
Y1261	SGGSSQVYFMTLGRT
T1264	SSQVYFMTLGRTSLL

	HGK iso5
S5	___MANDSPAKSLVD
T35	VEVVGNGTYGQVYKG
Y36	EVVGNGTYGQVYKGR
Y86	HRNIATYYGAFIKKS
T124	VKNTKGNTLKEDWIA
S175	KLVDFGVSAQLDRTV
T181	VSAQLDRTVGRRNTF
T187	RTVGRRNTFIGTPYW
Y193	NTFIGTPYWMAPEVI
S264	KWSKKFFSFIEGCLV
K285	PSTEQLLKHPFIRDQ
Y323	KDETEYEYSGSEEEE
S324	DETEYEYSGSEEEEE
S326	TEYEYSGSEEEEEEV
Y467	RVEREQEYIRRQLEE
-	gap
-	gap
S505	RRPHPQHSQQPPPPQ
Y529	APEPKAHYEPADRAR
-	gap
-	gap
-	gap
-	gap
S545-p	VQWSHLAsLKNNVsP
S551-p	AsLKNNVsPVSRSHs
S558-p	sPVSRSHsFSDPSPK
S560	VSRSHsFSDPSPKFA
S563	SHsFSDPSPKFAHHH
T619	PPRVPVRTTSRSPVL
T620	PRVPVRTTSRSPVLS
S621	RVPVRTTSRSPVLSR
S623	PVRTTSRSPVLSRRD
S631	PVLSRRDSPLQGSGQ
S636	RDSPLQGSGQQNSQA
S641	QGSGQQNSQAGQRNS
S648	SQAGQRNSTSIEPRL
T649	QAGQRNSTSIEPRLL
-	gap
S669	KLVPRPGSGSSSGSS
S671	VPRPGSGSSSGSSNS
S672	PRPGSGSSSGSSNSG
S673	RPGSGSSSGSSNSGS
S675	GSGSSSGSSNSGSQP
S676	SGSSSGSSNSGSQPG
S678	SSSGSSNSGSQPGSH
S684	NSGSQPGSHPGSQSG
S688	QPGSHPGSQSGSGER
S690	GSHPGSQSGSGERFR
S692	HPGSQSGSGERFRVR
S700	GERFRVRSSSKSEGS
S701	ERFRVRSSSKSEGSP
S702	RFRVRSSSKSEGSPS
S704	RVRSSSKSEGSPSQR
S707	SSSKSEGSPSQRLEN
S709	SKSEGSPSQRLENAV
S795	PEDTRAASSLNLSNG
S796	EDTRAASSLNLSNGE
S800	AASSLNLSNGETESV
T804	LNLSNGETESVKTMI
S806	LSNGETESVKTMIVH
S818	IVHDDVESEPAMTPS
T823	VESEPAMTPSKEGTL
S825	SEPAMTPSKEGTLIV
K826	EPAMTPSKEGTLIVR
T829	MTPSKEGTLIVRQTQ
-	gap
-	gap
-	gap
T835	GTLIVRQTQSASSTL
S837	LIVRQTQSASSTLQK
S840	RQTQSASSTLQKHKS
T841	QTQSASSTLQKHKSS
S848	TLQKHKSSSSFTPFI
S849	LQKHKSSSSFTPFID
S850	QKHKSSSSFTPFIDP
T852	HKSSSSFTPFIDPRL
S863	DPRLLQISPSSGTTV
S865	RLLQISPSSGTTVTS
S866	LLQISPSSGTTVTSV
T868	QISPSSGTTVTSVVG
T869	ISPSSGTTVTSVVGF
T871	PSSGTTVTSVVGFSC
S872	SSGTTVTSVVGFSCD
S895	QDPTRKGSVVNVNPT
T902	SVVNVNPTNTRPQSD
S908	PTNTRPQSDTPEIRK
T910	NTRPQSDTPEIRKYK
Y987	KKDKLRVYYLSWLRN
S990	KLRVYYLSWLRNKIL
Y1021	DLEGCVHYKVVKYER
S1227	SVRSGGSSQVYFMTL
Y1230	SGGSSQVYFMTLGRT
T1233	SSQVYFMTLGRTSLL

	HGK iso7
-	gap
-	gap
-	gap
Y26	HRNIATYYGAFIKKS
T64	VKNTKGNTLKEDWIA
S115	KLVDFGVSAQLDRTV
T121	VSAQLDRTVGRRNtF
T127-p	RTVGRRNtFIGTPYW
Y133	NtFIGTPYWMAPEVI
S204	KWSKKFFSFIEGCLV
K225	PSTEQLLKHPFIRDQ
Y263	KDETEYEYSGSEEEE
S264	DETEYEYSGSEEEEE
S266	TEYEYSGSEEEEEEV
Y407	RVEREQEYIRRQLEE
Y460	QLQQEQAYLLSLQHD
S463	QEQAYLLSLQHDHRR
S476	RRPHPQHSQQPPPPQ
Y500	APEPKAHYEPADRAR
S538	VLEPPVPSRSESFSN
S540	EPPVPSRSESFSNGN
S542	PVPSRSESFSNGNSE
S544	PSRSESFSNGNSESV
S570	VQWSHLASLKNNVsP
S576-p	ASLKNNVsPVSRSHs
S583-p	sPVSRSHsFSDPsPK
S585	VSRSHsFSDPsPKFA
S588-p	SHsFSDPsPKFAHHH
T644	PPRVPVRTTSRSPVL
T645	PRVPVRTTSRSPVLS
S646	RVPVRTTSRSPVLSR
S648	PVRTTSRSPVLSRRD
S656-p	PVLSRRDsPLQGSGQ
S661	RDsPLQGSGQQNsQA
S666-p	QGSGQQNsQAGQRNs
S673-p	sQAGQRNstSSIEPR
T674-p	QAGQRNstSSIEPRL
S676	GQRNstSSIEPRLLW
S695	KLVPRPGSGSSSGSS
S697	VPRPGSGSSSGSSNS
S698	PRPGSGSSSGSSNSG
S699	RPGSGSSSGSSNSGS
S701	GSGSSSGSSNSGSQP
S702	SGSSSGSSNSGSQPG
S704	SSSGSSNSGSQPGSH
S710	NSGSQPGSHPGSQSG
S714	QPGSHPGSQSGSGER
S716	GSHPGSQSGSGERFR
S718	HPGSQSGSGERFRVR
S726-p	GERFRVRsssKSEGs
S727-p	ERFRVRsssKSEGsP
S728-p	RFRVRsssKSEGsPs
S730	RVRsssKSEGsPsQR
S733-p	sssKSEGsPsQRLEN
S735-p	sKSEGsPsQRLENAV
S821-p	PEDTRAAssLNLSNG
S822-p	EDTRAAssLNLSNGE
S826	AAssLNLSNGETESV
T830	LNLSNGETESVKTMI
S832	LSNGETESVKTMIVH
S844	IVHDDVESEPAMTPS
T849	VESEPAMTPSKEGTL
S851	SEPAMTPSKEGTLIV
K852	EPAMTPSKEGTLIVR
T855	MTPSKEGTLIVRQTQ
-	gap
-	gap
-	gap
T861	GTLIVRQTQSASSTL
S863	LIVRQTQSASSTLQK
S866	RQTQSASSTLQKHKS
T867	QTQSASSTLQKHKSS
S874	TLQKHKSSSSFTPFI
S875	LQKHKSSSSFTPFID
S876	QKHKSSSSFTPFIDP
T878	HKSSSSFTPFIDPRL
S889	DPRLLQISPSSGTTV
S891	RLLQISPSSGTTVTS
S892	LLQISPSSGTTVTSV
T894	QISPSSGTTVTSVVG
T895	ISPSSGTTVTSVVGF
T897	PSSGTTVTSVVGFSC
S898	SSGTTVTSVVGFSCD
S921	QDPTRKGSVVNVNPT
T928	SVVNVNPTNTRPQSD
S934	PTNTRPQSDTPEIRK
T936	NTRPQSDTPEIRKYK
Y1013	KKDKLRVYYLSWLRN
S1016	KLRVYYLSWLRNKIL
Y1047	DLEGCVHYKVVKYER
S1245	SVRSGGSSQVyFMTL
Y1248-p	SGGSSQVyFMTLGRT
T1251	SSQVyFMTLGRTSLL

	mouse ► Hide Isoforms
S5	___MANDSPAKSLVD
T35	VEVVGNGTYGQVYKG
Y36	EVVGNGTYGQVYKGR
Y85	HRNIATYYGAFIKKS
T123	VKNTKGNTLKEDWIA
S174	KLVDFGVSAQLDRtV
T180-p	VSAQLDRtVGRRNtF
T186-p	RtVGRRNtFIGTPyW
Y192-p	NtFIGTPyWMAPEVI
S263	KWSKKFFSFIEGCLV
K284	PSTEQLLKHPFIRDQ
Y322-p	KDETEYEysGsEEEE
S323-p	DETEYEysGsEEEEE
S325-p	TEYEysGsEEEEEEV
Y466	RVEREQEYIRRQLEE
-	gap
-	gap
-	gap
Y527	APEPKPHYDPADRAR
-	gap
-	gap
-	gap
-	gap
S543-p	VQWSHLAsLKNNVsP
S549-p	AsLKNNVsPVSRSHs
S556-p	sPVSRSHsFsDPsPK
S558-p	VSRSHsFsDPsPKFA
S561-p	SHsFsDPsPKFAHHH
T617	PPRVPVRTtsRsPVL
T618-p	PRVPVRTtsRsPVLS
S619-p	RVPVRTtsRsPVLSR
S621-p	PVRTtsRsPVLSRRD
S629-p	PVLSRRDsPLQGGGQ
G634	RDsPLQGGGQQNSQA
S639	QGGGQQNSQAGQRNs
S646-p	SQAGQRNstSsIEPR
T647-p	QAGQRNstSsIEPRL
S649-p	GQRNstSsIEPRLLW
S668	KLVPRPGSGSSSGSS
S670	VPRPGSGSSSGSSNS
S671	PRPGSGSSSGSSNSG
S672	RPGSGSSSGSSNSGS
S674	GSGSSSGSSNSGSQP
S675	SGSSSGSSNSGSQPG
S677	SSSGSSNSGSQPGSH
S683	NSGSQPGSHPGsQsG
S687-p	QPGSHPGsQsGsGER
S689-p	GSHPGsQsGsGERFR
S691-p	HPGsQsGsGERFRVR
S699-p	GERFRVRsSsKSEGs
S700	ERFRVRsSsKSEGsP
S701-p	RFRVRsSsKSEGsPs
S703	RVRsSsKSEGsPsPR
S706-p	sSsKSEGsPsPRQES
S708-p	sKSEGsPsPRQESAA
S794-p	PEDTRAAssPNLsNG
S795-p	EDTRAAssPNLsNGE
S799-p	AAssPNLsNGETESV
T803	PNLsNGETESVKTMI
S805	LsNGETESVKTMIVH
S817	IVHDDVESEPAMTPs
T822	VESEPAMTPskEGTL
S824-p	SEPAMTPskEGTLIV
K825-a	EPAMTPskEGTLIVR
T828	MTPskEGTLIVRQTQ
-	gap
-	gap
-	gap
T834	GTLIVRQTQSASSTL
S836	LIVRQTQSASSTLQK
S839	RQTQSASSTLQKHKS
T840	QTQSASSTLQKHKSs
S847-p	TLQKHKSsssFtPFI
S848-p	LQKHKSsssFtPFID
S849-p	QKHKSsssFtPFIDP
T851-p	HKSsssFtPFIDPRL
S862	DPRLLQISPSSGTtV
S864	RLLQISPSSGTtVts
S865	LLQISPSSGTtVtsV
T867	QISPSSGTtVtsVVG
T868-p	ISPSSGTtVtsVVGF
T870-p	PSSGTtVtsVVGFSC
S871-p	SSGTtVtsVVGFSCD
S894-p	QDPTRKGsVVNVNPT
T901	sVVNVNPTNTRPQSD
S907	PTNTRPQSDtPEIRK
T909-p	NTRPQSDtPEIRKYK
Y986	KKDKLRVYYLsWLRN
S989-p	KLRVYYLsWLRNKIL
Y1020-p	DLEGCVHyKVVKYER
S1218	SVRSGGSSQVYFMTL
Y1221	SGGSSQVYFMTLGRT
T1224	SSQVYFMTLGRTSLL

	HGK iso3
-	gap
-	gap
-	gap
Y49	HRNIATYYGAFIKKS
T87	VKNTKGNTLKEDWIA
S138	KLVDFGVSAQLDRTV
T144	VSAQLDRTVGRRNTF
T150	RTVGRRNTFIGKGPP
-	gap
S190	KWSKKFFSFIEGCLV
K211	PSTEQLLKHPFIRDQ
Y249	KDETEYEYSGSEEEE
S250	DETEYEYSGSEEEEE
S252	TEYEYSGSEEEEEEV
Y393	RVEREQEYIRRQLEE
Y446	QLQQEQAYLLSLQHD
S449	QEQAYLLSLQHDHRR
-	gap
Y485	APEPKPHYDPADRAR
-	gap
-	gap
-	gap
-	gap
S501	VQWSHLASLKNNVSP
S507	ASLKNNVSPVSRSHS
S514	SPVSRSHSFSDPSPK
S516	VSRSHSFSDPSPKFA
S519	SHSFSDPSPKFAHHH
T575	PPRVPVRTTSRSPVL
T576	PRVPVRTTSRSPVLS
S577	RVPVRTTSRSPVLSR
S579	PVRTTSRSPVLSRRD
S587	PVLSRRDSPLQGGGQ
G592	RDSPLQGGGQQNSQA
S597	QGGGQQNSQAGQRNS
S604	SQAGQRNSTSSIEPR
T605	QAGQRNSTSSIEPRL
S607	GQRNSTSSIEPRLLW
S626	KLVPRPGSGSSSGSS
S628	VPRPGSGSSSGSSNS
S629	PRPGSGSSSGSSNSG
S630	RPGSGSSSGSSNSGS
S632	GSGSSSGSSNSGSQP
S633	SGSSSGSSNSGSQPG
S635	SSSGSSNSGSQPGSH
S641	NSGSQPGSHPGSQSG
S645	QPGSHPGSQSGSGER
S647	GSHPGSQSGSGERFR
S649	HPGSQSGSGERFRVR
S657	GERFRVRSSSKSEGS
S658	ERFRVRSSSKSEGSP
S659	RFRVRSSSKSEGSPS
S661	RVRSSSKSEGSPSPR
S664	SSSKSEGSPSPRQES
S666	SKSEGSPSPRQESAA
S752	PEDTRAASSPNLSNG
S753	EDTRAASSPNLSNGE
S757	AASSPNLSNGETESV
T761	PNLSNGETESVKTMI
S763	LSNGETESVKTMIVH
S775	IVHDDVESEPAMTPS
T780	VESEPAMTPSKEGTL
S782	SEPAMTPSKEGTLIV
K783	EPAMTPSKEGTLIVR
T786	MTPSKEGTLIVRQSt
S792	GTLIVRQStVDQKRA
T793-p	TLIVRQStVDQKRAs
S800-p	tVDQKRAsHHESNGF
T856	DKLTANETQsASStL
S858-p	LTANETQsASStLQK
S861	NETQsASStLQKHKS
T862-p	ETQsASStLQKHKSS
S869	tLQKHKSSSSFTPFI
S870	LQKHKSSSSFTPFID
S871	QKHKSSSSFTPFIDP
T873	HKSSSSFTPFIDPRL
S884	DPRLLQISPSSGTTV
S886	RLLQISPSSGTTVTS
S887	LLQISPSSGTTVTSV
T889	QISPSSGTTVTSVVG
T890	ISPSSGTTVTSVVGF
T892	PSSGTTVTSVVGFSC
S893	SSGTTVTSVVGFSCD
S916	QDPTRKGSVVNVNPT
T923	SVVNVNPTNTRPQSD
S929	PTNTRPQSDTPEIRK
T931	NTRPQSDTPEIRKYK
Y1008	KKDKLRVYYLSWLRN
S1011	KLRVYYLSWLRNKIL
Y1042	DLEGCVHYKVVKYER
S1240	SVRSGGSSQVYFMTL
Y1243	SGGSSQVYFMTLGRT
T1246	SSQVYFMTLGRTSLL

	rat ► Hide Isoforms
-	gap
-	gap
-	gap
Y31	HRNIATYYGAFIKKS
T69	VKNTKGNTLKEDWIA
S120	KLVDFGVSAQLDRTV
T126	VSAQLDRTVGRRNtF
T132-p	RTVGRRNtFIGTPYW
Y138	NtFIGTPYWMAPEVI
S209	KWSKKFFSFIEGCLV
K230	PSTEQLLKHPFIRDQ
Y268	KDETEYEYSGSEEEE
S269	DETEYEYSGSEEEEE
S271	TEYEYSGSEEEEEEV
Y412	RVEREQEYIRRQLEE
-	gap
-	gap
-	gap
Y472	APEPKPHYDPADRAR
-	gap
-	gap
-	gap
-	gap
S488	VQWSHLASLKNNVSP
S494	ASLKNNVSPVSRSHS
S501	SPVSRSHSFSDPSPK
S503	VSRSHSFSDPSPKFA
S506	SHSFSDPSPKFAHHH
T562	PPRVPVRTTSRSPVL
T563	PRVPVRTTSRSPVLS
S564	RVPVRTTSRSPVLSR
S566	PVRTTSRSPVLSRRD
S574	PVLSRRDSPLQGSGQ
S579	RDSPLQGSGQQNSQA
S584	QGSGQQNSQAGQRNS
S591	SQAGQRNSTSSIEPR
T592	QAGQRNSTSSIEPRL
S594	GQRNSTSSIEPRLLW
S613	KLVPRPGSGSSSGSS
S615	VPRPGSGSSSGSSNS
S616	PRPGSGSSSGSSNSG
S617	RPGSGSSSGSSNSGS
S619	GSGSSSGSSNSGSQP
S620	SGSSSGSSNSGSQPG
S622	SSSGSSNSGSQPGSH
S628	NSGSQPGSHPGSQSG
S632	QPGSHPGSQSGSGER
S634	GSHPGSQSGSGERFR
S636	HPGSQSGSGERFRVR
S644	GERFRVRSSSKSEGS
S645	ERFRVRSSSKSEGSP
S646	RFRVRSSSKSEGSPS
S648	RVRSSSKSEGSPSQR
S651	SSSKSEGSPSQRLEN
S653	SKSEGSPSQRLENAA
S739	PEDTRAASSLNLSNG
S740	EDTRAASSLNLSNGE
S744	AASSLNLSNGETESV
T748	LNLSNGETESVKTMI
S750	LSNGETESVKTMIVH
S762	IVHDDVESEPAMTPS
T767	VESEPAMTPSKEGTL
S769	SEPAMTPSKEGTLIV
K770	EPAMTPSKEGTLIVR
T773	MTPSKEGTLIVRQTQ
-	gap
-	gap
-	gap
T779	GTLIVRQTQSASSTL
S781	LIVRQTQSASSTLQK
S784	RQTQSASSTLQKHKS
T785	QTQSASSTLQKHKSS
S792	TLQKHKSSSSFTPFI
S793	LQKHKSSSSFTPFID
S794	QKHKSSSSFTPFIDP
T796	HKSSSSFTPFIDPRL
S807	DPRLLQISPSSGTTV
S809	RLLQISPSSGTTVTS
S810	LLQISPSSGTTVTSV
T812	QISPSSGTTVTSVVG
T813	ISPSSGTTVTSVVGF
T815	PSSGTTVTSVVGFSC
S816	SSGTTVTSVVGFSCD
S839-p	QDPTRKGsVVNVNPT
T846	sVVNVNPTNTRPQSD
S852	PTNTRPQSDTPEIRK
T854	NTRPQSDTPEIRKYK
Y931	KKDKLRVYYLSWLRN
S934	KLRVYYLSWLRNKIL
Y965	DLEGCVHYKVVKYER
S1163	SVRSGGSSQVYFMTL
Y1166	SGGSSQVYFMTLGRT
T1169	SSQVYFMTLGRTSLL

	HGK iso3
-	gap
-	gap
-	gap
Y48	HRNIATYYGAFIKKS
T86	VKNTKGNTLKEDWIA
S137	KLVDFGVSAQLDRTV
T143	VSAQLDRTVGRRNTF
T149	RTVGRRNTFIGTPYW
Y155	NTFIGTPYWMAPEPP
G195	KWHLKHSGSIEGCLV
K215	PFTEQLLKHPFIRDQ
Y253	KDETEYEYSGSEEEE
S254	DETEYEYSGSEEEEE
S256	TEYEYSGSEEEEEEV
Y397	RVEREQEYIRRQLEE
Y450	QLQQEQAYLLSLQHD
S453	QEQAYLLSLQHDHRR
-	gap
Y488	APEPKPHYDPADRAR
-	gap
-	gap
-	gap
-	gap
S504	VQWSHLASLKNNVSP
S510	ASLKNNVSPVSRSHS
S517	SPVSRSHSFSDPSPK
S519	VSRSHSFSDPSPKFA
S522	SHSFSDPSPKFAHHH
T578	PPRVPVRTTSRSPVL
T579	PRVPVRTTSRSPVLS
S580	RVPVRTTSRSPVLSR
S582	PVRTTSRSPVLSRRD
S590	PVLSRRDSPLQGSGQ
S595	RDSPLQGSGQQNSQA
S600	QGSGQQNSQAGQRNS
S607	SQAGQRNSTSSIEPR
T608	QAGQRNSTSSIEPRL
S610	GQRNSTSSIEPRLLW
S629	KLVPRPGSGSSSGSS
S631	VPRPGSGSSSGSSNS
S632	PRPGSGSSSGSSNSG
S633	RPGSGSSSGSSNSGS
S635	GSGSSSGSSNSGSQP
S636	SGSSSGSSNSGSQPG
S638	SSSGSSNSGSQPGSH
S644	NSGSQPGSHPGSQSG
S648	QPGSHPGSQSGSGER
S650	GSHPGSQSGSGERFR
S652	HPGSQSGSGERFRVR
S660	GERFRVRSSSKSEGS
S661	ERFRVRSSSKSEGSP
S662	RFRVRSSSKSEGSPS
S664	RVRSSSKSEGSPSQR
S667	SSSKSEGSPSQRLEN
S669	SKSEGSPSQRLENAA
S755	PEDTRAASSLNLSNG
S756	EDTRAASSLNLSNGE
S760	AASSLNLSNGETESV
T764	LNLSNGETESVKTMI
S766	LSNGETESVKTMIVH
S778	IVHDDVESEPAMTPS
T783	VESEPAMTPSKEGTL
S785	SEPAMTPSKEGTLIV
K786	EPAMTPSKEGTLIVR
T789	MTPSKEGTLIVRQSt
S795	GTLIVRQStVDQKRA
T796-p	TLIVRQStVDQKRAS
S803	tVDQKRASHHESNGF
T859	DKLTANETQSASSTL
S861	LTANETQSASSTLQK
S864	NETQSASSTLQKHKS
T865	ETQSASSTLQKHKSS
S872	TLQKHKSSSSFTPFI
S873	LQKHKSSSSFTPFID
S874	QKHKSSSSFTPFIDP
T876	HKSSSSFTPFIDPRL
S887	DPRLLQISPSSGTTV
S889	RLLQISPSSGTTVTS
S890	LLQISPSSGTTVTSV
T892	QISPSSGTTVTSVVG
T893	ISPSSGTTVTSVVGF
T895	PSSGTTVTSVVGFSC
S896	SSGTTVTSVVGFSCD
S919	QDPTRKGSVVNVNPT
T926	SVVNVNPTNTRPQSD
S932	PTNTRPQSDTPEIRK
T934	NTRPQSDTPEIRKYK
Y1011	KKDKLRVYYLSWLRN
S1014	KLRVYYLSWLRNKIL
Y1045	DLEGCVHYKVVKYER
S1243	SVRSGGSSQVYFMTL
Y1246	SGGSSQVYFMTLGRT
T1249	SSQVYFMTLGRTSLL

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