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Protein Page:
HGK (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HGK a Ser/Thr kinase of the STE20 subfamily. May play a role in the response to environmental stress and cytokines such as TNF-alpha. May interact with the SH3 domain of the adapter proteins Nck. Binds, via its CNH regulatory domain, to the N- terminal region of SPG3A. Upregulated in primary tumors and tumor cell lines. Required for anchorage-independent growth and ras-dependent focus formation in multiple cell lines. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, STE; EC 2.7.11.1; STE group; STE20 family; MSN subfamily
Cellular Component: cytoplasm
Molecular Function: protein serine/threonine kinase activity; protein binding; ATP binding; receptor signaling protein serine/threonine kinase activity; small GTPase regulator activity
Biological Process: regulation of catalytic activity; protein amino acid phosphorylation; regulation of JNK cascade
Reference #:  O95819 (UniProtKB)
Alt. Names/Synonyms: FLH21957; FLJ10410; FLJ20373; FLJ90111; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; HGK; HPK/GCK-like kinase HGK; KIAA0687; M4K4; MAP4K4; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; Mitogen-activated protein kinase kinase kinase kinase 4; Nck-interacting kinase; NIK; ZC1
Gene Symbols: MAP4K4
Molecular weight: 142,101 Da
Basal Isoelectric point: 7.09  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HGK

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 3 S5-p ___MANDsPAKSLVD
0 1 T35-p VEVVGNGtyGQVYKG
0 4 Y36-p EVVGNGtyGQVYKGR
0 8 Y86-p HRNIATYyGAFIKKS
0 2 T124-p VKNTKGNtLKEDWIA
0 1 Y132-p LKEDWIAyISREILR
0 4 S175-p KLVDFGVsAQLDRtV
0 19 T181-p VsAQLDRtVGRRNtF
0 94 T187-p RtVGRRNtFIGTPyW
0 1 Y193-p NtFIGTPyWMAPEVI
0 16 S264-p KWSKKFFsFIEGCLV
0 1 K285-ub PSTEQLLkHPFIRDQ
0 1 Y323-p KDETEYEysGsEEEE
0 4 S324-p DETEYEysGsEEEEE
0 5 S326-p TEYEysGsEEEEEEV
0 1 T351-p VNVPGEStLRRDFLR
0 7 Y467-p RVEREQEyIRRQLEE
0 7 Y520-p QLQQEQAyLLsLQHD
0 4 S523-p QEQAyLLsLQHDHRR
0 10 S536-p RRPHPQHsQQPPPPQ
0 1 S550-p QQERSKPsFHAPEPK
0 71 Y560-p APEPKAHyEPADRAR
0 2 S580-p FRKTNHSsPEAQSKQ
0 5 S598-p VLEPPVPsRsEsFsN
0 1 S600-p EPPVPsRsEsFsNGN
0 3 S602-p PVPsRsEsFsNGNSE
0 1 S604-p PsRsEsFsNGNSESV
0 2 - gap
0 2 - gap
0 14 - gap
0 2 - gap
0 4 - gap
0 1 T627-p EPQVPVRttsRsPVL
0 3 T628-p PQVPVRttsRsPVLS
0 19 S629-p QVPVRttsRsPVLSR
0 31 S631-p PVRttsRsPVLSRRD
0 32 S639-p PVLSRRDsPLQGsGQ
0 3 S644-p RDsPLQGsGQQNsQA
0 9 S649-p QGsGQQNsQAGQRNs
0 11 S656-p sQAGQRNsTSIEPRL
0 2 T657 QAGQRNsTSIEPRLL
0 3 - gap
0 7 S677-p KLVPRPGsGsssGss
0 4 S679-p VPRPGsGsssGssNs
0 2 S680-p PRPGsGsssGssNsG
0 2 S681-p RPGsGsssGssNsGS
0 3 S683-p GsGsssGssNsGSQP
0 1 S684-p sGsssGssNsGSQPG
0 1 S686-p sssGssNsGSQPGsH
0 9 S692-p NsGSQPGsHPGsQsG
0 13 S696-p QPGsHPGsQsGsGER
0 8 S698-p GsHPGsQsGsGERFR
0 15 S700-p HPGsQsGsGERFRVR
0 51 S708-p GERFRVRsssKsEGs
1 8 S709-p ERFRVRsssKsEGsP
1 109 S710-p RFRVRsssKsEGsPs
0 3 S712-p RVRsssKsEGsPsQR
0 14 S715-p sssKsEGsPsQRLEN
0 17 S717-p sKsEGsPsQRLENAV
0 1 S791-p EGADESTsGPEDTRA
0 22 S800-p PEDTRAAssLNLsNG
0 10 S801-p EDTRAAssLNLsNGE
0 18 S805-p AAssLNLsNGEtEsV
0 1 T809-p LNLsNGEtEsVKTMI
0 1 S811-p LsNGEtEsVKTMIVH
0 11 S823-p IVHDDVEsEPAMtPs
0 7 T828-p VEsEPAMtPsKEGtL
0 7 S830-p sEPAMtPsKEGtLIV
0 1 K831 EPAMtPsKEGtLIVR
0 12 T834-p MtPsKEGtLIVRQtQ
0 5 - gap
0 32 - gap
0 1 - gap
0 1 - gap
0 1 T840-p GtLIVRQtQsASStL
0 3 S842-p LIVRQtQsASStLQK
0 1 S845 RQtQsASStLQKHKs
0 5 T846-p QtQsASStLQKHKss
0 2 S852-p StLQKHKssssFtPF
0 2 S853-p tLQKHKssssFtPFI
0 2 S854-p LQKHKssssFtPFID
0 6 S855-p QKHKssssFtPFIDP
0 4 T857-p HKssssFtPFIDPRL
0 2 S868-p DPRLLQIsPssGttV
0 1 S870-p RLLQIsPssGttVts
0 1 S871-p LLQIsPssGttVtsV
0 2 T873-p QIsPssGttVtsVVG
0 3 T874-p IsPssGttVtsVVGF
0 3 T876-p PssGttVtsVVGFSC
0 5 S877-p ssGttVtsVVGFSCD
0 27 S900-p QDPTRKGsVVNVNPt
0 1 T907-p sVVNVNPtNTRPQsD
0 4 S913-p PtNTRPQsDtPEIRK
0 10 T915-p NTRPQsDtPEIRKYK
0 1 Y992-p KKDKLRVyYLsWLRN
0 8 S995-p KLRVyYLsWLRNKIL
0 1 Y1026 DLEGCVHYKVVKYER
0 1 S1224-p SVRSGGSsQVyFMtL
0 11 Y1227-p SGGSsQVyFMtLGRT
0 1 T1230-p SsQVyFMtLGRTSLL
  HGK iso3  
- gap
- gap
- gap
Y66 HRNIATYYGAFIKKS
T104 VKNTKGNTLKEDWIA
Y112 LKEDWIAYISREILR
S155 KLVDFGVSAQLDRTV
T161 VSAQLDRTVGRRNTF
T167 RTVGRRNTFIGTPYW
Y173 NTFIGTPYWMAPEVI
S244 KWSKKFFSFIEGCLV
K265 PSTEQLLKHPFIRDQ
Y303 KDETEYEYSGSEEEE
S304 DETEYEYSGSEEEEE
S306 TEYEYSGSEEEEEEV
T331 VNVPGESTLRRDFLR
Y447 RVEREQEYIRRQLEE
- gap
- gap
S485 RRPHPQHSQQPPPPQ
S499 QQERSKPSFHAPEPK
Y509 APEPKAHYEPADRAR
- gap
- gap
- gap
- gap
- gap
S525 VQWSHLASLKNNVSP
S531 ASLKNNVSPVSRSHs
S538-p SPVSRSHsFsDPsPK
S540-p VSRSHsFsDPsPKFA
S543-p SHsFsDPsPKFAHHH
T599 PPRVPVRTTSRSPVL
T600 PRVPVRTTSRSPVLS
S601 RVPVRTTSRSPVLSR
S603 PVRTTSRSPVLSRRD
S611-p PVLSRRDsPLQGSGQ
S616 RDsPLQGSGQQNsQA
S621-p QGSGQQNsQAGQRNs
S628-p sQAGQRNsTSsIEPR
T629 QAGQRNsTSsIEPRL
S631-p GQRNsTSsIEPRLLW
S650 KLVPRPGSGSSSGSS
S652 VPRPGSGSSSGSSNS
S653 PRPGSGSSSGSSNSG
S654 RPGSGSSSGSSNSGS
S656 GSGSSSGSSNSGSQP
S657 SGSSSGSSNSGSQPG
S659 SSSGSSNSGSQPGSH
S665 NSGSQPGSHPGSQSG
S669 QPGSHPGSQSGSGER
S671 GSHPGSQSGSGERFR
S673 HPGSQSGSGERFRVR
S681 GERFRVRSSSKSEGS
S682 ERFRVRSSSKSEGSP
S683 RFRVRSSSKSEGSPS
S685 RVRSSSKSEGSPSQR
S688 SSSKSEGSPSQRLEN
S690 SKSEGSPSQRLENAV
S767 EGADESTSGPEDTRA
S776 PEDTRAASSLNLSNG
S777 EDTRAASSLNLSNGE
S781 AASSLNLSNGETESV
T785 LNLSNGETESVKTMI
S787 LSNGETESVKTMIVH
S799 IVHDDVESEPAMtPs
T804-p VESEPAMtPsKEGtL
S806-p SEPAMtPsKEGtLIV
K807 EPAMtPsKEGtLIVR
T810-p MtPsKEGtLIVRQst
S816-p GtLIVRQstVDQKRA
T817-p tLIVRQstVDQKRAS
S824 tVDQKRASHHESNGF
S860 TSSSPSSSQPTPTMS
T880 DKLTANETQSASstL
S882 LTANETQSASstLQK
S885-p NETQSASstLQKHKS
T886-p ETQSASstLQKHKSS
S892 stLQKHKSSSSFTPF
S893 tLQKHKSSSSFTPFI
S894 LQKHKSSSSFTPFID
S895 QKHKSSSSFTPFIDP
T897 HKSSSSFTPFIDPRL
S908 DPRLLQISPSSGTTV
S910 RLLQISPSSGTTVTS
S911 LLQISPSSGTTVTSV
T913 QISPSSGTTVTSVVG
T914 ISPSSGTTVTSVVGF
T916 PSSGTTVTSVVGFSC
S917 SSGTTVTSVVGFSCD
S940 QDPTRKGSVVNVNPT
T947 SVVNVNPTNTRPQSD
S953 PTNTRPQSDTPEIRK
T955 NTRPQSDTPEIRKYK
Y1032 KKDKLRVYYLSWLRN
S1035 KLRVYYLSWLRNKIL
Y1066 DLEGCVHYKVVKYER
S1264 SVRSGGSSQVYFMTL
Y1267 SGGSSQVYFMTLGRT
T1270 SSQVYFMTLGRTSLL
  HGK iso5  
S5 ___MANDSPAKSLVD
T35 VEVVGNGTYGQVYKG
Y36 EVVGNGTYGQVYKGR
Y86 HRNIATYYGAFIKKS
T124 VKNTKGNTLKEDWIA
Y132 LKEDWIAYISREILR
S175 KLVDFGVSAQLDRTV
T181 VSAQLDRTVGRRNTF
T187 RTVGRRNTFIGTPYW
Y193 NTFIGTPYWMAPEVI
S264 KWSKKFFSFIEGCLV
K285 PSTEQLLKHPFIRDQ
Y323 KDETEYEYSGSEEEE
S324 DETEYEYSGSEEEEE
S326 TEYEYSGSEEEEEEV
T351 VNVPGESTLRRDFLR
Y467 RVEREQEYIRRQLEE
- gap
- gap
S505 RRPHPQHSQQPPPPQ
S519 QQERSKPSFHAPEPK
Y529 APEPKAHYEPADRAR
- gap
- gap
- gap
- gap
- gap
S545-p VQWSHLAsLKNNVsP
S551-p AsLKNNVsPVSRSHs
S558-p sPVSRSHsFsDPsPK
S560-p VSRSHsFsDPsPKFA
S563-p SHsFsDPsPKFAHHH
T619 PPRVPVRTTSRSPVL
T620 PRVPVRTTSRSPVLS
S621 RVPVRTTSRSPVLSR
S623 PVRTTSRSPVLSRRD
S631 PVLSRRDSPLQGSGQ
S636 RDSPLQGSGQQNSQA
S641 QGSGQQNSQAGQRNS
S648 SQAGQRNSTSIEPRL
T649 QAGQRNSTSIEPRLL
- gap
S669 KLVPRPGSGSSSGSS
S671 VPRPGSGSSSGSSNS
S672 PRPGSGSSSGSSNSG
S673 RPGSGSSSGSSNSGS
S675 GSGSSSGSSNSGSQP
S676 SGSSSGSSNSGSQPG
S678 SSSGSSNSGSQPGSH
S684 NSGSQPGSHPGSQSG
S688 QPGSHPGSQSGSGER
S690 GSHPGSQSGSGERFR
S692 HPGSQSGSGERFRVR
S700 GERFRVRSSSKSEGS
S701 ERFRVRSSSKSEGSP
S702 RFRVRSSSKSEGSPS
S704 RVRSSSKSEGSPSQR
S707 SSSKSEGSPSQRLEN
S709 SKSEGSPSQRLENAV
S786 EGADESTSGPEDTRA
S795 PEDTRAASSLNLSNG
S796 EDTRAASSLNLSNGE
S800 AASSLNLSNGETESV
T804 LNLSNGETESVKTMI
S806 LSNGETESVKTMIVH
S818 IVHDDVESEPAMTPS
T823 VESEPAMTPSKEGTL
S825 SEPAMTPSKEGTLIV
K826 EPAMTPSKEGTLIVR
T829 MTPSKEGTLIVRQTQ
- gap
- gap
- gap
- gap
T835 GTLIVRQTQSASSTL
S837 LIVRQTQSASSTLQK
S840 RQTQSASSTLQKHKS
T841 QTQSASSTLQKHKSS
S847 STLQKHKSSSSFTPF
S848 TLQKHKSSSSFTPFI
S849 LQKHKSSSSFTPFID
S850 QKHKSSSSFTPFIDP
T852 HKSSSSFTPFIDPRL
S863 DPRLLQISPSSGTTV
S865 RLLQISPSSGTTVTS
S866 LLQISPSSGTTVTSV
T868 QISPSSGTTVTSVVG
T869 ISPSSGTTVTSVVGF
T871 PSSGTTVTSVVGFSC
S872 SSGTTVTSVVGFSCD
S895 QDPTRKGSVVNVNPT
T902 SVVNVNPTNTRPQSD
S908 PTNTRPQSDTPEIRK
T910 NTRPQSDTPEIRKYK
Y987 KKDKLRVYYLSWLRN
S990 KLRVYYLSWLRNKIL
Y1021 DLEGCVHYKVVKYER
S1227 SVRSGGSSQVYFMTL
Y1230 SGGSSQVYFMTLGRT
T1233 SSQVYFMTLGRTSLL
  HGK iso7  
- gap
- gap
- gap
Y26 HRNIATYYGAFIKKS
T64 VKNTKGNTLKEDWIA
Y72 LKEDWIAYISREILR
S115 KLVDFGVSAQLDRTV
T121 VSAQLDRTVGRRNtF
T127-p RTVGRRNtFIGTPYW
Y133 NtFIGTPYWMAPEVI
S204 KWSKKFFSFIEGCLV
K225 PSTEQLLKHPFIRDQ
Y263 KDETEYEYSGSEEEE
S264 DETEYEYSGSEEEEE
S266 TEYEYSGSEEEEEEV
T291 VNVPGESTLRRDFLR
Y407 RVEREQEYIRRQLEE
Y460 QLQQEQAYLLSLQHD
S463 QEQAYLLSLQHDHRR
S476 RRPHPQHSQQPPPPQ
S490 QQERSKPSFHAPEPK
Y500 APEPKAHYEPADRAR
S520 FRKTNHSSPEAQSKQ
S538 VLEPPVPSRSESFSN
S540 EPPVPSRSESFSNGN
S542 PVPSRSESFSNGNSE
S544 PSRSESFSNGNSESV
S570 VQWSHLASLKNNVsP
S576-p ASLKNNVsPVSRSHs
S583-p sPVSRSHsFsDPsPK
S585-p VSRSHsFsDPsPKFA
S588-p SHsFsDPsPKFAHHH
T644 PPRVPVRTTSRSPVL
T645 PRVPVRTTSRSPVLS
S646 RVPVRTTSRSPVLSR
S648 PVRTTSRSPVLSRRD
S656-p PVLSRRDsPLQGSGQ
S661 RDsPLQGSGQQNsQA
S666-p QGSGQQNsQAGQRNs
S673-p sQAGQRNstSsIEPR
T674-p QAGQRNstSsIEPRL
S676-p GQRNstSsIEPRLLW
S695 KLVPRPGSGSSSGSS
S697 VPRPGSGSSSGSSNS
S698 PRPGSGSSSGSSNSG
S699 RPGSGSSSGSSNSGS
S701 GSGSSSGSSNSGSQP
S702 SGSSSGSSNSGSQPG
S704 SSSGSSNSGSQPGSH
S710 NSGSQPGSHPGSQSG
S714 QPGSHPGSQSGSGER
S716 GSHPGSQSGSGERFR
S718 HPGSQSGSGERFRVR
S726-p GERFRVRsssKSEGs
S727-p ERFRVRsssKSEGsP
S728-p RFRVRsssKSEGsPs
S730 RVRsssKSEGsPsQR
S733-p sssKSEGsPsQRLEN
S735-p sKSEGsPsQRLENAV
S812 EGADESTSGPEDTRA
S821-p PEDTRAAssLNLSNG
S822-p EDTRAAssLNLSNGE
S826 AAssLNLSNGETESV
T830 LNLSNGETESVKTMI
S832 LSNGETESVKTMIVH
S844 IVHDDVESEPAMTPS
T849 VESEPAMTPSKEGTL
S851 SEPAMTPSKEGTLIV
K852 EPAMTPSKEGTLIVR
T855 MTPSKEGTLIVRQTQ
- gap
- gap
- gap
- gap
T861 GTLIVRQTQSASSTL
S863 LIVRQTQSASSTLQK
S866 RQTQSASSTLQKHKS
T867 QTQSASSTLQKHKSS
S873 STLQKHKSSSSFTPF
S874 TLQKHKSSSSFTPFI
S875 LQKHKSSSSFTPFID
S876 QKHKSSSSFTPFIDP
T878 HKSSSSFTPFIDPRL
S889 DPRLLQISPSSGTTV
S891 RLLQISPSSGTTVTS
S892 LLQISPSSGTTVTSV
T894 QISPSSGTTVTSVVG
T895 ISPSSGTTVTSVVGF
T897 PSSGTTVTSVVGFSC
S898 SSGTTVTSVVGFSCD
S921 QDPTRKGSVVNVNPT
T928 SVVNVNPTNTRPQSD
S934 PTNTRPQSDTPEIRK
T936 NTRPQSDTPEIRKYK
Y1013 KKDKLRVYYLSWLRN
S1016 KLRVYYLSWLRNKIL
Y1047 DLEGCVHYKVVKYER
S1245 SVRSGGSSQVyFMTL
Y1248-p SGGSSQVyFMTLGRT
T1251 SSQVyFMTLGRTSLL
  mouse

► Hide Isoforms
 
S5 ___MANDSPAKSLVD
T35 VEVVGNGTYGQVYKG
Y36 EVVGNGTYGQVYKGR
Y85 HRNIATYYGAFIKKS
T123 VKNTKGNTLKEDWIA
Y131 LKEDWIAYISREILR
S174-p KLVDFGVsAQLDRtV
T180-p VsAQLDRtVGRRNtF
T186-p RtVGRRNtFIGTPyW
Y192-p NtFIGTPyWMAPEVI
S263 KWSKKFFSFIEGCLV
K284 PSTEQLLKHPFIRDQ
Y322-p KDETEYEysGsEEEE
S323-p DETEYEysGsEEEEE
S325-p TEYEysGsEEEEEEV
T350 VNVPGESTLRRDFLR
Y466 RVEREQEYIRRQLEE
- gap
- gap
- gap
S517 QQDRSKPSFHAPEPK
Y527 APEPKPHYDPADRAR
- gap
- gap
- gap
- gap
- gap
S543-p VQWSHLAsLKNNVsP
S549-p AsLKNNVsPVSRSHs
S556-p sPVSRSHsFsDPsPK
S558-p VSRSHsFsDPsPKFA
S561-p SHsFsDPsPKFAHHH
T617 PPRVPVRTtsRsPVL
T618-p PRVPVRTtsRsPVLS
S619-p RVPVRTtsRsPVLSR
S621-p PVRTtsRsPVLSRRD
S629-p PVLSRRDsPLQGGGQ
G634 RDsPLQGGGQQNSQA
S639 QGGGQQNSQAGQRNs
S646-p SQAGQRNstSsIEPR
T647-p QAGQRNstSsIEPRL
S649-p GQRNstSsIEPRLLW
S668 KLVPRPGSGSSSGSS
S670 VPRPGSGSSSGSSNS
S671 PRPGSGSSSGSSNSG
S672 RPGSGSSSGSSNSGS
S674 GSGSSSGSSNSGSQP
S675 SGSSSGSSNSGSQPG
S677 SSSGSSNSGSQPGSH
S683 NSGSQPGSHPGsQsG
S687-p QPGSHPGsQsGsGER
S689-p GSHPGsQsGsGERFR
S691-p HPGsQsGsGERFRVR
S699-p GERFRVRsSsKSEGs
S700 ERFRVRsSsKSEGsP
S701-p RFRVRsSsKSEGsPs
S703 RVRsSsKSEGsPsPR
S706-p sSsKSEGsPsPRQES
S708-p sKSEGsPsPRQESAA
S785 EGADDSTSGPEDTRA
S794-p PEDTRAAssPNLsNG
S795-p EDTRAAssPNLsNGE
S799-p AAssPNLsNGETESV
T803 PNLsNGETESVKTMI
S805 LsNGETESVKTMIVH
S817 IVHDDVESEPAMTPs
T822 VESEPAMTPskEGTL
S824-p SEPAMTPskEGTLIV
K825-ac EPAMTPskEGTLIVR
T828 MTPskEGTLIVRQTQ
- gap
- gap
- gap
- gap
T834 GTLIVRQTQSASSTL
S836 LIVRQTQSASSTLQK
S839 RQTQSASSTLQKHKs
T840 QTQSASSTLQKHKss
S846-p STLQKHKssssFtPF
S847-p TLQKHKssssFtPFI
S848-p LQKHKssssFtPFID
S849-p QKHKssssFtPFIDP
T851-p HKssssFtPFIDPRL
S862 DPRLLQISPSSGTtV
S864 RLLQISPSSGTtVts
S865 LLQISPSSGTtVtsV
T867 QISPSSGTtVtsVVG
T868-p ISPSSGTtVtsVVGF
T870-p PSSGTtVtsVVGFSC
S871-p SSGTtVtsVVGFSCD
S894-p QDPTRKGsVVNVNPT
T901 sVVNVNPTNTRPQSD
S907 PTNTRPQSDtPEIRK
T909-p NTRPQSDtPEIRKYK
Y986 KKDKLRVYYLsWLRN
S989-p KLRVYYLsWLRNKIL
Y1020-p DLEGCVHyKVVKYER
S1218 SVRSGGSSQVYFMTL
Y1221 SGGSSQVYFMTLGRT
T1224 SSQVYFMTLGRTSLL
  HGK iso3  
- gap
- gap
- gap
Y49 HRNIATYYGAFIKKS
T87 VKNTKGNTLKEDWIA
Y95 LKEDWIAYISREILR
S138 KLVDFGVSAQLDRTV
T144 VSAQLDRTVGRRNTF
T150 RTVGRRNTFIGKGPP
- gap
S190 KWSKKFFSFIEGCLV
K211 PSTEQLLKHPFIRDQ
Y249 KDETEYEYSGSEEEE
S250 DETEYEYSGSEEEEE
S252 TEYEYSGSEEEEEEV
T277 VNVPGESTLRRDFLR
Y393 RVEREQEYIRRQLEE
Y446 QLQQEQAYLLSLQHD
S449 QEQAYLLSLQHDHRR
- gap
S475 QQERSKPSFHAPEPK
Y485 APEPKPHYDPADRAR
- gap
- gap
- gap
- gap
- gap
S501 VQWSHLASLKNNVSP
S507 ASLKNNVSPVSRSHS
S514 SPVSRSHSFSDPSPK
S516 VSRSHSFSDPSPKFA
S519 SHSFSDPSPKFAHHH
T575 PPRVPVRTTSRSPVL
T576 PRVPVRTTSRSPVLS
S577 RVPVRTTSRSPVLSR
S579 PVRTTSRSPVLSRRD
S587 PVLSRRDSPLQGGGQ
G592 RDSPLQGGGQQNSQA
S597 QGGGQQNSQAGQRNS
S604 SQAGQRNSTSSIEPR
T605 QAGQRNSTSSIEPRL
S607 GQRNSTSSIEPRLLW
S626 KLVPRPGSGSSSGSS
S628 VPRPGSGSSSGSSNS
S629 PRPGSGSSSGSSNSG
S630 RPGSGSSSGSSNSGS
S632 GSGSSSGSSNSGSQP
S633 SGSSSGSSNSGSQPG
S635 SSSGSSNSGSQPGSH
S641 NSGSQPGSHPGSQSG
S645 QPGSHPGSQSGSGER
S647 GSHPGSQSGSGERFR
S649 HPGSQSGSGERFRVR
S657 GERFRVRSSSKSEGS
S658 ERFRVRSSSKSEGSP
S659 RFRVRSSSKSEGSPS
S661 RVRSSSKSEGSPSPR
S664 SSSKSEGSPSPRQES
S666 SKSEGSPSPRQESAA
S743 EGADDSTSGPEDTRA
S752 PEDTRAASSPNLSNG
S753 EDTRAASSPNLSNGE
S757 AASSPNLSNGETESV
T761 PNLSNGETESVKTMI
S763 LSNGETESVKTMIVH
S775 IVHDDVESEPAMTPS
T780 VESEPAMTPSKEGTL
S782 SEPAMTPSKEGTLIV
K783 EPAMTPSKEGTLIVR
T786 MTPSKEGTLIVRQSt
S792 GTLIVRQStVDQKRA
T793-p TLIVRQStVDQKRAs
S800-p tVDQKRAsHHESNGF
S836-p TSSSPSSsQPTPTMS
T856 DKLTANETQsASStL
S858-p LTANETQsASStLQK
S861 NETQsASStLQKHKS
T862-p ETQsASStLQKHKSS
S868 StLQKHKSSSSFTPF
S869 tLQKHKSSSSFTPFI
S870 LQKHKSSSSFTPFID
S871 QKHKSSSSFTPFIDP
T873 HKSSSSFTPFIDPRL
S884 DPRLLQISPSSGTTV
S886 RLLQISPSSGTTVTS
S887 LLQISPSSGTTVTSV
T889 QISPSSGTTVTSVVG
T890 ISPSSGTTVTSVVGF
T892 PSSGTTVTSVVGFSC
S893 SSGTTVTSVVGFSCD
S916 QDPTRKGSVVNVNPT
T923 SVVNVNPTNTRPQSD
S929 PTNTRPQSDTPEIRK
T931 NTRPQSDTPEIRKYK
Y1008 KKDKLRVYYLSWLRN
S1011 KLRVYYLSWLRNKIL
Y1042 DLEGCVHYKVVKYER
S1240 SVRSGGSSQVYFMTL
Y1243 SGGSSQVYFMTLGRT
T1246 SSQVYFMTLGRTSLL
  rat

► Hide Isoforms
 
- gap
- gap
- gap
Y31 HRNIATYYGAFIKKS
T69 VKNTKGNTLKEDWIA
Y77 LKEDWIAYISREILR
S120 KLVDFGVSAQLDRTV
T126 VSAQLDRTVGRRNtF
T132-p RTVGRRNtFIGTPYW
Y138 NtFIGTPYWMAPEVI
S209 KWSKKFFSFIEGCLV
K230 PSTEQLLKHPFIRDQ
Y268 KDETEYEYSGSEEEE
S269 DETEYEYSGSEEEEE
S271 TEYEYSGSEEEEEEV
T296 VNVPGESTLRRDFLR
Y412 RVEREQEYIRRQLEE
- gap
- gap
- gap
S462 QQDRSKPSYHAPEPK
Y472 APEPKPHYDPADRAR
- gap
- gap
- gap
- gap
- gap
S488 VQWSHLASLKNNVSP
S494 ASLKNNVSPVSRSHS
S501 SPVSRSHSFSDPSPK
S503 VSRSHSFSDPSPKFA
S506 SHSFSDPSPKFAHHH
T562 PPRVPVRTTSRSPVL
T563 PRVPVRTTSRSPVLS
S564 RVPVRTTSRSPVLSR
S566 PVRTTSRSPVLSRRD
S574-p PVLSRRDsPLQGSGQ
S579 RDsPLQGSGQQNSQA
S584 QGSGQQNSQAGQRNs
S591-p SQAGQRNsTSSIEPR
T592 QAGQRNsTSSIEPRL
S594 GQRNsTSSIEPRLLW
S613 KLVPRPGSGSSSGSS
S615 VPRPGSGSSSGSSNS
S616 PRPGSGSSSGSSNSG
S617 RPGSGSSSGSSNSGS
S619 GSGSSSGSSNSGSQP
S620 SGSSSGSSNSGSQPG
S622 SSSGSSNSGSQPGSH
S628 NSGSQPGSHPGSQSG
S632 QPGSHPGSQSGSGER
S634 GSHPGSQSGSGERFR
S636 HPGSQSGSGERFRVR
S644 GERFRVRSSSKSEGS
S645 ERFRVRSSSKSEGSP
S646 RFRVRSSSKSEGSPS
S648 RVRSSSKSEGSPSQR
S651 SSSKSEGSPSQRLEN
S653 SKSEGSPSQRLENAA
S730 EGADDSTSGPEDTRA
S739 PEDTRAASSLNLsNG
S740 EDTRAASSLNLsNGE
S744-p AASSLNLsNGETESV
T748 LNLsNGETESVKTMI
S750 LsNGETESVKTMIVH
S762 IVHDDVESEPAMTPS
T767 VESEPAMTPSKEGTL
S769 SEPAMTPSKEGTLIV
K770 EPAMTPSKEGTLIVR
T773 MTPSKEGTLIVRQTQ
- gap
- gap
- gap
- gap
T779 GTLIVRQTQSASSTL
S781 LIVRQTQSASSTLQK
S784 RQTQSASSTLQKHKS
T785 QTQSASSTLQKHKSS
S791 STLQKHKSSSSFTPF
S792 TLQKHKSSSSFTPFI
S793 LQKHKSSSSFTPFID
S794 QKHKSSSSFTPFIDP
T796 HKSSSSFTPFIDPRL
S807 DPRLLQISPSSGTTV
S809 RLLQISPSSGTTVTS
S810 LLQISPSSGTTVTSV
T812 QISPSSGTTVTSVVG
T813 ISPSSGTTVTSVVGF
T815 PSSGTTVTSVVGFSC
S816 SSGTTVTSVVGFSCD
S839-p QDPTRKGsVVNVNPT
T846 sVVNVNPTNTRPQSD
S852 PTNTRPQSDTPEIRK
T854 NTRPQSDTPEIRKYK
Y931 KKDKLRVYYLSWLRN
S934 KLRVYYLSWLRNKIL
Y965 DLEGCVHYKVVKYER
S1163 SVRSGGSSQVYFMTL
Y1166 SGGSSQVYFMTLGRT
T1169 SSQVYFMTLGRTSLL
  HGK iso3  
- gap
- gap
- gap
Y48 HRNIATYYGAFIKKS
T86 VKNTKGNTLKEDWIA
Y94 LKEDWIAYISREILR
S137 KLVDFGVSAQLDRTV
T143 VSAQLDRTVGRRNTF
T149 RTVGRRNTFIGTPYW
Y155 NTFIGTPYWMAPEPP
- gap
K215 PFTEQLLKHPFIRDQ
Y253 KDETEYEYSGSEEEE
S254 DETEYEYSGSEEEEE
S256 TEYEYSGSEEEEEEV
T281 VNVPGESTLRRDFLR
Y397 RVEREQEYIRRQLEE
Y450 QLQQEQAYLLSLQHD
S453 QEQAYLLSLQHDHRR
- gap
S478 QQDRSKPSYHAPEPK
Y488 APEPKPHYDPADRAR
- gap
- gap
- gap
- gap
- gap
S504 VQWSHLASLKNNVSP
S510 ASLKNNVSPVSRSHS
S517 SPVSRSHSFSDPSPK
S519 VSRSHSFSDPSPKFA
S522 SHSFSDPSPKFAHHH
T578 PPRVPVRTTSRSPVL
T579 PRVPVRTTSRSPVLS
S580 RVPVRTTSRSPVLSR
S582 PVRTTSRSPVLSRRD
S590 PVLSRRDSPLQGSGQ
S595 RDSPLQGSGQQNSQA
S600 QGSGQQNSQAGQRNS
S607 SQAGQRNSTSSIEPR
T608 QAGQRNSTSSIEPRL
S610 GQRNSTSSIEPRLLW
S629 KLVPRPGSGSSSGSS
S631 VPRPGSGSSSGSSNS
S632 PRPGSGSSSGSSNSG
S633 RPGSGSSSGSSNSGS
S635 GSGSSSGSSNSGSQP
S636 SGSSSGSSNSGSQPG
S638 SSSGSSNSGSQPGSH
S644 NSGSQPGSHPGSQSG
S648 QPGSHPGSQSGSGER
S650 GSHPGSQSGSGERFR
S652 HPGSQSGSGERFRVR
S660 GERFRVRSSSKSEGS
S661 ERFRVRSSSKSEGSP
S662 RFRVRSSSKSEGSPS
S664 RVRSSSKSEGSPSQR
S667 SSSKSEGSPSQRLEN
S669 SKSEGSPSQRLENAA
S746 EGADDSTSGPEDTRA
S755 PEDTRAASSLNLSNG
S756 EDTRAASSLNLSNGE
S760 AASSLNLSNGETESV
T764 LNLSNGETESVKTMI
S766 LSNGETESVKTMIVH
S778 IVHDDVESEPAMTPS
T783 VESEPAMTPSKEGTL
S785 SEPAMTPSKEGTLIV
K786 EPAMTPSKEGTLIVR
T789 MTPSKEGTLIVRQSt
S795 GTLIVRQStVDQKRA
T796-p TLIVRQStVDQKRAS
S803 tVDQKRASHHESNGF
S839 TSSSPSSSQPTPTMS
T859 DKLTANETQSASSTL
S861 LTANETQSASSTLQK
S864 NETQSASSTLQKHKS
T865 ETQSASSTLQKHKSS
S871 STLQKHKSSSSFTPF
S872 TLQKHKSSSSFTPFI
S873 LQKHKSSSSFTPFID
S874 QKHKSSSSFTPFIDP
T876 HKSSSSFTPFIDPRL
S887 DPRLLQISPSSGTTV
S889 RLLQISPSSGTTVTS
S890 LLQISPSSGTTVTSV
T892 QISPSSGTTVTSVVG
T893 ISPSSGTTVTSVVGF
T895 PSSGTTVTSVVGFSC
S896 SSGTTVTSVVGFSCD
S919 QDPTRKGSVVNVNPT
T926 SVVNVNPTNTRPQSD
S932 PTNTRPQSDTPEIRK
T934 NTRPQSDTPEIRKYK
Y1011 KKDKLRVYYLSWLRN
S1014 KLRVYYLSWLRNKIL
Y1045 DLEGCVHYKVVKYER
S1243 SVRSGGSSQVYFMTL
Y1246 SGGSSQVYFMTLGRT
T1249 SSQVYFMTLGRTSLL
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