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GluR4
an integral membrane protein belonging to the glutamate-gated ion channel family. L-glutamate (Glu) acts as an excitatory neurotransmitter at many synapses in the central nervous system. Glutamate receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA(quisqualate) > glutamate > kainate. Each of the four GluR proteins (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Channel, ligand-gated |
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Cellular Component: postsynaptic membrane; kainate selective glutamate receptor complex; cell soma; postsynaptic density; plasma membrane; terminal button; cell junction
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Molecular Function: extracellular-glutamate-gated ion channel activity; kainate selective glutamate receptor activity; ionotropic glutamate receptor activity; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
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Biological Process: synaptic transmission; glutamate signaling pathway; ionotropic glutamate receptor signaling pathway; transport; positive regulation of synaptic transmission, glutamatergic
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Reference #:
P48058 (UniProtKB)
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| Alt. Names/Synonyms: AMPA-selective glutamate receptor 4; GluR-4; GluR-D; GLUR4; GLUR4C; GLURD; Glutamate receptor 4; Glutamate receptor ionotropic, AMPA 4; glutamate receptor, ionotrophic, AMPA 4; GRIA4 |
| Gene Symbols: GRIA4 |
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Molecular weight: 100,871 Da
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Basal Isoelectric point: 8.32
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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Parkinson's Disease
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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