Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
CYP46A1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CYP46A1 Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase; EC 1.14.13.98; Membrane protein, integral
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: iron ion binding; cholesterol 24-hydroxylase activity; heme binding; steroid hydroxylase activity
Biological Process: nervous system development; bile acid biosynthetic process; bile acid metabolic process; xenobiotic metabolic process; cholesterol catabolic process; sterol metabolic process
Reference #:  Q9Y6A2 (UniProtKB)
Alt. Names/Synonyms: CH24H; Cholesterol 24-hydroxylase; CP46; CP46A; CYP46; CYP46A1; Cytochrome P450 46A1; cytochrome P450, family 46; cytochrome P450, family 46, subfamily A, polypeptide 1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)
Gene Symbols: CYP46A1
Molecular weight: 56,821 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Select Structure to View Below

CYP46A1

Protein Structure Not Found.


STRING  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K69 DVFLDWAKKYGPVVR
0 2 S146-p RVIDLAFsRsSLVSL
0 1 S148-p IDLAFsRsSLVSLME
0 1 R255 RFLRQVGRDWVQRRR
0 1 K339 VDEVIGSKRyLDFED
0 2 Y341-p EVIGSKRyLDFEDLG
0 1 Y352-p EDLGRLQyLsQVLKE
0 1 S354-p LGRLQyLsQVLKESL
0 1 K358 QyLsQVLKESLRLYP
0 1 K422 RFGPGAPKPRFTYFP
0 1 K477 LQEQATLKPLDPVLC
  mouse

 
K69-ub DVFLDWAkKYGPVVR
S146-p KVMDLAFsRSSLVSL
S148 MDLAFsRSSLVSLME
K255-ub RLLRQVGkDWVQRRR
K339-ub VDEVVGSkRHLDYED
H341 EVVGSkRHLDYEDLG
Y352 EDLGRLQYLSQVLkE
S354 LGRLQYLSQVLkESL
K358-ub QYLSQVLkESLRLYP
K422-ub RFGPGAPkPRFTYFP
K477 LQEQATLKPLDPVLC
  rat

 
K69 DVFLDWAKKYGPVVR
S146 RVMDLAFSRSSLVSL
S148 MDLAFSRSSLVSLMG
K255 RLLRQVGKDWVQRRR
K339 VDEVVGSKRHLDYED
H341 EVVGSKRHLDYEDLG
Y352 EDLGRLQYLSQVLKE
S354 LGRLQYLSQVLKESL
K358 QYLSQVLKESLRLYP
K422 RFGPGAPKPRFTYFP
K477-ub LQEQATLkPLDPVLC
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.