Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Belongs to the cytochrome P450 family. Note: This description may include information from UniProtKB.
Protein type: Lipid Metabolism - primary bile acid biosynthesis; EC 126.96.36.199; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 14q32.1
Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane
Molecular Function: iron ion binding; cholesterol 24-hydroxylase activity; heme binding; steroid hydroxylase activity
Biological Process: bile acid biosynthetic process; nervous system development; bile acid metabolic process; xenobiotic metabolic process; cholesterol catabolic process; sterol metabolic process
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.