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Protein Page:
CALCOCO1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
CALCOCO1 Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. Belongs to the CALCOCO family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Cellular Component: intracellular membrane-bound organelle; cytoplasm; nuclear chromatin; nucleus
Molecular Function: protein C-terminus binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; sequence-specific DNA binding; transcription coactivator activity; transcription cofactor activity; beta-catenin binding; chromatin binding
Biological Process: steroid hormone receptor signaling pathway; Wnt receptor signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; signal transduction
Reference #:  Q9P1Z2 (UniProtKB)
Alt. Names/Synonyms: CACO1; calcium binding and coiled-coil domain 1; Calcium-binding and coiled-coil domain-containing protein 1; CALCOCO1; Calphoglin; Cocoa; Coiled-coil coactivator protein; coiled-coil leucine zipper coactivator 1; inorganic pyrophosphatase activator; KIAA1536; PP13275; Sarcoma antigen NY-SAR-3
Gene Symbols: CALCOCO1
Molecular weight: 77,336 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
Select Structure to View Below

CALCOCO1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S4-p ____MEEsPLSRAPS
1 0 K29-sm RTYIPNTkVECHYTL
0 1 D134-ca LVTLEEAdGGSDILL
0 1 S208 QYKGISRSHGEITEE
0 1 S477-p RELTELRsALRVLQK
0 1 S562-p CERGDPGssPAGPRE
0 5 S563-p ERGDPGssPAGPREA
0 1 S571-p PAGPREAsPLVVISQ
0 1 T650-p TSTGGPAtPTWKECP
  mouse

 
S4 ____MEESSLSRAPS
K29 RTYIPNTKVECHYTL
D134 LVTLEEADGGSDILL
S208-p QYKGLSRsHGELSEE
S477 RELTELRSALRVLQK
S562 CESGNTSSsPPGPRE
S563-p ESGNTSSsPPGPREP
S571 PPGPREPSSLVVINQ
N650 ASPGVPANPPWKECP
  rat

 
S4 ____MEESSLSRAPS
K29 RTYVPNTKVECHYTL
D134 LVTLEEADGGSDILL
S208 QYKGLSRSHGELSEE
S477 RELTELRSALRVLQK
S562 CERGNTSSSPPGPRE
S563 ERGNTSSSPPGPRES
S571 PPGPRESSSLVVINQ
I650 ASTGVPAIPAWKECP
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