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Protein Page:
NDRG4 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
g O-GlcNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
NDRG4 Contributes to the maintenance of intracerebral BDNF levels within the normal range, which is necessary for the preservation of spatial learning and the resistance to neuronal cell death caused by ischemic stress. May enhance growth factor-induced ERK1 and ERK2 phosphorylation, including that induced by PDGF and FGF. May attenuate NGF-promoted ELK1 phosphorylation in a microtubule-dependent manner. Expressed predominantly in brain and heart. In the brain, detected in astrocytes. Isoform 1 and isoform 2 are only expressed in brain. Isoform 3 is expressed in both heart and brain. Up-regulated in glioblastoma multiforme cells. Belongs to the NDRG family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Cellular Component: cytoplasm; cytosol
Biological Process: response to stress; cell differentiation; cell growth
Reference #:  Q9ULP0 (UniProtKB)
Alt. Names/Synonyms: BDM1; Brain development-related molecule 1; DKFZp686I1615; FLJ30586; FLJ42011; KIAA1180; MGC19632; NDRG family member 4; NDRG4; Protein NDRG4; SMAP-8; smooth muscle-associated protein 8; Vascular smooth muscle cell-associated protein 8
Gene Symbols: NDRG4
Molecular weight: 38,459 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

NDRG4
Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  NetworKIN  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene


Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


  MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


        human

► Hide Isoforms 		 
0 1 K27 VVIRGSPKGNRPAIL
0 2 Y118-p IGVGAGAyVLAKFAL
0 1 K223 PGTVPNAKTLRCPVM
0 1 T253-p CNSKLDPtTTTFLKM
0 17 S298 YLKDRRLSGGAVPSA
0 8 S304 LSGGAVPSASMTRLA
0 11 S306 GGAVPSASMTRLARS
0 3 T308 AVPSASMTRLARSRt
0 4 T315-p TRLARSRtAsLTSAs
0 8 S317-p LARSRtAsLTSAsSV
0 1 T319 RSRtAsLTSAsSVDG
0 2 S320 SRtAsLTSAsSVDGS
0 2 S322-p tAsLTSAsSVDGSRP
0 2 S323 AsLTSAsSVDGSRPQ
0 1 S335 RPQACTHSESSEGLG
0 1 S337 QACTHSESSEGLGQV
  NDRG4 iso2  
K27 VVIRGSPKGNRPAIL
Y118 IGVGAGAYVLAKFAL
K223 PGTVPNAKTLRCPVM
T253 CNSKLDPTTTTFLKM
- gap
S291-p QGMGYMPsAsMTRLA
S293-p MGYMPsAsMTRLARS
T295 YMPsAsMTRLARSRT
T302 TRLARSRTASLTSAS
S304 LARSRTASLTSASSV
T306 RSRTASLTSASSVDG
S307 SRTASLTSASSVDGS
S309 TASLTSASSVDGSRP
S310 ASLTSASSVDGSRPQ
S322 RPQACTHSESSEGLG
S324 QACTHSESSEGLGQV
  mouse

► Hide Isoforms 		 
K27-u VVIRGSPkGNRPAIL
Y118 IGVGAGAYVLAKFAL
K223-u PGTVPNAkTLRCPVM
T253 CNSKLDPTTTTFLKM
S298-p HLKDRRLsGGAVPsA
S304-p LsGGAVPsAsMtRLA
S306-p GGAVPsAsMtRLARS
T308-p AVPsAsMtRLARSRt
T315-p tRLARSRtAsLtsAs
S317-p LARSRtAsLtsAssV
T319-p RSRtAsLtsAssVDG
S320-p SRtAsLtsAssVDGS
S322-p tAsLtsAssVDGSRP
S323-p AsLtsAssVDGSRPQ
S335-p RPQPCAHsDsSEGMG
S337-p QPCAHsDsSEGMGQV
  NDRG4 iso2  
K27 VVIRGSPKGNRPAIL
Y118 IGVGAGAYVLAKFAL
K223 PGTVPNAKTLRCPVM
T253 CNSKLDPTTTTFLKM
- gap
S291-p QGMGYMPsAsMtRLA
S293-p MGYMPsAsMtRLARS
T295-p YMPsAsMtRLARSRT
T302 tRLARSRTASLTSAS
S304 LARSRTASLTSASSV
T306 RSRTASLTSASSVDG
S307 SRTASLTSASSVDGS
S309 TASLTSASSVDGSRP
S310 ASLTSASSVDGSRPQ
S322 RPQPCAHSDSSEGMG
S324 QPCAHSDSSEGMGQV
  rat

 
K27 VVIRGSPKGNRPAIL
Y118 IGVGAGAYVLAKFAL
K223 PGTVPNAKTLRCPVM
T253 CNSKLDPTTTTFLKM
S298 HLKDRRLSGGAVPSA
S304 LSGGAVPSASMTRLA
S306 GGAVPSASMTRLARS
T308 AVPSASMTRLARSRT
T315 TRLARSRTAsLTSAs
S317-p LARSRTAsLTSAssV
T319 RSRTAsLTSAssVDG
S320 SRTAsLTSAssVDGS
S322-p TAsLTSAssVDGSRP
S323-p AsLTSAssVDGSRPQ
S335 RPQPCTHSDSSEGMG
S337 QPCTHSDSSEGMGQV
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