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Protein Page:
TNC (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
TNC Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis
Cellular Component: extracellular matrix; extracellular space; membrane; extracellular region; basement membrane
Molecular Function: syndecan binding
Biological Process: osteoblast differentiation; extracellular matrix organization and biogenesis; response to ethanol; wound healing; response to mechanical stimulus; positive regulation of cell proliferation; response to wounding; negative regulation of cell adhesion; cell adhesion; axon regeneration in the peripheral nervous system; neuromuscular junction development; odontogenesis of dentine-containing teeth
Reference #:  P24821 (UniProtKB)
Alt. Names/Synonyms: 150-225; Cytotactin; Glioma-associated-extracellular matrix antigen; GMEM; GP; GP 150-225; Hexabrachion; hexabrachion (tenascin); HXB; JI; MGC167029; Myotendinous antigen; Neuronectin; TENA; Tenascin; tenascin C; Tenascin-C; tenascin-C isoform 14/AD1/16; TN; TN-C; TNC
Gene Symbols: TNC
Molecular weight: 240,853 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TNC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S65-p LPVGSQCsVDLEsAs
0 2 S70-p QCsVDLEsAsGEKDL
0 6 S72-p sVDLEsAsGEKDLAP
0 1 R154 CLQPATGRLDTRPFC
0 1 K375 AGVDCSEKRCPADCH
0 1 Y491-p MCVCDDGyTGEDCRD
0 1 K719-ac LPAPEGLkFKSIKET
0 1 T800-p PGLKRVTtTRLDAPS
0 1 S807 tTRLDAPSQIEVKDV
0 2 T891 PAKETFTTGLDAPRN
0 1 S903-p PRNLRRVsQtDNSIT
0 1 T905-p NLRRVsQtDNSITLE
0 1 T1007-p SLTLLWKtPLAKFDR
0 1 Y1019-p FDRYRLNysLPtGQW
0 1 S1020-p DRYRLNysLPtGQWV
0 1 T1023-p RLNysLPtGQWVGVQ
0 1 Y1145 TPYTVSIYGVIQGYR
0 1 Y1418-p TPYRVSIyGVIRGYR
0 1 T1492-p NISGAERtAHISGLP
0 1 T1502-p ISGLPPStDFIVYLS
0 1 T1576 LLDPQEFTLSGTQRK
0 2 S1699-p GISKGRRsQtVsAIA
0 2 T1701-p SKGRRsQtVsAIATT
0 1 S1703-p GRRsQtVsAIATTAM
0 1 T1751-p YVPITGGtPSMVTVD
0 1 T1760-p SMVTVDGtKTQTRLV
0 1 Y1775-p KLIPGVEyLVsIIAM
0 1 S1778-p PGVEyLVsIIAMKGF
0 1 T1842-p GEKVPEItRtVsGNT
0 1 T1844-p KVPEItRtVsGNTVE
0 1 S1846-p PEItRtVsGNTVEYA
0 1 T1878-p KGPQKSStITAKFTt
0 1 T1885-p tITAKFTtDLDsPRD
0 1 S1889-p KFTtDLDsPRDLTAT
0 1 T1902-p ATEVQSEtALLtWRP
0 1 T1906-p QSEtALLtWRPPRAS
0 1 Y2070-p KITAQGQyELRVDLR
0 1 S2091 FAVYDKFSVGDAKTR
0 1 T2129-p FSTFDKDtDSAItNC
0 1 T2134-p KDtDSAItNCALSYK
  mouse

 
S65 LPMGSQCSVDLEsAs
S70-p QCSVDLEsAsGEKDL
S72-p SVDLEsAsGEKDLTP
R154-m1 CLQPAEGrLDTRPFC
K375-ac AGADCSEkRCPADCH
Y491 MCICDDDYTGEDCRD
K719 LPAPEGLKFKSIKET
T800 PGLKKVTTTRLDAPs
S807-p TTRLDAPsHIEVKDV
T891-p PAKETFItGLDAPRN
S903 PRNLRRVSQTDNSIT
T905 NLRRVSQTDNSITLE
T1007 SLTFFWTTPLAKFDR
Y1019 FDRYRLNYSLPTGQS
S1020 DRYRLNYSLPTGQSM
T1023 RLNYSLPTGQSMEVQ
Y1145-p TSYRVSIyGVARGYR
Y1327 TPYRVSIYGVIQGYR
T1401 NISGAERTAHISGLP
T1411 ISGLPPSTDFIVYLS
T1485-p LLDPQEFtLSGTQRK
S1608 GISRGRRSQPVSAIA
P1610 SRGRRSQPVSAIATT
S1612 GRRSQPVSAIATTAM
A1660 YVPMTGGAPSMVTVD
T1669 SMVTVDGTDTETRLV
Y1684 KLTPGVEYRVSVIAM
S1687 PGVEYRVSVIAMKGF
T1751 GERVPEVTRTVSGNT
T1753 RVPEVTRTVSGNTVE
S1755 PEVTRTVSGNTVEYE
T1787 KGQQKSSTIATKFTT
T1794 TIATKFTTDLDSPRE
S1798 KFTTDLDSPREFTAT
T1811 ATEVQSETALLTWRP
T1815 QSETALLTWRPPRAS
Y1979 KITAQGQYELRVDLQ
S2000-p YAVYDRFsVGDAKSR
T2038 FSTYDKDTDSAITNC
T2043 KDTDSAITNCALSYK
  rat

 
S65 LPMGSQCSVDLESTS
S70 QCSVDLESTSGEKDL
S72 SVDLESTSGEKDLSP
R154 CLQPAEGRLDSRPFC
K375 AGADCSEKRCPADCH
Y491 MCICDDDYTGEDCRD
K719 LPAPEGLKFKSIKET
T800 PGLKKVTTTRLDAPS
S807 TTRLDAPSQIEVRDI
T891 PAKETFITGLDAPRN
S903 PRNLRRVSQTDNSIT
T905 NLRRVSQTDNSITLE
T1007 SLTLFWKTPLAKFDR
Y1019 FDRYRLNYSLPTGQS
S1020 DRYRLNYSLPTGQSI
T1023 RLNYSLPTGQSIEIQ
Y1145 TPYRVSIYGVARGYK
Y1327 TPYRVSIYGVIQGYR
T1401 NISGAERTAHISGLP
T1411 ISGLPPSTDFIVYLS
- gap
S1517 GISRGRRSQPVSAIA
P1519 SRGRRSQPVSAIATT
S1521 GRRSQPVSAIATTAM
P1569 YVPVTGGPPSMVTVD
T1578 SMVTVDGTDTETRLV
Y1593 RLTPGVEYHVSVIAM
S1596 PGVEYHVSVIAMKGF
T1660 GERVPEITRTVSGNT
T1662 RVPEITRTVSGNTVE
S1664 PEITRTVSGNTVEFE
T1696 KGHQKSSTIATKFTT
T1703 TIATKFTTDLDSPRE
S1707 KFTTDLDSPRELTAT
T1720 ATEVQSETAFLTWRP
T1724 QSETAFLTWRPPRAS
Y1888 KITAQGQYELRVDLQ
S1909 YAVYDRFSVGDAkSR
T1947 FSTYDKDTDSAITNC
T1952 KDTDSAITNCALSYK
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