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Protein Page:
TNC (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
TNC Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Cellular Component: extracellular matrix; extracellular space; extracellular region; basement membrane
Molecular Function: syndecan binding
Biological Process: extracellular matrix organization and biogenesis; response to ethanol; wound healing; response to mechanical stimulus; positive regulation of cell proliferation; response to wounding; negative regulation of cell adhesion; cell adhesion; axon regeneration in the peripheral nervous system; neuromuscular junction development; odontogenesis of dentine-containing teeth
Reference #:  P24821 (UniProtKB)
Alt. Names/Synonyms: 150-225; Cytotactin; Glioma-associated-extracellular matrix antigen; GMEM; GP; GP 150-225; Hexabrachion; hexabrachion (tenascin); HXB; JI; MGC167029; Myotendinous antigen; Neuronectin; TENA; Tenascin; tenascin C; Tenascin-C; tenascin-C isoform 14/AD1/16; TN; TN-C; TNC
Gene Symbols: TNC
Molecular weight: 240,853 Da
Basal Isoelectric point: 4.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TNC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S70 QCSVDLESAsGEKDL
0 5 S72-p SVDLESAsGEKDLAP
0 1 R154 CLQPATGRLDTRPFC
0 2 T891 PAKETFTTGLDAPRN
0 1 T1576 LLDPQEFTLSGTQRK
0 2 S1699-p GISKGRRsQtVSAIA
0 2 T1701-p SKGRRsQtVSAIATT
0 1 T1902-p ATEVQSEtALLtWRP
0 1 T1906-p QSEtALLtWRPPRAS
0 1 S2091 FAVYDKFSVGDAKTR
  mouse

 
S70-p QCSVDLEsAsGEKDL
S72-p SVDLEsAsGEKDLTP
R154-m1 CLQPAEGrLDTRPFC
T891-p PAKETFItGLDAPRN
T1485-p LLDPQEFtLSGTQRK
S1608 GISRGRRSQPVSAIA
P1610 SRGRRSQPVSAIATT
T1811 ATEVQSETALLTWRP
T1815 QSETALLTWRPPRAS
S2000-p YAVYDRFsVGDAKSR
  rat

 
S70 QCSVDLESTSGEKDL
S72 SVDLESTSGEKDLSP
R154 CLQPAEGRLDSRPFC
T891 PAKETFITGLDAPRN
- gap
S1517 GISRGRRSQPVSAIA
P1519 SRGRRSQPVSAIATT
T1720 ATEVQSETAFLTWRP
T1724 QSETAFLTWRPPRAS
S1909 YAVYDRFSVGDAKSR
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