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Protein Page:
INDO (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
INDO Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.52; Oxidoreductase; Cell cycle regulation
Chromosomal Location of Human Ortholog: 8p12-p11
Cellular Component: stereocilium bundle; smooth muscle contractile fiber; cytosol
Molecular Function: electron carrier activity; metal ion binding; indoleamine 2,3-dioxygenase activity; heme binding; tryptophan 2,3-dioxygenase activity
Biological Process: regulation of activated T cell proliferation; positive regulation of T-helper 2 type immune response; negative regulation of interleukin-10 production; positive regulation of chronic inflammatory response; positive regulation of interleukin-12 production; tryptophan catabolic process to kynurenine; response to lipopolysaccharide; female pregnancy; negative regulation of T cell proliferation; cytokine production during acute inflammatory response; multicellular organismal response to stress; tryptophan catabolic process; positive regulation of T cell tolerance induction
Reference #:  P14902 (UniProtKB)
Alt. Names/Synonyms: I23O1; IDO; IDO-1; IDO1; INDO; indole 2,3-dioxygenase; Indoleamine 2,3-dioxygenase 1; indoleamine-pyrrole 2,3 dioxygenase; Indoleamine-pyrrole 2,3-dioxygenase
Gene Symbols: IDO1
Molecular weight: 45,326 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

INDO

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y111 PRNIAVPYCQLSKKL
0 1 L211 ASCLEKALQVFHQIH
1 0 Y249 QLSDGLVYEGFWEDP
0 1 Y332-p DAGLREAyDACVKAL
0 1 S372-p NKTSEDPsKLEAKGT
0 1 T390-p DLMNFLKtVRSTTEK
  mouse

 
Y115-p PRNIAVPyCELSEKL
- under review  
Y253-p KLPEGLLyEGVWDTP
Y336 NEDLTKAYNECVNGL
S376 GDKSEEPSNVESRGT
S394 NPMTFLRSVKDTTEK
  rat

 
Y115 PRNLAVPYCELSEKL
K215-ac AASLEKAkEIFKRMR
Y253 KLPEGLLYEGVWDTP
Y336 NEDLKEAYNECVNGL
S376 GHKSEEPSNTENRGT
S394 DVMNFLRSVKDTTKK
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