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Protein Page:
INDO (human)

Overview
INDO Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.52; Cell cycle regulation; Oxidoreductase
Cellular Component: smooth muscle contractile fiber; stereocilium bundle; cytosol
Molecular Function: electron carrier activity; metal ion binding; heme binding; indoleamine 2,3-dioxygenase activity; tryptophan 2,3-dioxygenase activity
Biological Process: positive regulation of T-helper 2 type immune response; negative regulation of interleukin-10 production; positive regulation of chronic inflammatory response; positive regulation of apoptosis; positive regulation of interleukin-12 production; tryptophan catabolic process to kynurenine; negative regulation of activated T cell proliferation; response to lipopolysaccharide; female pregnancy; cytokine production during acute inflammatory response; tryptophan catabolic process; multicellular organismal response to stress; positive regulation of T cell tolerance induction
Reference #:  P14902 (UniProtKB)
Alt. Names/Synonyms: I23O1; IDO; IDO-1; IDO1; INDO; indole 2,3-dioxygenase; Indoleamine 2,3-dioxygenase 1; indoleamine-pyrrole 2,3 dioxygenase; Indoleamine-pyrrole 2,3-dioxygenase
Gene Symbols: IDO1
Molecular weight: 45,326 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

INDO

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
1 0 Y111 PRNIAVPYCQLSKKL
1 0 Y249 QLSDGLVYEGFWEDP
  mouse

 
Y115-p PRNIAVPyCELSEKL
Y253-p KLPEGLLyEGVWDTP
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