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INDO (human)

Overview INDO Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family. Note: This description may include information from UniProtKB. Protein type: Amino Acid Metabolism - tryptophan; EC 1.13.11.52; Cell cycle regulation; Oxidoreductase Cellular Component: smooth muscle contractile fiber; stereocilium bundle; cytosol Molecular Function: amino acid binding; electron carrier activity; metal ion binding; indoleamine 2,3-dioxygenase activity; heme binding; oxygen binding; tryptophan 2,3-dioxygenase activity Biological Process: positive regulation of T-helper 2 type immune response; positive regulation of chronic inflammatory response; negative regulation of interleukin-10 production; tryptophan catabolic process to kynurenine; positive regulation of interleukin-12 production; positive regulation of apoptosis; behavior; negative regulation of activated T cell proliferation; response to lipopolysaccharide; female pregnancy; cytokine production during acute inflammatory response; tryptophan catabolic process; multicellular organismal response to stress; positive regulation of T cell tolerance induction Reference #:  P14902 (UniProtKB) Alt. Names/Synonyms: I23O1; IDO; IDO-1; IDO1; INDO; indole 2,3-dioxygenase; Indoleamine 2,3-dioxygenase 1; indoleamine-pyrrole 2,3 dioxygenase; Indoleamine-pyrrole 2,3-dioxygenase Gene Symbols: IDO1 Molecular weight: 45,326 Da Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below INDO 2D0T - A/B=1-403 (human) 2D0U - A/B=1-403 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 2D0T 2D0U  |  ENZYME  |  Phospho3D  |  DISEASE  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
1	0		Y111	PRNIAVPYCQLSKKL
1	0		Y249	QLSDGLVYEGFWEDP
0	1		Y332-p	DAGLREAyDACVKAL
0	1		S372-p	NKTSEDPsKLEAKGT
0	1		T390-p	DLMNFLKtVRSTTEK

	mouse
Y115-p	PRNIAVPyCELSEKL
Y253-p	KLPEGLLyEGVWDTP
Y336	NEDLTKAYNECVNGL
S376	GDKSEEPSNVESRGT
S394	NPMTFLRSVKDTTEK

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