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IL33
Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
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| Protein type: Cytokine |
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Cellular Component: extracellular space; extracellular region; nucleus
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Molecular Function: cytokine activity
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Biological Process: negative regulation of T-helper 1 type immune response; positive regulation of T-helper 2 type immune response; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response
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Reference #:
Q8BVZ5 (UniProtKB)
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| Alt. Names/Synonyms: 9230117N10Rik; IL-33; Il1f11; Il33; interleukin 33; Interleukin-33; NF-HEV; nuclear factor from high endothelial venules |
| Gene Symbols: Il33 |
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Molecular weight: 29,991 Da
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Basal Isoelectric point: 8.83
Predict pI for various phosphorylation states
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