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Protein Page:
IL33 (mouse)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
IL33 Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cytokine
Cellular Component: extracellular space; extracellular region; cytoplasmic vesicle; chromosome; nucleus
Molecular Function: cytokine activity
Biological Process: negative regulation of T-helper 1 type immune response; positive regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; negative regulation of interferon-gamma production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of macrophage activation; positive regulation of inflammatory response
Reference #:  Q8BVZ5 (UniProtKB)
Alt. Names/Synonyms: 9230117N10Rik; IL-33; Il1f11; Il33; interleukin 33; Interleukin-33; NF-HEV; nuclear factor from high endothelial venules
Gene Symbols: Il33
Molecular weight: 29,991 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
Select Structure to View Below

IL33

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       mouse

 
0 1 K16 NSKISPAKFSSTAGE
0 1 S170-p SPCPASQsGDGVDGK
  human

 
K16-ac TNKISTAkWKNTASK
S173 SQHPSNESGDGVDGK
  rat

 
K16 NSKISPAKCDSTSGR
S168 ESSFPAQSGDGVDGK
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