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IL10 (human)

Overview IL10 Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells. Belongs to the IL-10 family. Note: This description may include information from UniProtKB. Protein type: Motility/polarity/chemotaxis; Cytokine; Secreted; Secreted, signal peptide Cellular Component: extracellular space; intracellular Molecular Function: growth factor activity; cytokine activity; interleukin-10 receptor binding Biological Process: B cell proliferation; negative regulation of chronic inflammatory response to antigenic stimulus; regulation of isotype switching; positive regulation of transcription, DNA-dependent; leukocyte chemotaxis; response to glucocorticoid stimulus; negative regulation of B cell proliferation; negative regulation of membrane protein ectodomain proteolysis; response to insulin stimulus; negative regulation of interferon-alpha biosynthetic process; negative regulation of T cell proliferation; cytoplasmic sequestering of NF-kappaB; cell-cell signaling; positive regulation of MHC class II biosynthetic process; response to molecule of bacterial origin; negative regulation of interferon-gamma production; negative regulation of interleukin-6 production; negative regulation of tumor necrosis factor biosynthetic process; hemopoiesis; inflammatory response; response to drug; negative regulation of interleukin-12 production; positive regulation of B cell apoptosis; T-helper 2 type immune response; negative regulation of myeloid dendritic cell activation; negative regulation of nitric oxide biosynthetic process; negative regulation of tumor necrosis factor production; negative regulation of cytokine secretion during immune response; regulation of gene expression; B cell differentiation; defense response to bacterium; negative regulation of MHC class II biosynthetic process; positive regulation of transcription factor activity; receptor biosynthetic process; regulation of sensory perception of pain; response to activity; negative regulation of apoptosis; positive regulation of cytokine secretion Reference #:  P22301 (UniProtKB) Alt. Names/Synonyms: CSIF; Cytokine synthesis inhibitory factor; IL-10; IL10; IL10A; interleukin 10; Interleukin-10; MGC126450; MGC126451; TGIF Gene Symbols: IL10 Molecular weight: 20,517 Da Basal Isoelectric point: 8.19  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below IL10 1ILK - A=28-178 (human) 1INR - A=19-178 (human) 1LK3 - A/B=26-178 (human) 2H24 - A=19-178 (human) 2ILK - A=19-178 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1ILK 1INR 1LK3 2H24 2ILK  |  Phospho3D  |  DISEASE 124092 180300  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

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