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Protein Page:
ICOSLG (human)

Overview
ICOSLG Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. Belongs to the immunoglobulin superfamily. BTN/MOG family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane; external side of plasma membrane
Molecular Function: receptor binding
Biological Process: hyperosmotic response; positive regulation of interleukin-4 biosynthetic process; B cell activation; T cell activation; T cell costimulation; defense response; signal transduction; positive regulation of activated T cell proliferation
Reference #:  O75144 (UniProtKB)
Alt. Names/Synonyms: B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS ligand; ICOS-L; ICOSL; ICOSLG; inducible T-cell co-stimulator ligand; KIAA0653; LICOS; transmembrane protein B7-H2 ICOS ligand
Gene Symbols: ICOSLG
Molecular weight: 33,349 Da
Basal Isoelectric point: 5.15  Predict pI for various phosphorylation states
Select Structure to View Below

ICOSLG

Protein Structure Not Found.


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Modification Sites and Domains  

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