Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Protein Page:
HPSE2 (human)

Overview
HPSE2 Binds heparin and heparan sulfate with high affinity, but lacks heparanase activity. Inhibits HPSE, possibly by competing for its substrates (in vitro). Defects in HPSE2 are the cause of urofacial syndrome (UFS). A rare autosomal recessive characterized by facial grimacing when attempting to smile and failure of the urinary bladder to void completely despite a lack of anatomical bladder outflow obstruction or overt neurological damage. Affected individuals often have reflux of infected urine from the bladder to the upper renal tract, with a risk of kidney damage and renal failure. Belongs to the glycosyl hydrolase 79 family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Glycan Metabolism - glycosaminoglycan degradation; Hydrolase; EC 3.2.-.-
Cellular Component: proteinaceous extracellular matrix; plasma membrane; intracellular
Molecular Function: heparan sulfate proteoglycan binding; heparanase activity
Biological Process: glycosaminoglycan catabolic process; glycosaminoglycan metabolic process; carbohydrate metabolic process
Reference #:  Q8WWQ2 (UniProtKB)
Alt. Names/Synonyms: FLJ11684; FLJ44022; heparanase 2; heparanase 3; Heparanase-2; heparanase-like protein; HPA2; HPR2; HPSE2; MGC133234
Gene Symbols: HPSE2
Molecular weight: 66,596 Da
Basal Isoelectric point: 9.95  Predict pI for various phosphorylation states
Select Structure to View Below

HPSE2

Protein Structure Not Found.


STRING  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  DISEASE  |  Scansite  |  Pfam  |  ENZYME  |  Phospho.ELM  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 21 T120-p LRFGGKRtDFLQFQN
0 3 S300-p IRIYSRAsLyGPNIG
0 1 Y302-p IYSRAsLyGPNIGRP
0 1 T351-p KVMDFLKtRLLDTLS
0 1 T370-p KIQKVVNtYTPGKKI
  mouse

 
T120-p LRFGGKRtDFLQFQN
S300 IRVYSRASLYGPNIG
Y302 VYSRASLYGPNIGRP
T351 KVMDFLKTRLLDTLS
T370 KIQKVVNTYTPGKKI
  rat

 
T120 LRFGGKRTDFLQFQN
G300 IRIYSRAGLYGPSIG
Y302 IYSRAGLYGPSIGRP
T351 KVMDFLKTRLLDTLS
T370 KIQKVVNTYTPGKKI
Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.