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Protein Page:
HPRT1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HPRT1 Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS). LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation. Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT); also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Nucleotide Metabolism - purine; EC 2.4.2.8; Transferase; Xenobiotic Metabolism - drug metabolism - other enzymes
Chromosomal Location of Human Ortholog: Xq26.1
Cellular Component: cytoplasm; cytosol
Molecular Function: protein binding; protein homodimerization activity; nucleotide binding; magnesium ion binding; hypoxanthine phosphoribosyltransferase activity
Biological Process: grooming behavior; hypoxanthine metabolic process; lymphocyte proliferation; IMP salvage; striatum development; GMP salvage; nucleobase, nucleoside and nucleotide metabolic process; cytolysis; dendrite morphogenesis; response to amphetamine; locomotory behavior; adenine salvage; purine nucleotide biosynthetic process; dopamine metabolic process; purine salvage; purine base metabolic process; cerebral cortex neuron differentiation; protein homotetramerization; GMP catabolic process; positive regulation of dopamine metabolic process; IMP metabolic process; hypoxanthine salvage; purine ribonucleoside salvage; guanine salvage; central nervous system neuron development
Disease: Kelley-seegmiller Syndrome; Lesch-nyhan Syndrome
Reference #:  P00492 (UniProtKB)
Alt. Names/Synonyms: HGPRT; HGPRTase; HPRT; HPRT1; hypoxanthine phosphoribosyltransferase 1; Hypoxanthine-guanine phosphoribosyltransferase
Gene Symbols: HPRT1
Molecular weight: 24,579 Da
Basal Isoelectric point: 6.21  Predict pI for various phosphorylation states
Select Structure to View Below

HPRT1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 S5-p ___MATRsPGVVIsD
0 4 S11-p RsPGVVIsDDEPGYD
0 2 K83 ADLLDYIKALNRNSD
0 1 K83 ADLLDYIKALNRNSD
0 1 S92-p LNRNSDRsIPMtVDF
0 1 T96-p SDRsIPMtVDFIRLk
0 1 K103-ub tVDFIRLksYCNDQS
0 1 S104-p VDFIRLksYCNDQST
0 1 K115-ac DQSTGDIkVIGGDDL
0 4 K115-ub DQSTGDIkVIGGDDL
0 3 K128 DLSTLTGKNVLIVED
0 2 T142-p DIIDTGKtMQtLLsL
0 1 T145-p DTGKtMQtLLsLVRQ
0 2 S148-p KtMQtLLsLVRQYNP
0 1 R151 QtLLsLVRQYNPKMV
0 13 R151 QtLLsLVRQYNPKMV
0 1 K156 LVRQYNPKMVkVASL
0 2 K156 LVRQYNPKMVkVASL
0 1 K159 QYNPKMVKVASLLVK
0 8 K159-ub QYNPKMVkVASLLVK
0 1 K166 kVASLLVKRTPRSVG
0 4 K175-ub TPRSVGYkPDFVGFE
  mouse

 
S5 ___MPTRSPSVVIsD
S11-p RSPSVVIsDDEPGYD
K83-ac ADLLDYIkALNRNSD
K83-ub ADLLDYIkALNRNSD
S92 LNRNSDRSIPMTVDF
T96 SDRSIPMTVDFIRLk
K103-ub TVDFIRLkSYCNDQS
S104 VDFIRLkSYCNDQST
K115 DQSTGDIKVIGGDDL
K115-ub DQSTGDIkVIGGDDL
K128-ub DLSTLTGkNVLIVED
T142 DIIDTGKTMQTLLsL
T145 DTGKTMQTLLsLVkQ
S148-p KTMQTLLsLVkQYSP
K151 QTLLsLVKQYSPkMV
K151-ub QTLLsLVkQYSPkMV
K156 LVkQYSPKMVkVASL
K156-ub LVkQYSPkMVkVASL
K159 QYSPkMVKVASLLVK
K159-ub QYSPkMVkVASLLVK
K166 kVASLLVKRTSRSVG
R175 TSRSVGYRPDFVGFE
  rat

 
S5 ___MSTLSPSVVISD
S11 LSPSVVISDDEPGYD
K83-ac ADLLDYIkALNRNSD
K83 ADLLDYIKALNRNSD
S92 LNRNSDRSIPMTVDF
T96 SDRSIPMTVDFIRLK
K103 TVDFIRLKSYCNDQS
S104 VDFIRLKSYCNDQST
K115 DQSTGDIKVIGGDDL
K115-ub DQSTGDIkVIGGDDL
K128 DLSTLTGKNVLIVED
T142-p DIIDTGKtMQTLLSL
T145 DTGKtMQTLLSLVkQ
S148 KtMQTLLSLVkQYSP
K151-ac QTLLSLVkQYSPkMV
K151-ub QTLLSLVkQYSPkMV
K156-ac LVkQYSPkMVkVASL
K156-ub LVkQYSPkMVkVASL
K159-ac QYSPkMVkVASLLVk
K159 QYSPkMVKVASLLVk
K166-ac kVASLLVkRTSRSVG
R175 TSRSVGYRPDFVGFE
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