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Protein Page:
HES1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HES1 Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. Note: This description may include information from UniProtKB.
Protein type: Transcription factor; Motility/polarity/chemotaxis; Cell development/differentiation
Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; histone deacetylase binding; transcription factor binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; midbrain-hindbrain boundary morphogenesis; radial glial cell differentiation in the forebrain; hindbrain morphogenesis; somatic stem cell maintenance; regulation of fat cell differentiation; regulation of timing of neuron differentiation; cell maturation; positive regulation of JAK-STAT cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of cell proliferation; midbrain development; adenohypophysis development; protein complex assembly; trochlear nerve development; positive regulation of T cell proliferation; cell adhesion; positive regulation of mitotic cell cycle, embryonic; oculomotor nerve development; positive regulation of BMP signaling pathway; positive regulation of Notch signaling pathway; positive regulation of DNA binding; positive regulation of astrocyte differentiation; STAT protein nuclear translocation; nervous system development; smoothened signaling pathway; Notch signaling pathway; cell migration; auditory receptor cell fate determination; thymus development; liver development; endocrine pancreas development; negative regulation of oligodendrocyte differentiation; telencephalon development; lateral inhibition; negative regulation of auditory receptor cell differentiation; neuron morphogenesis during differentiation; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; lung development
Reference #:  Q14469 (UniProtKB)
Alt. Names/Synonyms: BHLHB39; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1; hairy and enhancer of split 1, (Drosophila); Hairy homolog; Hairy-like protein; HES-1; HES1; hHL; HL; HRY; Transcription factor HES-1
Gene Symbols: HES1
Molecular weight: 29,541 Da
Basal Isoelectric point: 9.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HES1

Protein Structure Not Found.


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Sites Implicated In
cytoskeletal reorganization: S37‑p, S38‑p
transcription, altered: S37‑p, S38‑p
molecular association, regulation: S37‑p, S38‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S11-p DIMEKNSsSPVAATP
0 1 T24-p TPASVNTtPDKPKTA
0 2 S32-p PDKPKTAsEHRKssK
1 0 S37-p TAsEHRKssKPIMEK
1 1 S38-p AsEHRKssKPIMEKR
0 1 S55-p ARINESLsQLKtLIL
0 1 T59-p ESLsQLKtLILDALK
0 1 K86-ub DILEMTVkHLRNLQR
0 1 T97-p NLQRAQMtAALSTDP
0 1 K109-ub TDPSVLGkYRAGFSE
1 0 S262 SVGPNAVSPSSGPSL
  mouse

 
S11 DIMEKNSSSPVAATP
T24 TPASVNTTPDKPKTA
S32 PDKPKTASEHRKSSK
S37 TASEHRKSSKPIMEK
S38 ASEHRKSSKPIMEKR
S55 ARINESLSQLKTLIL
T59 ESLSQLKTLILDALK
K86 DILEMTVKHLRNLQR
T97 NLQRAQMTAALSTDP
K109 TDPSVLGKYRAGFSE
S264 SVGPNAVSPSSGSSL
  rat

 
S11 DIMEKNSSSPVAATP
T24 TPASVNTTPDKPKTA
S32 PDKPKTASEHRKSSK
S37 TASEHRKSSKPIMEK
S38 ASEHRKSSKPIMEKR
S55 ARINESLSQLKTLIL
T59 ESLSQLKTLILDALK
K86 DILEMTVKHLRNLQR
T97 NLQRAQMTAALSTDP
K109 TDPSVLGKYRAGFSE
S263-p SVGPNAVsPSSGSSL
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