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HES1 (human)

Overview HES1 Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. Note: This description may include information from UniProtKB. Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Cellular Component: cytoplasm; nucleus Molecular Function: protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; histone deacetylase binding; transcription factor activity; transcription factor binding Biological Process: hindbrain morphogenesis; midbrain-hindbrain boundary morphogenesis; radial glial cell differentiation in the forebrain; somatic stem cell maintenance; regulation of fat cell differentiation; regulation of timing of neuron differentiation; cell maturation; positive regulation of JAK-STAT cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; midbrain development; positive regulation of cell proliferation; adenohypophysis development; protein complex assembly; trochlear nerve development; positive regulation of T cell proliferation; cell adhesion; oculomotor nerve development; positive regulation of mitotic cell cycle, embryonic; positive regulation of BMP signaling pathway; positive regulation of Notch signaling pathway; STAT protein nuclear translocation; positive regulation of DNA binding; positive regulation of astrocyte differentiation; nervous system development; cell migration; smoothened signaling pathway; Notch signaling pathway; pharyngeal system development; thymus development; auditory receptor cell fate determination; in utero embryonic development; liver development; endocrine pancreas development; negative regulation of oligodendrocyte differentiation; telencephalon development; lateral inhibition; negative regulation of auditory receptor cell differentiation; neuron morphogenesis during differentiation; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; lung development Reference #:  Q14469 (UniProtKB) Alt. Names/Synonyms: BHLHB39; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1; hairy and enhancer of split 1, (Drosophila); Hairy homolog; Hairy-like protein; HES-1; HES1; hHL; HL; HRY; Transcription factor HES-1 Gene Symbols: HES1 Molecular weight: 29,541 Da Basal Isoelectric point: 9.66  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HES1

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	Sites Implicated In
cytoskeletal reorganization: S37‑p, S38‑p transcription, altered: S37‑p, S38‑p molecular association, regulation: S37‑p, S38‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		T24-p	TPASVNTtPDKPKTA
0	2		S32-p	PDKPKTAsEHRKssK
1	0		S37-p	TAsEHRKssKPIMEK
1	1		S38-p	AsEHRKssKPIMEKR
0	1		S55-p	ARINESLsQLKtLIL
0	1		T59-p	ESLsQLKtLILDALK
0	1		K86-u	DILEMTVkHLRNLQR
0	1		K109-u	TDPSVLGkYRAGFSE
1	0		S262	SVGPNAVSPSSGPSL

	mouse
T24	TPASVNTTPDKPKTA
S32	PDKPKTASEHRKSSK
S37	TASEHRKSSKPIMEK
S38	ASEHRKSSKPIMEKR
S55	ARINESLSQLKTLIL
T59	ESLSQLKTLILDALK
K86	DILEMTVKHLRNLQR
K109	TDPSVLGKYRAGFSE
S264	SVGPNAVSPSSGSSL

	rat
T24	TPASVNTTPDKPKTA
S32	PDKPKTASEHRKSSK
S37	TASEHRKSSKPIMEK
S38	ASEHRKSSKPIMEKR
S55	ARINESLSQLKTLIL
T59	ESLSQLKTLILDALK
K86	DILEMTVKHLRNLQR
K109	TDPSVLGKYRAGFSE
S263-p	SVGPNAVsPSSGSSL

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