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Protein Page:
HES1 (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
HES1 Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; histone deacetylase binding; transcription factor binding; transcription factor activity
Biological Process: radial glial cell differentiation in the forebrain; midbrain-hindbrain boundary morphogenesis; hindbrain morphogenesis; regulation of fat cell differentiation; somatic stem cell maintenance; regulation of timing of neuron differentiation; cell maturation; positive regulation of JAK-STAT cascade; negative regulation of transcription from RNA polymerase II promoter; positive regulation of tyrosine phosphorylation of Stat3 protein; midbrain development; positive regulation of cell proliferation; adenohypophysis development; trochlear nerve development; positive regulation of T cell proliferation; protein complex assembly; cell adhesion; oculomotor nerve development; positive regulation of mitotic cell cycle, embryonic; positive regulation of BMP signaling pathway; positive regulation of Notch signaling pathway; STAT protein nuclear translocation; positive regulation of astrocyte differentiation; positive regulation of DNA binding; nervous system development; cell migration; smoothened signaling pathway; Notch signaling pathway; pharyngeal system development; thymus development; auditory receptor cell fate determination; liver development; endocrine pancreas development; negative regulation of oligodendrocyte differentiation; telencephalon development; lateral inhibition; negative regulation of auditory receptor cell differentiation; neuron morphogenesis during differentiation; artery morphogenesis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; lung development
Reference #:  Q14469 (UniProtKB)
Alt. Names/Synonyms: BHLHB39; Class B basic helix-loop-helix protein 39; FLJ20408; Hairy and enhancer of split 1; hairy and enhancer of split 1, (Drosophila); Hairy homolog; Hairy-like protein; HES-1; HES1; hHL; HL; HRY; Transcription factor HES-1
Gene Symbols: HES1
Molecular weight: 29,541 Da
Basal Isoelectric point: 9.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HES1

Protein Structure Not Found.


STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene


Sites Implicated In
cytoskeletal reorganization: S37‑p, S38‑p
transcription, altered: S37‑p, S38‑p
molecular association, regulation: S37‑p, S38‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S11-p DIMEKNSsSPVAATP
0 1 T24-p TPASVNTtPDKPKTA
0 2 S32-p PDKPKTAsEHRKssK
1 0 S37-p TAsEHRKssKPIMEK
1 1 S38-p AsEHRKssKPIMEKR
0 1 K86-u DILEMTVkHLRNLQR
0 1 K109-u TDPSVLGkYRAGFSE
1 0 S262 SVGPNAVSPSSGPSL
  mouse

 
S11 DIMEKNSSSPVAATP
T24 TPASVNTTPDKPKTA
S32 PDKPKTASEHRKSSK
S37 TASEHRKSSKPIMEK
S38 ASEHRKSSKPIMEKR
K86 DILEMTVKHLRNLQR
K109 TDPSVLGKYRAGFSE
S264 SVGPNAVSPSSGSSL
  rat

 
S11 DIMEKNSSSPVAATP
T24 TPASVNTTPDKPKTA
S32 PDKPKTASEHRKSSK
S37 TASEHRKSSKPIMEK
S38 ASEHRKSSKPIMEKR
K86 DILEMTVKHLRNLQR
K109 TDPSVLGKYRAGFSE
S263-p SVGPNAVsPSSGSSL
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