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GFM2 (human)

Overview GFM2 Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation. Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Cellular Component: mitochondrion Molecular Function: GTPase activity; GTP binding; translation elongation factor activity Biological Process: mitochondrial translation; GTP catabolic process; ribosome disassembly Reference #:  Q969S9 (UniProtKB) Alt. Names/Synonyms: EF-G2mt; EFG2; Elongation factor G 2, mitochondrial; Elongation factor G2; G elongation factor, mitochondrial 2; GFM2; hEFG2; mEF-G 2; mitochondrial elongation factor G2; mitochondrial ribosome recycling factor 2; MRRF2; MST027; MSTP027; Ribosome-releasing factor 2, mitochondrial; RRF2; RRF2M; RRF2mt Gene Symbols: GFM2 Molecular weight: 86,601 Da Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states

Select Structure to View Below GFM2

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	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S11-p	NLRIFAMsHQtIPSV
0	1		T14-p	IFAMsHQtIPSVYIN
0	44		K233-a	IGEAKTFkGVVDVVM
0	1		K271-a	MNDPELLkETTEARN
0	1		S426-p	DQHVEIPsLTAGNIA
0	1		K451-u	GDTIVSSkSSALAAA
0	1		Y556-p	REYGLETyLGPLQVA
0	1		Y564-p	LGPLQVAyRETILNS
0	1		Y611-p	MPVIEFEyAEsINEG
0	1		S614-p	IEFEyAEsINEGLLK
0	1		T651	PIQDVAITLHSLTIH

	mouse
N11	KWRIFAVNHQRTFSV
R14	IFAVNHQRTFSVHLN
Q233	IGEARTFQGVVDVVN
K271	ASDRELLKETIEARN
S426	DQHVEIPSLTAGNIA
K451	GDTIVSSKSSALAAA
Y555	REYGLETYLGPLQVA
Y563	LGPLQVAYRETILNS
-	under review
-	under review
T648-p	PVQDVAMtLHSLMIH

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