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FOXP2 (human)

Overview FOXP2 Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB. Protein type: C2H2-type zinc finger protein; DNA binding protein Cellular Component: transcription factor complex; cytoplasm Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein homodimerization activity; DNA binding; zinc ion binding; protein heterodimerization activity; sequence-specific DNA binding; double-stranded DNA binding; chromatin binding; transcription factor binding; DNA bending activity; transcription factor activity Biological Process: skeletal muscle development; caudate nucleus development; camera-type eye development; righting reflex; putamen development; vocal learning; pattern specification process; post-embryonic development; smooth muscle development; embryonic development; regulation of transcription factor activity; positive regulation of mesenchymal cell proliferation; cerebellum development; cerebral cortex development; negative regulation of transcription, DNA-dependent; alveolus development; growth Reference #:  O15409 (UniProtKB) Alt. Names/Synonyms: CAG repeat protein 44; CAGH44; DKFZp686H1726; forkhead box P2; Forkhead box protein P2; forkhead/winged-helix transcription factor; FOXP2; SPCH1; TNRC10; trinucleotide repeat containing 10; Trinucleotide repeat-containing gene 10 protein Gene Symbols: FOXP2 Molecular weight: 79,919 Da Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below FOXP2 2A07 - H/F/J/K/I/G=502-594 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB  |  Phospho3D  |  DISEASE 602081 605317  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		K421	SEPKPSPKPLNLVSS
0	1		Y540-p	WFTRTFAyFRRNAAT
0	1		Y580-p	WTVDEVEyQKRRSQK
0	1		S591-p	RSQKITGsPTLVKNI
0	1		S688	EDEDCPMSLVTTANH
0	2		S711	EIEEEPLSEDLE___

	mouse
K420	SEPKPSPKPLNLVSS
Y539	WFTRTFAYFRRNAAT
Y579	WTVDEVEYQKRRSQK
S590	RSQKITGSPTLVKNI
S687-p	EDEDCPMsLVTTANH
S710-p	EIEEEPLsEDLE___

	rat
K442-u	SEPKPSPkPLNLVSS
Y561	WFTRTFAYFRRNAAT
Y601	WTVDEVEYQKRRSQK
S612	RSQKITGSPTLVKNI
S709	EDEDCPMSLVTTANH
S732	EIEEEPLSEDLE___

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