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Protein Page:
FOXP2 (human)

Overview
FOXP2 Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Involved in neural mechanisms mediating the development of speech and language. Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. 9 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA binding protein
Cellular Component: cytoplasm; nucleus
Molecular Function: protein homodimerization activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; metal ion binding; chromatin binding; DNA bending activity; transcription factor activity
Biological Process: caudate nucleus development; skeletal muscle development; camera-type eye development; transcription, DNA-dependent; righting reflex; putamen development; vocal learning; pattern specification process; post-embryonic development; smooth muscle development; embryonic development; positive regulation of mesenchymal cell proliferation; cerebellum development; cerebral cortex development; negative regulation of transcription, DNA-dependent; alveolus development; growth
Reference #:  O15409 (UniProtKB)
Alt. Names/Synonyms: CAG repeat protein 44; CAGH44; DKFZp686H1726; forkhead box P2; Forkhead box protein P2; forkhead/winged-helix transcription factor; FOXP2; SPCH1; TNRC10; trinucleotide repeat containing 10; Trinucleotide repeat-containing gene 10 protein
Gene Symbols: FOXP2
Molecular weight: 79,919 Da
Basal Isoelectric point: 6.06  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

FOXP2

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S591-p RSQKITGsPTLVKNI
0 2 S711 EIEEEPLSEDLE___
  mouse

 
S590 RSQKITGSPTLVKNI
S710-p EIEEEPLsEDLE___
  rat

 
S612 RSQKITGSPTLVKNI
S732 EIEEEPLSEDLE___
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