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Protein Page:
FAM20C (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
FAM20C an atypical serine protein kinase that localizes within the Golgi apparatus and is secreted. Distantly related to the Drosophila Golgi-localized kinase Four-jointed. Phosphorylates secretory proteins including the caseins and members of the small integrin-binding ligand, N-linked glycoprotein (SIBLING) protein family, which modulate biomineralization. Colocalizes with the Golgi resident protein GM130. Preferentially phosphorylates its targets within the S-x-E/pS motif. Requires Mn2+ as an alternative to Mg2+ as the activating cation. Defects in FAM20C are the cause of Raine syndrome (RNS). RNS is an autosomal recessive osteosclerotic bone dysplasia with neonatal lethal outcome. Clinical features include generalized osteosclerosis, craniofacial dysplasia and microcephaly. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Secreted, signal peptide
Cellular Component: Golgi apparatus; extracellular space
Molecular Function: protein serine/threonine kinase activity; calcium ion binding
Biological Process: positive regulation of osteoblast differentiation; regulation of fibroblast growth factor receptor signaling pathway; positive regulation of bone mineralization; skeletal development; regulation of phosphorus metabolic process; protein amino acid phosphorylation
Reference #:  Q8IXL6 (UniProtKB)
Alt. Names/Synonyms: Dentin matrix protein 4; DKFZp547C074; DMP-4; DMP4; FAM20C; family with sequence similarity 20, member C; Protein FAM20C; RNS
Gene Symbols: FAM20C
Molecular weight: 66,234 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
Select Structure to View Below

FAM20C

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S41-ga ERRGARPsGEPGCsC
0 1 S47-ga PsGEPGCsCAQPAAE
0 1 S74-ga PGEPPAAssAAGDAG
0 1 S75-ga GEPPAAssAAGDAGW
0 1 T87-ga AGWPNKHtLRILQDF
0 1 S100-p DFSSDPSsNLSSHSL
0 1 S148-ga RDPGPRRsEsPPGPG
0 1 S150-ga PGPRRsEsPPGPGGD
0 1 S254-p EALLHDLssQRITsV
0 1 S255-p ALLHDLssQRITsVA
0 1 S260-p LssQRITsVAMKSGG
0 1 Y279-p LIMTFQNyGQALFKP
0 1 A581 LDTEHRAASAR____
0 1 S582 DTEHRAASAR_____
  mouse

 
S41 DRRATRSSGEPGCSC
S47 SSGEPGCSCAQPAAE
- gap
S70 ARSRPGESAGGDAGW
T82 AGWPNKHTLRILQDF
S95 DFSSDPASNLTSHSL
R143 RDPGPRPRVPPPGPS
P145 PGPRPRVPPPGPSGD
G249 DALLRDLGSQKITSV
S250 ALLRDLGSQKITSVA
S255 LGSQKITSVAMKSGG
Y274 LIMTFQNYGQALFKP
S576-p LATEHRAstER____
T577-p ATEHRAstER_____
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