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Protein Page:
Klotho (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
Klotho May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. Defects in KL are a cause of hyperphosphatemic familial tumoral calcinosis (HFTC). A severe metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Some patients manifest recurrent, transient, painful swellings of the long bones associated with the radiographic findings of periosteal reaction and cortical hyperostosis and absence of skin involvement. Belongs to the glycosyl hydrolase 1 family. Klotho subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Hydrolase; EC 3.2.1.31; Membrane protein, integral
Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; extracellular region; integral to membrane
Molecular Function: vitamin D binding; signal transducer activity; beta-glucosidase activity; beta-glucuronidase activity; fibroblast growth factor binding; hormone activity; fibroblast growth factor receptor binding
Biological Process: calcium ion homeostasis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; carbohydrate metabolic process; energy reserve metabolic process; insulin receptor signaling pathway; innate immune response; positive regulation of bone mineralization; acute inflammatory response; aging
Reference #:  Q9UEF7 (UniProtKB)
Alt. Names/Synonyms: KL; KLOT; Klotho; Klotho peptide
Gene Symbols: KL
Molecular weight: 116,181 Da
Basal Isoelectric point: 8.06  Predict pI for various phosphorylation states
Select Structure to View Below

Klotho

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y497 PKSSALFYQkLIEKN
0 1 K499-ac SSALFYQkLIEKNGF
0 1 K794-ac PYFTEDEkKLIQGTF
0 1 K854 VVPWGLRKVLNWLKF
0 1 Q885 GLHAEDDQLRVYYMQ
0 1 Q892 QLRVYYMQNYINEAL
0 4 K942-ac FEPKASMkHYRKIID
0 1 K946 ASMkHYRKIIDSNGF
0 1 S981-p SFFHTRKsLLAFIAF
  mouse

 
Y499-p PKSSALFyQKLIEDN
K501 SSALFyQKLIEDNGF
K796 PYFTEDEKKLVRGSF
K856-ub VVPWGLRkVLNWLRF
S887-p DPHAEQDsLRIYYIk
K894-ub sLRIYYIkNYVNEAL
K944 FEPKPSMKHYRkIID
K948-ub PSMKHYRkIIDSNGF
S983 GFFQTRKSLLVFISF
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