Home

Epiregulin (human)

Overview Epiregulin Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. Note: This description may include information from UniProtKB. Protein type: Membrane protein, integral Cellular Component: extracellular space; integral to plasma membrane; extracellular region Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding Biological Process: response to peptide hormone stimulus; wound healing; positive regulation of smooth muscle cell proliferation; positive regulation of interleukin-6 biosynthetic process; female meiosis; negative regulation of smooth muscle cell differentiation; negative regulation of cell proliferation; positive regulation of fibroblast proliferation; primary follicle stage, oogenesis; positive regulation of epidermal growth factor receptor activity; cell-cell signaling; positive regulation of cell proliferation; positive regulation of innate immune response; ovarian cumulus expansion; angiogenesis; negative regulation of epithelial cell proliferation; positive regulation of cytokine production; epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; positive regulation of cytokine biosynthetic process; keratinocyte proliferation; luteinizing hormone signaling pathway; oocyte maturation; keratinocyte differentiation; ovulation; organ morphogenesis; positive regulation of cell division; positive regulation of protein kinase activity; mRNA transcription; negative regulation of transcription, DNA-dependent; positive regulation of DNA replication; positive regulation of phosphorylation Reference #:  O14944 (UniProtKB) Alt. Names/Synonyms: Epiregulin; EPR; ER; EREG; Proepiregulin Gene Symbols: EREG Molecular weight: 19,044 Da Basal Isoelectric point: 7.49  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below Epiregulin 1K36 - A=63-108 (human) 1K37 - A=63-108 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1K36 1K37  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y144-p	TYYFCRWyRNRKSKE

	mouse
Y137	IYYFCRWYKNRKSKK

	rat
Y137	MYYFCRWYRNRKSKK

Home  |  Curator Login With enhanced literature mining using Linguamatics I2E Produced by 3rd Millennium  |  Design by Digizyme ©2003-2013 Cell Signaling Technology, Inc.