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Protein Page:
Epiregulin (human)

Epiregulin Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component: extracellular space; integral to plasma membrane; extracellular region; intracellular
Molecular Function: protein binding; growth factor activity; epidermal growth factor receptor binding
Biological Process: axon guidance; wound healing; activation of MAPKK activity; nerve growth factor receptor signaling pathway; activation of MAPK activity; positive regulation of smooth muscle cell proliferation; positive regulation of interleukin-6 biosynthetic process; female meiosis; negative regulation of smooth muscle cell differentiation; negative regulation of cell proliferation; primary follicle stage, oogenesis; positive regulation of fibroblast proliferation; cell-cell signaling; positive regulation of epidermal growth factor receptor activity; small GTPase mediated signal transduction; positive regulation of innate immune response; positive regulation of cell proliferation; ovarian cumulus expansion; angiogenesis; negative regulation of epithelial cell proliferation; positive regulation of cytokine production; epidermal growth factor receptor signaling pathway; anatomical structure morphogenesis; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; positive regulation of mitosis; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; positive regulation of cytokine biosynthetic process; keratinocyte proliferation; luteinizing hormone signaling pathway; oocyte maturation; ovulation; keratinocyte differentiation; organ morphogenesis; positive regulation of protein kinase activity; Ras protein signal transduction; mRNA transcription; insulin receptor signaling pathway; innate immune response; negative regulation of transcription, DNA-dependent; vascular endothelial growth factor receptor signaling pathway; positive regulation of DNA replication; positive regulation of phosphorylation
Reference #:  O14944 (UniProtKB)
Alt. Names/Synonyms: Epiregulin; EPR; ER; EREG; Proepiregulin
Gene Symbols: EREG
Molecular weight: 19,044 Da
Basal Isoelectric point: 7.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  

Show Multiple Sequence Alignment


LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.




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