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Protein Page:
EFNB3 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EFNB3 Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons. Belongs to the ephrin family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Ligand, receptor tyrosine kinase; Cell development/differentiation
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: transmembrane-ephrin receptor activity; ephrin receptor binding
Biological Process: axon guidance; nervous system development; viral reproduction; cell-cell signaling; axon choice point recognition; ephrin receptor signaling pathway; adult walking behavior
Reference #:  Q15768 (UniProtKB)
Alt. Names/Synonyms: EFL6; EFNB3; EPH-related receptor transmembrane ligand ELK-L3; EPH-related receptor tyrosine kinase ligand 8; Ephrin B3; Ephrin-B3; EPLG8; LERK-8; LERK8
Gene Symbols: EFNB3
Molecular weight: 35,835 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Select Structure to View Below

EFNB3

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 S268-p SRHPGPGsFGRGGsL
0 1 R271 PGPGsFGRGGsLGLG
0 7 S274-p GsFGRGGsLGLGGGG
0 6 Y311-p DPPFCPHyEKVSGDy
0 21 Y318-p yEKVSGDyGHPVyIV
0 14 Y323-p GDyGHPVyIVQDGPP
0 1 S332 VQDGPPQSPPNIyyK
0 3 Y337-p PQSPPNIyyKV____
0 1 Y338-p QSPPNIyyKV_____
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
  mouse

 
S268 SRHPGPGSFGrGGsL
R271-m1 PGPGSFGrGGsLGLG
S274-p GSFGrGGsLGLGGGG
Y311 DPPFCPHYEKVSGDy
Y318-p YEKVSGDyGHPVyIV
Y323-p GDyGHPVyIVQDGPP
S332-p VQDGPPQsPPNIYYK
Y337 PQsPPNIYYKV____
Y338 QsPPNIYYKV_____
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
3481 : Phospho-Ephrin B (Tyr324/329) Antibody
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