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Protein Page:
EFHC1 (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitination
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
EFHC1 microtubule-associated protein (MAP) that is abundant in sperm flagella and motile cilia but expressed at low levels in the adult brain. It is not present in immotile primary cilia. May enhance calcium influx through CACNA1E and stimulate programmed cell death. Interacts with the C-terminus of CACNA1E. Implicated in neuronal migration and may play a role during brain development. Mutations in EFHC1 gene have been previously reported in patients with epilepsies, including those with juvenile myoclonic epilepsy. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Cellular Component: cell soma; axoneme
Molecular Function: protein C-terminus binding; calcium ion binding
Reference #:  Q5JVL4 (UniProtKB)
Alt. Names/Synonyms: dJ304B14.2; EF-hand domain (C-terminal) containing 1; EF-hand domain-containing protein 1; EFHC1; FLJ10466; FLJ37290; Myoclonin-1
Gene Symbols: EFHC1
Molecular weight: 73,990 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Select Structure to View Below

EFHC1

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 T111-p QEDVPMStEEQyRIR
0 2 Y115-p PMStEEQyRIRQVNI
0 1 R296 PLLMNRQRVPKVLVE
0 1 T341-p SLTILGRtFFIyDCD
0 1 Y345-p LGRtFFIyDCDPFtR
0 1 T351-p IyDCDPFtRRYYKEK
0 1 S524-p ESNAAQYsPEALASI
  mouse

 
M111 QEDVPISMEEHYRIR
Y115 PISMEEHYRIRHVNI
R296-m1 PLLMNRQrMPKVLVE
T341 PLTILGRTFFIYDCD
Y345 LGRTFFIYDCDPFTR
T351 IYDCDPFTRQFYKDK
S524 ESNASQYSPEALASI
  rat

 
M111 QEDVPISMEEHYRIR
Y115 PISMEEHYRIRRVNI
R296 PLLMNRQRMPKVLVD
T341 PLTILGRTFFIYDCD
Y345 LGRTFFIYDCDPFTR
T351 IYDCDPFTRQFYKDK
S524 ESNASQYSPEALASI
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