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Protein Page:
EFEMP1 (human)

Overview
EFEMP1 Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. Defects in EFEMP1 are a cause of Doyne honeycomb retinal dystrophy (DHRD); also known as malattia leventinese (MLVT) (ML). DHRD is an autosomal dominant disease characterized by yellow-white deposits known as drusen that accumulate beneath the retinal pigment epithelium. Belongs to the fibulin family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region
Molecular Function: protein binding; epidermal growth factor receptor activity; growth factor activity; calcium ion binding; epidermal growth factor receptor binding
Biological Process: epidermal growth factor receptor signaling pathway; extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; visual perception; negative regulation of chondrocyte differentiation
Reference #:  Q12805 (UniProtKB)
Alt. Names/Synonyms: DHRD; DRAD; EFEMP1; EGF-containing fibulin-like extracellular matrix protein 1; Extracellular protein S1-5; FBLN3; FBNL; FIBL-3; Fibrillin-like protein; fibulin 3; Fibulin-3; FLJ35535; MGC111353; MLVT; MTLV; S1-5
Gene Symbols: EFEMP1
Molecular weight: 54,641 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Select Structure to View Below

EFEMP1

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 Y33-p YTQCTDGyEWDPVRQ
0 1 S151-p ADPQRIPsNPSHRIQ
0 1 S408-p RSDRSVPsDIFQIQA
0 1 T425-p IYANTINtFRIKSGN
0 1 S454-p AMLVLVKsLsGPREH
0 1 S456-p LVLVKsLsGPREHIV
  mouse

 
Y33 YTQCTDGYEWDPIRQ
S151 ADPQRIPSNPSHRIQ
S408 RSDRSVPSDIFQIQA
T425 IYANTINTFRIKSGN
S454 AMLVLVKSLSGPREY
S456 LVLVKSLSGPREYIV
  rat

 
Y33 YTQCTDGYEWDPVRQ
S151 ADPQRIPSNPSHRIQ
S408 RSDRSVPSDIFQIQA
T425 IYANTINTFRIKSGN
S454 AMLVLVKSLTGPREH
T456 LVLVKSLTGPREHIV
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