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DYNLL2 (human)

Overview DYNLL2 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures. Belongs to the dynein light chain family. Note: This description may include information from UniProtKB. Protein type: Motor protein; Microtubule binding protein; Motility/polarity/chemotaxis Cellular Component: dynein complex; centrosome; microtubule; plasma membrane; myosin complex; cytosol Molecular Function: cytoskeletal protein binding; motor activity Biological Process: transport; apoptosis; antigen processing and presentation of exogenous peptide antigen via MHC class II; microtubule-based process; synaptic target recognition Reference #:  Q96FJ2 (UniProtKB) Alt. Names/Synonyms: 8 kDa dynein light chain b; DLC2; DLC8b; DNCL1B; DYL2; Dynein light chain 2, cytoplasmic; Dynein light chain LC8-type 2; dynein, light chain, LC8-type 2; DYNLL2; MGC17810; radial spoke 22 homolog; RSPH22 Gene Symbols: DYNLL2 Molecular weight: 10,350 Da Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states

Select Structure to View Below DYNLL2 2XQQ - A/D/C/B=1-89 (human) 3P8M - A/B=1-89 (human) 1PWJ - A=1-89 (mouse) 1PWK - A=1-89 (mouse)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 2XQQ 3P8M  |  DISEASE  |  Source  |  UCSD-Nature  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains
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	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S14	VIKNADMSEDMQQDA
0	2		Y32	ATQAMEKyNIEKDIA
0	1		Y41	IEKDIAAyIKKEFDK
0	1		S64	IVGRNFGsyVTHETK
0	186		Y65	VGRNFGsyVTHETKH
1	0		S88	VAILLFKsG______

	mouse
S14	VIKNADMsEDMQQDA
Y32	ATQAMEKYNIEKDIA
Y41	IEKDIAAYIKKEFDK
S64	IVGRNFGSyVTHETK
Y65	VGRNFGSyVTHETKH
S88	VAILLFKSG______

	rat
S14	VIKNADMSEDMQQDA
Y32	ATQAMEKyNIEKDIA
Y41	IEKDIAAYIKKEFDK
S64	IVGRNFGSyVTHETK
Y65	VGRNFGSyVTHETKH
S88	VAILLFKSG______

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