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Protein Page:
DDC (human)
p Phosphorylation
a Acetylation
m Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
u Ubiquitination
s Sumoylation
n Neddylation
gl O-GlcNAc
ga O-GalNAc
h Palmitoylation
ad Adenylylation
sn S-Nitrosylation
ca Caspase cleavage

Overview
DDC Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Homodimer. Belongs to the group II decarboxylase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - histidine; Lyase; EC 4.1.1.28; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - tryptophan
Cellular Component: synaptic vesicle; cell soma; axon; cytosol
Molecular Function: amino acid binding; aromatic-L-amino-acid decarboxylase activity; protein domain specific binding; protein binding; pyridoxal phosphate binding
Biological Process: circadian rhythm; amino acid metabolic process; catecholamine biosynthetic process; indolalkylamine biosynthetic process; multicellular organismal aging; isoquinoline alkaloid metabolic process; dopamine biosynthetic process; serotonin biosynthetic process; synaptic vesicle amine transport; phytoalexin metabolic process; response to pyrethroid
Reference #:  P20711 (UniProtKB)
Alt. Names/Synonyms: AADC; Aromatic-L-amino-acid decarboxylase; DDC; DOPA decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase)
Gene Symbols: DDC
Molecular weight: 53,926 Da
Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states
CST Pathways:  Parkinson's Disease
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DDC

Protein Structure Not Found.


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Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 1 K205 AGLIGGVKLKAIPSD
0 1 K207 LIGGVKLKAIPSDGN
  mouse

 
K205-u AGLIGGIkLkAVPSD
K207-u LIGGIkLkAVPSDGN
  rat

 
K205 AGLIGGVKIKAIPSD
K207 LIGGVKIKAIPSDGN
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