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DDC (human)

Overview DDC Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Homodimer. Belongs to the group II decarboxylase family. Note: This description may include information from UniProtKB. Protein type: Amino Acid Metabolism - histidine; Amino Acid Metabolism - tryptophan; EC 4.1.1.28; Amino Acid Metabolism - tyrosine; Lyase; Amino Acid Metabolism - phenylalanine Cellular Component: synaptic vesicle; cell soma; axon; cytosol Molecular Function: protein domain specific binding; aromatic-L-amino-acid decarboxylase activity; amino acid binding; protein binding; pyridoxal phosphate binding Biological Process: circadian rhythm; amino acid metabolic process; catecholamine biosynthetic process; indolalkylamine biosynthetic process; multicellular organismal aging; isoquinoline alkaloid metabolic process; dopamine biosynthetic process; serotonin biosynthetic process; synaptic vesicle amine transport; phytoalexin metabolic process; response to pyrethroid Reference #:  P20711 (UniProtKB) Alt. Names/Synonyms: AADC; Aromatic-L-amino-acid decarboxylase; DDC; DOPA decarboxylase; dopa decarboxylase (aromatic L-amino acid decarboxylase) Gene Symbols: DDC Molecular weight: 53,926 Da Basal Isoelectric point: 6.77  Predict pI for various phosphorylation states CST Pathways:  Parkinson's Disease Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DDC 3RBL - A/B=1-480 (human) 3RCH - A/B=1-480 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 3RBL 3RCH  |  ENZYME  |  DISEASE 107930 608643  |  Source  |  InnateDB  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		Y20-p	MVDYMANyMEGIEGR
0	1		K205	AGLIGGVKLKAIPSD
0	1		K207	LIGGVKLKAIPSDGN

	mouse
Y20	MVDYIADYLDGIEGR
K205-u	AGLIGGIkLkAVPSD
K207-u	LIGGIkLkAVPSDGN

	rat
Y20	MVDYIADYLDGIEGR
K205	AGLIGGVKIKAIPSD
K207	LIGGVKIKAIPSDGN

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