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Protein Page:
DBH (human)

Overview
DBH Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Motility/polarity/chemotaxis; Oxidoreductase; EC 1.14.17.1; Membrane protein, integral; Cell cycle regulation; Amino Acid Metabolism - tyrosine
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: membrane; cytoplasm; extracellular region; integral to membrane
Molecular Function: copper ion binding; L-ascorbic acid binding; dopamine beta-monooxygenase activity; catalytic activity
Biological Process: fear response; dopamine catabolic process; maternal behavior; response to amphetamine; cytokine production; locomotory behavior; response to pain; behavioral response to ethanol; leukocyte mediated immunity; glucose homeostasis; memory; regulation of cell proliferation; norepinephrine biosynthetic process; synaptic transmission; catecholamine biosynthetic process; homoiothermy; positive regulation of vasoconstriction; visual learning; blood vessel remodeling; leukocyte migration
Reference #:  P09172 (UniProtKB)
Alt. Names/Synonyms: DBH; DBM; Dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenase; DOPO; Soluble dopamine beta-hydroxylase
Gene Symbols: DBH
Molecular weight: 69,065 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DBH

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y310-p ALGAKAFyYPEEAGL
0 1 Y327-p GGPGSSRyLRLEVHy
0 1 Y334-p yLRLEVHyHNPLVIE
0 1 Y353-p SSGIRLYyTAKLRRF
0 1 T422-p LTGRKVVtVLVRDGR
0 1 S587-p QPLPKVIstLEEPTP
0 1 T588-p PLPKVIstLEEPTPQ
0 1 S603-p CPTSQGRsPAGPTVV
  mouse

 
Y314 ALGAKAFYYPKEAGV
F331 GGPGSSPFLRLEVHY
Y338 FLRLEVHYHNPRKIQ
Y357 SSGIRLHYTATLRRY
T426 LTGRKVVTVLARDGQ
S591 QPLPKITSTLEEPTP
T592 PLPKITSTLEEPTPR
S607 CPIRQTQSPANPTVP
  rat

 
Y313 ALGAKAFYYPEEAGV
F330 GSSGSSRFLRLEVHY
Y337 FLRLEVHYHNPRNIQ
Y356 SSGIRLHYTASLRPN
T425 LTGRKVITVLARDGQ
S590 QPLPNITSAVEEPDP
A591 PLPNITSAVEEPDPR
G606 CPIRQTRGPAGPFVV
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