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Protein Page:
DBH (human)

Overview
DBH Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tyrosine; EC 1.14.17.1; Apoptosis; Motility/polarity/chemotaxis; Cell cycle regulation; Oxidoreductase; Membrane protein, integral
Cellular Component: membrane; cytoplasm; integral to membrane; extracellular region
Molecular Function: copper ion binding; L-ascorbic acid binding; dopamine beta-monooxygenase activity; catalytic activity
Biological Process: fear response; dopamine catabolic process; maternal behavior; response to amphetamine; cytokine production; locomotory behavior; response to pain; behavioral response to ethanol; leukocyte mediated immunity; glucose homeostasis; memory; regulation of cell proliferation; norepinephrine biosynthetic process; synaptic transmission; catecholamine biosynthetic process; homoiothermy; positive regulation of vasoconstriction; visual learning; blood vessel remodeling; leukocyte migration
Reference #:  P09172 (UniProtKB)
Alt. Names/Synonyms: DBH; DBM; Dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenase; DOPO; Soluble dopamine beta-hydroxylase
Gene Symbols: DBH
Molecular weight: 69,065 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

DBH

Protein Structure Not Found.


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Modification Sites and Domains  

Modification Sites in Parent Protein, Orthologs, and Isoforms  
 

Show Multiple Sequence Alignment


 SS 

SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 MS 

MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

 
0 3 Y310-p ALGAKAFyYPEEAGL
  mouse

 
Y314 ALGAKAFYYPKEAGV
  rat

 
Y313 ALGAKAFYYPEEAGV
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