Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tyrosine; EC 22.214.171.124; Apoptosis; Motility/polarity/chemotaxis; Cell cycle regulation; Oxidoreductase; Membrane protein, integral
Cellular Component: membrane; cytoplasm; integral to membrane; extracellular region
SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.