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DBH (human)

Overview DBH Conversion of dopamine to noradrenaline. Homotetramer composed of two non-covalently bound disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. Belongs to the copper type II ascorbate-dependent monooxygenase family. Note: This description may include information from UniProtKB. Protein type: Cell cycle regulation; Membrane protein, integral; EC 1.14.17.1; Oxidoreductase; Apoptosis; Motility/polarity/chemotaxis; Amino Acid Metabolism - tyrosine Cellular Component: cell soma; membrane; apical part of cell; cytoplasm; dendrite; extracellular region; integral to membrane; terminal button; secretory granule Molecular Function: copper ion binding; L-ascorbic acid binding; dopamine beta-monooxygenase activity; catalytic activity Biological Process: response to peptide hormone stimulus; fear response; dopamine catabolic process; response to pain; locomotory behavior; behavioral response to ethanol; leukocyte mediated immunity; glucose homeostasis; response to estradiol stimulus; norepinephrine biosynthetic process; regulation of apoptosis; synaptic transmission; catecholamine biosynthetic process; homoiothermy; visual learning; response to iron ion; octopamine metabolic process; sensory perception of taste; maternal behavior; response to amphetamine; multicellular organismal aging; cytokine production; social behavior; memory; regulation of cell proliferation; response to copper ion; response to ozone; positive regulation of vasoconstriction; blood vessel remodeling; leukocyte migration Reference #:  P09172 (UniProtKB) Alt. Names/Synonyms: DBH; DBM; Dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenase; DOPO; Soluble dopamine beta-hydroxylase Gene Symbols: DBH Molecular weight: 69,065 Da Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below DBH 1ZHB - F/C/I/L=556-564 (rat)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  ENZYME  |  DISEASE 168600 223360 609312  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	3		Y310-p	ALGAKAFyYPEEAGL
0	1		Y327-p	GGPGSSRyLRLEVHy
0	1		Y334-p	yLRLEVHyHNPLVIE
0	1		Y353-p	SSGIRLYyTAKLRRF
0	1		T422-p	LTGRKVVtVLVRDGR
0	1		S587-p	QPLPKVIstLEEPTP
0	1		T588-p	PLPKVIstLEEPTPQ
0	1		S603-p	CPTSQGRsPAGPTVV

	mouse
Y314	ALGAKAFYYPKEAGV
F331	GGPGSSPFLRLEVHY
Y338	FLRLEVHYHNPRKIQ
Y357	SSGIRLPYTATLRRY
T426	LTGRKVVTVLARDGQ
S591	QPLPKITSTLEEPTP
T592	PLPKITSTLEEPTPR
S607	CPIRQTQSPANPTVP

	rat
Y313	ALGAKAFYYPEEAGV
F330	GSSGSSRFLRLEVHY
Y337	FLRLEVHYHNPRNIQ
Y356	SSGIRLHYTASLRPN
T425	LTGRKVITVLARDGQ
S590	QPLPNITSAVEEPDP
A591	PLPNITSAVEEPDPR
G606	CPIRQTRGPAGPFVV

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