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Protein Page:
HSL (human)
p Phosphorylation
ac Acetylation
me Methylation
m1 Mono-methylation
m2 Di-methylation
m3 Tri-methylation
ub Ubiquitylation
sm Sumoylation
ne Neddylation
gl O-GlcNAc
ga O-GalNAc
pa Palmitoylation
ad Adenylation
sn S-Nitrosylation
ca Caspase cleavage
sc Succinylation

Overview
HSL hormone sensitive lipase is a lipolytic enzyme of the 'GDXG' family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin. Note: This description may include information from UniProtKB.
Protein type: Lipase; EC 3.1.1.79
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: lipid particle; caveola; cytosol
Molecular Function: hormone-sensitive lipase activity; triacylglycerol lipase activity; protein binding; protein kinase binding
Biological Process: cholesterol metabolic process; triacylglycerol catabolic process; diacylglycerol catabolic process; protein amino acid phosphorylation; lipid catabolic process; long-chain fatty acid catabolic process
Disease: Abdominal Obesity-metabolic Syndrome 4
Reference #:  Q05469 (UniProtKB)
Alt. Names/Synonyms: Hormone-sensitive lipase; hormone-sensitive lipase testicular isoform; HSL; LHS; lipase, hormone-sensitive; LIPE; LIPS
Gene Symbols: LIPE
Molecular weight: 116,598 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

HSL

Protein Structure Not Found.


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Sites Implicated In
enzymatic activity, induced: S853‑p, S855‑p, S950‑p, S951‑p
molecular association, regulation: S855‑p, S950‑p, S951‑p

Modification Sites and Domains Show Modification Legend
Click here to view phosphorylation modifications only

Modification Sites in Parent Protein, Orthologs, and Isoforms Show Modification Legend
 

Show Multiple Sequence Alignment


 LTP 

LTP: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.


 HTP 

HTP: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.


       human

► Hide Isoforms
 
0 1 T188-p PEQSDKQtTPVQGAK
0 1 S196-p TPVQGAKsKQGSLTE
0 1 S200 GAKsKQGSLTELGFL
0 1 N301 TASRLIHNMDLRTMT
0 3 S335 GETAQRLSGVFAGVR
0 3 Y393 HLLHKSRYVASNRRS
0 1 K624-ub EELSSLIkSNGQRSL
0 1 S645-p QQAPRSRsLIVHFHG
0 2 Y741-p VALRAAAyGVRVPDG
0 1 S781 LLPLSVLSKCVSAYA
0 1 S798 KTEDHSNSDQKALGM
0 2 - gap
0 3 - gap
0 1 - gap
0 1 - gap
25 9 S853-p IAEPMRRsVsEAALA
19 16 S855-p EPMRRsVsEAALAQP
0 1 T868 QPQGPLGTDSLKNLT
0 2 S870 QGPLGTDSLKNLTLR
1 0 T891 NSETSSDTPEMSLSA
0 1 S897 DTPEMSLSAETLSPS
0 1 A918 FLLPPEDAGEEAEAK
0 1 - under review  
7 5 S950-p EGFHPRRssQGAtQM
17 24 S951-p GFHPRRssQGAtQMP
0 3 T955-p RRssQGAtQMPLYSS
0 1 S961 AtQMPLYSSPIVKNP
0 1 T1015-p RNLGQPVtLRVVEDL
0 1 - under review  
4139 : Phospho-HSL (Ser563) Antibody
4137 : Phospho-HSL (Ser565) Antibody
  HSL iso2  
- gap
- gap
- gap
- under review  
S34 GETAQRLSGVFAGVR
Y92 HLLHKSRYVASNRRS
K323 EELSSLIKSNGQRSL
S344 QQAPRSRSLIVHFHG
Y440 VALRAAAYGVRVPDG
S480 LLPLSVLSKCVSAYA
S497 KTEDHSNSDQKALGM
- gap
- gap
- gap
- gap
S552-p IAEPMRRsVSEAALA
S554 EPMRRsVSEAALAQP
T567 QPQGPLGTDSLKNLT
S569 QGPLGTDSLKNLTLR
T590 NSETSSDTPEMSLSA
S596 DTPEMSLSAETLSPS
A617 FLLPPEDAGEEAEAK
S628 AEAKNELSPMDRGLG
S649 EGFHPRRSSQGATQM
S650 GFHPRRSSQGATQMP
T654 RRSSQGATQMPLYSS
S660 ATQMPLYSSPIVKNP
T714 RNLGQPVTLRVVEDL
H775 DGGCGGRH_______
  mouse

► Hide Isoforms
 
- gap
- gap
- gap
- under review  
S34-p GETARRLsNVFAGVR
Y92 HLLHKSRYVASNRKS
K323 KVLNSLAKSEGPRLE
- gap
Y439 VSLRAAAYGVRVPDG
S479 LLPLSVLSKCVSAYS
S496-p EAEDHFDsDQKALGV
S512-p GLVQRDTsLFLRDLR
S542-p RKPQKTTsPtAESVR
T544-p PQKTTsPtAESVRPt
T551-p tAESVRPtESMRRsV
S557-p PtESMRRsVsEAALA
S559-p ESMRRsVsEAALAQP
T572-p QPEGLLGtDtLKKLT
T574-p EGLLGtDtLKKLTIK
S591 SNSEPSDSPEMSQsM
S597-p DSPEMSQsMETLGPS
S618 FFLRPGNSQEEAEAK
R629 AEAKDEVRPMDGVPR
S650-p EGFHPRRssQGVLHM
S651-p GFHPRRssQGVLHMP
L655 RRssQGVLHMPLYtS
T661-p VLHMPLYtSPIVKNP
T715 RDLGQPVTLKVVEDL
N759 TPPAAPLN_______
4139 : Phospho-HSL (Ser563) Antibody
4137 : Phospho-HSL (Ser565) Antibody
4126 : Phospho-HSL (Ser660) Antibody
  HSL iso3  
T199 SDPTAQQTPLVQGAK
S207 PLVQGAKSKQGsLTE
S211-p GAKSKQGsLTESGFL
S313-p TASAFSHsMDLRTMT
S347 GETARRLSNVFAGVR
Y405 HLLHKSRYVASNRKS
K636 KVLNSLAKSEGPRLE
- gap
Y752 VSLRAAAYGVRVPDG
S792 LLPLSVLSKCVSAYS
S809 EAEDHFDSDQKALGV
S825 GLVQRDTSLFLRDLR
S855 RKPQKTTSPTAESVR
T857 PQKTTSPTAESVRPT
T864 TAESVRPTESMRRSV
S870 PTESMRRSVSEAALA
S872 ESMRRSVSEAALAQP
T885 QPEGLLGTDTLKKLT
T887 EGLLGTDTLKKLTIK
S904 SNSEPSDSPEMSQSM
S910 DSPEMSQSMETLGPS
S931 FFLRPGNSQEEAEAK
R942 AEAKDEVRPMDGVPR
S963 EGFHPRRSSQGVLHM
S964 GFHPRRSSQGVLHMP
L968 RRSSQGVLHMPLYTS
T974 VLHMPLYTSPIVKNP
T1028 RDLGQPVTLKVVEDL
N1072 TPPAAPLN_______
  rat

► Hide Isoforms
 
T187 SDPTAQQTPLVQGVK
S195 PLVQGVKSDQGSLIE
S199 GVKSDQGSLIESGIL
S300 TASAFSHSMDLRTMT
S334 GETARRLSNVFAGVR
Y392-p HLLHKSRyVASNRRS
K623 KMLNSLAKSEGPRLE
- gap
Y739 VSLRAAAYGVRVPDG
S779-p LLPLSVLsKCVSAYS
S796 ETEDHFDSDQKALGV
S812 GLVQRDTSLFLRDLR
- gap
T845 HKTPLPATETLRPTD
T857 PTDSGRLTESMRRsV
S863-p LTESMRRsVsEAALA
S865-p ESMRRsVsEAALAQP
T878 QPEGLLGTDSLKKLT
S880 EGLLGTDSLKKLTIK
S900-p GNSEPSDsPEMSQsM
S906-p DsPEMSQsMETLGPS
S927-p FFLRSGNsQEEAETR
S938-p AETRDDIsPMDGIPR
S959-p DGFHPRRssQGVLHM
S960-p GFHPRRssQGVLHMP
L964 RRssQGVLHMPLYSS
S970 VLHMPLYSSPIVKNP
T1024 KDLGQPVTLKVVEDL
T1068-p TPPAAPLt_______
4137 : Phospho-HSL (Ser565) Antibody
4126 : Phospho-HSL (Ser660) Antibody
  HSL iso2  
- gap
- gap
- gap
- under review  
S34 GETARRLSNVFAGVR
Y92 HLLHKSRYVASNRRS
K323 KMLNSLAKSEGPRLE
- gap
Y439 VSLRAAAYGVRVPDG
S479 LLPLSVLSKCVSAYS
S496 ETEDHFDSDQKALGV
S512 GLVQRDTSLFLRDLR
- gap
T545 HKTPLPATETLRPTD
T557 PTDSGRLTESMRRSV
S563 LTESMRRSVSEAALA
S565 ESMRRSVSEAALAQP
T578 QPEGLLGTDSLKKLT
S580 EGLLGTDSLKKLTIK
S600 GNSEPSDSPEMSQSM
S606 DSPEMSQSMETLGPS
S627 FFLRSGNSQEEAETR
S638 AETRDDISPMDGIPR
S659-p DGFHPRRsSQGVLHM
S660 GFHPRRsSQGVLHMP
L664 RRsSQGVLHMPLYSS
S670 VLHMPLYSSPIVKNP
T724 KDLGQPVTLKVVEDL
T768 TPPAAPLT_______
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