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HSL (human)

Overview HSL hormone sensitive lipase is a lipolytic enzyme of the 'GDXG' family. Plays a rate limiting step in triglyceride lipolysis. In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Rapidly activated by cAMP-dependent phosphorylation under the influence of catecholamines. Dephosphorylation and inactivation are controlled by insulin. Note: This description may include information from UniProtKB. Protein type: EC 3.1.1.79; Lipase Cellular Component: extracellular space; lipid particle; caveola; cytosol Molecular Function: hormone-sensitive lipase activity; triacylglycerol lipase activity; protein binding; acylglycerol lipase activity; protein kinase binding Biological Process: response to drug; cholesterol metabolic process; triacylglycerol catabolic process; diacylglycerol catabolic process; lipid metabolic process; female pregnancy; protein amino acid phosphorylation; lipid catabolic process Reference #:  Q05469 (UniProtKB) Alt. Names/Synonyms: Hormone-sensitive lipase; hormone-sensitive lipase testicular isoform; HSL; LHS; lipase, hormone-sensitive; LIPE; LIPS Gene Symbols: LIPE Molecular weight: 116,598 Da Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®

Select Structure to View Below HSL

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	Sites Implicated In
enzymatic activity, induced: S853‑p, S855‑p, S950‑p, S951‑p molecular association, regulation: S855‑p, S950‑p, S951‑p

	Modification Sites and Domains	Show Modification Legend
Click here to view phosphorylation modifications only

	Modification Sites in Parent Protein, Orthologs, and Isoforms	Show Modification Legend

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human ► Hide Isoforms
0	1		T188-p	PEQSDKQtTPVQGAK
0	1		S196-p	TPVQGAKsKQGSLTE
0	1		S200	GAKsKQGSLTELGFL
0	1		T313-p	TMTQSLVtLAEDNIA
0	1		S324-p	DNIAFFSsQGPGEtA
0	1		T330-p	SsQGPGEtAQRLSGV
0	2		S335	GEtAQRLSGVFAGVR
0	3		Y393-p	HLLHKSRyVASNRRS
0	1		K624-u	EELSSLIkSNGQRSL
0	1		S645-p	QQAPRSRsLIVHFHG
0	2		Y741-p	VALRAAAyGVRVPDG
0	1		A814	GLVRRDTALLLRDFR
0	1		-	gap
0	1		-	gap
22	5		S853-p	IAEPMRRsVsEAALA
17	8		S855-p	EPMRRsVsEAALAQP
0	1		S870	QGPLGTDSLKNLTLR
1	0		T891	NSETSSDTPEMSLSA
6	2		S950-p	EGFHPRRssQGATQM
15	16		S951-p	GFHPRRssQGATQMP
0	1		T1015-p	RNLGQPVtLRVVEDL

	HSL iso2
-	gap
-	gap
-	gap
T12	TMTQSLVTLAEDNIA
S23	DNIAFFSSQGPGETA
T29	SSQGPGETAQRLSGV
S34	GETAQRLSGVFAGVR
Y92	HLLHKSRYVASNRRS
K323	EELSSLIKSNGQRSL
S344	QQAPRSRSLIVHFHG
Y440	VALRAAAYGVRVPDG
A513	GLVRRDTALLLRDFR
-	gap
-	gap
S552-p	IAEPMRRsVSEAALA
S554	EPMRRsVSEAALAQP
S569	QGPLGTDSLKNLTLR
T590	NSETSSDTPEMSLSA
S649	EGFHPRRSSQGATQM
S650	GFHPRRSSQGATQMP
T714	RNLGQPVTLRVVEDL

	mouse
T199	SDPTAQQTPLVQGAK
S207	PLVQGAKSKQGsLTE
S211-p	GAKSKQGsLTESGFL
T325	TMTQSLVTLAEDNMA
S336	DNMAFFSSQGPGETA
T342	SSQGPGETARRLsNV
S347-p	GETARRLsNVFAGVR
Y405	HLLHKSRYVASNRKS
K636	KVLNSLAKSEGPRLE
A656	HQAPRSRALVVHIHG
Y752	VSLRAAAYGVRVPDG
S825-p	GLVQRDTsLFLRDLR
S855-p	RKPQKTTsPtAESVR
T857-p	PQKTTsPtAESVRPT
S870-p	PTESMRRsVsEAALA
S872-p	ESMRRsVsEAALAQP
T887-p	EGLLGTDtLKKLTIK
S904	SNSEPSDSPEMSQSM
S963-p	EGFHPRRssQGVLHM
S964-p	GFHPRRssQGVLHMP
T1028	RDLGQPVTLKVVEDL

	rat ► Hide Isoforms
T187	SDPTAQQTPLVQGVK
S195	PLVQGVKSDQGSLIE
S199	GVKSDQGSLIESGIL
A312	TMTQSLVALAEDNMA
S323	DNMAFFSSQGPGETA
T329	SSQGPGETARRLSNV
S334	GETARRLSNVFAGVR
Y392-p	HLLHKSRyVASNRRS
K623	KMLNSLAKSEGPRLE
A643	QQAPRSRALVVHIHG
Y739	VSLRAAAYGVRVPDG
S812	GLVQRDTSLFLRDLR
T845	HKTPLPATETLRPTD
T847	TPLPATETLRPTDSG
S863-p	LTESMRRsVsEAALA
S865-p	ESMRRsVsEAALAQP
S880	EGLLGTDSLKKLTIK
S900-p	GNSEPSDsPEMSQSM
S959-p	DGFHPRRssQGVLHM
S960-p	GFHPRRssQGVLHMP
T1024	KDLGQPVTLKVVEDL

	HSL iso2
-	gap
-	gap
-	gap
A12	TMTQSLVALAEDNMA
S23	DNMAFFSSQGPGETA
T29	SSQGPGETARRLSNV
S34	GETARRLSNVFAGVR
Y92	HLLHKSRYVASNRRS
K323	KMLNSLAKSEGPRLE
A343	QQAPRSRALVVHIHG
Y439	VSLRAAAYGVRVPDG
S512	GLVQRDTSLFLRDLR
T545	HKTPLPATETLRPTD
T547	TPLPATETLRPTDSG
S563	LTESMRRSVSEAALA
S565	ESMRRSVSEAALAQP
S580	EGLLGTDSLKKLTIK
S600	GNSEPSDSPEMSQSM
S659	DGFHPRRSSQGVLHM
S660	GFHPRRSSQGVLHMP
T724	KDLGQPVTLKVVEDL

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