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GMCSF (mouse)

Overview GMCSF Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. Note: This description may include information from UniProtKB. Protein type: Secreted; Cytokine; Secreted, signal peptide Cellular Component: extracellular space; extracellular region Molecular Function: growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; positive regulation of interleukin-23 production; myeloid dendritic cell differentiation; regulation of cell proliferation; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of gene expression; positive regulation of cell proliferation; immune response; positive regulation of DNA replication; negative regulation of apoptosis Reference #:  P01587 (UniProtKB) Alt. Names/Synonyms: colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; Csf2; Csfgm; GM-CSF; granulocyte-macrophage colony stimulating factor 2; Granulocyte-macrophage colony-stimulating factor; MGC151255; MGC151257; MGI-IGM; OTTMUSP00000005830; put. GM-CSF Gene Symbols: Csf2 Molecular weight: 16,091 Da Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states

Select Structure to View Below GMCSF 1CSG - A/B=18-144 (human) 2GMF - A/B=18-144 (human) 3CXE - B=18-144 (human)

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	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			mouse
0	1		N83	FEQGLRGNFTKLKGA
0	1		N92	TKLKGALNMTASYYQ
0	1		T116	DCETQVTTYADFIDS

	human
S86-p	YKQGLRGsLTKLKGP
T95-p	TKLKGPLtMMASHYK
T119-p	SCATQIItFESFKEN

	rat
N86	YKQGLRGNLTKLNGA
T95	TKLNGALTMIASHYQ
T119	DCEIEVTTFEDFIKN

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