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GMCSF (human)

Overview GMCSF Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. Note: This description may include information from UniProtKB. Protein type: Secreted; Secreted, signal peptide; Cytokine Cellular Component: extracellular space; extracellular region Molecular Function: protein binding; growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; positive regulation of tyrosine phosphorylation of Stat5 protein; positive regulation of interleukin-23 production; positive regulation of cell proliferation; myeloid dendritic cell differentiation; immune response; positive regulation of DNA replication; negative regulation of apoptosis Reference #:  P04141 (UniProtKB) Alt. Names/Synonyms: colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; CSF2; GM-CSF; GMCSF; granulocyte-macrophage colony stimulating factor; Granulocyte-macrophage colony-stimulating factor; MGC131935; MGC138897; Molgramostin; Sargramostim Gene Symbols: CSF2 Molecular weight: 16,295 Da Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states

Select Structure to View Below GMCSF 1CSG - A/B=18-144 (human) 2GMF - A/B=18-144 (human) 3CXE - B=18-144 (human)

STRING  |  Scansite  |  Phospho.ELM  |  Pfam  |  RCSB PDB 1CSG 2GMF 3CXE  |  Phospho3D  |  DISEASE  |  Source  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene

	Modification Sites and Domains

	Modification Sites in Parent Protein, Orthologs, and Isoforms

SS  SS: The number of records in which this modification site was determined using site-specific methods. SS methods include amino acid sequencing, site-directed mutagenesis, modification site-specific antibodies, specific MS strategies, etc.	MS  MS: The number of records in which this modification site was assigned using ONLY proteomic discovery-mode mass spectrometry.			human
0	1		S86-p	YKQGLRGsLTKLKGP
0	1		T95-p	TKLKGPLtMMASHYK
0	1		T119-p	SCATQIItFESFKEN

	mouse
N83	FEQGLRGNFTKLKGA
N92	TKLKGALNMTASYYQ
T116	DCETQVTTYADFIDS

	rat
N86	YKQGLRGNLTKLNGA
T95	TKLNGALTMIASHYQ
T119	DCEIEVTTFEDFIKN

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